Clinical trials: Procalcitonin
Ventilator Associated Pneumonia
Research Title: Efficacy and Safety of Point- Of-care Procalcitonin Test to Reduce Antibiotic Exposure in VAP
Several studies have shown that PCT guidance can reduce the duration of antibiotic treatment for patients with bacterial infections in the ICU, without compromising the safety outcomes.
- Trial name
- NCT03982667
- Testing
- PCT-guided group
- Where
- 2 sites in Malaysia
- Volunteers
- 100 people
- Sponsor
- Mohd Zulfakar Mazlan, MBBS
COPD Exacerbation, COPD
PCT-guided Treatment Regarding Antibiotic Use for Acute COPD Exacerbations
This study the investigators will examine whether procalcitonin-guided treatment regarding antibiotic therapy is non-inferior to usual care in patients who are admitted because of an acute COPD exacerbation when it comes to…
- Conditions
- COPD Exacerbation, COPD, Acute Copd Exacerbation
- Trial name
- PRECISION (NCT05854901)
- Testing
- Procalcitonin, Physician's decision
- Where
- 11 sites in Netherlands
- Volunteers
- 693 people
- Sponsor
- Erasmus Medical Center
Blood Culture Contamination, Bacteremia
Diagnostic Performance of Plasma Procalcitonin for the Detection of Blood Cultures Contaminations
In blood cultures, species considered as potentially contaminating (coagulase negative staphylococci (CNS), Bacillus spp., Corynebacterium spp., Cutibacterium acnes, Micrococcus spp., viridans group streptococci, and Clostridium…
- Conditions
- Blood Culture Contamination, Bacteremia, Contamination
- Trial name
- NCT04573894
- Testing
- Procalcitonin dosage
- Where
- France
- Volunteers
- 147 people
- Sponsor
- Central Hospital, Nancy, France
Fever
Procalcitonin Levels in Patients With Fever and a Central Line
Procalcitonin (PCT) is one of many inflammatory markers which rises in response to infection. Many studies have shown this marker to be more indicative of a patient's clinical course in comparison to other inflammatory markers…
- Trial name
- NCT01175005
- Volunteers
- 62 people
- Sponsor
- Phoenix Children's Hospital
Lower Respiratory Tract Infection (LRTI)
Procalcitonin Antibiotic Consensus Trial (ProACT)
The ProACT study is a 5 year, multicenter study that will test the effect of implementation of a novel procalcitonin guideline on antibiotic use and adverse outcomes in Emergency Department (ED) patients with Lower Respiratory…
- Trial name
- ProACT (NCT02130986)
- Testing
- Procalcitonin level, Results of procalcitonin (PCT) level to treating clinician, Provide procalcitonin guideline to treating clinician
- Where
- 13 sites in United States
- Volunteers
- 1,664 people
- Sponsor
- University of Pittsburgh
Sepsis
Assessing the Procalcitonin-guidance and Molecular-guided Diagnosis for Therapy of Severe Infections (the MODIFY Trial)
MODIFY is a randomized, open-labeled, and prospective study that will be conducted in multiple Intensive Care Units (ICUs) and departments of Internal Medicine across Greece.
- Trial name
- MODIFY (NCT05909683)
- Testing
- Change of antimicrobials based on BCID2 and Reveal Rapid AST tests. Stop of antimicrobials based on PCT results., Standard of Care
- Where
- 15 sites in Greece
- Volunteers
- 190 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Bacterial Infections, Bacteremia
Procalcitonin Level and Kinetics in Children With Bacterial Infections
The purposes of this study are: 1. To determine whether procalcitonin level at admission of pediatric patients with bacterial infections can be used as a marker for prediction of defervescence and hospitalization length 2.
- Conditions
- Bacterial Infections, Bacteremia, Meningitis, Urinary Tract Infection
- Trial name
- NCT00714402
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Shaare Zedek Medical Center
Antimicrobial Stewardship, Exacerbation of Allergic Asthma
POCT PCT in Outpatient LRTI
Lower respiratory tract infections (LRTI) in patients with chronic lung diseases are a common acute reason to consult respiratory practitioners and often lead to inadequate prescription of antibiotics.
- Conditions
- Antimicrobial Stewardship, Exacerbation of Allergic Asthma, Exacerbation Copd, Community-acquired Pneumonia
- Trial name
- POCT-PCT (NCT05380869)
- Testing
- Point-of-care Test
- Where
- Germany
- Volunteers
- 114 people
- Sponsor
- Hannover Medical School
Covid19, Outcome, Fatal
International Study of Inflammation in COVID-19
This is a prospective multi-center observational study which purpose is to evaluate the ability of blood-based inflammatory markers to risk-stratify patients hospitalized for Covid-19.
