Clinical trials: Probiotic Therapy
Autism Spectrum Disorder, Anxiety
Open-label Pilot Study Synbiotic Treatment for Autism Spectrum Disorder
The objective of this study is to conduct a open-label pilot study evaluating the feasibility, tolerability and preliminary efficacy of a 12-week course of synbiotic in improving anxiety symptoms in children with ASD.
- Trial name
- NCT06126185
- Testing
- 12-week course of synbiotic
- Where
- Hong Kong
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Gingivitis, Orthodontic Appliance Complication
Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodontic Treatment
Orthodontic treatment with fixed appliances can be necessary to correct malocclusions in adolescence or adulthood. It its known that orthodontic treatment induces aseptic pseudo-inflammatory reactions.
- Trial name
- NCT04598633
- Testing
- Lactobacillus reuteri Prodentis®-lozenges (DSM 17938, ATCC PTA 5289)
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg
Microbiota, Probiotic Therapy
Microbiota and Probiotic Therapy in Ulcerative Colitis Patients
This study aimed to evaluate the role of microbiota and probiotics in Egyptian patients with ulcerative colitis.
- Conditions
- Microbiota, Probiotic Therapy, Ulcerative Colitis
- Trial name
- NCT07180186
- Testing
- Mesalamine, Probiotics (Bacillus Clausii), Mesalamine and probiotics (Bacillus Clausii)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Upper Respiratory Tract Infections
LiveSpo Navax® Supports the Treatment of Acute Rhinosinusitis and Otitis Media
Acute respiratory tract infections (ARTIs), such as acute rhinosinusitis (ARS) and acute otitis media (AOM), are common worldwide and caused by viruses or bacteria entering the body through the mouth and nose.
- Trial name
- NCT05804123
- Testing
- 0.9% NaCl physiological saline Nasal-spraying, LiveSpo Navax®, Augmentin 500Mg Tablet
- Where
- Vietnam
- Volunteers
- 175 people
- Sponsor
- Anabio R&D
Irritable Bowel Syndrome-IBS
Effect of Different Dietary Therapies on Intestinal Barrier Integrity in Patients With Irritable Bowel Syndrome
This study aims to evaluate the effects of different dietary treatments on intestinal integrity in female subjects aged 19-50 years previously diagnosed with constipation-predominant irritable bowel syndrome (IBS).
- Trial name
- NCT06421922
- Testing
- Group 1 received a regular constipation diet, Group 2 received a constipation diet rich in soluble fiber, Group 3 received a constipation diet supplemented with probiotic yogurt.
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gulhane Training and Research Hospital
Dental Caries, Oral Health
Effect of Probiotics Containing Yogurts on the Composition of Biofilms in Patients Under Orthodontic Treatment
Aim: To assess in vivo if the intake of yogurt containing Bifidobacterium animalis ssp. lactis DN- 1173010 probiotic for a period of 2 weeks affects the salivary levels or biofilms of mutans streptococci and the lactobacilli of…
- Trial name
- NCT01657539
- Testing
- Yogurt containing probiotics
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Chronic Kidney Disease
Observational Study of Kibow Biotics in Chronic Kidney Failure Patients on Dialysis
A specifically formulated probiotic product comprised of defined and tested microbial strains may afford renoprotection in what has been generally called "Enteric DialysisTM".
- Trial name
- NCT01450709
- Testing
- Kibow Biotics
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kibow Pharma
Hepatic Cirrhosis, Minimal Hepatic Encephalopathy
Hyperproteic Diet Plus Lactobacillus Reuteri and Nitazoxanide in Minimal Hepatic Encephalopathy
Hepatic encephalopathy is a serious complication of cirrhosis which relays under the burden of diseases with therapeutical difficulties for its given morbidity and mortality and the high recurrence it poses.
- Trial name
- NCT01135628
- Testing
- Auxiliary Treatment, Hyperproteic and fiber-rich diet, Nitazoxanide
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Vulvovaginal Candidiasis
Oral Lactobacillus Crispatus Lc-G22 as Adjunctive Therapy for Vulvovaginal Candidiasis
This single-center, randomized, single-blind, placebo-controlled trial aimed to evaluate the efficacy and safety of oral Lactobacillus crispatus Lc-G22 as adjunctive therapy to clotrimazole for preventing recurrence of…
- Trial name
- NCT07727967
- Testing
- Lactobacillus crispatus Lc-G22
- Where
- China
- Volunteers
- 100 people
- Sponsor
- BioGrowing Co., Ltd
Rotavirus Gastroenteritis
Enteroadsorbent Polymethylsiloxane vs Probiotic Lactobacillus Reuteri in the Treatment of Rotaviral Gastroenteritis
This study evaluates a new drug, new enteroadsorbent polymethylsiloxane (Enterosgel) in the treatment of rotavirus gastroenteritis in children.
- Trial name
- NCT04116307
- Testing
- Polymethylsiloxane, Lactobacillus reuteri
- Where
- Croatia
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Hospital for Infectious Diseases, Croatia
Acute Gastroenteritis
Novel Diagnostics and Probiotics to Improve Management of Paediatric Acute Gastroenteritis
Many children admitted to hospital in Botswana without bloody diarrhoea are presumed to have viral gastroenteritis and so not treated with antibiotics - but they may indeed have a treatable cause for their illness.
- Trial name
- NCT02025452
- Testing
- Rapid diagnostic, Probiotic
- Where
- 3 sites in Botswana
- Volunteers
- 76 people
- Sponsor
- Jeffrey Pernica
Gingivitis; Chronic, Smoking
Synbiotic as an Adjunct to Mechanical Treatment of Gingivitis
The aim of this study is to evaluate the efficacy of oral administration of synbiotic tablets on the clinical parameters and the levels of selected inflammatory mediators in gingival crevicular fluid (GCF) in smokers and…
- Trial name
- NCT03455192
- Testing
- Synbiotic Supplement
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Depression / Major Depressive Disorder
Adjunctive Probiotic Therapy in Major Depressive Disorder (ProMOOD)
A double-blind, randomized controlled trial (RCT) aimed at evaluating the efficacy of probiotic supplementation in patients undergoing concurrent antidepressant therapy.
- Trial name
- ProMOOD (NCT07786285)
- Testing
- OMNi-BiOTiC® STRESS Repair
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University Maribor
Obesity &Amp; Overweight, Digestive Disorders
Probiotic Intervention for Digestive Health in Obese Patients Initiating GLP-RA Treatment
Obesity is a prevalent chronic disease affecting 17% of the French population. Treatment involves multiple factors, with pharmacotherapy playing an increasingly important role.
- Trial name
- PROBIO-GLP1 (NCT07213323)
- Testing
- Probiotics (Natural product)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Non Alcoholic Fatty Liver
Efficacy and Safety of a Probiotic Composition as Adjunct in MAFL Management
Some studies have shown beneficial results with probiotics on hepatic function of subjects with fatty liver, but significant variability has been noted among probiotic formulations.
- Trial name
- NCT04823676
- Testing
- Probiotic composition
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- AB Biotics, SA
Helicobacter Pylori Infection, Infections
The Effect of Probiotics on Gut Microbiotain After Helicobacter Pylori Eradication
The purpose of this study is to evaluate the effect of probiotics during vonoprazan-amoxicillin dual therapy on the gut microbiota in Helicobacter pylori eradication and to investigate whether the eradication rate of H.pylori…
- Conditions
- Helicobacter Pylori Infection, Infections, Intestinal Bacteria Flora Disturbance
- Trial name
- NCT05658055
- Testing
- Vonoprazan, Amoxicillin, probiotics
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
SARS-CoV Infection, Corona Virus Infection
Microbiome Therapy in Covid-19 Primary Care Support
This double-blind, randomized, placebo-controlled study aims to investigate whether a throat spray containing probiotic bacteria (i.e.
- Trial name
- MiCel (NCT04793997)
- Testing
- Microbiome spray
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Infantile Colic
Combined Probiotics is More Effective in the Treatment of Infantile Colic
All participants are randomized into 1 of 3 treatment arms, the mixture L acidophilus, B longum and B. bifidum group, Lactobacillus reuteri or placebo group.
- Trial name
- NCT03877458
- Testing
- L. acidophilus TYCA06, B. longum BLI-02 and B. bifidum VDD088, L. reuteri GL-104
- Where
- Taiwan
- Volunteers
- 99 people
- Sponsor
- China Medical University Hospital
Attention Deficit and Hyperactivity Disorders
Multi-strain Probiotics for ADHD
Probiotics are widely used as supplement for various neurodevelopmental disorders. The mechanism of their therapeutic potential lies in the "gut-brain axis", a two-way communication pathway through the neuroendocrine system.
- Trial name
- NCT06226584
- Testing
- multiple-strain probiotics
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Tsyr-Huey Mental Hospital
Cancer
The Use of Lactobacillus Plantarum 299v in Treatment of Cancer Patients Who Received Home Enteral Nutrition
The aim of the study is to assess the impact of Lactobacillus plantarum 299v on nutritional status, tolerance of enteral diet and the quality of life.
- Trial name
- NCT03940768
- Testing
- Lactobacillus plantarum 299v
- Where
- Poland
- Volunteers
- 35 people
- Sponsor
- Medical University of Gdansk