Clinical trials: Probiotic Therapy
Inflammatory Bowel Diseases
Efficacy of LiveSpo COLON as a Supportive Treatment for Inflammatory Bowel Disease (IBD)
Inflammatory bowel disease (IBD) is a prevalent condition, comprising two major types: (1) Crohn disease (chronic enteritis characterized by abdominal pain, stool irregularities, fatigue, weight loss, and malnutrition) and (2)…
- Trial name
- NCT06637683
- Testing
- LiveSpo COLON, Routine treatment
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Anabio R&D
Asthma Patients
EFFECTIVENESS of PROBIOTICS in ADULTS with MODERATE to SEVERE PERSISTENT ASTHMA
The objective of this study is to compare the effectiveness of probiotic as an adjuvant to standard therapy versus standard therapy alone in adult with moderate to severe persistent asthma in terms of 1.
- Trial name
- NCT06657066
- Testing
- Beclomethasone 200mcg, salbutamol 100mcg , Beclomethasone 200 mcg/Formoterol 6 mcg, 250 mg of lyophilized saccharomyces boulardii, Control (Standard treatment)
- Where
- Pakistan
- Volunteers
- 74 people
- Sponsor
- King Edward Medical University
Colorectal Cancer
Effect of Probiotics Supplementation on the Side Effects of Radiation Therapy Among Colorectal Cancer Patients
Colorectal cancer (CRC) is one of the most common types of cancer worldwide in general and in Jordan in specific. The studies that investigate the role of Probiotics supplementation in improving the inflammatory response…
- Trial name
- NCT03742596
- Testing
- Probiotic Formula Capsule, Control
- Where
- Jordan
- Sponsor
- King Hussein Cancer Center
Type 2 Diabetes Mellitus, Obesity
RCT Examining Effects of Probiotics in T2DM Individuals
Background: The connection between gut health and diabetes status is increasingly recognized. Gut microbiota composition in diabetic differs from non-diabetic individuals.
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Hypertension, Hyperlipidemia
- Trial name
- NCT01752803
- Testing
- Probiotic
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Inflammation
Effect of Probiotic Supplementation on Immune Function in Healthy Infants
The purpose of this study is to understand how a probiotic might change the immune response of healthy infants.
- Trial name
- ProBoost (NCT01542320)
- Testing
- Lactobacillus reuteri DSM 17938
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Emory University
Radiation Proctitis, Probiotics
The Effects of Probiotics Combined With Glutamine in the Prevention and Treatment of Radiation Proctitis
Radiation proctitis is a common complication after radiation therapy for pelvic tumors. The investigators found that live bifidobacterium and lactobacillus tablets combined with compound glutamine enteric-coated capsules can…
- Conditions
- Radiation Proctitis, Probiotics, Glutamine, Gut Microbiota
- Trial name
- NCT05406882
- Testing
- Live Combined Bifidobacterium and Lactobacillus Tablets、Compound Glutamine Entersoluble capsules
- Where
- 2 sites in China
- Volunteers
- 176 people
- Sponsor
- West China Hospital
Inflammatory Bowel Diseases, Crohn Disease
Effect of a Probiotic Mixture on the Gut Microbiome and Fatigue in Patients With Quiescent Inflammatory Bowel Disease
The study is proposed as a single-site randomized double-blind placebo-controlled trial requiring 4 study visits, where two of the visits are combined with their appointment for routine clinical care.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT03266484
- Testing
- Probiotic Mixture
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Probiotics Plus Chemotherapy
Probiotics Combined With Chemotherapy for Patients With Advanced NSCLC
Based on the theory of intestinal lung axis, the effect of new therapy on patients with advanced NSCLC was observed by adjusting the intestinal micro-ecology and combining existing platinum-based doublet chemotherapy.
- Trial name
- NCT03642548
- Testing
- bifico
- Volunteers
- 180 people
- Sponsor
- Shanghai 10th People's Hospital
Diarrhea
A Comparison of Three Medications to Treat Diarrhea in Adults.
A comparison of three medications to treat diarrhea in adults.
- Trial name
- NCT00807326
- Testing
- Loperamide/simeticone 2 mg/125 mg caplets, Loperamide/simeticone 2 mg/125 mg chewable tablets, Probiotic Saccharomyces boulardii 250 mg capsules
- Where
- 6 sites in India, Mexico
- Volunteers
- 415 people
- Sponsor
- McNeil AB
Constipation
Drink Milk Consumption Benefits With Culture Probiotic in the Treatment of Constipation
Constipation is defined as a disorder characterized by persistent difficulty to evacuate or a feeling of incomplete evacuation and / or infrequent bowel movements.
- Trial name
- NCT02446080
- Testing
- Milk drink with probiotic culture, Milk drink
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centro Universitário Univates
Communicable Diseases, Infection
Probiotics to Promote Intestinal Health
The purpose of this study is to evaluate the effectiveness of bacteria called Lactobacillus GG, a Probiotic, in preventing the growth of resistant bacteria in the digestive tract in patients on broad spectrum antimicrobials.
