Clinical trials: Probiotic Therapy
NASH, NAFLD
RE and Probiotics in MAFLD/NAFLD
This project aims to evaluate the roles of the autonomic nervous system (ANS) and gut microbiota as correlates of clinical improvement in metabolic dysfunction-associated fatty liver disease (MAFLD) and non-alcoholic fatty liver…
- Conditions
- NASH, NAFLD, MAFLD
- Trial name
- NCT06563921
- Testing
- physical exercise programme, probiotics supplementation
- Volunteers
- 180 people
- Sponsor
- Nicolaus Copernicus University
Periodontitis, Probiotics
Effects of Probiotic Therapy in the Treatment of Periodontitis.
The aim of this study is to evaluate the effect of the probiotic therapy as an adjunct to non-surgical periodontal treatment in patients diagnosed with Generalized Chronic Periodontitis.
- Trial name
- NCT03408548
- Testing
- Scaling root planning, Probiotic
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- University of Sao Paulo
Respiratory Tract Infections
Study of the Effect of Probiotics on Respiratory Morbidity After Influenza Vaccination of Elderly in Nursing Homes
The purpose of this study is to determine whether probiotic treatment improves the protection against respiratory infections after influenza vaccination in elderly living in nursing homes.
- Trial name
- NCT00849277
- Testing
- Lactobacillus casei Shirota
- Where
- Belgium
- Volunteers
- 737 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Impulsive Behavior, Compulsive Disorder
Treating Impulsivity in Adults With Probiotics
A multicentre randomized double-blind placebo controlled parallel design (10 weeks) study investigating probiotic supplementation in highly impulsive adults (18-65 yrs; N=180).
- Conditions
- Impulsive Behavior, Compulsive Disorder, ADHD, Borderline Personality Disorder
- Trial name
- PROBIA (NCT03495375)
- Testing
- Treatment with a probiotic
- Where
- 3 sites in Germany, Hungary and 1 more
- Volunteers
- 180 people
- Sponsor
- Hospital Vall d'Hebron
Hypertension
Effect of Probiotics on Primary Hypertension
Gut microbiota was found to play a causal role in the pathogenesis of hypertension. Probiotics were shown to have a potential anti-hypertensive effect in human/rodent studies.
- Trial name
- NCT05095350
- Testing
- Probiotic powder
- Where
- 6 sites in China
- Volunteers
- 115 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Depression
Fermented Milk Product With Probiotic and Its Impact on Mood of Patients With Treatment Resistant Depression
This study aims to assess the impact of a chronic dietary intervention (8 weeks) with probiotics, specifically Fermented Milk Product with Probiotic (FMPP), on the mood of individuals with Major Depressive Disorder (MDD)…
- Trial name
- NCT03317678
- Testing
- BioKefir, Non-fermented milk
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rush University Medical Center
HELICOBACTER PYLORI INFECTIONS, Helicobacter Infection
Vonoprazan vs Proton Pump Inhibitor With Vitamin D or Probiotics Based Triple Therapy for Eradication of Helicobacter Pylori Infection
Helicobacter pylori is a Gram-negative, spiral-shaped bacterium that infects up to 50% of the world's population, residing in the gastric mucosa and using the mucus layer for protection from the stomach's high acidity.
- Conditions
- HELICOBACTER PYLORI INFECTIONS, Helicobacter Infection, Helicobacter Pylori Gastrointestinal Tract Infection, Helicobacter Pylori Infected Patients
- Trial name
- NCT07293910
- Testing
- Vonoparazan, Vitamin D, Probiotic
- Where
- Egypt
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Tanta University
Inflammation
Effect of Probiotic Supplementation on Immune Function in Healthy Infants
The purpose of this study is to understand how a probiotic might change the immune response of healthy infants.
- Trial name
- ProBoost (NCT01542320)
- Testing
- Lactobacillus reuteri DSM 17938
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Emory University
Periodontal Disease
Effects of Adjunctive Synbiotic Supplementation to Non-Surgical Periodontal Therapy in Smokers With Periodontitis
The aim of this study is to evaluate the effects of adjunctive synbiotic supplementation combined with non-surgical periodontal therapy in smokers with periodontitis.
- Trial name
- NCT07672379
- Testing
- Synbiotic supplementation
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people
- Sponsor
- Biruni University
Coronavirus Infection
Efficacy of Probiotics in the Treatment of Hospitalised Patients With Novel Coronavirus Infection
The treatment of the new coronavirus infection (COVID-19) and COVID-19-associated diarrhoea and liver injury remains challenging. Optimizing treatment approaches for COVID-19 remains an issue.
