Clinical trials: Processes, Metabolic
Brain Death
Optical Assessment on Brain Death Via a Oxygen Supply Procedure
This study aims to evaluate brain death with optical probes. The changes of hemodynamic parameters including oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb) were detected by near infrared spectroscopy probes attached on the…
- Trial name
- NCT03864887
- Testing
- Oxygen supply of high-low-high procedure, Oxygen supply of low-high-low procedure, Optical monitor for hemodynamic parameter.
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Coronary Artery Disease, Percutaneous Coronary Intervention
Evaluation of Novel Risk Factors and Clinical Outcomes of Acute Myocardial Infarction
The aim of this study is to investigate the potential novel risk factors for acute myocardial infarction. Predictors of poor outcomes will be also evaluated.
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Myocardial Infarction
- Trial name
- NCT02641184
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Zhejiang Provincial People's Hospital
Cystic Fibrosis, Glucose Metabolism Disorders
The Relationship Between Diet and Glycemic Response and Inflammatory Markers in Children With Cystic Fibrosis
The aim of this study is to determine the relationship between diets of children with cystic fibrosis and glycemic responses and some inflammatory markers.
- Trial name
- NCT05748444
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- büşra başpınar
Cardiovascular Diseases, Hypertension
Implementing Digital Health in a Learning Health System
The need for new models of integrated care that can improve the efficiency of healthcare and reduce the costs are key priorities for health systems across the United States.
- Conditions
- Cardiovascular Diseases, Hypertension, Heart Failure, Atrial Fibrillation
- Trial name
- ASE-INNOVATE (NCT03713333)
- Testing
- Digital Health Device Diagnostics
- Where
- United States
- Volunteers
- 374 people
- Sponsor
- Scripps Health
Pulmonary Disease, Chronic Obstructive, Osteoporosis
CT-Based Modeling of Bone Micro-Architecture and Fracture-Risk in COPD
The goal of this translational study is to establish a newly emerging CT-based tool for the characterization of changes in bone micro-architecture and assessment of their implications for fracture-risk in a population of COPD…
- Trial name
- NCT03534934
- Testing
- Vital signs, Urine Pregnancy Test, Questionnaires
- Where
- 2 sites in United States
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Punam K Saha
Hepatic Encephalopathy
Efficacy and Safety of AXA1665 in Cirrhotic Subjects With Prior Overt Hepatic Encephalopathy
This is a global study to compare the effects of AXA1665, an orally active mixture of amino acids, compared to placebo, on cognitive and physical function, as well as the safety and tolerability of AXA1665.
- Trial name
- EMMPOWER (NCT04816916)
- Testing
- AXA1665
- Where
- 40 sites in United States, Canada and 5 more
- Volunteers
- 12 people
- Sponsor
- Axcella Health, Inc
Myocardial Infarction
Effect of Statin Treatment on Insulin Sensitivity During Myocardial Infarction
Stress hyperglycemia during myocardial infarction (MI) is related to mortality at short and long term. Recent studies, however, revealed that chronic statin treatment may decrease both insulin sensitivity and secretion…
- Trial name
- NCT01205347
- Testing
- Simvastatin 80mg, Simvastatin 10mg
- Where
- Brazil
- Volunteers
- 27 people
- Sponsor
- Brasilia Heart Study Group
Chronic Myeloproliferative Disorders, Fatigue
American Ginseng in Treating Patients With Fatigue Caused by Cancer
RATIONALE: American ginseng may reduce fatigue in patients with cancer. It is not yet known whether American ginseng is more effective than a placebo in treating cancer-related fatigue.
- Conditions
- Chronic Myeloproliferative Disorders, Fatigue, Leukemia, Lymphoma
- Trial name
- NCT00719563
- Testing
- American ginseng
- Where
- 326 sites in United States
- Volunteers
- 364 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Immune Deficiency Disorders, Severe Combined Immunodeficiency
Immune Disorder HSCT Protocol
This study hypothesizes that a reduced intensity immunosuppressive preparative regimen will establish engraftment of donor hematopoietic cells with acceptable early and delayed toxicity in patients with immune function disorders.
- Conditions
- Immune Deficiency Disorders, Severe Combined Immunodeficiency, Chronic Granulomatous Disease, X-linked Agammaglobulinemia
- Trial name
- NCT01821781
- Testing
- Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Washington University School of Medicine
Diabetic Foot, Arterial Occlusive Disease
Urokinase Therapy in Diabetic Foot Syndrome
The purpose of this study is to evaluate whether a treatment with urokinase (500 000 or 1 000 000 IU) can lead to ulcer-healing, lower rate of major amputation, and prolonged survival in patients with diabetic foot syndrome.
