Clinical trials: Probiotic Therapy
Vulvovaginal Candidiasis
Oral Lactobacillus Crispatus Lc-G22 as Adjunctive Therapy for Vulvovaginal Candidiasis
This single-center, randomized, single-blind, placebo-controlled trial aimed to evaluate the efficacy and safety of oral Lactobacillus crispatus Lc-G22 as adjunctive therapy to clotrimazole for preventing recurrence of…
- Trial name
- NCT07727967
- Testing
- Lactobacillus crispatus Lc-G22
- Where
- China
- Volunteers
- 100 people
- Sponsor
- BioGrowing Co., Ltd
Non Alcoholic Fatty Liver
Efficacy and Safety of a Probiotic Composition as Adjunct in MAFL Management
Some studies have shown beneficial results with probiotics on hepatic function of subjects with fatty liver, but significant variability has been noted among probiotic formulations.
- Trial name
- NCT04823676
- Testing
- Probiotic composition
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- AB Biotics, SA
Antibiotic Associated Diarrhea
Effect of a Lacidofil® STRONG in Healthy Adults Taking Antibiotic Treatment
The objectives of this study are to evaluate stool consistency and stool frequency during and up to 8 weeks following a 7 day antibiotic treatment with Amoxicillin/Clavulanic Acid 875mg BID.
- Trial name
- NCT01941160
- Testing
- Lacidofil® STRONG
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- KGK Science Inc.
Vulvovaginal Candidiasis (VVC)
Evaluation of the Efficacy of a Probiotic Product as an Adjuvant Treatment for Vulvovaginal Candidiasis
Open-label, randomized clinical trial with a control group and a 4-week intervention period. The study will evaluate the efficacy of the probiotic supplement Bioithas WOMAN® as an adjunctive treatment in women with clinically…
- Trial name
- NCT07603895
- Testing
- Bioithas WOMAN®
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Bioithas SL
Periodontal Disease, Oral Deseases
Oral-Spray Bacillus Spore Probiotics for Periodontal Disease Prevention and Supprotive Treatment in the Elderly
Periodontal diseases are strongly associated with dysbiosis of the oral microbiome within the biofilm. Key pathogens, including Streptococcus mutans, Aggregatibacter actinomycetemcomitans, and Porphyromonas gingivalis, contribute…
- Trial name
- NCT07258303
- Testing
- oral-spray 0.9% NaCl physiological saline solution, LiveSpo Smile CARE
- Where
- Vietnam
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Anabio R&D
Vaginitis
Effects of LiveSpo X-SECRET in SupportiveTreatment of Vaginitis
Vaginitis is a common reproductive infection in women worldwide, particularly in tropical and underdeveloped countries. Traditional antibiotic treatments can disrupt the balance of beneficial bacteria, requiring repeated use…
- Trial name
- NCT06165354
- Testing
- 0.9% NaCl physiological saline, LiveSpo X-secret
- Where
- 2 sites in Vietnam
- Volunteers
- 120 people
- Sponsor
- Anabio R&D
Breast Pain
L.Fermentum CECT5716 in Treatment of Breast Pain
The main objective of this intervention study is to evaluate the efficacy of Lactobacillus fermentum CECT5716 to reduce the presence in the milk of genera Staphylococcus and Streptococcus as risk factors for mastitis in women…
- Trial name
- NCT02093338
- Testing
- Lactobacillus fermentum CECT5716
- Where
- Spain
- Volunteers
- 127 people
- Sponsor
- Biosearch S.A.
Infant Colic
Infant Colic Treatment With Probiotics
This study evaluates the efficacy of Bifidobacterium breve CECT7263 and the mixture B. breve CECT7263/Lactobacillus fermentum CECT5716 in the treatment of infant colic. Group 1 will receive B.
- Trial name
- NCT03467334
- Testing
- B. breve, B. breve plus L. fermentum, Simethicone 20 MG
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Mónica Olivares Martín; PhD
Clostridium Difficile Infection
Safety and Clinical Effectiveness of Oral Probiotic MIYA-BM to Prevent Recurrent Clostridium Difficile Infections
Patients with confirmed C. difficile infection (CDI) who meet eligibility requirements will be invited to participate. All study patients must receive treatment for CDI with metronidazole or vancomycin.
- Trial name
- NCT01077245
- Testing
- MIYA-BM Fine Granules (CBM588)
- Sponsor
- Osel, Inc.
COVID-19, Coronavirus Infection
Study to Evaluate the Effect of a Probiotic in COVID-19
A prospective case-control pilot study to evaluate the possible effect of a probiotic mixture in the improvement of symptoms, the reduction in the number of days of hospitalization and the increase in the percentage of patients…
- Trial name
- NCT04390477
- Testing
- Probiotic
- Where
- 2 sites in Spain
- Volunteers
- 41 people
- Sponsor
- Bioithas SL
Helicobacter Pylori Infection
Assessment of the Adjuvant Role of Dietary Supplementation of Antibiotic-tolerant Probiotics in Standard Therapy for the Eradication of Helicobacter Pylori Infection.
