Clinical trials: Priming, open to volunteers
Stress, Healthy Subjects
The Effects of Chicory Root-derived Prebiotic on Mood and Stress Responsiveness in Healthy Adults With Mild to Moderate Levels of Stress and Anxiety
Emerging evidence from preclinical research suggests that prebiotic fibres may play a beneficial role in supporting mental health through modulation of the gut-brain axis-a complex communication network linking the…
- Conditions
- Stress, Healthy Subjects, Anxiety, Mild to Moderate
- Trial name
- PRIME (NCT07058324)
- Testing
- Prebiotic fiber
- Where
- Germany
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Diminished Ovarian Reserve
DPOS Versus GnRH Antagonist Protocol for Oocyte Accumulation in Low Ovarian Reserve Patients: An RCT
One of the barriers in patients with diminished ovarian reserve (DOR) is the significantly reduced number of oocytes resulting in fewer oocytes collected and embryos formed.
- Trial name
- DPOS (NCT05847283)
- Testing
- Dydrogesterone priming ovarian stiumulation protocol, GnRH antagonist protocol
- Where
- 2 sites in Vietnam
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- Tam Anh TP. Ho Chi Minh General Hospital
Cerebral Palsy, Typically Developing Children
Repetitive Transcranial Magnetic Stimulation on Motor Function and Meta-Plasticity in Cerebral Palsy: TMS-EEG Study
This project examines the use of repetitive transcranial magnetic stimulation (rTMS) as a therapeutic approach to improve motor function in children with cerebral palsy (CP).
- Trial name
- NCT07567053
- Testing
- MRI, HD-EEG Recording, rTMS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cook Children's Health Care System
Chikungunya, Chikungunya Fever
A Phase I Study of PepGNP-ChikV in Healthy Volunteers
This is a Phase I, randomized, single-blind, placebo-controlled, study of four separate dose cohorts, with a 42-day interval between each vaccine dose, of a novel Chikungunya Peptide Immunotherapy Vaccine in Healthy Adults (18-60…
- Conditions
- Chikungunya, Chikungunya Fever, Chikungunya Virus Infection, Chikungunya Virus Infections
- Trial name
- NCT07394426
- Testing
- PepGNP-ChikV
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gylden Pharma Ltd
Post-traumatic Stress Disorder (PTSD), Emotional Contagion
Attachment and Post-Traumatic Stress Disorder in Military Personnel: Characterization of the French Military Population, Exploration of Biopsychosocial Factors, and Study of the Impact of Security Priming on Emotional Contagion Capacities
Post-traumatic stress disorder (PTSD) is a pathology that impairs the quality of life of sufferers. In military personnel, it can lead to military incapacity.
- Trial name
- AT-HOME (NCT06996275)
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Malaria
Comparing Safety and Protective Efficacy of Vaccine Candidate PfSPZ-CVac and MVA ME-TRAP/ ChAd63 ME-TRAP in Adults
This is a single centre, randomized, placebo-controlled phase 1/2 study comparing two malaria vaccine candidates. The first vaccine candidate PfSPZ-CVac (Plasmodium falciparum sporozoites (PfSPZ) challenge administered with a…
- Trial name
- NCT05441410
- Testing
- Pyronaridine Tetraphosphate, Artesunate Drug Combination, PfSPZ Challenge (NF54), MVA ME-TRAP
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Coronavirus, SARS-CoV-2 Infection
Next Generation T-cell Vaccine Against Coronavirus Disease (COVID-19)
The study aims to investigate the safety and immunogenicity of one dose vs two doses of a T-cell priming next-generation vaccine against Coronavirus disease.
- Conditions
- Coronavirus, SARS-CoV-2 Infection, COVID-19
- Trial name
- NCT05633446
- Testing
- PepGNP-COVID19 (One vaccination), Water for injection (One vaccination), PepGNP-COVID19 (Two vaccinations)
- Where
- 2 sites in Philippines
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Gylden Pharma Ltd
Myopia Progression
Prospective Research on the Intervention of Myoless2.0 Effectiveness (PRIME) in Pediatric Population
The Goal of the study is to evaluate the rate of myopia progression with open ring myopia control spectacle lens designs compared to a commercial peripheral plus myopia control spectacle lens (CML) in European children with…
- Trial name
- PRIME (NCT07394556)
- Testing
- myopia control lens
- Where
- 3 sites in Portugal, Spain and 1 more
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Indizen Optical Technologies, S.L.U.
Aphasia
Sentence Production Training in Aphasia
This project focuses on developing a novel treatment for sentence production and comprehension in aphasia, using implicit priming.
