Clinical trials: Processes, Metabolic
Neonatal Screening, Kernicterus
Bilistick Point-of-care System 2.0 Bilirubin Validation
This is a validation study involving the Bilistick System 2.0 point-of-care bilirubin measuring device. The validation will be conducted by comparing bilirubin measurements utilizing the standard-of-care blood sample collected…
- Conditions
- Neonatal Screening, Kernicterus, Newborn Jaundice, Point-of-Care Testing
- Trial name
- NCT06058910
- Testing
- Bilistick System 2.0 point-of-care testing device
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kettering Health Network
C-reactive Protein, Inflammation
Obesity, Inflammation and Oxidative Stress
The purpose of this study is to determine whether or not Vitamin C (1000 mg/day) can reduce markers of inflammation, especially C-reactive protein (CRP), in obese persons with baseline CRP greater than 1 mg/dl.
- Conditions
- C-reactive Protein, Inflammation, Obesity, Oxidative Stress
- Trial name
- NCT01028976
- Testing
- Vitamin C (ascorbic acid)
- Where
- United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Chronic Kidney Disease, Renal Dialysis
A Phase 3 Study in Patients With Chronic Kidney Disease and Hyperphosphatemia on Peritoneal Dialysis
This is a multi-center, open-labeled, non-comparative study to examine the safety and efficacy of ASP1585 in chronic kidney disease and hyperphosphatemia patients on peritoneal dialysis.
- Conditions
- Chronic Kidney Disease, Renal Dialysis, Renal Insufficiency
- Trial name
- NCT01017276
- Testing
- ASP1585
- Where
- 3 sites in Japan
- Volunteers
- 35 people
- Sponsor
- Astellas Pharma Inc
Anemia
Accuracy of Non Invasive Hemoglobin Measure by SpHb Device in Post Operative Anemia Diagnosis
Non invasive Hemoglobin monitoring by SpHb device had been developed to assess Hemoglobin level during hemorrhagic surgery. It's accuracy to detect post operative anemia on a single post operative measure has been recently…
- Trial name
- SpHb_gyneco (NCT06497335)
- Testing
- non invasive hemoglobin measure
- Volunteers
- 150 people
- Sponsor
- University Hospital, Angers
Healthy, Chronic Kidney Diseases
Effect of the Consumption of Ferric Hydroxide Adipate on Urinary Phosphorus Excretion.
Ferric hydroxide adipate is a ferric iron supplement containing iron hydroxide and a dietary organic acid that was developed at MRC Human Nutrition Research.
- Trial name
- NCT01991574
- Testing
- Calcium acetate, Iron Hydroxide Adipate
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical Research Council
End-Stage Renal Disease
Vitamin D3 Supplementation in Dialysis Patients
Vitamin D deficiency is highly prevalent among dialysis patients, and has been associated with cardiovascular risk factors such as increased aortic pulse wave velocity, blood pressure, inflammation, and brain natriuretic peptide.
- Trial name
- NCT01312714
- Testing
- Cholecalciferol
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Regional Hospital Holstebro
Atrial Fibrillation, Coronary Heart Disease
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
Health inequality and genetic disparity are a significant issue in the United Kingdom (UK). This study focuses on diseases that are associated with significant morbidity and mortality in the UK, and specifically examines the…
- Conditions
- Atrial Fibrillation, Coronary Heart Disease, Cardiovascular Diseases, Heart Failure
- Trial name
- EMPOWER (NCT03987633)
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Future Genetics Limited
Surgical Site Infection in Obese Women Undergoing C-section
Use of 48 Hour Course of Antibiotics to Prevent Surgical Site Infection in Obese Patients Undergoing Cesarean Delivery
The purpose of this study is to evaluate if preoperative antibiotics, followed by 48 hour course of broad spectrum antibiotics prevents wound infection complications in patients that are obese who undergo cesarean section.
- Trial name
- SSI (NCT01194115)
- Testing
- cephalexin & metronidazole
- Where
- United States
- Volunteers
- 475 people
- Sponsor
- University of Cincinnati
Obesity
Omega-3 Fatty Acid Supplementation and Fractional Iron Absorption in Obese South African Women
In South Africa the prevalence of obesity in women of reproductive age is high; these women also have a high risk for iron deficiency (ID).
- Trial name
- NCT05220735
- Testing
- Omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA)
- Where
- South Africa
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Diabetic Foot Ulcer, Wound Healing
Systemic Biochemical Signature and Functional Quality Index of Calcaneal Bone Marrow Aspirate in Adults Undergoing Foot or Ankle Surgery
This observational prospective cohort study will evaluate whether routine blood tests are associated with the functional quality of calcaneal bone marrow aspirate mesenchymal stem cells in adults undergoing clinically indicated…
- Conditions
- Diabetic Foot Ulcer, Wound Healing, Foot Ulcer Due to Type 2 Diabetes Mellitus, Diabetes Mellitus Type 2
- Trial name
- IQF-BMA (NCT07802106)
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Sao Francisco
Macular Degeneration
Scotoma Reduction in AMD Patients Treated With Ranibizumab
This is a trial aimed at patients with advanced wet macular degeneration and macular scarring treated wiht intravitreal injections of Lucentis.
