Clinical trials: Probiotic Therapy
Hyperbilirubinemia, Neonatal
Effectiveness of Phototherapy With and Without Probiotics
Raised serum bilirubin levels can cause kernicterus and premature infants are at increased risk due to metabolic immaturity. The standard treatment for neonatal jaundice is phototherapy but probiotics along with it can reduce the…
- Trial name
- NCT06173856
- Testing
- LED phototherapy
- Where
- Pakistan
- Volunteers
- 76 people
- Sponsor
- Fatima Jinnah Medical University
Preoperative Cardiac Surgery Patients
The Effect of Prophylactic Pre Operative Probiotic Therapy on Endotoxin Levels in Cardiac Surgery Patients
The primary hypothesis for the study is that pre-operative prophylactic probiotic Lactobacilli tablets will reduce the severity and incidence of endotoxin rise in post cardiopulmonary bypass in cardiac surgery patients.
- Trial name
- NCT00256022
- Testing
- Lactobacillus Probiotic, Lactose Powder
- Sponsor
- Melbourne Health
Clostridium Difficile Infection
Safety and Clinical Effectiveness of Oral Probiotic MIYA-BM to Prevent Recurrent Clostridium Difficile Infections
Patients with confirmed C. difficile infection (CDI) who meet eligibility requirements will be invited to participate. All study patients must receive treatment for CDI with metronidazole or vancomycin.
- Trial name
- NCT01077245
- Testing
- MIYA-BM Fine Granules (CBM588)
- Sponsor
- Osel, Inc.
Multiple Sclerosis, Clinically Isolated Syndrome (CIS)
Prebiotic vs Probiotic in Multiple Sclerosis
This is a randomized crossover-designed study to explore the immunologic effects of Prebiotics, as opposed to direct supplementation with beneficial bacteria (Probiotics) in the immune system of patients with MS and Clinically…
- Trial name
- MS (NCT04038541)
- Testing
- Prebiotics (Prebiotin Prebiotic Fiber Stick Pac), Probiotics (Visbiome®)
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Columbia University
Chronic Periodontitis Complex
Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis.
Currently, with the increase of bacterial resistance to antibiotics associated with its side effects, it is necessary to find other adjuncts to combat the disease that are an alternative to the use of antibiotics.
- Trial name
- NCT03692819
- Testing
- Amoxicillin 500 Mg, Lactobacillus reuteri Oral Drops
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Depression
Probiotics Therapy of Mood Disorders
The evaluation of the influence of a probiotics therapy on mood improvement and the reduction of depressive symptoms in women in the perimenopausal age group.
- Trial name
- NCT04753944
- Testing
- Active Comparator: Probiotic
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Pomeranian Medical University Szczecin
COVID-19, Coronavirus Infection
Study to Evaluate the Effect of a Probiotic in COVID-19
A prospective case-control pilot study to evaluate the possible effect of a probiotic mixture in the improvement of symptoms, the reduction in the number of days of hospitalization and the increase in the percentage of patients…
- Trial name
- NCT04390477
- Testing
- Probiotic
- Where
- 2 sites in Spain
- Volunteers
- 41 people
- Sponsor
- Bioithas SL
Communicable Diseases, Infection
Probiotics to Promote Intestinal Health
The purpose of this study is to evaluate the effectiveness of bacteria called Lactobacillus GG, a Probiotic, in preventing the growth of resistant bacteria in the digestive tract in patients on broad spectrum antimicrobials.
- Conditions
- Communicable Diseases, Infection, Anti-Infective Agents, Therapeutic Uses
- Trial name
- NCT02046512
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Washington University School of Medicine
Acute Watery Diarrhoea
Efficacy of Zinc Sulfate With Probiotics for the Treatment of Acute Diarrhea in Children
Diarrheal disease is one of the major causes of morbidity and mortality in children under five. Disease is treated symptomatically with oral rehydration (ORS) as a basic measure.
- Trial name
- Zinc (NCT01140074)
- Testing
- Zinc Sulfate
- Where
- 2 sites in Poland
- Volunteers
- 256 people
- Sponsor
- University Hospital No 1 Wroclaw
Cognitive/Functional Effects, Constipation, Impaction, and Bowel Obstruction
Probiotic Therapy in Preventing Gastrointestinal Complications in Patients Undergoing Chemotherapy and Pelvic Radiation Therapy
RATIONALE: Probiotic therapy may reduce or prevent gastrointestinal complications in patients undergoing chemotherapy and pelvic radiation therapy.
