Clinical trials: Problem Drinking
Schizophrenia, Schizoaffective Disorder
Efficacy of Quetiapine in the Treatment of Patients With Schizophrenia and a Comorbid Substance Use Disorder
The purpose of this study is to examine the efficacy of quetiapine (Seroquel) in reducing substance use in persons diagnosed with schizophrenia.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Psychotic Disorder, Substance Abuse
- Trial name
- NCT00156715
- Testing
- Quetiapine
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Alcohol Drinking, Alcohol Abuse
Using Counter Attitudinal Advocacy to Change Drinking Behavior
High volume drinking by young adults has proven resistant to change, so new approaches are needed. We adapt a theory-based attitude change strategy for use in alcohol prevention.
- Trial name
- NCT04042909
- Testing
- Counter Attitudinal Advocacy, Personalized Normative Feedback
- Where
- 2 sites in United States
- Volunteers
- 591 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcoholism, Alcohol Abuse
Study of the Effectiveness of Quetiapine for the Treatment of Alcohol Dependency
The purpose of this study is to determine whether quetiapine fumarate extended release is effective in the treatment of alcohol dependence in very heavy drinkers.
- Trial name
- NCT00498628
- Testing
- Quetiapine fumarate
- Where
- 7 sites in United States
- Volunteers
- 224 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Abuse
Telephone Disease Management At-Risk Drinking (TDM II)
The aim of this study is to test for improvements in treatment outcomes for primary care patients with at-risk drinking when cared for using telephone disease management (TDM) compared to those treated with usual care.
- Trial name
- NCT00123409
- Testing
- Telephone disease management, Usual Care
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- US Department of Veterans Affairs
Alcohol Drinking
Topiramate Treatment of Problem Drinkers
The purpose of this study is to evaluate the safety and efficacy of topiramate in reducing drinking and heavy drinking frequency in problem drinkers.
- Trial name
- NCT00626925
- Testing
- topiramate
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- UConn Health
HIV/AIDS, Alcohol Abuse
An Economic and Relationship-strengthening Intervention for HIV-affected Couples Who Drink Alcohol in Malawi
A couples-based alcohol-reduction and economic and relationship-strengthening intervention for HIV-affected couples in Malawi.
- Trial name
- NCT04906616
- Testing
- Mlambe
- Where
- Malawi
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol Abuse, Alcohol Use Disorder
Examining Alcohol Consumption, Perceptions, and User Experience of Alcohol Moderation Strategies
The primary aims of the study are to assess the user experience and initial efficacy of a mobile application designed to reduce problematic alcohol use.
- Conditions
- Alcohol Abuse, Alcohol Use Disorder, Alcohol Abuse, Episodic
- Trial name
- ALCMOD (NCT04286867)
- Testing
- Alcohol Moderation Mobile Application, Alcohol Moderation Drink Tracker
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Kent State University
HIV Infections, Alcohol Abuse
Brief Electronic Intervention for Heavy Drinking and Sex Risk Among MSM Seeking HIV Testing
The overall objective of this research is to use both qualitative and quantitative data to inform the development of a technology-based intervention for heavy drinking and sexual risk behavior among men who have sex with men…
- Trial name
- NCT03435783
- Testing
- Brief Electronic Intervention, Attention-Matched Control
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Abuse
Placebo-Controlled Cross Over Trial of Chlorzoxazone Intake
The overall goals of this study are to (1) expand knowledge about interactions of chlorzoxazone with alcohol by assessing the effects of chlorzoxazone compared to placebo in moderate and heavy social alcohol users and (2) to…
- Trial name
- NCT01342341
- Testing
- Parafon Forte
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol Abuse
Buproprion for Binge Drinking
The present proposal is an innovative and translational clinical trial derived from exciting preclinical findings to test the hypothesis that treatment with the melanocortin activator bupropion can reduce binge drinking in…
- Trial name
- NCT03169244
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of North Carolina, Chapel Hill
Dating Violence, Alcohol Drinking
Evaluation of PRYSHM for LGBTQIA2S+ Youth
The overarching goal of the proposed project is to develop an innovative, online synchronous DV and AU prevention curriculum created specifically for SGMY (ages 15 to 18); conduct a pilot randomized controlled trial to assess its…
- Trial name
- PRYSHM (NCT05521906)
- Testing
- Promoting Resilient Youth with Strong Hearts and Minds (PRYSHM)
- Where
- United States
- Volunteers
- 314 people
- Sponsor
- University of Nebraska Lincoln
Human Immunodeficiency Virus, Hepatitis C
Computer-based Intervention for Alcohol-using HIV/HCV+ Women
The study harnessed the multidisciplinary expertise of our research team to develop a brief, computer-based, alcohol reduction intervention tailored for HIV/HCV co-infected women and evaluate its efficacy.