- Conditions
- Covid19, Outcome, Fatal, Respiratory Failure, Acute Kidney Injury
- Trial name
- ISIC (NCT04818866)
- Testing
- SuPAR, C-reactive protein, Ferritin, D-Dimer, Procalcitonin, Interleukin-6, Lactate Dehydrogenase
- Where
- United States
- Volunteers
- 4,463 people
- Sponsor
- University of Michigan
Sepsis
Diagnostic and Prognostic Value of Serial Procalcitonin (PCT) Measurements in Critically Ill Patients
In 2005, the Food and Drug Administration (FDA) approved procalcitonin in conjunction with other laboratory markers to aid in the risk assessment of critically ill patients with severe infection (sepsis).
- Trial name
- PCT (NCT01362920)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The Cleveland Clinic
Essential Hypertension.
Inflammatory Response to Salt in Essential Hypertension
Salt is a main environmental risk factor involved in atherosclerotic complications and in the high risk of a variety of cardiovascular (CV) diseases including hypertension, left ventricular hypertrophy (LVH), chronic kidney…
- Trial name
- NCT01665534
- Testing
- High salt intake
- Volunteers
- 32 people
- Sponsor
- Carmine Zoccali
Sepsis
Procalcitonin and Duration of AntiBiotherapy In Late Onset Sepsis of Neonate
The duration of antibiotic (ATB) therapy in late onset sepsis (LOS) of the neonate is currently not based on scientific data. The current PROABIS trial will study the use of a biological marker, procalcitonin (PCT), to guide ATB…
- Trial name
- PROABIS (NCT03730636)
- Testing
- PCT dosage
- Where
- France
- Volunteers
- 511 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Obstructive Pulmonary Disease
Clinical Trial Assessing the Value of an Antibiotic Protocol Guided by Serum Procalcitonin in Acute Exacerbations of Chronic Obstructive Pulmonary Disease in Intensive Care
Investigators propose to conduct a prospective, randomized, controlled, multicenter assessing the interests of an antibiotic protocol guided by serum procalcitonin (PCT) on morbidity and mortality in patients with chronic…
- Trial name
- BPCTréa (NCT02521636)
- Testing
- Antibiotic therapy randomization, Serum PCT dosage
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Caen
Pneumonia, Acute Exacerbation of Chronic Obstructive Airways Disease
Procalcitonin as a Marker of Antibiotic Therapy in Patients With Lower Respiratory Tract Infections
The purpose of this study is to investigate weather or not the use of a procalcitonin(PCT)-based treatment in the daily clinical work could lower the consumption of antibiotics in patients with lower respiratory tract infections.
- Trial name
- NCT02171338
- Testing
- PCT-level, Antibiotic treatment based on PCT-level
- Where
- Denmark
- Volunteers
- 55 people
- Sponsor
- Holbaek Sygehus
Pleural Effusion
Use of Procalcitonin in the Diagnosis of Pleural Effusion
Among several markers of inflammation and sepsis, procalcitonin (PCT) markers is being studied to investigate their accuracy for the diagnosis of bacterial infections.
- Trial name
- NCT00172835
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Infection
Procalcitonin to Guide Obtaining Bloodcultures in the ICU Intensive Care Infection Score
PROBIC Rationale: Procalcitonin measurements can reduce the number of blood cultures in the ICU. Objective: The investigators suggest that PCT is a marker for blood stream infection in all patients in the ICU in whom attending…
- Trial name
- ProBIC/ICIS (NCT01847079)
- Testing
- Procalcitonin
- Where
- 2 sites in Netherlands
- Volunteers
- 1,130 people
- Sponsor
- Erasmus Medical Center
Infective Endocarditis
The Predictive Value of Lubricin in Patients With Infective Endocarditis
The main goal of this study is to evaluate the predictability of the disease by measuring the serum lubricin levels in patients with infective endocarditis and in non-patients
- Trial name
- NCT06266741
- Testing
- Lubricin
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Aydin Adnan Menderes University
Healthy
Determination of Normal Reference Values of CRP, Procalcitonin, and Lactate Levels for the Nanōmix eLab® System
The main objective of this clinical study is to determine the normal reference range of the Nanōmix eLab® (eLab) C-Reactive Protein, Procalcitonin and Lactate Assay.
- Trial name
- NCT03619109
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Nanomix
Sepsis
Evaluation of Serum Procalcitonin in Critically Ill Patients With Suspected Sepsis
Procalcitonin is a promising marker of sepsis in critically ill patients. Procalcitonin have better diagnostic accuracy compared to White blood cell count and C - reactive protein.
- Trial name
- NCT03506152
- Testing
- Serum Procalcitonin
- Where
- Pakistan
- Volunteers
- 103 people
- Sponsor
- Aga Khan University
Chronic Obstructive Pulmonary Disease
Diagnostic Values of C-reactive Protein and Procalcitonin in Predicting Bacterial Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease is a serious disease . Exacerbations of Chronic obstructive pulmonary disease is an acute worsening condition of Chronic obstructive pulmonary disease, which always accompanied by clinical…
- Trial name
- NCT03923803
- Testing
- C- reactive protein, Pro calcitonin
- Volunteers
- 90 people
- Sponsor
- Assiut University