Clinical trials: Probiotic Therapy
Overactive Bladder (OAB)
Efficacy of Probiotics for OAB Patients With Anxiety
The goal of this clinical trial is to learn if probiotics can help improve symptoms in adults with overactive bladder (OAB) and anxiety. The main questions it aims to answer are: 1.
- Trial name
- NCT07635212
- Testing
- Multi-strain Probiotic Compound
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Qilu Hospital of Shandong University
Irritable Bowel Syndrome
Probiotics in the Treatment of Irritable Bowel Syndrome
Evidence have shown benefits of gut flora modulation in treatment of irritable bowel syndrome (IBS), but few reports are available on the effects of multistrain probiotics and there are few reports available in this regard from…
- Trial name
- NCT01837472
- Testing
- Probiotic
- Where
- Iran
- Volunteers
- 132 people
- Sponsor
- Isfahan University of Medical Sciences
Peri-implant Mucositis
Limosilactobacillus Reuteri as an Adjuvant in the Treatment of Peri-implant Mucositis
Mechanical debridement is the traditional method for the treatment of peri-implant mucositis and its success depends on the patient's correct oral hygiene.
- Trial name
- LRRCT (NCT05758103)
- Testing
- Limosilactobacillus reuteri Prodentis® (combining L. reuteri DSM 17938 and L. reuteri ATCC PTA 5289 strains)
- Where
- Portugal
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Malo Clinic
Acute Gastroenteritis
Efficacy and Safety of Probiotics in the Treatment of Acute Gastroenteritis in Children
Primary Objective: o To assess the efficacy of the probiotics in reducing the duration of diarrhea in children suffering from acute gastroenteritis.
- Trial name
- SABINA (NCT03539913)
- Testing
- Probiotic : Saccharomyces boulardii, Probiotic : Bacillus clausii
- Where
- 8 sites in Argentina
- Volunteers
- 317 people
- Sponsor
- Biocodex
Chronic Periodontitis
Probiotics Effects to Initial Periodontal Treatment
The aim of this study is to evaluate the clinical and microbiological effects of Bifidobacterium animalis subsp. lactis DN-173010 containing yoghurt as an adjunct to mechanical periodontal treatment.
- Trial name
- NCT05408364
- Testing
- probiotic or natural yoghurt, SRP
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marmara University
Inflammatory Bowel Diseases, Crohn Disease
Effect of a Probiotic Mixture on the Gut Microbiome and Fatigue in Patients With Quiescent Inflammatory Bowel Disease
The study is proposed as a single-site randomized double-blind placebo-controlled trial requiring 4 study visits, where two of the visits are combined with their appointment for routine clinical care.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT03266484
- Testing
- Probiotic Mixture
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Irritable Bowel Syndrome
Probiotics in the Treatment of Irritable Bowel Syndrome
The aim of the present study is to assess the efficacy of two different probiotic products, lacto-fermented sauerkraut and the supplement Mutaflor, in the treatment of irritable bowel syndrome.
- Trial name
- NCT02953171
- Testing
- Raw, lacto-fermented sauerkraut, Mutaflor, Pasteurized sauerkraut
- Where
- Norway
- Volunteers
- 140 people
- Sponsor
- University of Copenhagen
Limited Stage Small Cell Lung Cancer
Study of Probiotics Combined With Concurrent Hyperfractionated ChemoRadiotherapy and Adebrelimab Immunomaintenance in the Treatment of Limited-stage Small Cell Lung Cancer (LS-SCLC)
ADRIATIC study explored the benefits of immune maintenance therapy after LS-SCLC radiotherapy and chemotherapy. In the presence of immunotherapy, is it necessary to increase the dosage of radiotherapy and can it further improve…
- Trial name
- NCT06943235
- Testing
- Probiotics, concurrent Hyperfractionated Radiotherapy, Immunotherapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fudan University
Overweight , Obesity
Study on the Efficacy of Probiotics in the Treatment of Childhood Obesity and Their Effects on Gut Microbiota
This interventional study aims to evaluate the efficacy of a probiotics supplementation (Bifidobacterium longum subsp. longum Dipro-O and Bifidobacterium longum subsp.
- Trial name
- NCT07448220
- Testing
- Probiotic
- Where
- 2 sites in China, Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Min-Tze LIONG
Eczema, Atopic Dermatitis
Management of Eczema by Specific Probiotic Strains
To investigate the therapeutic effect of a selected probiotic mixture on the severity of AD in infants aged 0-15 months. The probiotic mixture has been studied in laboratory setting and has proven IL-10 stimulating effects.
