Clinical trials: Probiotic Therapy
Indirect Hyperbilirubinemia
Efficacy of Bifidobacterium Animalis Subsp. Lactis in the Treatment of Indirect Hyperbilirubinemia in Term Neonates
This study aims to evaluate the effectiveness of adjunctive oral Bifidobacterium animalis subsp. lactis in term neonates with indirect hyperbilirubinemia receiving phototherapy.
- Trial name
- NCT07773012
- Testing
- Bifidobacterium animalis subsp. lactis, Standard Phototherapy
- Where
- Vietnam
- Volunteers
- 90 people
- Sponsor
- Can Tho University of Medicine and Pharmacy
Acute Alcoholic Hepatitis
Novel Therapies in Moderately Severe Acute Alcoholic Hepatitis
This study is being done to find out whether a diet supplemented with a probiotic nutrient can improve alcoholic hepatitis and gut complications compared to routine standard care.
- Trial name
- NTAH-Mod (NCT01922895)
- Testing
- Lactobacillus Rhamnosus GG
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Texas Southwestern Medical Center
Atopic Dermatitis, Probiotics
Effect of Probiotics in the Atopic Dermatitis
This study was designed to evaluate the efficacy of probiotics in the treatment of atopic dermatitis. Probiotics in AD patients were effective in reducing SCORAD index levels, but not effective in skin prick test positivity…
- Trial name
- NCT01224132
- Testing
- probiotic ® pur
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Vaginal Candidiasis
Postbiotic as Adjunct Treatment for Vaginal Candidiasis
This project aims to study the efficacy of oral administration of postbiotic at 1g/day as an adjunct treatment against vaginal candidiasis in women for 4-weeks compared to placebo.
- Trial name
- NCT06474247
- Testing
- Postbiotic
- Where
- 2 sites in India, Malaysia
- Volunteers
- 99 people
- Sponsor
- Min-Tze LIONG
Healthy Adult Participants, Periodontal Disease
Clinical, Microbiological and Immunological Effects of the Adjuvant Use of Systemic Antibiotics and Probiotics in the Non-surgical Treatment of Periodontitis
Although robust evidence supports the benefits of antibiotics in periodontal treatment, the potential adverse effects of this therapy cannot be overlooked.
- Trial name
- NCT07592416
- Testing
- Amoxicilin and Metronidazole, Probiotic Therapy
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Schizophrenia, Bipolar Disorder
A 12-weeks Study to Evaluate the Dietary Fiber and Probiotics Treatment in Prevention and Intervention of Weight-gain and Cognitive Impairment of Schizophrenia or Bipolar Disorder
In this study, the investigators will evaluate the efficacy, safety and related mechanism of dietary fiber and probiotics alone and in combination as a add-on treatment in improving the antipsychotic induced weight gain, the…
- Trial name
- NCT03379597
- Testing
- Bifico (Live combined bifidobacterium,Lactobacillus and Enterococcus capsules, Oral), Dietary fiber
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Central South University
Fertility Issues
Study to Investigate the Treatment Benefit of Probiotic Lactobacillus Crispatus M247 in Women Undergoing Homologous Level 2 Assisted Reproductive Technology (ART) Procedures
The present study is aimed to explore the treatment effect from the intake of probiotic Lactobacillus crispatus M247 in the improvement of clinical and psychological aspects in women undergoing homologous level 2 ART procedures.
- Trial name
- NCT05871242
- Testing
- Probiotic Lactobacillus crispatus M247
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Dr. Amjad Khan
Fibromyalgia
The Effect of Probiotic and Prebiotic Use on Fibromyalgia Syndrome
The aim of the present study is to determine the effectiveness of probiotic and prebiotic treatments in patients with fibromyalgia syndrome.
- Trial name
- NCT04607278
- Testing
- Probiotic, Prebiotic
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Ankara University
Diarrhea, Rotavirus Infection
Use of Nitazoxanide and Probiotics in Acute Diarrhea Secondary to Rotavirus
Nitazoxanide has proved an cytoprotective effect against rotavirus infection. How it could be clinically important in time of hospitalization and reduction of duration of diarrhea secondary to rotavirus?
- Trial name
- NCT00683982
- Testing
- Nitazoxanide, Probiotic mix preparation, Oral hydration solutions
- Where
- Bolivia
- Volunteers
- 75 people
- Sponsor
- Centro Pediatrico Albina de Patino
Parkinson Disease (PD), Gut Microbiota
Developing Precision Microbiota-Based Cocktail Modification Therapy to Delay the Progression of Parkinson's Disease (PD) - Use Preclinical Human Trials to Confirm the Impact of the Optimal "Probiotic Y7, Tryptophan and Branched-chain Amino Acid" Cocktail Formula on Early Stage PD Patients
Preclinical human trials will be utilized to validate the research direction, followed by clinical trials to assess the impact of a cocktail formula product containing the optimal probiotic Y7 combined metabolites on motor…
- Conditions
- Parkinson Disease (PD), Gut Microbiota, Probiotic
- Trial name
- NCT07619560
- Testing
- Y7
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Medical University
PCOS
Effect of Dietary Modifacation on Microbiota in Overweight and Obese Polycystic Ovary Syndrome Patients
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age. The pathogenesis of PCOS is not fully understood.
