Clinical trials: Primary Parkinsonism
Neurocognitive Disorders
DRIVing Simulator and People With NeuroCognitive Disorders
The ageing of the population is leading to an increasing number of older drivers on the roads. At the same time, the proportion of older people with pathological ageing and neurocognitive disorders (NCD) is increasing.
- Trial name
- DRIVS-NCD (NCT06320639)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Gustave Eiffel
Dyskinesias, Parkinson Disease
Evaluation of the Efficacy and Safety of Modified Release AFQ056 in Parkinson's Patients With L-dopa Induced Dyskinesias
This study will assess the efficacy and safety of modified release AFQ056 in patients that have Parkinson's Disease L-dopa Induced Dyskinesias (PD-LID)
- Conditions
- Dyskinesias, Parkinson Disease, Movement Disorders, Parkinsonian Disorders
- Trial name
- NCT01491529
- Testing
- AFQ056
- Where
- 39 sites in United States, Austria and 8 more
- Volunteers
- 154 people
- Sponsor
- Novartis Pharmaceuticals
Parkinson's Disease, Somatosensory Disorders
Somatosensory Dysfunction as the Underlying Mechanism of Upper Limbs Motor Blocks in People With Parkinson's Disease
Motor blocks during gait and upper limb movements (FOULs) are a disabling and common motor impairment in mild to severe stages of Parkinson's disease (PD).
- Trial name
- NCT02610257
- Testing
- Mechanical stimulus (vibration) applied on the forearm
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Parkinson Disease
Personalized Real-Time DBS and PD Mechanisms
A prospective cohort of patients scheduled to undergo deep brain stimulation (DBS) implantation surgery for the treatment of Parkinson's disease as per standard of care will be invited to participate in this study.
- Trial name
- NCT06013956
- Testing
- Neurostimulation, Carbidopa 25/Levodopa 100Mg Tab
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- David Escobar
Parkinson Disease
Study of Feasibility and Efficacy of Telecommunication Platforms as an Adjunctive Clinical Tool for a Parkinson's Disease Clinic
Telecommunication Platforms are new technology founded to build better short messages service alternative. Their use have increasingly drawn a wider range of interest as a text communication and video chat system between health…
- Trial name
- NCT04695353
- Testing
- Telemedicine: Virtual visits (videoconferences, texts)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Universitario de Burgos
Parkinson Disease Dementia
To Evaluate the Safety of DBS in Patients With Primary Parkinson's Disease
To evaluate the safety of implantable rechargeable computer deep nerve stimulation system produced by Jiangsu Changyida Medical Technology Co., Ltd. for patients with primary Parkinson's disease
- Trial name
- NCT06494956
- Testing
- Implant device
- Volunteers
- 3 people
- Sponsor
- Jiangsu CED Medtech Co., Ltd
Parkinson Disease, Aging
Mobilise-D: Extension Study
The goal of this observational study is to investigate the ability of a mobility monitor to measure and predict outcomes in Parkinson's disease (PD).
- Trial name
- NCT05874739
- Where
- United Kingdom
- Volunteers
- 651 people, healthy volunteers welcome
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Parkinson Disease
Primary Parkinsonian Pain Diagnostic Questionnaire: Development and Validation of This Questionnaire
Development and validation of a diagnosis questionnaire of parkinsonian primary pain: the "Primary Parkinsonian Pain Diagnostic Questionnaire" (3PDQ)
- Trial name
- 3PDQ (NCT03940872)
- Testing
- Self-questionnaire 3PDQ
- Where
- 10 sites in France
- Volunteers
- 227 people
- Sponsor
- University Hospital, Toulouse
Parkinson Disease, Deglutition Disorders
Describe to Better Understand, the Mealtime of People With Parkinson's Disease Dependent on Food Intake
The main objective is to describe strategies (verbal, non-verbal (gesture, intonation), and environmental), designed and used by the assisting/aided dyad to feed a dysphagic dependent person by articulating the safe and hedonic…
- Trial name
- AideAlimPark (NCT05898139)
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Toulouse
Parkinson Disease
Exploring the Effects of Exercise on Memory and Cognition in Parkinson´s Disease
The study aims to assess the effects of cardiovascular (aerobic) training on memory formation and cognitive function in people with Parkinson's disease.
- Trial name
- EMCo (NCT06580977)
- Testing
- cardiovascular training, stretching
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heidelberg University
Parkinson's Disease, Multiple Sclerosis
Blood Lactate Concentrations With and Without Exercise in Parkinson's Disease and Multiple Sclerosis Patients
Fatigue is one of the most common and debilitating symptoms experienced in Parkinson's Disease (PD) and Multiple Sclerosis (MS).
