Clinical trials: Probiotic Therapy
Ulcerative Colitis
Trial on Profermin and Fresubin in Ulcerative Colitis
This study aim to investigate the effect of Profermin versus Fresubin in the dietetic treatment of active ulcerative colitis.
- Trial name
- CUPE2 (NCT01193894)
- Testing
- Profermin, Fresubin
- Where
- Denmark
- Volunteers
- 73 people
- Sponsor
- Nordisk Rebalance A/S
Chronic Rhinosinusitis
Safety and Efficacy of Lactococcus Lactis Probiotic Bacteria for the Treatment of Chronic Rhinosinusitis
Despite advances in medical treatments and surgery for chronic rhinosinusitis (CRS), there remains a large number of patients who continue to suffer from chronic sinusitis despite standard therapies.
- Trial name
- NCT04048174
- Testing
- Topical probiotic treatment with Lactococcus lactis W136, Saline irrigation
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Irritable Bowel Syndrome, Small Intestinal Bacterial Overgrowth
The Efficacy of Probiotics as an Adjunct to Treatment of SIBO With Rifaximin
The goal of this clinical trial is to test the effectiveness of probiotic bacterial supplements as an additional therapeutic modality in patients with small intestine bacterial overgrowth who receive oral antibiotic treatment…
- Conditions
- Irritable Bowel Syndrome, Small Intestinal Bacterial Overgrowth, SIBO
- Trial name
- NCT06223685
- Testing
- Rifaximin (Xifaxan) 1200mg/day, Probiotic, XIFAXAN® (Rifaximin) 1600mg/day
- Where
- Poland
- Volunteers
- 129 people
- Sponsor
- Pomeranian Medical University Szczecin
IBS in Celiac Desease
Probiotics for the Treatment of Irritable Bowel Syndrome in Celiac Patients
Probiotics play an important role in preventing overgrowth of potentially pathogenic bacteria and maintaining the integrity of the gut mucosal barrier.
- Trial name
- ProCel (NCT01699191)
- Testing
- Probiotic
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Bari
Acute Pancreatitis
Therapeutic Effect of Bifidobacterium Longum in Patients with Acute Pancreatitis: a Randomized, Double-Blind, Placebo-Controlled Trial
The purpose of this clinical trial is to investigate the impact of Bifidobacterium longum(BL) on the clinical prognosis of patients with acute pancreatitis(AP), to analyze the correlation between BL and intestinal barrier…
- Trial name
- NCT06639516
- Testing
- Bifidobacterium longum, Standard clinical treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Endometriosis, Probiotics
The Role of Probiotics in the Treatment of Endometriosis (ProMetrioS): a Randomised Double-blinded Placebo-controlled Cross-over Trial
ProMetrioS is a randomised blinded placebo-controlled cross-over trial investigating the effect of specific multistrain probiotics in patients with endometriosis.
- Trial name
- ProMetrioS (NCT06929364)
- Testing
- Omni Biotic Stress
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- The Gut Microbiome Center (Centar za crijevni mikrobiom)
Anorexia Nervosa, Constipation
The Role of Lactobacillus Reuteri in Children and Adolescents With Anorexia Nervosa
The aim of this study is to investigate whether Lactobacillus reuteri could have a beneficial role in treatment of children and adolescents with Anorexia nervosa who develop motility disorder due to the malnutrition regarding the…
- Trial name
- NCT02004288
- Testing
- Lactobacillus reuteri Protectis DSM17938
- Where
- Croatia
- Volunteers
- 31 people
- Sponsor
- BioGaia AB
Non-small Cell Lung Cancer Stage II, Non-small Cell Lung Cancer Stage ⅢA
Clinical Study of Neoadjuvant Chemotherapy and Immunotherapy Combined With Probiotics in Patients With Resectable NSCLC
To evaluate the safety and effect of neoadjuvant chemotherapy and immunotherapy combined with probiotics for resectable NSCLC patients.
- Conditions
- Non-small Cell Lung Cancer Stage II, Non-small Cell Lung Cancer Stage ⅢA, Non-small Cell Lung Cancer Stage IIIB
- Trial name
- NCT04699721
- Testing
- Probiotics (BiFico)+nivolumab 4.5mg/kg+Paclitaxel (albumin-bound type) 260mg / m2+ Carboplatin AUC5
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Xiangya Hospital of Central South University
Healthy, Hyperuricemia, Gout
Acute Effects of a Urate-lowering Bacterial Therapeutic on Small Intestinal Transcriptomics and Glycomics in Healthy Subjects
This is a pilot study investigating how a novel probiotic supplement (BEO001), with and without a dietary fiber (beta-glucan), affects the lining of the small intestine in healthy people.
