Clinical trials: Primary Sclerosing Cholangitis
PSC
Global Prospective, Observational Cohort of Adult Patients With Primary Sclerosing Cholangitis (WIND-PSC Study)
Develop an appropriate real-world data comparator cohort to support the design, execution, and serve as an external control for interventional clinical trials in PSC.
- Trial name
- WIND-PSC (NCT06297993)
- Where
- 18 sites in United States, Canada and 4 more
- Volunteers
- 2,000 people
- Sponsor
- PSC Partners Seeking a Cure
Primary Sclerosing Cholangitis, Trisomy 7
Erlotinib for Chemoprevention in Trisomy 7 Positive Primary Sclerosing Cholangitis (PSC)
Primary sclerosing cholangitis (PSC) is a chronic inflammatory condition of the bile ducts of unknown etiology. It is characterized by diffuse inflammation and stricturing of the entire biliary tree, eventually resulting in…
- Conditions
- Primary Sclerosing Cholangitis, Trisomy 7, Cholangiocarcinoma, Chemoprevention
- Trial name
- NCT00955149
- Testing
- Erlotinib (Tarceva)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mayo Clinic
Primary Sclerosing Cholangitis
NPD Measurements in PSC Patients
Primary Sclerosing Cholangitis (PSC) is a chronic disorder of the liver causing jaundice and liver damage. When Cystic Fibrosis affects the liver, the damaged liver looks like the liver in PSC.
- Trial name
- NCT00476814
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Primary Sclerosing Cholangitis
CS0159 in Chinese Patients With PSC (Primary Sclerosing Cholangitis)
A phase II Study of CS0159 in Chinese patients with PSC(Primary Sclerosing Cholangitis)
- Trial name
- NCT05896137
- Testing
- CS0159
- Where
- 11 sites in China
- Volunteers
- 50 people
- Sponsor
- Cascade Pharmaceuticals, Inc
Healthy Volunteers, Primary Sclerosing Cholangitis
A Study of TAK-781 in Healthy Volunteers and in Participants With Non-Cirrhotic Primary Sclerosing Cholangitis (PSC)
The main aim of this study is to see if the drug TAK-781 is safe for healthy volunteers and for participants with PSC. The study will also look at how well participants can tolerate TAK-781.
- Trial name
- NCT07229911
- Testing
- TAK-781
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Takeda
Primary Sclerosing Cholangitis
A Study Evaluating the Safety and Efficacy of Curcumin in Patients With Primary Sclerosing Cholangitis (PSC)
The purpose of this study is to determine whether curcumin, a drug and naturally-occurring plant compound, is safe and effective in the treatment of primary sclerosing cholangitis (PSC).
- Trial name
- NCT02978339
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- John E. Eaton
Primary Sclerosing Cholangitis, Compensated Cirrhosis
Safety and Tolerability of Cilofexor in Participants With Primary Sclerosing Cholangitis (PSC) and Compensated Cirrhosis
The primary objective of this study is to assess the safety and tolerability of escalating doses of cilofexor (CILO) in participants with primary sclerosing cholangitis (PSC) and compensated cirrhosis.
- Trial name
- NCT04060147
- Testing
- Cilofexor
- Where
- 16 sites in United States
- Volunteers
- 11 people
- Sponsor
- Gilead Sciences
PSC
PET/MRI of Primary Sclerosing Cholangitis
This study aims to use positron emission tomography (PET)/magnetic resonance imaging (MRI) to diagnose and quantify PSC-related biliary tract fibrosis and to improve upon the currently available non-invasive diagnostic…
- Trial name
- NCT06252610
- Testing
- Radiotracer Injection, Contrast Media, Magnetic Resonance, Imaging
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Primary Sclerosing Cholangitis
Phase 2a Evaluation of Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Patients With Primary Sclerosing Cholangitis (PSC)
A Phase 2a, multicenter, randomized, double-blind, dose-ranging, placebo-controlled, study to evaluate the safety, tolerability, and PK of PLN-74809 in participants with primary sclerosing cholangitis and suspected liver fibrosis
- Trial name
- NCT04480840
- Testing
- PLN-74809
- Where
- 60 sites in United States, Australia and 7 more
- Volunteers
- 121 people
- Sponsor
- Pliant Therapeutics, Inc.
Immunoglobulin G4 Related Sclerosing Disease
Leflunomide for Maintenance of Remission in IgG4 Related Disease
The study has been designed as a 12-month, open-label, randomized, controlled study comparing the use of prednisone mono-therapy and prednisone and leflunomide combination therapy in treating patients with IgG4-related disease.
