Clinical trials: Processes, Metabolic
Diabetes, End Stage Renal Disease
Continuous Glucose Monitoring and Inflammation in Nondiabetic and Diabetic Patients Undergone Hemodialysis
Evaluation of different glycemic variations between the dialysis period and non-dialysis period in two groups: nondiabetic and diabetic patients undergone two different hemodialysis methods.
- Trial name
- NCT01049152
- Testing
- Continuous Glucose Monitoring (CGM)
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- University of Pavia
Time Restricted Feeding, Renal Insufficiency, Chronic
Effects of TRF on Obese Patients With CKD Stage 3-4
Obesity is associated with glomerular hyperfiltration leading to renal impairment and is a risk factor for the progression of kidney disease.Weight loss can reduce proteinuria and improve eGFR.Intermittent fasting is safe and…
- Conditions
- Time Restricted Feeding, Renal Insufficiency, Chronic, Obesity
- Trial name
- NCT05037747
- Testing
- Time-restricted feeding(TRF)
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Type 1 Diabetes, Insulin-requiring Type 2 Diabetes Mellitus
Use of Closed Loop Insulin Delivery for Glucose Control in Patients With Insulin Dependent Diabetes Mellitus After Kidney Transplantation
This study will be a prospective, single center, randomized controlled parallel group open-label trial. Participants with insulin requiring diabetes mellitus who have been offered an organ for living or deceased donor kidney…
- Conditions
- Type 1 Diabetes, Insulin-requiring Type 2 Diabetes Mellitus, End Stage Renal Disease (ESRD)
- Trial name
- NCT04189510
- Testing
- Artificial Pancreas, Multiple Daily Injections
- Sponsor
- University of Virginia
Hunter Syndrome
A Safety and Dose Ranging Study of Idursulfase (Intrathecal) Administration Via an Intrathecal Drug Delivery Device in Pediatric Patients With Hunter Syndrome Who Have Central Nervous System Involvement and Are Receiving Treatment With Elaprase®
Elaprase (idursulfase), a large molecular protein, is not expected to cross the blood brain barrier at therapeutic levels when administered intravenously.
- Trial name
- NCT00920647
- Testing
- Control, Idursulfase IT (1 mg), Idursulfase IT (10 mg)
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 16 people
- Sponsor
- Shire
Infant, Low Birth Weight, Hyperglycemia
Gluconeogenesis in Very Low Birth Weight Infants Who Are Receiving Nutrition By Intravenous Infusion
RATIONALE: Very low birth weight infants have problems maintaining normal blood sugar levels. Gluconeogenesis is the production of sugar from amino acids and fats.
- Trial name
- NCT00005889
- Testing
- alanine, amino acids, glucagon
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- National Center for Research Resources (NCRR)
Hepatic Encephalopathy, Ascites
Tackling 30-day Readmissions in Patients With Cirrhosis: The SALTYFOOD Trial
The purpose of this study is to determine the feasibility of a home meal delivery program for patients with cirrhosis and ascites and to determine the effectiveness of a salt-restricted (2 gram sodium) meal delivery program in…
- Conditions
- Hepatic Encephalopathy, Ascites, Liver Diseases, Cirrhosis
- Trial name
- NCT03493204
- Testing
- Meal delivery, Standard pamphlet with Dietary Advice
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Michigan
Cystinosis
Randomized Study of New Formulation Ophthalmic Cysteamine Hydrochloride for Corneal Cystine Accumulation in Patients With Cystinosis
OBJECTIVES: I. Determine the proportion of patients with cystinosis who experience a serious adverse effect when treated with a new formulation of cysteamine hydrochloride for corneal cystine accumulation. II.
- Trial name
- NCT00010426
- Testing
- cysteamine hydrochloride
- Volunteers
- 30 people
- Sponsor
- FDA Office of Orphan Products Development
Chronic Myeloproliferative Disorders, Leukemia
Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer
RATIONALE: Collecting and storing samples of tissue, blood, and body fluid from patients with cancer to study in the laboratory may help the study of cancer in the future.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Lymphoproliferative Disorder
- Trial name
- NCT01137643
- Testing
- biologic sample preservation procedure, cytology specimen collection procedure
- Where
- United States
- Volunteers
- 15,000 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Heart Failure, Congestive, Pulmonary Disease, Chronic Obstructive
Capturing Outcomes of Clinical Activities Performed by a Rounding Pharmacist Practising in a Team Environment
We, the researchers, propose to link a clinical pharmacist with an internal medicine or family medicine team to provide pharmaceutical care to all patients assigned to the team.
- Conditions
- Heart Failure, Congestive, Pulmonary Disease, Chronic Obstructive, Pneumonia, Diabetes Mellitus, Type 2
- Trial name
- NCT00351676
- Testing
- Integration of a team based clinical pharmacist, Optimizing therapeutic treatments, Optimizing processes of care
- Where
- 3 sites in Canada
- Volunteers
- 452 people
- Sponsor
- University of Alberta
Low Back Pain, Obesity
The Effect of Traction Forces in People With Obesity Suffering From Chronic Low Back Pain
The purpose of the research study is to assess the impact of traction forces on changes in systemic markers concentrations of spinal structure damage in people with obesity.