Randomized, double-blind, placebo-controlled clinical study to assess the adjuvant role of dietary supplementation of antibiotic-tolerant probiotics, derived from Lactobacillus acidophilus and Bifidobacterium animalis, in…
- Trial name
- NCT06499649
- Testing
- IBSA Probiotics
- Where
- Italy
- Volunteers
- 270 people
- Sponsor
- IBSA Farmaceutici Italia Srl
Candidiasis, Vaginosis, Bacterial
Use of Boric Acid in Combination With Probiotics for the Treatment of Vaginal Infections
The purpose of this study is to determine whether a formula of boric acid and probiotics for vaginal application is effective in the treatment of symptomatic episodes of vulvovaginitis in comparison to pharmacological reference…
- Trial name
- DOBO (NCT02860845)
- Testing
- Boric acid and probiotics, Antibiotic (Clindamycin), Antifungal (Clotrimazole)
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Laboratorios Ordesa
Ulcerative Colitis Chronic Moderate
Probiotic Treatment of Ulcerative Colitis With Trichuris Suis Ova (TSO)
The PROCTO trial is a double-blind randomized, placebo-controlled, 24-week, comparative, exploratory phase II proof of concept trial.
- Trial name
- PROCTO (NCT03565939)
- Testing
- Trichuris suis ova
- Where
- Denmark
- Volunteers
- 119 people
- Sponsor
- ParaTech A/S
Type 2 Diabetes, Chronic Obstructive Pulmonary Disease
Probiotic on Type 2 Diabetes and Chronic Obstruction Pulmonary Disease
This trial is a randomized, double-blind, parallel placebo clinical trial, the purpose of which is to investigate whether the adjuvant therapy of using probiotics during the treatment of diabetic patients can decrease blood sugar…
- Trial name
- NCT05492448
- Testing
- L. salivarius AP-32 and L. reuteri GL-104, L. reuteri GL-104
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Glac Biotech Co., Ltd
Smoking Cessation
Efficacy of 2 Probiotics During Nicotine Replacement Therapy on Withdrawal Symptoms Associated With Smoking Cessation
Quitting smoking is a big decision, a decision to achieve better health. Trying to quit smoking can be stressful. The prospect of dealing with withdrawal symptoms, fear or failure to change the routine, can also be sources of…
- Trial name
- NCT02492022
- Testing
- Probiotic L008-1, Probiotic L008-2
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Lallemand Health Solutions
Bacterial Vaginosis (BV)
Efficacy and Safety of Vaginal Lactobacillus Dual Probiotic Capsules in Bacterial Vaginosis
Primary Objective: To confirm that the clinical cure rate of Vaginal Lactobacillus Dual Probiotic Capsules for bacterial vaginosis (BV) is superior to placebo at the 21-30 day post-treatment visit (Day 21 to Day 30).
- Trial name
- BV (NCT07418957)
- Testing
- Vaginal Lactobacillus Dual Probiotic Capsules
- Where
- China
- Volunteers
- 402 people
- Sponsor
- Guangdong Longchuangji Pharmaceutical Co., Ltd.
Antibiotic Therapy
Probiotic Product in Healthy Adults Undergoing Antibiotic Treatment
This is randomized, double-blind, placebo controlled, single centre; 21 days phase II clinical trial on healthy volunteers. Following baseline visit at the day of randomization, treatment with Augmentin 875mg for 7 days will be…
- Trial name
- NCT01667653
- Testing
- Probiotic
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Danisco
Fibromyalgia
Use of a Probiotic in the Treatment of Fibromyalgia (FIBROPROB)
This study aims to understand the efficacy of two probiotic interventions as prophylaxes of fibromyalgia symptoms in individuals diagnosed.
- Trial name
- FIBROPROB (NCT04435886)
- Testing
- Probiotic
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Biopolis S.L.
Ulcerative Colitis
Trial on Profermin and Fresubin in Ulcerative Colitis
This study aim to investigate the effect of Profermin versus Fresubin in the dietetic treatment of active ulcerative colitis.
- Trial name
- CUPE2 (NCT01193894)
- Testing
- Profermin, Fresubin
- Where
- Denmark
- Volunteers
- 73 people
- Sponsor
- Nordisk Rebalance A/S
Anorexia Nervosa, Constipation
The Role of Lactobacillus Reuteri in Children and Adolescents With Anorexia Nervosa
The aim of this study is to investigate whether Lactobacillus reuteri could have a beneficial role in treatment of children and adolescents with Anorexia nervosa who develop motility disorder due to the malnutrition regarding the…
- Trial name
- NCT02004288
- Testing
- Lactobacillus reuteri Protectis DSM17938
- Where
- Croatia
- Volunteers
- 31 people
- Sponsor
- BioGaia AB