- Trial name
- NCT05415501
- Testing
- Sentence training
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Purdue University
HPV 16 Infection, HPV-Related Carcinoma
Clinical Trial Assessing the Safety and Immunologic Correlates of Heterologous Prime-Boost With pNGVL4a-Sig/E7(Detox)/HSP70 and TA-HPV in Healthy Donors Followed by Peripheral Blood Collection
This healthy related donor clinical trial is linked to a recipient clinical trial protocol for therapeutic purposes. In this healthy donor protocol, haploidentical relatives of a patient with recurrent or metastatic human…
- Conditions
- HPV 16 Infection, HPV-Related Carcinoma, Recurrence, Metastatic Cancer
- Trial name
- J21112LINKED (NCT06508138)
- Testing
- pNGVL4a-Sig/E7(detox)/HSP70 plasmid DNA; TA-HPV vaccinia virus
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
HIV
Clinical Trial to Evaluate the Safety and Immunogenicity of a Priming Regimen of 426c.Mod.Core-C4b Followed by HxB2.WT.Core-C4b Boosts, Both Adjuvanted With 3M-052 AF + Alum, in Adult Participants Without HIV and in Overall Good Health
This is a partially randomized, open-label phase 1 study to evaluate the safety and immunogenicity of a priming regimen of 426c.Mod.Core-C4b adjuvanted with 3M-052 AF + Alum followed by boosts with HxB2.WT.Core-C4b adjuvanted…
- Trial name
- NCT06796686
- Testing
- 426c.Mod.Core-C4b, HxB2.WT.Core-C4b, 3M-052-AF adjuvant
- Where
- 6 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Stroke
Explore the Effects of Cortical Priming on Visuomotor Stepping Learning in Persons With Chronic Stroke
This research study aims to understand the relationship between brain stimulation and leg skill learning in both healthy adults and persons with chronic stroke.
- Trial name
- NCT06681207
- Testing
- anodal transcranial direct current stimulation (a-tDCS)
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Stroke
Proximal Priority Versus Distal Priority Robotic Priming Effects in Patients With Chronic Stroke
This is a single-blind randomized comparative efficacy study involving 54-72 participants with chronic stroke. Participants will be randomized into proximal priority robotic group or distal priority robotic group and receive 18…
- Trial name
- NCT04446273
- Testing
- Bi-Manu-Track
- Where
- 4 sites in Taiwan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Prior Myocardial Infarction
PRIor Myocardial Infarction Identification on Electrocardiogram
Abstract Background: Chronic myocardial infarction (MI) is a serious cardiovascular disease associated with high mortality rates, making early diagnosis and timely intervention essential for improving patient outcomes.
- Trial name
- PRIME (NCT06811194)
- Where
- China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- The Third People's Hospital of Chengdu
Neisseria Meningitidis
MenB-FHbp or MenACWY-TT/MenB-FHbp Vaccine in MenB-4C Primed Young Adults
The goal of this clinical trial is to determine the immunogenicity of certain vaccines in protecting against meningitis B (MenB) in young adults who have previously received a different MenB vaccine.
- Trial name
- NCT07197762
- Testing
- Trumenba, PENBRAYA
- Where
- 2 sites in United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Emory University
Patient Preference, Patient Outcomes
The PRIME Study: A Randomized, Controlled, Prospective Study
To investigate the outcomes of patients undergoing bilateral RLE surgery with treatment of dexamethasone intracanilicular insert compared to topical standard care steroid.
- Conditions
- Patient Preference, Patient Outcomes, Post-Operative Inflammation, Grade of Post-Operative Cystoid Macular Edema
- Trial name
- NCT04549935
- Testing
- Dextenza, Topical Prednisolone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision - MT
Kaposi Sarcoma
Precision Imaging to Evaluate Kaposi Sarcoma
AIMS 2 \& 3: In this study the investigators seek to formally compare reproducibility and accuracy of KS lesion size measurements between SkinScan3D and the current standard of care manual measurement method.
- Trial name
- PRIME-KS (NCT06898203)
- Testing
- SkinScan3D
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Workplace Wellbeing
Primed to Thrive: Investigating the Combined Impact of Mindfulness Education and Meditation Practice on Psychological and Workplace Outcomes
Employees commonly experience stress and reduced well-being that can affect workplace functioning. This interventional study will evaluate whether combining mindfulness-related educational materials with a brief daily guided…
- Trial name
- BEGIN III (NCT07534683)
- Testing
- Meditation, Mindful Educational Material
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Red Blood Cell Transfusion
The Effect of Retrograde Autologous Priming on Transfusion Requirements After Cardiac Surgery
The TheRAPy vanguard trial is a multicentre, multiple period randomized, cluster crossover vanguard trial testing the feasibility of a full-scale trial to evaluate whether a centre-based policy of routine use of RAP versus a…
- Trial name
- TheRAPy (NCT06230198)
- Testing
- retrograde autologous priming (RAP), Crystalloid priming
- Where
- 4 sites in Canada
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute