Clinical trials: Probe-based Confocal Laser Endomicroscopy
Gastroesophageal Reflux Disease
Diagnostic Value of Flexible Spectral Imaging Color Enhancement (FICE) Plus Probe-based Confocal Laser Endomicroscopy (pCLE) for Minimal Change Esophageal Reflux Disease (MERD) Diagnosis
Gastroesophageal reflux disease (GERD) patients without obvious mucosal break by endoscopy were examined by FICE, followed by confocal. Validity scores for MERD diagnosis were analyzed.
- Trial name
- NCT02336100
- Testing
- Endoscopy (FICE and pCLE)
- Where
- Thailand
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- King Chulalongkorn Memorial Hospital
Undifferentiated Gastric Cancer
Role of Probe-based Confocal Laser Endomicroscopy Targeted Biopsy in the Molecular Study of Undifferentiated Gastric Cancer
The purpose of this study is to conduct a study on genetic pathology, obtaining of pure cancer tissues is mandatory. Although the endoscopy with biopsy has been a gold standard for diagnosing gastric cancer, percentage of cancer…
- Trial name
- NCT02799420
- Testing
- GastroFlex UHD, Cellvizio; Mauna Kea Technologies, Paris, France, white light endoscopy (WLE)
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Yonsei University
Esophageal Neoplasms, Artificial Intelligence
Automatic Diagnosis of Early Esophageal Squamous Neoplasia Using pCLE With AI
Detection and differentiation of esophageal squamous neoplasia (ESN) are of value in improving patient outcomes. Probe-based confocal laser endomicroscopy (pCLE) can diagnose ESN accurately.However this requires much experience…
- Conditions
- Esophageal Neoplasms, Artificial Intelligence, Confocal Laser Endomicroscopy
- Trial name
- NCT04136236
- Testing
- The diagnosis of Artificial Intelligence and endoscopist
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Shandong University
Intestinal Metaplasia, Intestinal Dysplasia
Comparison Between Probe-based Confocal Laser Endomicroscopy, White-light Endoscopy and Virtual Chromoendoscopy
The investigators hypothesis that 1. clinical applicability and overall diagnostic sensitivity and specificity of pCLE for diagnosing gastric preneoplastic and neoplastic lesions is acceptable 2.
- Trial name
- pCLE-GCEP (NCT01398579)
- Testing
- Gastroscopy
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- National University Hospital, Singapore
Diagnostic Yield of Gastric Neoplasia
PCLE for the Diagnosis of Gastric Intestinal Metaplasia, Intraepithelial Neoplasia, and Carcinoma
Early detection of gastric intestinal metaplasia (GIM) intraepithelial neoplasia (IN), and gastric cancer are essential to improve patients' outcomes.
- Trial name
- PCLE (NCT02515721)
- Testing
- pCLE-TB, virtual chromoendoscopy-TB
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Shandong University
Gastric Intestinal Metaplasia
The Learning Curve of Probe-based Confocal Laser Endomicroscopy (pCLE) Images Interpretation in Gastric Intestinal Metaplasia (GIM)
The Learning Curve of Probe-based Confocal Laser Endomicroscopy (pCLE) images interpretation in Gastric Intestinal Metaplasia (GIM) Objective: The aim of this study is to evaluate the learning curve of pCLE images interpretation…
- Trial name
- NCT01491724
- Where
- Thailand
- Volunteers
- 5 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Gastric Cancer, Intestinal Metaplasia
New Classification of Stomach Using Probe-based Confocal Laser Endomicroscopy
The aim of the present study was to propose a new pCLE classification of gastric pit patterns and vessel architecture, and to assess the accuracy and interobserver agreement of this new pCLE classification system in the stomach.
- Conditions
- Gastric Cancer, Intestinal Metaplasia, Atrophic Gastritis, Inflammation
- Trial name
- NCT01896310
- Testing
- probe-based confocal laser endomicroscopy
- Where
- China
- Volunteers
- 272 people
- Sponsor
- Shandong University
Laryngeal Leiomyoma, Probe-based Confocal Laser Endomicroscopy
Diagnosis of Laryngeal Lesions Using the Probe-based Confocal Laser Endomicroscopy
To evaluate the diagnosis of laryngeal lesions using the Probe-based Confocal Laser Endomicroscopy in vivo.
- Trial name
- NCT04139889
- Testing
- Confocal Laser Endomicroscopy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Colorectal Neoplasms, Confocal Laser Endomicroscopy
Clinical Validation of Multimodal Digestive Endoscopy
According to the latest global cancer epidemiological data published by the International Agency for Research on Cancer, colorectal cancer (CRC) ranks 3rd in total incidence and 2nd in total mortality among all malignancies…
- Conditions
- Colorectal Neoplasms, Confocal Laser Endomicroscopy, Endoscopy, Digestive System, Molecular Imaging
- Trial name
- NCT05575765
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Nasopharyngeal Carcinoma, Squamous Cell Carcinoma of the Head and Neck
The Diagnosis of NPC Using the Probe-based Confocal Laser Endomicroscopy
To evaluate the use of probe-based confocal laser endomicroscopy (pCLE) in human nasopharyngeal mucosa for the differentiation of the nasopharyngeal squamous cell carcinomas.
- Trial name
- NCT03202173
- Testing
- 10% fluorescein
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Pleural Diseases, Pleural Neoplasms
Mini Invasive Endomicroscopy of the Pleura for Malignancies Diagnosis
Recently, probe based confocal laser endomicroscopy showed to be able to distinguish malignant from benign pleura during medical thoracoscopy. However The clinical usefulness of this new tool remains to be determined.
- Trial name
- NCT04731129
- Testing
- Probe based confocal laser endomicroscopy of the pleura
- Where
- Belgium
- Volunteers
- 59 people
- Sponsor
- University of Liege
Esophageal Squamous Intraepithelial Neoplasia
Detection of Early Esophageal Squamous Neoplasia
The aim of the present study： 1. To investigate the diagnosing value of pCLE for early esophageal squamous neoplasia. 2. To assess the detection rate of early esophageal squamous neoplasia by virtual chromoendoscopy
- Trial name
- NCT01909518
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shandong University
Gastric Cancer
A Pilot Study on Usefulness of Probe-based Confocal Laser Endomicroscopy Targeted Gastric Biopsy
The purpose of this study is to conduct a study on genetic pathology, obtaining of pure cancer tissues is mandatory. Although the endoscopy with biopsy has been a gold standard for diagnosing gastric cancer, percentage of cancer…
- Trial name
- NCT02089373
- Testing
- Probe-based confocal laser endomicroscopy, White light endoscopy
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Rectal Cancer
Targeted Optical Biopsy for Local Rectal Scars in Rectal Cancer Patients After Neoadjuvant Chemoradiotherapy
Currently, low concordance (36%) is found between clinical complete response and pathologic complete response in patients with rectal cancer after neoadjuvant chemoradiotherapy.
- Trial name
- NCT05316103
- Testing
- Probe-based confocal laser endomicroscopy targeted optical biopsy
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Probe-based Confocal Laser Endomicroscopy, Artificial Intelligence
Automatic Classification of Colorectal Polyps Using Probe-based Endomicroscopy With Artificial Intelligence
Probe-based confocal laser endomicroscopy (pCLE) is an endoscopic technique that enables real-time histological evaluation of gastrointestinal mucosa during ongoing endoscopy examination.
- Conditions
- Probe-based Confocal Laser Endomicroscopy, Artificial Intelligence, Colorectal Polyps
- Trial name
- NCT03787784
- Testing
- AI presentation
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shandong University
Gastric Diseases, Artificial Intelligence
Automatic Real-time Diagnosis of Gastric Mucosal Disease Using pCLE With Artificial Intelligence
Probe-based confocal laser endomicroscopy (pCLE) is an endoscopic technique that enables real-time histological evaluation of gastric mucosal disease during ongoing endoscopy examination.
- Conditions
- Gastric Diseases, Artificial Intelligence, Confocal Laser Endomicroscopy
- Trial name
- NCT03784209
- Testing
- The diagnosis of Artificial Intelligence and endoscopist
- Where
- China
- Volunteers
- 951 people
- Sponsor
- Shandong University
Pleural Effusion Disorder
Confocal Laser Endomicroscopy Assisted Ultrasound Guided Pleural Biopsy
This study aimed to evaluate the diagnostic yield and safety of confocal laser endomicroscopy and ultrasound-guided pleural biopsy in diagnosing patients with unknown pleural effusion.
- Trial name
- Confocal laser (NCT07040241)
- Testing
- Confocoal laser endomicroscopy-assisted ultrasound-guided pleural biopsy, Ultrasound-guided pleural biopsy
- Volunteers
- 260 people
- Sponsor
- China-Japan Friendship Hospital
Ulcerative Colitis, Artificial Intelligence
Automatic Evaluation of Inflammation Activity in Ulcerative Colitis Using pCLE With Artificial Intelligence
Probe-based confocal laser endomicroscopy (pCLE) is an endoscopic technique that enables to evaluate the inflammation activity of ulcerative colitis with excellent correlation with histopathology.
- Conditions
- Ulcerative Colitis, Artificial Intelligence, Confocal Laser Endomicroscopy
- Trial name
- NCT04131530
- Testing
- The diagnosis of Artificial Intelligence and endoscopist
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shandong University
Diffuse Parenchymal Lung Diseases
Validation of Alveolar Probe-based Confocal Laser Endomicroscopy Descriptors in Diffuse Parenchymal Lung Diseases
Diffuse parenchymal lung diseases (DPLD) include a variety of respiratory conditions that affect either the pulmonary interstitium or the alveolar space .
- Trial name
- Microsemio-PI (NCT02961335)
- Testing
- Bronchoscopy, Confocal microendoscopy, Biopsy sampling
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Rouen
Pleural Carcinomatosis
Probe Based Confocal Laser Endomicroscopy During Thoracoscopy for Pleural Malignancies Diagnosis.
Probe based confocal laser endomicroscopy (pCLE) is a new optical endoscopic technique, generating fluorescent light emission from the tissue of interest and allowing in vivo live imaging at a cellular level ("optical biopsies").
- Trial name
- NCT03805971
- Testing
- Study of the pleural cavity with a confocal laser endomicroscope.
- Where
- Belgium
- Volunteers
- 65 people
- Sponsor
- University of Liege