Clinical trials: Primary Sjögren Syndrome
Primary Sjögren Syndrome
Vaccine Coverage and Primary Sjögren'Syndrome
Evaluation of vaccination coverage for influenza, pneumococcus and DTP in patients with pSS and investigated the reasons for non-vaccination.
- Trial name
- VACGREN (NCT04224454)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 111 people
- Sponsor
- University Hospital, Montpellier
Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies
Early Clinical Study of UTAA09 Injection in the Treatment of Relapsed/Refractory Autoimmune Diseases
Main purpose: To evaluate the safety of UTAA09 injection in the treatment of relapsed/refractory (R/R) autoimmune disease (AID).
- Conditions
- Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies, Systemic Sclerosis, IgG4 Related Disease
- Trial name
- NCT06361745
- Testing
- T cell injection targeting CD19 chimeric antigen receptor
- Where
- China
- Volunteers
- 10 people
- Sponsor
- PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Sjogren's Syndrome
Immune Profile of Saliva and Serum of Patients With Primary Sjögren´s Syndrome
Primary Sjögren's syndrome (pSS) is a chronic systemic inflammatory disease, which mainly affects the lacrimal and salivary glands, leading to sicca syndrome.
- Trial name
- pSS (NCT03711214)
- Testing
- Periodontal scaling
- Where
- 3 sites in Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Primary Sjögren Syndrome, Vaginitis Candida
Sjögren and Gynecologic Considerations
Sjögren's syndrome is an autoimmune disorder characterized by glandular and extra-glandular manifestations. It is called primary Sjögren's syndrome (pSS) in absence of another connective tissue disease.
- Conditions
- Primary Sjögren Syndrome, Vaginitis Candida, Vaginitis, Sexual Dysfunction
- Trial name
- NCT05670535
- Testing
- Visual analogue scale (VAS) for dyspareunia, Visual analogue scale (VAS) for vaginal dryness, The European League Against Rheumatism Sjögren's Syndrome Disease Activity Index (ESSDAI)
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people
- Sponsor
- Ankara City Hospital Bilkent
Autoimmune Diseases, Systemic Lupus Erythematosus
Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA U CAR-T Cell Injection for the Treatment of Relapsed/Refractory Autoimmune Diseases
A single arm, open-label pilot study is designed to determine the safety and effectiveness of anti-CD19/BCMA U CAR T cells in patients with autoimmune diseases. 60 patients are planned to be enrolled in the dose-escalation trial.
- Conditions
- Autoimmune Diseases, Systemic Lupus Erythematosus, Systemic Sclerosis, Primary Sjögren Syndrome
- Trial name
- NCT07246096
- Testing
- anti-CD19/BCMA U CAR T cells
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Changhai Hospital
Primary Sjögren's Syndrome (pSS)
Artificial Intelligence Based Models for Primary Sjögren's Syndrome Diagnosis
The goal of this observational study is to develop and validate artificial intelligence (AI)-driven models for improving the diagnosis of Primary Sjögren's Syndrome (PSS) using routine laboratory test data.
- Trial name
- NCT06982482
- Where
- China
- Volunteers
- 27,432 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Xerostomia, Hyposalivation
Quality of Life and Sjögren Syndrome
The aims of this study are: To compare salivary pH changes and stimulation efficacy of two different Gustatory Stimulants of Salivation (GSSS) in patients with Primary Sjögren Syndrome (PSS); To evaluate Primary Sjögren syndrome…
- Conditions
- Xerostomia, Hyposalivation, Quality of Life, Sjogren's Syndrome
- Trial name
- NCT03578900
- Testing
- Xeros, Citric Acid based Mouthwash
- Volunteers
- 289 people
- Sponsor
- Grupo de Investigação em Bioquímica e Biologia Oral
Small Fiber Neuropathy, Primary Sjögren Syndrome
Cutaneous Silent Period Assessment in Primary Sjögren's Syndrome
Primary Sjögren's syndrome (pSS) is a chronic, immune-mediated inflammatory disease mainly characterized by exocrine gland involvement.
- Trial name
- NCT05380804
- Testing
- cutaneous silent period (CSP) measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Marmara University
Primary Sjögren Syndrome, PET
Exploring the Novel Value of PSMA PET in Sjögren's Syndrome: Integrated Analysis With Established FAPI PET Imaging
Primary Sjögren's syndrome (pSS) is a chronic autoimmune exocrinopathy characterized by lymphocytic infiltration, progressive destruction of salivary gland acini, and varying degrees of functional impairment and fibrosis.
- Trial name
- NCT07324733
- Testing
- ⁶⁸Ga-PSMA PET/CT, ⁶⁸Ga-FAPI PET/CT
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Sjogren's Syndrome
Hydroxychloroquine Blood Levels in Primary Sjögren Syndrome Patients
Introduction. Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by chronic inflammatory infiltration of the salivary and lacrimal glands causing dry eye and mouth.