- Trial name
- BAMBOO (NCT01230190)
- Testing
- Ecologic ® Panda II
- Where
- Netherlands
- Volunteers
- healthy volunteers welcome
- Sponsor
- Agentschap NL
Uterine Endometrial Repair
Effects of Probiotics and Electrophysiologic Therapy on Endometrium Repair
This study aimed to investigate the effects of probiotics in combination with pelvic floor muscle electrophysiologic therapy on the uterine endometrial repair and reproductive prognosis in patients after surgery for intrauterine…
- Trial name
- NCT03969472
- Testing
- probiotics, Electrophysiologic Therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Vernal Keratoconjunctivitis
Lactobacillus Rhamnosus GG Oral Treatment Efficacy on Vernal Keratoconjunctivitis Treatment
This interventional study aims to evaluate the efficacy of oral administration of Lactobacillus Rhamnosus GG in preventing relapses of ocular inflammation in Vernal Keratoconjunctivitis (VKC) patients.
- Trial name
- NCT00445120
- Testing
- Lactobacillus Rhamnosus GG
- Where
- 3 sites in Italy
- Volunteers
- 48 people
- Sponsor
- Campus Bio-Medico University
Unresectable Metastatic Colorectal Cancer
Probiotics Combined With Standard Chemotherapy Plus Targeted Therapy in Patients With Metastatic Colorectal Cancer
Bifico (also known as "bifidobacterium trifidum live powder") is a probiotic preparation that has been marketed and widely used in China.
- Trial name
- NCT04131803
- Testing
- Bifico combined with chemotherapy plus targeted therapy, chemotherapy plus targeted therapy
- Volunteers
- 140 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Periodontitis
Probiotic Use in Chronic Periodontitis Patients
Aim: to evaluate the additional effects of the 12 weeks usage of a Streptococcus containing probiotic tablet after scaling and rootplaning compared to a placebo tablet.
- Trial name
- NCT02403960
- Testing
- probiotic
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Orthodontic Appliance Complication
Using Probiotics to Improve Oral Hygiene During Orthodontic Treatment
Fifty patients needing non-extraction-based metallic orthodontic treatment will be divided randomly into the probiotic group and the control group.
- Trial name
- NCT06641960
- Testing
- Probiotics, Traditional treatment
- Where
- Syria
- Volunteers
- 50 people
- Sponsor
- Damascus University
Bacterial Vaginosis
Probiotics as Adjuvant Treatment for Bacterial Vaginosis
The investigators are trying to determine if oral probiotics (Umeta-Miyue, Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14) (30 days)with metronidazole vaginal suppositories(7 days) is better than using metronidazole…
- Trial name
- NCT03894813
- Testing
- "Probiotics" and "Metronidazole", Metronidazole Vaginal
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Peking University Shenzhen Hospital
Pneumonia, Probiotics
Role of Probiotics as Adjunct Therapy Along With Standard Care in Decreasing Hospital Stay and Improving Symptoms in Pediatric Patients Admitted With Severe Pneumonia
Probiotics as adjuvant therapy along with standard care can decrease hospital stay and improve symptoms (fever, tachypnea,cough) in pediatric patients admitted with severe pneumonia.
- Trial name
- NCT06323642
- Testing
- probiotic containing Lactobacillus rhamnosus GG.
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Acute Radiation Enteritis
Gegen Qinlian Tang and Probiotics for Radiation Enteritis
The purpose of this clinical study is to evaluate whether Bifidobacterium Triple Viable Capsules, alone or in combination with Gegen Qinlian Decoction, can effectively prevent and treat acute radiation enteritis in patients…
- Trial name
- GQBT-RE (NCT06836960)
- Testing
- Probiotic Therapy With Gegen Qinlian Tang
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jiujiang No.1 People's Hospital
Hepatic Encephalopathy
Secondary Prophylaxis of Hepatic Encephalopathy in Cirrhosis
Hepatic encephalopathy (HE), a challenging complication of advanced liver disease, occurs in approximately 30-45% of patients with cirrhosis.
- Trial name
- HE (NCT01178372)
- Testing
- Lactulose, Probiotics(VSL#3)
- Where
- India
- Sponsor
- Govind Ballabh Pant Hospital
Colic
Lactobacillus Reuteri DSM 17938 Versus Placebo in the Treatment of Infantile Colic
Infantile colic is a common medical condition which remains a frustrating problem for parents and health care providers with no clear treatment guidelines.
- Trial name
- NCT01541046
- Testing
- Biogaia L. reuteri DSM 17938
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- The Hospital for Sick Children