- Trial name
- Bugs4U-MoA (NCT07366749)
- Testing
- BEO001 Probiotic, BEO001 Probiotic + Beta-Glucan
- Where
- Sweden
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Acne Vulgaris
Comparing Efficacy of Azithromycin and Probiotics for Treatment of Acne Vulgaris
the goal of this clinical trial is to measure the efficacy of probiotics for treatment of acne vulgaris, to compare it with azithromycin and to measure the synergistic effect of azithromycin and probiotics for treatment of acne…
- Trial name
- NCT05629468
- Testing
- Azithromycin, Probiotic Formula, Benzoyl Peroxide 4 % Topical Cream
- Where
- Pakistan
- Volunteers
- 75 people
- Sponsor
- Pak Emirates Military Hospital
Probiotics, Cancer, Therapy-Related
The Effect of Survival, Response and Microbiota Change in Different Therapy Under Probiotic Supplement
Probiotics are a group of viable microorganisms including bacteria and yeasts that if consumed in sufficient amounts, may afford health benefits to the host.
- Trial name
- NCT06998823
- Testing
- Probiotics
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Dental Plaque, Dental Caries
Probiotic Treatment of Orthodontic Patients
The purpose of this study is to examine the effect of treatment with a lozenge containing the probiotic strain S. salivarius M18 on the formation, composition and virulence of dental plaque and in healthy orthodontic patients…
- Trial name
- NCT06751979
- Testing
- Probiotic treatment
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Gingivitis
Clinical and Microbiological Effects of Lactobacillus Rhamnosus in Treatment of Gingivitis
The aim of this randomized placebo- controlled clinical trial is to evaluate the effects of Lactobacillus rhamnosus SP1- containing probiotic sachet as an adjunct to scaling and root planning (SRP).
- Trial name
- NCT02809313
- Testing
- Treatment Gingivitis with Probiotic, Treatment Gingivitis conventional
- Where
- Chile
- Volunteers
- 36 people
- Sponsor
- Jorge Gamonal
Diarrhea Infectious
Probiotics Administration Via Colonoscopic Spray and Oral Administration in CDAD Patients
Clostridioides difficile (C. difficile) colitis is a common hospital-acquired disease, which increases hospitalization length and the mortality rate. Moreover, refractory or recurrent C. difficile colitis is an emerging disease.
- Trial name
- CDAD (NCT05770726)
- Testing
- Probiotics administration
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Cheng-Kung University Hospital
Helicobacter Pylori Infection
Probiotics in the Reduction of Adverse Effects and Dysbiosis of H. Pylori Eradication
The investigators aimed to assess the effect of probiotic supplementation with Vigiis 101-LAB during H. pylori eradication therapy with 14-day sequential therapy in the reduction of adverse effects and the restoration of the…
- Trial name
- NCT03722433
- Testing
- Vigiis 101-LAB and sequential therapy
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Covid19
Study to Investigate the Treatment Benefits of Probiotic Streptococcus Salivarius K12 for Hospitalised Patients (Non-ICU) With COVID-19
This is a randomised, open-label and controlled clinical trial aimed to investigate the adjuvant treatment benefits of probiotic Streptococcus salivarius K12 in hospitalised mild-to-moderate patients with COVID-19 disease.
- Trial name
- NCT05043376
- Testing
- Standard of care, BLIS K12
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- King Edward Medical University
Periodontitis, Adult, Periodontitis (Stage 3)
Microbiological and Clinical Effects of Pre- and Probiotics in Non-Surgical Periodontal Therapy
Periodontitis is a prevalent chronic inflammatory disease driven by a dysbiotic oral biofilm and a dysregulated host immune response.
- Conditions
- Periodontitis, Adult, Periodontitis (Stage 3), Periodontitis Stage IV
- Trial name
- PROPARO (NCT07443410)
- Testing
- Non-surgical periodontal therapy (NSPT) and supportive periodontal therapy (SPT), Probiotic lozenge (Limosilactobacillus reuteri; GUM® PerioBalance®), Vitamin B12 drops (natural elements)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Diabetes, Periodontitis
Non Surgical Therapy of Periodontitis in Diabetes Patients: the Adjunctive Use of Probiotics
The aim of this study is to evaluate the clinical and microbiological performance of a probiotic formulation (Sunstar GUM Periobalance) as adjunctive to non-surgical periodontal therapy in patients with diabetes.
- Trial name
- ProDiabet (NCT04069611)
- Testing
- Probiotic, Scaling and root planing
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Nonalcoholic Fatty Liver Disease
Treatment of Nonalcoholic Fatty Liver Disease With Probiotics and Prebiotics
The investigators' aim is to determine whether probiotic and prebiotic treatment plus lifestyle advice is more effective in reducing hepatic fat content than lifestyle advice alone in patients with Nonalcoholic Fatty Liver…
- Trial name
- NCT00870012
- Testing
- Lepicol probiotic & prebiotic formula, Simple lifestyle advice
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Sexually Transmitted Diseases
Effects of LiveSpo X-secret in Supporting Treatment of Sexually Transmitted Diseases
Sexually Transmitted Infections (STIs) are common gynecological infections worldwide, especially in tropical and underdeveloped countries, primarily affecting the reproductive age group.
- Trial name
- NCT05783856
- Testing
- LiveSpo X-secret, 0.9% NaCl physiological saline
- Where
- Vietnam
- Volunteers
- 100 people
- Sponsor
- Anabio R&D