- Trial name
- NCT04507074
- Testing
- lumbar traction therapy
- Where
- Poland
- Volunteers
- 49 people
- Sponsor
- Poznan University of Physical Education
Maternal Obesity Complicating Pregnancy, Birth,or Puerperium, Child Malnutrition
Addressing the Double Burden of Malnutrition in Guatemala
Globally, populations are experiencing increases in the double burden of malnutrition, commonly defined as maternal overweight/obesity and child stunting in the same household.
- Trial name
- NCT06750120
- Testing
- Family food ration, Optimal weight counseling, Enhanced Usual Care
- Where
- Guatemala
- Volunteers
- 1,532 people
- Sponsor
- Brigham and Women's Hospital
Atrial Fibrillation (AF), Hypertension
SGLT2i Improve Left Atrial Function in Patients With Paroxysmal Atrial Fibrillation, Hypertension and Abnormal Glucose Metabolism
Heart failure is the most important clinical endpoint event in atrial fibrillation (AF). Patients with AF complicated by heart failure have a significantly higher risk of all-cause mortality and cardiovascular mortality compared…
- Trial name
- NCT07482020
- Testing
- SGLT-2 inhibitors
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Huashan Hospital
Myocardial Infarction, Diabetes Mellitus
Role of SGLT2I in Patients With Myocardial Infarction
Role of sglt2I in diabetic patients with myocardial infarction
- Trial name
- NCT06245980
- Testing
- SGLT2 inhibitor
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Dongying Zhang
Parkinson Disease, Diabetes Mellitus
Health Indicators and Patient Reported Outcomes. Identification of Significative Items Aimed at Improving Health Care Procceses.
The objective of this study is to identify key indicators in the follow-up of subjects with different pathologies related to both the person's environment, as well as the perception of their health and general quality of life and…
- Conditions
- Parkinson Disease, Diabetes Mellitus, COVID-19, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- OUTCOMES (NCT05343962)
- Where
- Spain
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Instituto de Biomecanica de Valencia
Cardiovascular Complications, Leukemia
Study of Metabolic Syndrome in Adolescent and Young Adult Survivors of Childhood Leukemia Who Have Undergone Stem Cell Transplant
RATIONALE: Gathering information about how often metabolic syndrome occurs in young survivors of childhood leukemia who have undergone stem cell transplant may help doctors learn more about the disease and the long-term effects…
- Conditions
- Cardiovascular Complications, Leukemia, Long-term Effects Secondary to Cancer Therapy in Children, Metabolic Syndrome
- Trial name
- NCT00920842
- Where
- United States
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Diabetes, Atrial Fibrillation (AF)
Unrecognised Comorbidity Detection in Hospitalised Patients
Over two million people in the UK are unaware that they're living with a long-term (chronic) health condition, such as diabetes or a heart problem.
- Conditions
- Diabetes, Atrial Fibrillation (AF), Cardiac Disease
- Trial name
- CODETECT (NCT06881797)
- Where
- United Kingdom
- Volunteers
- 4,500,000 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Hunter Syndrome
Study of Intrathecal Idursulfase-IT Administered in Conjunction With Elaprase® in Pediatric Patients With Hunter Syndrome and Early Cognitive Impairment
Study HGT-HIT-094 is a multicenter study designed to determine the effect on clinical parameters of neurodevelopmental status of monthly IT administration of idursulfase-IT 10 mg for 12 months in pediatric patients with Hunter…
- Trial name
- AIM-IT (NCT02055118)
- Testing
- idursulfase-IT, No IT treatment
- Where
- 9 sites in United States, Australia and 5 more
- Volunteers
- 58 people
- Sponsor
- Shire
Covid19, Corona Virus Infection
Clinical Outcomes of High Dose Vitamin D Versus Standard Dose in COVID-19 Egyptian Patients
Vitamin D is a secosteroid hormone which may have beneficial role in reducing COVID-19 adverse outcomes by first regulating the renin angiotensin system (RAS).
- Conditions
- Covid19, Corona Virus Infection, Cytokine Storm, Vitamin D Deficiency
- Trial name
- NCT04738760
- Where
- Egypt
- Volunteers
- 116 people
- Sponsor
- Ain Shams University
Neurodegeneration With Brain Iron Accumulation (NBIA), Iron Metabolism Disorders
Brain Iron in Beta-Propeller Protein Associated Neurodegeneration (BPAN)
This study aims to quantify intracerebral iron load in patients with Beta-Propeller Protein-Associated Neurodegeneration (BPAN) using Quantitative Susceptibility Mapping (QSM) technique.
- Conditions
- Neurodegeneration With Brain Iron Accumulation (NBIA), Iron Metabolism Disorders, Brain Disease
- Trial name
- QUBIPAN (NCT07868120)
- Testing
- Standardized brain MRI including specific sequences usable for Quantitative Susceptibility Mapping (QSM)
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Bordeaux
Diabetes, Healthy
A Randomised, Single Centre, Double-blind, Two-period, Cross-over Trial in Healthy Subjects Investigating the Bioequivalence Between Subcutaneous Injections of Semaglutide Produced by Two Manufacturing Processes
This trial is conducted in Europe. The aim of the trial is to investigate the bioequivalence (assessment of the expected biological equivalence of two pharmaceutical drug products with identical active ingredient) between…
- Trial name
- NCT01766245
- Testing
- semaglutide
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
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