- Conditions
- Communicable Diseases, Infection, Anti-Infective Agents, Therapeutic Uses
- Trial name
- NCT02046512
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Washington University School of Medicine
Acute Gastroenteritis
Efficacy and Safety of Probiotics in the Treatment of Acute Gastroenteritis in Children
Primary Objective: o To assess the efficacy of the probiotics in reducing the duration of diarrhea in children suffering from acute gastroenteritis.
- Trial name
- SABINA (NCT03539913)
- Testing
- Probiotic : Saccharomyces boulardii, Probiotic : Bacillus clausii
- Where
- 8 sites in Argentina
- Volunteers
- 317 people
- Sponsor
- Biocodex
Covid19
Study to Investigate the Treatment Benefits of Probiotic Streptococcus Salivarius K12 for Hospitalised Patients (Non-ICU) With COVID-19
This is a randomised, open-label and controlled clinical trial aimed to investigate the adjuvant treatment benefits of probiotic Streptococcus salivarius K12 in hospitalised mild-to-moderate patients with COVID-19 disease.
- Trial name
- NCT05043376
- Testing
- Standard of care, BLIS K12
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- King Edward Medical University
Limited Stage Small Cell Lung Cancer
Study of Probiotics Combined With Concurrent Hyperfractionated ChemoRadiotherapy and Adebrelimab Immunomaintenance in the Treatment of Limited-stage Small Cell Lung Cancer (LS-SCLC)
ADRIATIC study explored the benefits of immune maintenance therapy after LS-SCLC radiotherapy and chemotherapy. In the presence of immunotherapy, is it necessary to increase the dosage of radiotherapy and can it further improve…
- Trial name
- NCT06943235
- Testing
- Probiotics, concurrent Hyperfractionated Radiotherapy, Immunotherapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fudan University
Necrotizing Enterocolitis
Effect of Pentoxifylline Versus Probiotic on Preterm Neonates With Necrotizing Enterocolitis
The aim of this study is to evaluate the effectiveness of pentoxifylline versus probiotics supplementation as adjuvant therapy for preterm neonates with necrotizing enterocolitis.
- Trial name
- NCT06422000
- Testing
- Pentoxifylline, Probiotic Formula
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Tanta University
Lumbar Degenerative Disease, Lumbar Spondylolisthesis
Perioperative Nutrition Management in Patients Undergoing Open Posterior Lumbar Surgery
Patients undergoing open posterior lumbar fusion surgery often experience postoperative gastrointestinal problems, such as bloating, constipation, and delayed passage of gas and stool, and may be at nutritional risk.
- Conditions
- Lumbar Degenerative Disease, Lumbar Spondylolisthesis, Lumbar Disc Herniation
- Trial name
- NCT07893938
- Testing
- Oral nutritional supplements (ONS), Carbohydrate loading (OCL), 'Probiotics (Bifidobacterium and Lactobacillus triple live capsules)'
- Where
- China
- Volunteers
- 90 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Bronchopulmonary Dysplasia
Effect of Caffeine Versus Probiotic on Preterm Neonates With Bronchopulmonary Dysplasia
The aim of this study is to evaluate the effectiveness of caffeine versus probiotics supplementation as adjuvant therapy for preterm neonates with Bronchopulmonary dysplasia (BPD).
- Trial name
- NCT05682807
- Testing
- Caffeine, Probiotic Formula
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Gastroenteritis, Diarrhea
The Treatment Effect of Bio-Three on Children With Enteritis
Diarrhea due to acute enteritis is a common symptom in the children. Lots of patients are infected by rotavirus or salmonella. Base on the past researches, there is benefit effect of probiotics on patients with diarrhea or acute…
- Trial name
- Bio-three (NCT01480947)
- Testing
- Bio-three
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Tooth Extraction, Post-Op Complication
Antibiotic Therapy in Erupted Tooth Extractions
Evaluation of the efficacy of amox+clav and of a probiotic after tooth extraction. the aim is to evaluate efficacy of antibiotic therapy after tooth extractions in preventing infections as compared to no therapy, and efficacy of…
- Conditions
- Tooth Extraction, Post-Op Complication, Amoxicillin
- Trial name
- NCT04082598
- Testing
- Amoxicillin Clavulanate, Bifidobacterium longum and Lactoferrin
- Volunteers
- 165 people
- Sponsor
- Antonio Barone
Multiple Sclerosis, Clinically Isolated Syndrome (CIS)
Prebiotic vs Probiotic in Multiple Sclerosis
This is a randomized crossover-designed study to explore the immunologic effects of Prebiotics, as opposed to direct supplementation with beneficial bacteria (Probiotics) in the immune system of patients with MS and Clinically…
- Trial name
- MS (NCT04038541)
- Testing
- Prebiotics (Prebiotin Prebiotic Fiber Stick Pac), Probiotics (Visbiome®)
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Columbia University