Clinical trials: Probiotic Therapy
Helicobacter Pylori Infection
Probiotics in the Reduction of Adverse Effects and Dysbiosis of H. Pylori Eradication
The investigators aimed to assess the effect of probiotic supplementation with Vigiis 101-LAB during H. pylori eradication therapy with 14-day sequential therapy in the reduction of adverse effects and the restoration of the…
- Trial name
- NCT03722433
- Testing
- Vigiis 101-LAB and sequential therapy
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Gingivitis; Chronic, Smoking
Synbiotic as an Adjunct to Mechanical Treatment of Gingivitis
The aim of this study is to evaluate the efficacy of oral administration of synbiotic tablets on the clinical parameters and the levels of selected inflammatory mediators in gingival crevicular fluid (GCF) in smokers and…
- Trial name
- NCT03455192
- Testing
- Synbiotic Supplement
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Overweight and Obesity
The Prevention And Treatment On Obesity And Weight Management By Oral Supplementation Of Probiotics And Prebiotics
The goal of this interventional study is to test whether consumption of Wonderlab probiotics with prebiotics could improve obesity and overweight in Chinese people who are aged 25-45 and overweight.
- Trial name
- NCT06030999
- Testing
- Study product A (Wonderlab wonder4shape), Study product B (Wonderlab wonder4shape)
- Where
- 2 sites in China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Shenzhen Precision Health Food Technology Co. Ltd.,
Helicobacter Pylori Infection
Assessment of the Adjuvant Role of Dietary Supplementation of Antibiotic-tolerant Probiotics in Standard Therapy for the Eradication of Helicobacter Pylori Infection.
Randomized, double-blind, placebo-controlled clinical study to assess the adjuvant role of dietary supplementation of antibiotic-tolerant probiotics, derived from Lactobacillus acidophilus and Bifidobacterium animalis, in…
- Trial name
- NCT06499649
- Testing
- IBSA Probiotics
- Where
- Italy
- Volunteers
- 270 people
- Sponsor
- IBSA Farmaceutici Italia Srl
Antibiotic Therapy
Probiotic Product in Healthy Adults Undergoing Antibiotic Treatment
This is randomized, double-blind, placebo controlled, single centre; 21 days phase II clinical trial on healthy volunteers. Following baseline visit at the day of randomization, treatment with Augmentin 875mg for 7 days will be…
- Trial name
- NCT01667653
- Testing
- Probiotic
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Danisco
Peri-implantitis
The Use of a Probiotic Lozenge in the Treatment of Peri-implantitis
This studies aims to investigate the effect of a probiotics in peri-implantitis patients as an adjunct to non-surgical therapy.
- Trial name
- NCT02520401
- Testing
- Probiotic - BioGaia
- Where
- Belgium
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hirschsprung Disease, Enterocolitis
Probiotics and Post-Pullthrough Hirschsprung's Disease-Associated Enterocolitis
This was a prospective case-controlled study investigating the role of probiotics in the management of Hirschsprung-associated enterocolitis (HAEC).
- Conditions
- Hirschsprung Disease, Enterocolitis, Hirschsprung's Disease Associated Enterocolitis
- Trial name
- NCT07098494
- Testing
- Saccharomyces Boulardii Probiotic Supplement
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Aswan University Hospital
Oral Lichen Planus
Efficacy of Probiotic Capsules With Topical Clobetasol Propionate in OLP Treatment
Oral lichen planus patients who will meet inclusion criteria will be divided into 2 groups -The intervention group (Group P): This group will be randomly allocated to take one capsule twice daily during meal time at morning and…
- Trial name
- NCT06119672
- Testing
- Probiotic Blend Oral capsules, Corticosteroids for Local Oral Treatment
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- October 6 University
Anal Cancer Squamous Cell
Prebiotics and Probiotics During Definitive Treatment With Chemotherapy-radiotherapy SCC of the Anal Canal (BISQUIT)
Phase II randomized study of the use of pre-and probiotics during the definitive treatment of chemotherapy-radiotherapy (Ch-RT) for patients with localized anal canal squamous cell cancer (ACSCC) with the objective of increasing…
- Trial name
- BISQUIT (NCT03870607)
- Testing
- prebiotics in combination with probiotics
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- AC Camargo Cancer Center
Diverticulitis, Colonic, Therapy
Probiotic After Acute Colonic Diverticulitis
The goal of this observational study is to assess the efficacy and safety of the probiotic Escherichia coli Nissle 1917 (EcN®, Ca.Di.Group S.p.A) in the treatment of symptomatic patients after an episode of both complicated and…
- Trial name
- NCT06040515
- Testing
- Probiotic Formula
- Where
- 12 sites in Italy
- Volunteers
- 145 people
- Sponsor
- Erasmo Spaziani
Unresectable Metastatic Colorectal Cancer
Probiotics Combined With Standard Chemotherapy Plus Targeted Therapy in Patients With Metastatic Colorectal Cancer
Bifico (also known as "bifidobacterium trifidum live powder") is a probiotic preparation that has been marketed and widely used in China.
