Clinical trials: Primary Prevention of Cardiovascular Disease
Cancer
Donor Natural Killer Cell Infusion in Preventing Relapse or Graft Failure in Patients Who Have Undergone Donor Bone Marrow Transplant
RATIONALE: Giving donor natural killer cells to patients who have undergone donor bone marrow transplant may make the transplant work better and keep cancer cells from coming back.
- Trial name
- NCT00569283
- Testing
- therapeutic allogeneic lymphocytes
- Where
- 2 sites in South Korea
- Volunteers
- 18 people
- Sponsor
- Asan Medical Center
Ebola Virus Disease, Marburg Virus Disease
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults
Primary Objective: To evaluate the safety and tolerability of cAd3-EBO-S and cAd3 Marburg vaccines when administered Intramuscular (IM) at a dose of 1 x 10^11 particle units (PU) to healthy adults.
- Trial name
- NCT04723602
- Testing
- cAd3-Marburg, cAd3-EBO-S
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Ventricular Tachycardia, Ischemic Cardiomyopathy
Impact of PREVENTIVE Substrate Ablation of Coronary Chronic Total Occlusion on Implantable cardioVerTer-Defibrillator Interventions
The aim of this study is to assess whether preventive substrate ablation of chronic total occlusion infarct-related artery (CTO-IRA) area in heart failure (HF) patients correlates with lower appropriate implantable cardiac…
- Trial name
- PREVENTIVE VT (NCT03421834)
- Testing
- Catheter ablation of ventricular tachycardia, Optimal medical treatment
- Where
- 5 sites in Croatia, Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Myocardial Infarction, Stroke (Including Ischaemic Stroke and Transient Ischaemic Attack)
Study to Gather Information to What Extent Patients Follow the Treatment Regimen of Low-dose Aspirin for Primary and Secondary Prevention of Diseases of the Heart and Blood Vessels
This study aims to gather information to what extent patients follow the treatment regimen of low-dose aspirin for primary and secondary prevention of diseases of the heart and blood vessels.
- Conditions
- Myocardial Infarction, Stroke (Including Ischaemic Stroke and Transient Ischaemic Attack), Unstable Angina, Angina
- Trial name
- PALACE (NCT04097912)
- Testing
- Acetylsalicylic Acid (Aspirin, BAYE4465)
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 99,999 people
- Sponsor
- Bayer
Ischemic Stroke
AI-Driven Health Management to Prevent Ischemic Stroke in High-Risk Adults
This study will evaluate whether an artificial intelligence (AI)-driven dynamic health management strategy can help prevent ischemic stroke in adults at high risk of stroke.
- Trial name
- AI-ExpoStroke (NCT07779668)
- Testing
- Usual Community-Based Health Management, AI-Driven Dynamic Health Management
- Volunteers
- 26,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Cancer
Voriconazole Compared With Itraconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
RATIONALE: Antifungals, such as voriconazole and itraconazole, may be effective in preventing fungal infections in patients who are undergoing allogeneic stem cell transplantation.
- Trial name
- NCT00079222
- Testing
- itraconazole, voriconazole
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Cardiovascular Diseases, Myocardial Infarction
Real World Evidence Study of Statin Use in Brazil
A cross-sectional real-world data study designed to assess the use of statins in individuals assisted within the primary care system in Brazil.
- Conditions
- Cardiovascular Diseases, Myocardial Infarction, Stroke, Hypertension
- Trial name
- RWE-Statins (NCT05285085)
- Testing
- Statin
- Where
- Brazil
- Volunteers
- 2,133,900 people, healthy volunteers welcome
- Sponsor
- Hospital Israelita Albert Einstein
Cardiovascular Risk Factor, Cardiovascular Disease
Training Programme in Physical Activity
The primary prevention of cardiovascular disease is an unresolved health problem. A sedentary lifestyle and a low cardiorespiratory condition both increase the risk of cardiovascular disease, at a similar extent as that promoted…
- Trial name
- NCT03717363
- Testing
- Training programme, Educational talk
- Where
- Spain
- Volunteers
- 147 people
- Sponsor
- Hospital Mutua de Terrassa
Prevention, Arterial Hypertension
Possibilities of Perceiving Information on the Primary Prevention of Cardiovascular Diseases in Persons Suffering From Essential Hypertension Through a Social Network
A randomized, prospective study conducted on the basis of a social network (Instagram platform), two-stage. At the first stage, the online school "Save Your Heart" was announced and 945 applicants were enrolled in the training.
- Trial name
- SocialCor (NCT04944472)
- Testing
- HDKQ questionnaire
- Where
- Russia
- Volunteers
- 125 people
- Sponsor
- Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
Heart Failure
Ability of L-carnitine to Prevent Heart Damage in Breast Cancer Patients Receiving Anthracycline Chemotherapy
Breast cancer is very common and afflicts 1 in 9 North American women. The treatment of breast cancer often requires the use of chemotherapy including "anthracyclines".
- Trial name
- NCT00247975
- Testing
- L-carnitine
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Atherosclerosis, Thromboembolism
Aspirin and Statins for Prevention of Atherosclerosis and Arterial Thromboembolism in Systemic Lupus Erythematosus
The purpose of this trial is to study if aspirin and statins (lipid-lowering agents) can reduce the progression of subclinical atherosclerosis in patients with systemic lupus erythematosus (SLE).