- Trial name
- 1ASSJHCQ (NCT04546542)
- Testing
- Parallel Assignment
- Where
- 2 sites in Brazil
- Volunteers
- 74 people
- Sponsor
- University of Sao Paulo General Hospital
Sjögren Syndrome, Sicca Syndrome
N-acetylcysteine for Primary Sjögren's Syndrome
N-acetylcysteine (NAC) allows the elimination of reactive oxygen species (ROSs) and it has an anti-inflammatory effect. For this reason, NAC has been used and researched for treatment of several diseases, such as autoimmune…
- Trial name
- NACSS (NCT04793646)
- Testing
- N-acetylcysteine syrup
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Systemic Lupus Erythematosus
The Therapeutic Value and Mechanism of Recombinant Human Interleukin-2 on Children With Rheumatic Diseases
The study aims to explore the therapeutic value and mechanism of Interleukin-2 on children with rheumatic diseases (Systemic Lupus Erythematosus, Primary Sjögren Syndrome, Juvenile Idiopathic Arthritis).
- Trial name
- SLE，pSS，JIA (NCT04397107)
- Testing
- IL-2
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Jilin University
Sjogren Syndrome, Xerostomia
Exosome and Mesenchymal Stem Cell Treatment for Salivary Gland Dysfunction in Primary Sjögren Syndrome
This study will evaluate the effects of exosome and mesenchymal stem cell injections into the submandibular glands of adults with primary Sjögren syndrome and salivary gland dysfunction or dry mouth.
- Conditions
- Sjogren Syndrome, Xerostomia, Exosome
- Trial name
- NCT07838454
- Testing
- exosomes derived from human umbilical cord mesenchymal stem cells, Mesenchymal Stem Cells (MSC)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Banu Erkal
Primary Sjögren's Syndrome (pSS)
New Clinical End-points in Patients With Primary Sjögren's Syndrome
There are no approved treatments for pSS and the clinical endpoints currently used in clinical trials are inadequate to capture all aspects of the disease that should be evaluated in clinical trials.
- Trial name
- NECESSITY (NCT05113004)
- Testing
- Hydroxychloroquine 400mg/d, Leflunomide 20mg/d, Mycophenolate mofetil 2000mg/d
- Where
- 7 sites in France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Primary Sjögren Syndrome, Small Fiber Neuropathy
Medico-economic and Quality of Life Impact of Sjogren-associated Small Fiber Neuropathy
BACKGROUND Sjögren's syndrome is an autoimmune disease whose prevalence is estimated between 200 and 500 patients per 100,000 persons in France (120 to 500,000 patients).
- Conditions
- Primary Sjögren Syndrome, Small Fiber Neuropathy, Quality of Life, Medico-economic Impact
- Trial name
- SFINESS-QoLEco (NCT03509064)
- Testing
- Collection sheet
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Primary Sjögren Syndrome
Neurotrophins Implications in Primary Sjögren Syndrome
Neurotrophins (NTs) constitute a family of growth factors, which regulated differentiation, proliferation, and survival of both neuronal cells and astrocytes.
- Trial name
- Neuro-SGSp (NCT01081184)
- Testing
- blood sample
- Where
- 2 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Primary Sjögren Syndrome
68Ga-P16-093 PET/CT Imaging in the Salivary Gland
Prostate specific membrane antigen (PSMA) is a type II transmembrane protein and acts as a glutamate carboxypeptidase enzyme. It is first described in prostate cancer cell lines and later identified in various tissues, include…
- Trial name
- NCT06049368
- Testing
- 68Ga-P16-093
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
KERATOCONJUNCTIVITIS SICCA, XEROSTOMIA
Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome
This study was designed to test the efficacy and safety of low laser therapy to treat the xerostomia of patients with primary Sjogren's Syndrome.
- Conditions
- KERATOCONJUNCTIVITIS SICCA, XEROSTOMIA, SICCA SYNDROME, PRIMARY SJOGREN SYNDROME
- Trial name
- NCT02066896
- Testing
- Lasertherapy
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Federal University of São Paulo
Primary Sjögren Syndrome
Study on Optimization and Evaluation of Integrated Chinese and Western Medicine for pSS Glandular Damage
ChatGPT In a randomized controlled trial, 136 patients with primary Sjögren's syndrome (pSS) meeting the inclusion criteria were enrolled and randomly divided into two groups of 68 each.
- Trial name
- NCT06519617
- Testing
- Yi Qi Yang Yin Decoction, Hydroxychloroquine Sulfate
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Qingwen Tao
SCAD, Addison Disease
Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity
This case control study aims to determine whether spontaneous coronary artery dissection (SCAD) is associated with autoimmune diseases and to update the incidence of SCAD in a population-based cohort.
- Conditions
- SCAD, Addison Disease, Ankylosing Spondylitis, Antiphospholipid Antibody Syndrome
- Trial name
- NCT03941184
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Mayo Clinic