- Trial name
- NCT03325023
- Testing
- Dietary and life style modification and probiotic Sanprobi Super Formula
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Poznan University of Medical Sciences
Pregnancy, Periodontal Disease
Effectiveness of Coenzyme Q10 and Probiotics in Periodontal Therapy During Pregnancy
This randomized controlled clinical trial aims to evaluate the effectiveness of adjunctive coenzyme Q10 and probiotic supplementation (Limosilactobacillus reuteri Prodentis®) in improving periodontal health in pregnant women…
- Conditions
- Pregnancy, Periodontal Disease, Gingivitis, Dental Plaque
- Trial name
- PREG-Q10 (NCT07029360)
- Testing
- Limosilactobacillus reuteri Prodentis®, Coenzyme Q10 Toothpaste
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Acute Diarrhea, Acute Gastroenteritis
Use of Probiotic Yogurt in the Treatment of Acute Diarrhea in Children
The purpose of this study is to determine the effect of probiotic yogurt in acute watery diarrhea in children. The investigators will compare the effect of two different probiotics products.
- Trial name
- NCT01564290
- Testing
- Probiotic yogurt
- Where
- Bolivia
- Volunteers
- 54 people
- Sponsor
- Centro Pediatrico Albina de Patino
Functional Abdominal Pain Syndrome
The Effects of Probiotics, Lactobacillus GG, in the Treatment of Abdominal Pain in Children With Functional Abdominal Pain Disorders
Recurrent or chronic abdominal pain is one of the common gastrointestinal problems in children. While most children do not have organic origins (so called functional abdominal pain disorders; FAPDs), the symptoms can nevertheless…
- Trial name
- NCT06310733
- Testing
- LGG
- Where
- Thailand
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Overweight and Obesity
The Prevention And Treatment On Obesity And Weight Management By Oral Supplementation Of Probiotics And Prebiotics
The goal of this interventional study is to test whether consumption of Wonderlab probiotics with prebiotics could improve obesity and overweight in Chinese people who are aged 25-45 and overweight.
- Trial name
- NCT06030999
- Testing
- Study product A (Wonderlab wonder4shape), Study product B (Wonderlab wonder4shape)
- Where
- 2 sites in China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Shenzhen Precision Health Food Technology Co. Ltd.,
Acute Diarrhea
Efficacy and Safety of Saccharomyces Boulardii in Treatment of Acute Diarrhea in Children Aged 6 Months to 5 Years Old
This study aimed to evaluate the effectiveness of saccharomyces-based treatment in children with acute diarrhea aged 6 months to 5 years compared to children treated with standard methods.
- Trial name
- NCT07813182
- Testing
- Saccharomyces Boulardii Probiotic Supplement, The child will be treated with standard method
- Where
- Vietnam
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
Adult Atopic Dermatitis
Probiotics in Adults: do They Improve Atopic Dermatitis?
Probiotics are suggested to have beneficial effects in atopic dermatitis (AD) treatment and prevention but their precise role is not yet clear.
- Trial name
- NCT01500941
- Testing
- probiotics, maltodextrin
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Lumbar Degenerative Disease, Lumbar Spondylolisthesis
Perioperative Nutrition Management in Patients Undergoing Open Posterior Lumbar Surgery
Patients undergoing open posterior lumbar fusion surgery often experience postoperative gastrointestinal problems, such as bloating, constipation, and delayed passage of gas and stool, and may be at nutritional risk.
- Conditions
- Lumbar Degenerative Disease, Lumbar Spondylolisthesis, Lumbar Disc Herniation
- Trial name
- NCT07893938
- Testing
- Oral nutritional supplements (ONS), Carbohydrate loading (OCL), 'Probiotics (Bifidobacterium and Lactobacillus triple live capsules)'
- Where
- China
- Volunteers
- 90 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Type 2 Diabetes, Chronic Obstructive Pulmonary Disease
Probiotic on Type 2 Diabetes and Chronic Obstruction Pulmonary Disease
This trial is a randomized, double-blind, parallel placebo clinical trial, the purpose of which is to investigate whether the adjuvant therapy of using probiotics during the treatment of diabetic patients can decrease blood sugar…
- Trial name
- NCT05492448
- Testing
- L. salivarius AP-32 and L. reuteri GL-104, L. reuteri GL-104
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Glac Biotech Co., Ltd
Severe Depression
Probiotic Supplementation in Severe Depression
Recent research demonstrates that the composition of the gut microbiome is a master regulator of key neurophysiological processes that are affected in depression.
- Trial name
- NCT02957591
- Testing
- Vivomixx®
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Psychiatric Hospital of the University of Basel