- Trial name
- PDMSLac (NCT02184494)
- Testing
- pro5 AIRdaptive Power Plate (Badhoevedorp, The Netherlands)
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Florida State University
Parkinson Disease
Clinical Study of Stalevo in the Treatment of Early Parkinson's Disease
The main goal of PD research is to develop disease-modifying drugs to delay or prevent the underlying neurodegenerative process.
- Trial name
- NCT04952194
- Testing
- Stalevo, Carbidopa and Levodopa Controlled Release Tablets
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Parkinson Disease, Constipation
Efficacy of Acupuncture for the Treatment of Parkinson's Disease Related Constipation
The purpose of the study is to evaluate the efficacy of acupuncture in treating Parkinson's disease related constipation (PDC). In the randomized controlled clinical trial study, patients meeting the criteria for inclusion will…
- Conditions
- Parkinson Disease, Constipation, Non-motor Symptom, Randomized Controlled Trial
- Trial name
- AFPDC (NCT06390761)
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xi'an No.3 Hospital
Parkinson Disease, Deep Brain Stimulation
Study on Brain Network Mechanism of Deep Brain Stimulation for Parkinson's Disease
As a surgical intervention, DBS can effectively relieve PD tremor, rigidity, bradykinesia and other symptoms. How to better screen patients suitable for DBS treatment and conduct reasonable preoperative and postoperative…
- Conditions
- Parkinson Disease, Deep Brain Stimulation, Non-motor Symptoms
- Trial name
- NCT05959161
- Testing
- DBS
- Volunteers
- 100 people
- Sponsor
- Tianjin Huanhu Hospital
Parkinson Disease
The Effect of Clinical Pilates Training on Balance and Postural Control of People With Parkinson's Disease.
Many studies showed that clinical pilates exercises has positive effects on static and dynamic balance of different populations. It was suggested that this type of exercise reduce the risk of falls and physical damage.
- Trial name
- NCT04063605
- Testing
- Clinical Pilates, Classic Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- European University of Lefke
Parkinson's Disease
Trial of Ursodeoxycholic Acid (UDCA) for Parkinson's Disease: The "UP" Study
The aim of this study is to explore the potential of Ursodeoxycholic acid (UDCA) to slow down the progression of Parkinson's Disease (PD) in a randomised, double-blind, placebo-controlled, "proof of concept" study.
- Trial name
- NCT03840005
- Testing
- Ursonorm
- Where
- 2 sites in United Kingdom
- Volunteers
- 31 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Dementia (Diagnosis), Parkinson Disease Dementia (PDD)
Enhancing Utility of Neuropsychological Evaluation for Earlier and Effective Diagnosis of Dementia in Parkinson's Disease
Dementia is observed in 80% of people living with advanced stage Parkinson's disease, however, there are inadequate opportunities for early and effective diagnosis of dementia in current clinical practice.
- Conditions
- Dementia (Diagnosis), Parkinson Disease Dementia (PDD), Parkinson Disease (PD)
- Trial name
- PDCogniCare (NCT07114354)
- Testing
- PDCogniCare platform
- Volunteers
- 275 people
- Sponsor
- The University of Queensland
Parkinson Disease, Amyotrophic Lateral Sclerosis
Incobotulinum Toxin A for Sialorrhea in Parkinson's Disease (PD)/Parkinsonism and Amyotrophic Lateral Sclerosis (ALS)
The purpose of this study is to evaluate the safety and efficacy of Incobotulinum Toxin A (Xeomin®) injections into the parotid and submandibular glands in patients with Parkinson's Disease/Parkinsonism and Amyotrophic Lateral…
- Trial name
- Xeomin (NCT01565395)
- Testing
- Incobotulinum Toxin A
- Where
- United States
- Sponsor
- Beth Israel Deaconess Medical Center
Advanced Stage Parkinson's Disease
An Open Label SLV308 Safety Extension to Study S308.3.002 in Patients With Parkinson's Disease Experiencing Motor Fluctuations.
This study is a multicenter, 9 months, open label extension study for all patients who are willing and eligible to continue from the pivotal, double-blind S308.3.002 study.
- Trial name
- NCT00407095
- Testing
- Pardoprunox
- Where
- 87 sites in United States, Albania and 11 more
- Volunteers
- 140 people
- Sponsor
- Solvay Pharmaceuticals
Parkinson Disease Psychosis
A Study to Evaluate the Efficacy, Safety and Tolerability of SEP-363856 in Subjects With Parkinson's Disease Psychosis
A study to evaluate the safety and tolerability of SEP-363856 in subjects with Parkinson's Disease Psychosis. This study is accepting male and female participants 55 years of age and older who have been diagnosed with Parkinson's…
- Trial name
- NCT02969369
- Testing
- SEP-363856
- Where
- 24 sites in United States
- Volunteers
- 39 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
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