- Trial name
- SALVAGE (NCT00467935)
- Testing
- intravitreal injection Lucentis (ranibizumab)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Retina Research Foundation
Aging
PEU in Elderly TCU Residents
Background: There is tremendous controversy regarding the adequacy/effectiveness of the nutritional care provided in VA Transitional Care Units (TCUs).
- Trial name
- NCT00242684
- Where
- United States
- Volunteers
- 446 people
- Sponsor
- US Department of Veterans Affairs
Sickle Cell Disease, Sickle Cell Anemia
Sickle Cell Disease (SCD) Bone Pain Study
A prospective study to determine how low bone mineral density and/or vertebral compression fractures associate with pain in adults with sickle cell disease
- Conditions
- Sickle Cell Disease, Sickle Cell Anemia, Low Bone Density, Osteoporosis
- Trial name
- NCT05283148
- Testing
- Dual-energy X-ray absorptiometry, Vertebral fracture analysis, Adult Sickle Cell Quality of Life Measurement System pain impact questionnaire
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of California, Davis
Physical Activity, Resistance Exercise
The Association of Resistance Exercise With the Inflammasome Activation in Obesity Subjects
The intervention study consist in 3 months of follow up to evaluate the effect of resistance exercise on NLRP3 and interleukin-18 (IL-18) gene expression, and IL-18 and IL-1b cytokines levels in obese subjects, due to, the…
- Conditions
- Physical Activity, Resistance Exercise, Inflammation, Obesity
- Trial name
- NCT05482178
- Testing
- Resistance exercise training plus hypocaloric diet, Hypocaloric diet
- Where
- Mexico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Elisa Barron-Cabrera
Renal Insufficiency, Chronic
Short-term Metabolic Effects of Ketosteril® Supplemented Low Protein Diet in Pre-dialysis Chronic Kidney Disease (CKD) Patients
Supplementation of ketoanalogues of essential amino acids improves the protein quality of protein restricted diets without burdening the kidneys.
- Trial name
- CKD (NCT03077048)
- Testing
- Ketosteril®
- Where
- Czechia
- Volunteers
- 23 people
- Sponsor
- Fresenius Kabi
Type 2 Diabetes, Inflammation
Low-Intermediate-Glycemic Index Caribbean Foods Versus High Glycemic Index Foods in Type 2 Diabetes
The purpose of this study is to determine whether low and intermediate GI Caribbean foods are effective in the management of type 2 diabetes.
- Conditions
- Type 2 Diabetes, Inflammation, Cardiovascular Disease
- Trial name
- NCT00818935
- Testing
- Low-Intermediate-Glycemic Index diets, High GI diet
- Where
- Jamaica
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University Hospital of the West Indies
Fibromyalgia
Safety Study of DS-5565 for Treatment of Fibromyalgia Pain in Subjects With Chronic Kidney Disease
DS-5565 (mirogabalin) is being studied as treatment for fibromyalgia (FM) pain. Because it is excreted through the kidneys, people who have reduced kidney function will not process the drug as well as with those with normal…
- Trial name
- NCT02496884
- Testing
- DS-5565
- Where
- 39 sites in United States, Bulgaria and 6 more
- Volunteers
- 56 people
- Sponsor
- Daiichi Sankyo
Non-Alcoholic Fatty Liver Disease, Liver Fat
Diet, Immunometabolism and Non-alcoholic Fatty Liver Disease
This study will assess the impact of 8-hour time restricted eating (8 hours of eating, 16 hours fasting) combined with a Mediterranean diet on metabolism and inflammation in adults with non-alcoholic fatty liver disease (NAFLD).
- Conditions
- Non-Alcoholic Fatty Liver Disease, Liver Fat, Obesity, Inflammation
- Trial name
- NCT05968378
- Testing
- Standard healthy eating advice, eTRE plus Mediterranean diet
- Where
- Ireland
- Volunteers
- 60 people
- Sponsor
- University College Dublin
Diabetes Mellitus, Atrial Fibrillation
Dapagliflozin in Patients With Atrial Fibrillation (DAPA-AF)
The study will investigate the effect of Dapagliflozin on atrial fibrillation (AF) burden. AF burden will be defined as the percent of time spent in AF over a 2-week period, assessed by noninvasive continuous heart rhythm…
- Trial name
- NCT05174052
- Testing
- Dapagliflozin 10Mg Tab
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Oklahoma
Inflammatory Response, Metabolic Disturbance
Acute Inflammatory and Metabolic Effect of High Fructose Intake
Fructose consumption is associated with the development of metabolic diseases and low-grade inflammation. However, the acute effect of a single meal rich in fructose on the metabolic and inflammatory response is not fully…
- Trial name
- NCT05573438
- Testing
- Group fructose, Group Sucrose, Group Glucose
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Adaliene Versiani M. Ferreira
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