- Trial name
- NCT04854941
- Testing
- Probiotics
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Antibiotic-Associated Diarrhea
Probiotics for Prevention of Antibiotic-associated Diarrhea
The purpose of this study is to evaluate if ingestion of a probiotic formula (Jarrow-Dophilus EPS)reduces incidence of diarrhea and improves the quality of life of patients receiving antibiotic therapy.
- Trial name
- NCT00641199
- Testing
- Jarro-Dophilus EPS probiotics
- Where
- Canada
- Volunteers
- 204 people
- Sponsor
- University of Saskatchewan
Smoking Cessation
Efficacy of 2 Probiotics During Nicotine Replacement Therapy on Withdrawal Symptoms Associated With Smoking Cessation
Quitting smoking is a big decision, a decision to achieve better health. Trying to quit smoking can be stressful. The prospect of dealing with withdrawal symptoms, fear or failure to change the routine, can also be sources of…
- Trial name
- NCT02492022
- Testing
- Probiotic L008-1, Probiotic L008-2
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Lallemand Health Solutions
Obsessive-Compulsive Disorder
Probiotic Treatment in Adult Obsessive-Compulsive Disorder
This study will evaluate the effectiveness of 12-weeks of probiotic treatment in adults with primary Obsessive-Compulsive Disorder and whether this treatment will alter the microbiota composition in these patients.
- Trial name
- NCT02334644
- Testing
- Probiotic Formula (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- McMaster University
CKD, PAD
lncRNAs as a Biomarker to Assess the Therapeutic Impact of Oral Absorbent ± Probiotics in CKD Patients With PAD
Participants with chronic kidney disease (CKD) are at a higher risk of developing atherosclerotic peripheral artery disease (PAD).
- Trial name
- NCT04788914
- Testing
- Active bamboo charcoal± probiotics
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Infections
The Effect of Probiotic Combination on Helicobacter Pylori Infection in Children
The combination of two Lactubacillus reuteri strains, ATC 55730 and ATCC PTA 6457 are marketed as GASTRUS® and has been proposed as better option in increasing Helicobacter pylori eradication rate compared to the single strain…
- Trial name
- Gastrus (NCT02645201)
- Testing
- Gastrus
- Where
- 5 sites in Belgium, Croatia and 3 more
- Sponsor
- University Medical Centre Ljubljana
Crohn's Disease
Treatment With Lactobacillus Rhamnosus and Lactobacillus Acidophilus for Patients With Active Colonic Crohn's Disease.
The purpose of this study is to determine whether a probiotic containing Lactobacillus Acidophilus and Lactobacillus Rhamnosus is effective as treatment for patients with active colonic Crohn's disease
- Trial name
- NCT00374374
- Testing
- Administration of probiotic
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Odense University Hospital
Bacterial Vaginosis (BV)
Efficacy and Safety of Vaginal Lactobacillus Dual Probiotic Capsules in Bacterial Vaginosis
Primary Objective: To confirm that the clinical cure rate of Vaginal Lactobacillus Dual Probiotic Capsules for bacterial vaginosis (BV) is superior to placebo at the 21-30 day post-treatment visit (Day 21 to Day 30).
- Trial name
- BV (NCT07418957)
- Testing
- Vaginal Lactobacillus Dual Probiotic Capsules
- Where
- China
- Volunteers
- 402 people
- Sponsor
- Guangdong Longchuangji Pharmaceutical Co., Ltd.
Antibiotic Therapy
Probiotic Product in Healthy Adults Undergoing Antibiotic Treatment
This is randomized, double-blind, placebo controlled, single centre; 21 days phase II clinical trial on healthy volunteers. Following baseline visit at the day of randomization, treatment with Augmentin 875mg for 7 days will be…
- Trial name
- NCT01667653
- Testing
- Probiotic
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Danisco
Fibromyalgia
Use of a Probiotic in the Treatment of Fibromyalgia (FIBROPROB)
This study aims to understand the efficacy of two probiotic interventions as prophylaxes of fibromyalgia symptoms in individuals diagnosed.
- Trial name
- FIBROPROB (NCT04435886)
- Testing
- Probiotic
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Biopolis S.L.
Irritable Bowel Syndrome
Combination of Alverine-simeticone and i3.1 Probiotic in IBS-D and IBS-M in Mexico
This randomized study evaluates the usefulness of the I31 probiotic formula, alone or in combination with alverine/simethicone, against placebo, in the treatment of diarrhea-predominant or mixed irritable bowel syndrome
- Trial name
- NCT04145856
- Testing
- I31 probiotic, I31 probiotic combined to Alverine/Simethicone
- Where
- Mexico
- Volunteers
- 55 people
- Sponsor
- Hospital Juarez de Mexico