- Conditions
- Atherosclerosis, Thromboembolism, Systemic Lupus Erythematosus
- Trial name
- NCT00371501
- Testing
- Rosuvastatin, aspirin
- Where
- Hong Kong
- Volunteers
- 72 people
- Sponsor
- Tuen Mun Hospital
Diabetes, Diabetic Foot
Optimized Care of People With Diabetes and Foot Complication in Primary Care
The goal of this observational study is to create and evaluate and new management, by using eHealth tools, to prevent diabetic foot ulcers. The main questions it aims to answer are: 1. Validation a.
- Conditions
- Diabetes, Diabetic Foot, Diabetes Mellitus, Diabetes Mellitus, Type 2
- Trial name
- NCT05692778
- Testing
- Patients being foot examined by using an eHealth tool, Patients being foot examined in traditional manner
- Where
- Sweden
- Volunteers
- 140 people
- Sponsor
- Sahlgrenska University Hospital
Diabetes Mellitus
ASCEND: A Study of Cardiovascular Events iN Diabetes
The purpose of this study is to determine whether 100mg daily aspirin versus placebo and/or supplementation with 1 gram daily omega-3 fatty acids or placebo prevents "serious vascular events" (i.e.
- Trial name
- NCT00135226
- Testing
- Aspirin, Omega-3 Ethyl Esters
- Where
- United Kingdom
- Volunteers
- 15,480 people
- Sponsor
- University of Oxford
Metabolic Syndrome, Primary Prevention of Atherosclerotic Cardiovascular Disease
A Tailored, Optimised, and Person-centred Programme to Promote Lifestyle Modification in People With Metabolic Syndrome
This is a mixed-methods study comprising a 2-arm randomised controlled trial and a qualitative study. This study aims to evaluate the effects of a lifestyle modification on the control of metabolic syndrome, with assessments…
- Trial name
- TOP-S (NCT06793930)
- Testing
- A tailored, optimised, and person-centred critical pathway to promote sustainable lifestyle modification, Brief advice
- Where
- Hong Kong
- Volunteers
- 152 people
- Sponsor
- The University of Hong Kong
Hip Arthroplasty, Total, Prevention of Venous Thromboembolism
ENhanced Recovery and ABbreviated LEngth of Anticoagulation for Thromboprophylaxis After Primary Hip Arthroplasty
Surgical hip replacement (total hip arthroplasty, THA) is associated with a high risk of venous thromboembolism, but the appropriate duration of postoperative medical thromboprophylaxis ("anticoagulation") remains highly…
- Trial name
- ENABLE-Hip (NCT06611319)
- Testing
- Prevention of Venous Thromboembolism
- Where
- 6 sites in Austria, Germany
- Volunteers
- 2,932 people
- Sponsor
- Prof. Stavros Konstantinides, MD
Breast Cancer, Neoplasm, Breast
Sacubitril/Valsartan in PriMAry preventIoN of the Cardiotoxicity of Systematic breaST canceR trEAtMent (MAINSTREAM)
Breast cancer is the most commonly cancer in women in the overall global population. According to the World Cancer Research Fund International, there were more than 2.25 million new cases of breast cancer in women in 2020.
- Conditions
- Breast Cancer, Neoplasm, Breast, Breast Diseases, Antihypertensive Agents
- Trial name
- NCT05465031
- Testing
- Sacubitril-valsartan
- Where
- 4 sites in Poland
- Volunteers
- 600 people
- Sponsor
- Silesian Centre for Heart Diseases
Cardiovascular Disease
Polypill For Prevention of Cardiovascular Disease
The purpose of this pilot study is to provide data on the feasibility of conducting a large clinical trial on the polypill (combination of aspirin, angiotensin converting enzyme inhibitor, thiazide diuretic, and statin) for…
- Trial name
- NCT00567307
- Testing
- Red Heart Pill 2b (Polypill), Standard Practice
- Where
- 3 sites in Sri Lanka
- Volunteers
- 216 people
- Sponsor
- Wake Forest University Health Sciences
Hereditary Angioedema, Hereditary Angioedema Type I
Dose-ranging Study of Oral PHA-022121 for Prophylaxis Against Angioedema Attacks in Patients With Hereditary Angioedema Type I or Type II
This study evaluates the safety and efficacy of PHA-022121 administered orally for prophylaxis against angioedema attacks in patients with hereditary angioedema (HAE).
- Conditions
- Hereditary Angioedema, Hereditary Angioedema Type I, Hereditary Angioedema Type II, Hereditary Angioedema Types I and II
- Trial name
- HAE CHAPTER-1 (NCT05047185)
- Testing
- Deucrictibant low dose, Deucrictibant high dose
- Where
- 19 sites in United States, Austria and 7 more
- Volunteers
- 34 people
- Sponsor
- Pharvaris Netherlands B.V.
Myocardial Infarction
Nitroprusside for Prevention of no-Reflow in Primary Angioplasty
In patients admitted with acute myocardial infarction, there is a total occlusion of a coronary artery. Even after emergency catheterization and angioplasty, in some patients, the resumed blood flow is suboptimal and impacts on…
- Trial name
- NCT00128791
- Testing
- Nitroprusside
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
Cardiovascular Risk Factor
Primary Prevention of Cardiovascular Disease Among Female Hospital Employees: The Heart Smart for Women Intervention
This study aims to show that a 6-week program designed specifically for women can lead to sustainable behavior change and improvement in heart disease risk factors over one year among a cohort of 46 female employees recruited…
- Trial name
- Heart Smart (NCT04166097)
- Testing
- Heart Smart Interventional Program
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Northwell Health