- Conditions
- Human Immunodeficiency Virus, Hepatitis C, Alcohol Abuse
- Trial name
- NCT03362476
- Testing
- Computer-based alcohol reduction intervention, Brief clinician-delivered MET, Standard of care
- Where
- 2 sites in United States, Russia
- Volunteers
- 200 people
- Sponsor
- New York University
Alcohol; Use, Problem
Probiotics, Immune Function, and the Brain in Alcohol Consumers
This pilot project is a brief, open-label clinical trial of probiotics as an intervention in heavy drinkers. Heavy drinkers who do not yet show significant signs of liver disease may stand to benefit from probiotics, but no…
- Trial name
- NCT05232682
- Testing
- Seed DS-01 Daily Synbiotic
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brown University
Stress Disorders, Post-Traumatic, Alcohol Abuse
Combined Treatment for Alcohol-Dependent Individuals With PTSD
This treatment intervention trial is designed for men and women with either alcohol misuse (e.g. hazardous or binge drinking) or alcohol use disorders (alcohol abuse or dependence) and comorbid PTSD.
- Conditions
- Stress Disorders, Post-Traumatic, Alcohol Abuse, Substance-Related Disorders
- Trial name
- NCT00262223
- Testing
- Seeking Safety, Sertraline
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Abuse, Alcohol Dependence
Disseminating Organizational SBI Services at Trauma Centers
The goal of the Disseminating Organizational Screening and Brief Interventions Services (DO-SBIS) investigation is to capitalize on the unique opportunity afforded by the American College of Surgeons' mandate by taking early…
- Trial name
- DO-SBIS (NCT00607620)
- Testing
- Brief Intervention
- Where
- United States
- Volunteers
- 878 people
- Sponsor
- University of Washington
Alcohol Dependence
Citicoline for Alcohol Dependence
The purpose of this study is to determine if citicoline, as an add-on therapy, will help reduce alcohol use in outpatients with alcohol dependence.
- Trial name
- NCT02074735
- Testing
- Citicoline
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Texas Southwestern Medical Center
Alcohol Dependence, Alcohol Abuse
ABT-436 for Alcohol Dependence
The primary efficacy endpoint examines the hypothesis that ABT-436 will decrease the weekly percentage of heavy drinking days during Study Weeks 2 through 12 (Days 8-84) as compared to placebo.
- Conditions
- Alcohol Dependence, Alcohol Abuse, Alcohol Use Disorders, Alcoholism
- Trial name
- NCT01613014
- Testing
- ABT-436
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Abuse, Cognitive Deficit in Attention
Pilot Study on Training Emerging Adults Skills in Navigating College
Lifetime risk for developing an alcohol use disorder increases with earlier onset of alcohol consumption. This risk may reflect a tendency for escalated alcohol intake among youth due to immature executive control, leading to…
- Trial name
- SINC (NCT05560425)
- Testing
- Koru Mindfulness (KM) Training, Navigating College (NC) Training
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Alcohol Dependence, Alcoholism
Topiramate for Alcohol Use in Posttraumatic Stress Disorder
Alcohol abuse and dependence (alcohol use disorders, AUDs) and posttraumatic stress disorder (PTSD) are both prevalent in Veterans.
- Conditions
- Alcohol Dependence, Alcoholism, Alcohol Abuse, Alcohol Use Disorder
- Trial name
- NCT01408641
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Maryland, Baltimore
Alcohol Abuse
Computer-delivered Screening and Brief Intervention for Alcohol Use in Pregnancy
The purpose of this study is to lay the ground work for a fully powered clinical trial of a computer-delivered screener and intervention for alcohol use during pregnancy. The pilot study will include: 1.
- Trial name
- NCT01643044
- Testing
- Computer-delivered, brief intervention on alcohol use
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Wayne State University