- Trial name
- NCT04131803
- Testing
- Bifico combined with chemotherapy plus targeted therapy, chemotherapy plus targeted therapy
- Volunteers
- 140 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cognitive/Functional Effects, Constipation, Impaction, and Bowel Obstruction
Probiotic Therapy in Preventing Gastrointestinal Complications in Patients Undergoing Chemotherapy and Pelvic Radiation Therapy
RATIONALE: Probiotic therapy may reduce or prevent gastrointestinal complications in patients undergoing chemotherapy and pelvic radiation therapy.
- Conditions
- Cognitive/Functional Effects, Constipation, Impaction, and Bowel Obstruction, Diarrhea, Fatigue
- Trial name
- NCT01473290
- Testing
- live freeze-dried lactic acid bacteria probiotic
- Sponsor
- Alliance for Clinical Trials in Oncology
Hypercholesterolemia
Probiotic BIO-25 as a Supplement to Statins for the Treatment of Hypercholesterolemia
The primary objective is to examine whether probiotics given to hypercholesterolemic patients treated with statins, would further decrease LDL-Cholesterol levels.
- Trial name
- NCT01849185
- Testing
- Food supplement
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Meir Medical Center
Head-and-neck Cancer
Effects of Probiotics in Preventing Oral Mucositis
The study will be a randomized double blind prospective placebo controlled clinical study and aims to determine the therapeutic efficacy of Probiotics in Oral Mucositis pathogenesis in patients undergoing head and neck…
- Trial name
- NCT03552458
- Testing
- Lactobacillus Reuteri Oral Solution [BioGaia]
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- National University Hospital, Singapore
Jaundice, Neonatal
The Effectiveness of Probiotics in Neonatal Jaundice
Hyperbilirubinemia is a prevalent problem in babies that necessitates medical attention. Probiotic administration as adjuvant therapy may have a positive impact on the pathological neonatal unconjugated hyperbilirubinemia.
- Trial name
- NCT06449508
- Testing
- Probiotic Formula
- Volunteers
- 44 people
- Sponsor
- Tanta University
Obesity
Probiotics Effect on Glucose and Lipid Metabolism and Gut Microbiota in Patients With Obesity
The purpose of this study is to determine whether the probiotics will be effective in the treatment of obesity
- Trial name
- NCT02733484
- Testing
- Probiotics
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai 10th People's Hospital
Obsessive-Compulsive Disorder
Probiotic Treatment in Adult Obsessive-Compulsive Disorder
This study will evaluate the effectiveness of 12-weeks of probiotic treatment in adults with primary Obsessive-Compulsive Disorder and whether this treatment will alter the microbiota composition in these patients.
- Trial name
- NCT02334644
- Testing
- Probiotic Formula (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- McMaster University
Diarrhea Dominant Irritable Bowel Syndrome
Saccharomyces Boulardii in Irritable Bowel Syndrome
Various studies have been conducted in past using different strains of probiotics in evaluating IBS symptoms. The results are by no means consistent and the overall impact of probiotics in IBS remains unclear.
- Trial name
- SB-IBS (NCT00589771)
- Testing
- Saccharomyces boulardii
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Aga Khan University
Antibiotic-associated Diarrhea
Clinical Pilot Trial on the Effect of a Probiotic Fermented Drink on Antibiotic-associated Diarrhea (AAD)
The aim of the study is to estimate the effect of a probiotic dairy drink on occurrence and duration of AAD and gastrointestinal symptoms during Helicobacter pylori (Hp) eradication therapy and during 4 weeks thereafter and…
- Trial name
- NCT02746198
- Testing
- probiotic dairy drink, acidified milk
- Where
- Germany
- Volunteers
- 125 people
- Sponsor
- Clinical Research Center Kiel GmbH
Chronic Liver Disease, Hepatic Encephalopathy
Effect of Probiotics in Treatment of Minimal Hepatic Encephalopathy (MHE) and Health Related Quality of Life
This study is a randomized, open, parallel group, active comparator, single center trial. Objectives of the study are hereby given below: To study the health related quality of life (HRQOL) in patients with chronic liver disease.
- Trial name
- MHE (NCT01008293)
- Testing
- VSL#3, Lactulose
- Where
- India
- Volunteers
- 120 people
- Sponsor
- CD Pharma India Pvt. Ltd.