- Conditions
- Cognitive/Functional Effects, Constipation, Impaction, and Bowel Obstruction, Diarrhea, Fatigue
- Trial name
- NCT01473290
- Testing
- live freeze-dried lactic acid bacteria probiotic
- Sponsor
- Alliance for Clinical Trials in Oncology
Periodontitis Stage III, Probiotic
Evaluation Of The Effect Of Streptococcus Salivarius K12 Probiotic In The Treatment Of Periodontitis
Aims: The use of oral probiotics as an adjunct to the treatment of periodontal diseases is known to be beneficial in antagonizing pathogenic microflora and regulating the host immune response.
- Trial name
- NCT06871540
- Testing
- Probiotic Agent, Non-Surgical Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AYŞENUR ŞAHİN
Periodontitis
Probiotics as Adjunct to Nonsurgical Periodontal Treatment
ProlacSan probiotic lozenges and gels contain L. plantarum and L. brevis strains with proven in vitro antimicrobial activity against P. gingivalis.
- Trial name
- NCT04137419
- Testing
- Probiotic lozenges
- Where
- Slovenia
- Volunteers
- 40 people
- Sponsor
- University of Ljubljana
Probiotics Plus Chemotherapy
Probiotics Combined With Chemotherapy for Patients With Advanced NSCLC
Based on the theory of intestinal lung axis, the effect of new therapy on patients with advanced NSCLC was observed by adjusting the intestinal micro-ecology and combining existing platinum-based doublet chemotherapy.
- Trial name
- NCT03642548
- Testing
- bifico
- Volunteers
- 180 people
- Sponsor
- Shanghai 10th People's Hospital
Obesity and Overweight, Obesity, Morbid
Impact of Nutritional Intervention With Probiotics and Prebiotics on Obesity.
Obesity is one of the most severe and prevalent non-communicable diseases worldwide, affecting an estimated one-third of the population in Spain.
- Conditions
- Obesity and Overweight, Obesity, Morbid, Metabolic Syndrome
- Trial name
- MicoBeBioticos (NCT06722443)
- Testing
- Probiotic, Prebiotic, Synbiotic
- Where
- Spain
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental
Helicobacter Pylori Infection
Assessment of the Adjuvant Role of Dietary Supplementation of Antibiotic-tolerant Probiotics in Standard Therapy for the Eradication of Helicobacter Pylori Infection.
Randomized, double-blind, placebo-controlled clinical study to assess the adjuvant role of dietary supplementation of antibiotic-tolerant probiotics, derived from Lactobacillus acidophilus and Bifidobacterium animalis, in…
- Trial name
- NCT06499649
- Testing
- IBSA Probiotics
- Where
- Italy
- Volunteers
- 270 people
- Sponsor
- IBSA Farmaceutici Italia Srl
Diabetes Mellitus Type II
Investigation of the Effect of E.-Coli-Nissle as Supporting Therapy to Standard Care of Diabetes Mellitus Type II
This is a pilot study to investigate the effect of e.-coli-nissle as supporting therapy to antidiabetic standard care in patients with diabetes mellitus type II
- Trial name
- PUNiDIA (NCT02144948)
- Testing
- e.-coli-nissle
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- GWT-TUD GmbH
Genitourinary; Infection, Complicating Pregnancy
Probiotic Supplementation as Prophylactic for Group B β-hemolytic Streptococcus (GBS) Infection
Streptococcus agalactiae, a Group B β-hemolytic streptococcus (GBS), is the leading cause of severe neonatal infection in developed countries.
- Trial name
- NCT06231056
- Testing
- Probiotic iNatal®
- Where
- Italy
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Liaquat University of Medical & Health Sciences
Candidiasis, Vaginosis, Bacterial
Use of Boric Acid in Combination With Probiotics for the Treatment of Vaginal Infections
The purpose of this study is to determine whether a formula of boric acid and probiotics for vaginal application is effective in the treatment of symptomatic episodes of vulvovaginitis in comparison to pharmacological reference…
- Trial name
- DOBO (NCT02860845)
- Testing
- Boric acid and probiotics, Antibiotic (Clindamycin), Antifungal (Clotrimazole)
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Laboratorios Ordesa
Atopic Dermatitis
Beginning Assessment of Cutaneous Treatment Efficacy of Roseomonas in Atopic Dermatitis
Background: Atopic dermatitis (AD) is a skin disease also called eczema. It is common in children and sometimes gets better on its own. However, chronic AD may cause asthma, food allergies, eye infections, and sleep problems.
- Trial name
- NCT03018275
- Testing
- Roseomonas mucosa
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ulcerative Colitis Chronic Moderate
Probiotic Treatment of Ulcerative Colitis With Trichuris Suis Ova (TSO)
The PROCTO trial is a double-blind randomized, placebo-controlled, 24-week, comparative, exploratory phase II proof of concept trial.
- Trial name
- PROCTO (NCT03565939)
- Testing
- Trichuris suis ova
- Where
- Denmark
- Volunteers
- 119 people
- Sponsor
- ParaTech A/S