Clinical trials: Primary Percutaneous Coronary Intervention
Individualized and Combined Effects of Smoking and Diabetes on the Antiplatelet Activity in Patients Undergoing Primary Percutaneous Coronary Intervention
Individualized and Combined Effects of Diabetes and Smoking on the Antiplatelet Activity of Ticagrelor in Acute Myocardial Infarction Patients Undergoing Primary PCI
Background:Diabetes and smoking are common factors found to increase platelet reactivity in patients undergoing primary PCI. Objective: Compare the individualized and combined effects of smoking and diabetes on the antiplatelet…
- Trial name
- NCT05911659
- Testing
- Ticagrelor
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mina Wageh Mohareb
Left Main Coronary Artery Disease With Acute Coronary Syndrome
Study of Percutaneous Coronary Intervention in Left Main Coronary Artery Disease in Patients With Acute Coronary Syndrome at Sohag University Hospitals
Acute coronary syndromes (ACS) encompass a spectrum of cardiovascular disorders characterized by the sudden onset of myocardial ischemia.
- Trial name
- NCT06328322
- Testing
- Percutaneous Coronary Intervention in Left Main Artery Disease
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
ST Elevation Myocardial Infarction
Early Initiation of Low Dose Tirofiban for PPCI in STEMI Patients.
Anti-platelet therapy is a key point of acute myocardial infarction (AMI) treatment. Nowadays, dual anti-platelet therapy based on aspirin and ADP-P2Y12 receptor inhibitor is the preferred treatment before primary percutaneous…
- Trial name
- NCT03797729
- Testing
- Tirofiban, Normal saline
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shanghai Zhongshan Hospital
Primary PCI
Different β -Blockers in STEMI and Primary PCI
Carvedilol, target dose: 50 mg daily; Bisoprolol, target dose: 10 mg daily; Metoprolol tartrate, target dose: 150 mg daily; Metroprolol succinate, target dose: 200 mg daily
- Trial name
- NCT04221919
- Testing
- β -Blockers
- Volunteers
- 1,200 people
- Sponsor
- Qilu Hospital of Shandong University
Left Ventricular Thrombus
Relation of Laboratory Indices to Left Ventricular Thrombus Formation in Patients With Acute Anterior ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention or Thrombolytic Therapy
to find the relationship between the different hematological indices including platelet indices, and blood cell ratios, to the development of LV thrombus in acute anterior STEMI patients managed by primary percutaneous coronary…
- Trial name
- NCT06152939
- Testing
- Primary percutaneous coronary intervention or thrombolytic therapy
- Volunteers
- 400 people
- Sponsor
- Assiut University
ST-elevation Myocardial Infarction
Standard (180mg) Versus Double (360mg) Loading Dose of Ticagrelor in Patients With ST-elevation Myocardial Infarction (STEMI), Undergoing Primary Percutaneous Coronary Intervention (PCI)
This is a multi-center, prospective, randomized, single-blind, investigator initiated, pharmacodynamic study of parallel design, performed at 3 institutions (Patras University Hospital; Evangelismos Athens General Hospital…
- Trial name
- NCT01575795
- Testing
- Ticagrelor
- Where
- Greece
- Volunteers
- 83 people
- Sponsor
- University of Patras
ST-elevation Myocardial Infarction (STEMI)
Long-term Clinical Outcome in Patients Undergoing Remote Ischemic Conditioning Before Primary Percutaneous Coronary Intervention for ST-elevation Myocardial Infarction: a Follow-up Study
The aim of this prospective follow-up study is to investigate 5-year clinical outcome in patients with ST-elevation myocardial infarction undergoing remote ischemic conditioning before primary percutaneous coronary intervention.
- Trial name
- NCT01665365
- Testing
- Remote ischemic perconditioning
- Where
- Denmark
- Volunteers
- 251 people
- Sponsor
- University of Aarhus
Acute Myocardial Infarction (AMI)
Dexrazoxane to Protect Against Hemorrhagic STEMI
This Phase Ila trial evaluates whether the intravenous administration of Dexrazoxane can reduce permanent heart muscle damage in patients undergoing standard stent procedures (PCI) for a severe heart attack (STEMI).