- Trial name
- NCT02703194
- Testing
- Prednisone, Leflunomide
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Chinese PLA General Hospital
IgG4-related Sclerosing Cholangitis, IgG4-related Disease
Bile Usefulness for Detecting IgG4-related Sclerosing Cholangitis
Immunoglobulin G4-related disease (IgG4-RD) is an uncommon inflammatory disorder that may affect multiple organ systems, including the biliary tree.
- Trial name
- NCT02616705
- Where
- 2 sites in United States, Japan
- Volunteers
- 511 people
- Sponsor
- Mayo Clinic
Primary Sclerosing Cholangitis
Norursodeoxycholic Acid in the Treatment of Primary Sclerosing Cholangitis
Evaluation of the efficacy of different doses of nor UDCA vs. placebo for the treatment of Primary Sclerosing Cholangitis (PSC). Identification of optimal dose(s)for the treatment of PSC.
- Trial name
- NUC-3 (NCT01755507)
- Testing
- norUDCA
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 159 people
- Sponsor
- Dr. Falk Pharma GmbH
Primary Sclerosing Cholangitis, Elastography
Disease Status in Primary Sclerosing Cholangitis by Elastography
Primary sclerosing cholangitis (PSC) is a chronic liver disease that can lead to liver cirrhosis, liver failure and liver cancer.
- Conditions
- Primary Sclerosing Cholangitis, Elastography, Hepatic Fibrosis, Magnetic Resonance Imaging
- Trial name
- NCT02446665
- Testing
- MR Elastography (MRE) and FibroScan
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- University Health Network, Toronto
Primary Sclerosing Cholangitis, Ulcerative Colitis
Gluten-free Diet in PSC and IBD
Primary sclerosing cholangitis (PSC) is a progressive disease of the biliary tree, which represents one of the most frequent indications for orthotopic liver transplantation (OLTx) in developed countries.
- Conditions
- Primary Sclerosing Cholangitis, Ulcerative Colitis, Biliary Tract Diseases, Biliary Disease Tract
- Trial name
- NCT06026449
- Testing
- Gluten-free diet
- Where
- Czechia
- Volunteers
- 51 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Primary Sclerosing Cholangitis
Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis
Primary sclerosing cholangitis (PSC), although uncommon, is a devastating and insidiously progressive liver disease, resulting from advancing inflammation, fibrosis and obliteration of the bile ducts in the liver, leading to…
- Trial name
- NCT01088607
- Testing
- ursodeoxycholic acid (UDCA)
- Where
- 12 sites in United States
- Volunteers
- 27 people
- Sponsor
- University of Tennessee
Primary Sclerosing Cholangitis (PSC)
Cholangioscopy in Primary Sclerosing Cholangitis (PSC)
To demonstrate the clinical utility of the addition of per oral cholangioscopy (POCS) to standard endoscopic retrograde cholangiopancreatography (ERCP) with brushing cytology for diagnosis and early detection of…
- Trial name
- NCT03766035
- Testing
- SpyGlass DS I - II
- Where
- 6 sites in United States, Canada and 2 more
- Volunteers
- 43 people
- Sponsor
- Boston Scientific Corporation
Primary Sclerosing Cholangitis
A Multi-center Evaluation of Aldafermin in a Randomized, Double-blind, Placebo-controlled Study in Subjects With Primary Sclerosing Cholangitis.
A multi-center evaluation of aldafermin in a randomized, double-blind, placebo-controlled study in subjects with Primary Sclerosing Cholangitis.
- Trial name
- ALPINE-PSC (NCT06654726)
- Testing
- aldafermin
- Sponsor
- NGM Biopharmaceuticals, Inc
Reduction of Intestinal Inflammatory Activity
Gluten-free Diet in Patients With Primary Sclerosing Cholangitis (PSC)
Gluten is a protein found in wheat and other cereals as barley and rye. It triggers an inflammatory reaction in the small-bowel of genetically predisposed persons.
- Trial name
- PSt-GFD (NCT04006886)
- Testing
- Gluten-free diet
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
PSC
Colangioids to Define the Genetic Factors Involved in Atypical Primary Sclerosing Cholangitis
Primary sclerosing cholangitis (PSC) is a rare, progressive and often fatal disease of the intrahepatic or extrahepatic bile ducts, with an estimated prevalence in Western countries of 1/10,000.
- Trial name
- CILIA (NCT06865924)
- Testing
- Use of assembloids as in vitro models to test new pharmacological approaches
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico