Clinical trials: Probiotics
Clostridium Difficile Infection
A Safety Trial to Evaluate an Orally Ingested Yeast Modified to Express a Tetra-specific Anti-toxin for Clostridioides Difficile
This is a Phase 1, first-in-human, double-blind, placebo-controlled, adaptive-design, single-site study, involving dose exploration cohorts.
- Trial name
- NCT07649096
- Testing
- FZ002
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Gut Microbiota, Bowel Preparation
The Change of Gut Microbiota After Bowel Preparation and the Effect of Probiotics
The purpose of this study is to investigate the relationship between the change of intestinal bacterial flora and the recovery, and the incidence of symptoms such as abdominal discomfort after colonoscopy.
- Conditions
- Gut Microbiota, Bowel Preparation, Colonoscopy
- Trial name
- NCT03760133
- Testing
- Duolac
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kosin University Gospel Hospital
Acute Diarrhea
Efficacy Of Probiotics vs. Zinc vs. Probiotics-Zinc Combination On Acute Diarrhea In Children
Background: Acute diarrhea in children is still a major health burden worldwide despite all efforts that have been made to reduce its incidence and prevalence.
- Trial name
- NCT03684538
- Testing
- Probiotics, Zinc, Probiotics & Zinc
- Where
- Lebanon
- Volunteers
- 240 people
- Sponsor
- Makassed General Hospital
Healthy Adult Subjects
Dietary Supplement With and Without a Probiotic
Complex oligosaccharides can alter the gut microbiome by aiding in the growth of certain organisms, and possibly, inhibiting others. The synergy with a probiotic may enhance gastrointestinal colonization.
- Trial name
- NCT04433208
- Testing
- Complex oligosaccharide, Probiotic, PPI
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Prolacta Bioscience
Gastrointestinal Discomfort, Bloating
Multi-strain Probiotic Supplement for Digestive Comfort and Well-being in Healthy Women
This study looks at whether a daily probiotic supplement can help improve mild-to-moderate stomach and digestive symptoms, such as gas and bloating, in women who also experience symptoms commonly associated with hormonal…
- Trial name
- NCT07831317
- Testing
- Active: Multi-strain probiotic dietary supplement
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Daily Nouri
Depression
Fermented Milk Product With Probiotic and Its Impact on Mood of Patients With Treatment Resistant Depression
This study aims to assess the impact of a chronic dietary intervention (8 weeks) with probiotics, specifically Fermented Milk Product with Probiotic (FMPP), on the mood of individuals with Major Depressive Disorder (MDD)…
- Trial name
- NCT03317678
- Testing
- BioKefir, Non-fermented milk
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rush University Medical Center
Pelvic Organ Prolapse, Inflammatory Response
Vaginal Probiotics and Pessaries and Their Impact on the Vaginal Microenvironment
In this study, the investigators are evaluating the effect of vaginal probiotics on the bothersome side effects of pessary use and the impact on the vaginal microenvironment (lactobacilli, anaerobic bacteria, mobiluncus bacteria…
- Conditions
- Pelvic Organ Prolapse, Inflammatory Response, Dysbiosis
- Trial name
- NCT04118049
- Testing
- BiopHreshTM vaginal probiotic supplement (Good Clean Love, Inc. Eugene, OR) and RestoreTM gel., Standard Care
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Hartford Hospital
Male Infertility, Oligozoospermia
Probiotics on Sperm Quality in Male Infertility Patients
This randomized, placebo-controlled pilot study aims to evaluate the effects of probiotic supplementation on sperm quality in male patients diagnosed with infertility.
- Conditions
- Male Infertility, Oligozoospermia, Asthenozoospermia, Teratozoospermia
- Trial name
- NCT07345455
- Testing
- Probiotics
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Mackay Memorial Hospital
Oral Bacteria, Halitosis
Effect of a Probiotic Water on Oral Health in Adults
The purpose of this study is to evaluate the effects of consuming a probiotic on salivary, plaque, and tongue bacteria, as well as oral malodor (bad breath).
- Trial name
- NCT04473404
- Testing
- Streptococcus salivarius DB-B5 - 2 billion CFU/day, Streptococcus salivarius DB-B5 - 10 billion CFU/day
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dose Biosystems Inc.
Hypercholesterolemia
Combination of AB-LIFE Probiotic Plus Monacolin K to Reduce Blood Cholesterol
This randomized study evaluates the effectiveness of a nutraceutical combining billion colony forming units (cfu) of three L. plantarum strains (CECT7527, CECT7528 and CECT7529) and 10 mg of monacolin K in reducing blood…
- Trial name
- NCT04677335
- Testing
- AB-LIFE with Monacolin K
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- AB Biotics, SA
Influenza
Study to Assess the Effect of Multistrain Probiotic on the Immune Response to the Influenza Vaccination
A randomized, triple-blinded, placebo-controlled, parallel group study, to assess the effect of multistrain probiotic on the immune response to the Influenza vaccination
- Trial name
- LUPIN (NCT06103994)
- Testing
- Multistrain probiotic
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Obesity, Abdominal Obesity
Study of Safety and Efficacy of a Probiotic and Postbiotic in Overweight Individuals
Investigate the effect of a probiotic (live bacteria) and postbiotic (heat-treated bacteria) strains in overweight individuals.
- Trial name
- KOBI (NCT05428137)
- Testing
- Probiotic, Postbiotic
- Where
- South Korea
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Stress, Skin Imperfections
Effects Of A Probiotic Formulation On Stress and Skin Health in Younger Adult Females
The goal of this clinical trial is to test to efficacy of a probiotic blend on stress and skin appearance in young females. It is hypothesized that those taking the probiotic blend will have decreased levels of perceived stress…
- Conditions
- Stress, Skin Imperfections, Skin Fine Lines
- Trial name
- Cosmebiome (NCT06057883)
- Testing
- Probiotic
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Lallemand Health Solutions
Hyperbilirubinemia, Neonatal
Effectiveness of Phototherapy With and Without Probiotics
Raised serum bilirubin levels can cause kernicterus and premature infants are at increased risk due to metabolic immaturity. The standard treatment for neonatal jaundice is phototherapy but probiotics along with it can reduce the…
- Trial name
- NCT06173856
- Testing
- LED phototherapy
- Where
- Pakistan
- Volunteers
- 76 people
- Sponsor
- Fatima Jinnah Medical University
Cerebral Palsy, Spastic
Effect of the Nutritional Support System on Neuromotor Alterations in Patients With Cerebral Palsy
Study to determine the impact of a nutritional support system (NSS) on neuromotor alterations in patients with cerebral palsy.
- Conditions
- Cerebral Palsy, Spastic, Malnutrition
- Trial name
- NSS-PC (NCT05648422)
- Testing
- Probiotics, NSS Nutritional Support System, Deworming
- Where
- Mexico
- Volunteers
- 144 people
- Sponsor
- Anahuac University
Gastroenteritis, Bacterial Infection
The Effect of Probiotics on E. Coli-induced Gastroenteritis
Background: The incidence of gastrointestinal infections is very high. In Western countries at least 30% of the population suffers from at least one food-borne infection per year.
- Conditions
- Gastroenteritis, Bacterial Infection, Diarrhea
- Trial name
- PROTETEC (NCT01709266)
- Testing
- Probiotics
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- NIZO Food Research
Diabetic Macular Edema
Lactiplantibacillus Plantarum 299v Probiotic Supplementation in Patients With Diabetic Macular Edema
This pilot prospective, interventional, longitudinal study, aims to evaluate the potential benefits of the probiotic supplement Lactobacillus plantarum 299v in patients with diabetic macular edema (DME).
- Trial name
- NCT07383701
- Testing
- Lactobacillus plantarum 299v
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Colonization, Asymptomatic, Colonization
Probiotic Delivered to the Small Intestine Changes Microbiota
This study will determine whether encapsulation of probiotic bacteria using natural plant protein can enhance bacterial colonisation.
- Trial name
- Probiotic (NCT07510282)
- Testing
- Probiotic containing L.rhamnosus R0011 strain, 200 ml yogurt drink
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University College Dublin
COVID-19, Vaccine Reaction
Modification of the COVID-19 Vaccine Response by an Intervention on the Intestinal Flora
The elderly, who are often in poorer health, have been particularly affected by the COVID-19 pandemic. Recent study results show that while vaccines have been very effective in the short term, protection for the elderly may not…
- Conditions
- COVID-19, Vaccine Reaction, Elderly
- Trial name
- PIRATES-COV (NCT05195151)
- Where
- Canada
- Volunteers
- 592 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Irritable Bowel Syndrome-IBS
Effect of Different Dietary Therapies on Intestinal Barrier Integrity in Patients With Irritable Bowel Syndrome
This study aims to evaluate the effects of different dietary treatments on intestinal integrity in female subjects aged 19-50 years previously diagnosed with constipation-predominant irritable bowel syndrome (IBS).
- Trial name
- NCT06421922
- Testing
- Group 1 received a regular constipation diet, Group 2 received a constipation diet rich in soluble fiber, Group 3 received a constipation diet supplemented with probiotic yogurt.
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gulhane Training and Research Hospital