- Trial name
- SHIELD-MI (NCT07502521)
- Testing
- Dexrazoxane, Normal Saline
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Rohan Dharmakumar
Coronary Artery Disease (CAD), Chronic Coronary Syndrome
"Expert IVUS-Eye" vs. IVUS-guided Left Main Bifurcation PCI
This is a prospective, randomized, controlled trial comparing two strategies for optimizing stent implantation during bifurcation stenting of the left main coronary artery (LM): an intravascular ultrasound (IVUS)-guided approach…
- Conditions
- Coronary Artery Disease (CAD), Chronic Coronary Syndrome, Left Main Coronary Artery Disease, Coronary Bifurcation Lesion
- Trial name
- EYE-IVUS LM (NCT07711106)
- Testing
- IVUS-Guided LM PCI, "Trained Eye" (Angiography-Guided) LM PCI
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Atrial Fibrillation
The Incidence and Predictors of Developing Atrial Fibrillation in Patients With Inferior ST-segment Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention
Is to analyze the incidence and predictors of developing AF in patients with inferior infarction who undergo PCI with and without atrial and SN branches occlusion
- Trial name
- NCT03854448
- Testing
- holter monitoring
- Volunteers
- 109 people
- Sponsor
- Assiut University
ST-elevation Myocardial Infarction (STEMI), Acute Myocardial Infarction (AMI)
Timing of Empagliflozin in Primary PCI: Pre-Reperfusion Versus Post-Reperfusion Versus Placebo in South Asian STEMI Patients
The goal of this clinical trial is to learn if giving the drug empagliflozin before versus after a heart procedure called primary PCI (percutaneous coronary intervention) affects how much heart muscle is damaged during a heart…
- Conditions
- ST-elevation Myocardial Infarction (STEMI), Acute Myocardial Infarction (AMI), Coronary Artery Disease
- Trial name
- TEMPO-STEMI (NCT07749014)
- Testing
- empagliflozin
- Where
- Pakistan
- Volunteers
- 480 people
- Sponsor
- Rehman Medical Institute - RMI
Myocardial Infarction
Nitroprusside for Prevention of no-Reflow in Primary Angioplasty
In patients admitted with acute myocardial infarction, there is a total occlusion of a coronary artery. Even after emergency catheterization and angioplasty, in some patients, the resumed blood flow is suboptimal and impacts on…
- Trial name
- NCT00128791
- Testing
- Nitroprusside
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
Reperfusion Injury, Myocardial
Effects of Melatonin on Reperfusion Injury
Acute myocardial infarction is a major cause of mortality and morbidity. Primary percutaneous coronary intervention (pPCI) is currently the most effective treatment strategy in acute myocardial infarction.
- Trial name
- NCT03303378
- Testing
- melatonin (Helsinn Chemical Co, Biasca, Switzerland)
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Chinese PLA General Hospital
ST Segment Elevation Myocardial Infarction (STEMI), Coenzyme Q10
Effect Supplementation of COenzyme Q10 in Acute STEMI Underwent PPCI
Left ventricular remodeling can still occur after primary percutaneous coronary intervention (PCI). Global longitudinal strain (GLS) assessment has been used as a predictor of left ventricular remodeling.
- Trial name
- ESCOMI (NCT06661018)
- Testing
- Coenzyme Q 10
- Where
- 2 sites in Indonesia
- Volunteers
- 46 people
- Sponsor
- Universitas Diponegoro
Patients With a First Acute Myocardial Infarction to be Treated With Primary Percutaneous Coronary Intervention (PCI).
Effect of Additional Treatment With EXenatide in Patients With an Acute Myocardial Infarction (the EXAMI Trial)
Myocardial infarction (MI) causes loss of myocytes and may lead to loss of ventricular function, morbidity and mortality. The most effective therapy is early reperfusion of the ischemic myocardium by percutaneous coronary…
- Trial name
- EXAMI (NCT01254123)
- Testing
- Exenatide infusion
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Amsterdam UMC, location VUmc
ST Elevation Myocardial Infarction
Early Discharge After Primary Percutaneous Coronary Intervention
When Primary percutaneous coronary intervention (PPCI) is performed expeditiously and at a high-volume centre, it is the optimal approach for ST elevation myocardial infarction (STEMI) .
- Trial name
- EDAPPCI (NCT01860079)
- Testing
- early discharge
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 900 people
- Sponsor
- Acibadem University
ST-elevation Myocardial Infarction (STEMI)
The Impact of Post Stenting Balloon Dilatation on Coronary Microcirculation in STEMI Patients Undergoing PPCI
This study aims to assess the impact of NC balloon post-dilatation on coronary microcirculation in patients with ST segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI).
- Trial name
- POSTDILSTEMI (NCT02788396)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Mid and South Essex NHS Foundation Trust