- Conditions
- Diabetic Foot, Arterial Occlusive Disease, Ischemia
- Trial name
- NCT00537498
- Testing
- Urokinase
- Where
- Germany
- Volunteers
- 77 people
- Sponsor
- medac GmbH
HIV-1-infection, Hepatitis C, Chronic
Switch to Genvoya Followed by HCV Therapy With Epclusa Followed by Simplification of HIV Therapy With Biktarvy in Patients With HIV-HCV Co-Infected Subjects on Opioid Substitution Therapy
The study hypothesis is to determine the feasibility of switching HIV-HCV co-infected patients receiving methadone or buprenorphine/naloxone as opioid substitution therapy with suppressed HIV RNA viral load on current…
- Conditions
- HIV-1-infection, Hepatitis C, Chronic, Methadone Dependence, Opioid Dependence
- Trial name
- NCT03549312
- Testing
- Genvoya, Epclusa, Biktarvy
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area
Psoriasis
INulin-type Fructans-induced Gut Microbiota Modulation Impact on GUT-SKIN Axis Parameters in Psoriasis
There is increasing evidence of a strong, bidirectional correlation between the gut and the skin, that associates gastrointestinal health with skin homeostasis and allostasis.
- Trial name
- INGUTSKIN (NCT05971992)
- Testing
- Chicory-derived inulin-type β-fructans, Maltodextrin
- Where
- 2 sites in Poland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Polish Academy of Sciences
Cognitive Performance, Inflammation
Peanut Consumption on Cognitive, Weight, and Inflammation
A multi-school, two-arm parallel cluster-randomized controlled trial will be conducted in 200 healthy young adolescents from Barcelona (Spain) to evaluate the effect of peanut consumption on cognitive performance, weight…
- Conditions
- Cognitive Performance, Inflammation, Weight Change, Body, Adolescents
- Trial name
- PEANUTY (NCT06127511)
- Testing
- Food (peanut)
- Where
- Spain
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Diabetes Mellitus, Type 2, PreDiabetes
Blood Markers of Early Pancreas Cancer
Identifying biomarkers of early pancreatic ductal adenocarcinoma (PDAC) could facilitate screening for individuals at higher than average risk and expedite the diagnosis in individuals with symptoms and substantially improve an…
- Conditions
- Diabetes Mellitus, Type 2, PreDiabetes, Pancreas Cyst, Chronic Pancreatitis
- Trial name
- NCT03568630
- Where
- United States
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Hyperphosphatemia, ESRD
Phosphate Kinetic Modeling 2
The study aims to investigate the concept of computer based Phosphate Kinetic Modeling (PKM) in the hemodialysis patient population.
- Trial name
- PKM2 (NCT01252771)
- Testing
- PKM Algorithm
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Fresenius Medical Care North America
Chronic Obstructive Pulmonary Disease
Hydrolyzed Casein and Whey Protein Supplementation and the Addition of Leucine to Induce Protein Anabolism in Malnourished COPD Patients
The aim of this study is the first aim of a NIH project that consists of 3 aims. The first aim examines the acute effects of two high-quality milk proteins (casein vs.
- Trial name
- NCT01154400
- Testing
- Casein protein hydrolysates, Whey protein hydrolysates, Casein protein hydrolysates + LEU
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Texas A&M University
Multiple Organ Dysfunction
Modulation of Microbiota Metabolism in Cardiac Surgery Patients
An imbalance in the microbiota (most often intestinal) largely determines the onset of a disease state, and often a critical state.
- Trial name
- MMMMODCS (NCT04921436)
- Testing
- cardiac surgery
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Dysequilibrium Syndrome, ESRD
Adding Urea to the Final Dialysis Fluid
At times patients with advanced renal failure present with severe hyperkalemia or acidosis and very high serum blood urea nitrogen (BUN) concentrations.
- Conditions
- Dysequilibrium Syndrome, ESRD, Hyperkalemia, Metabolic Acidosis
- Trial name
- Urea dialysate (NCT06366230)
- Testing
- Urea in the dialysate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Diabetes, Hypertension
Scripps Wired for Health Monitoring Study
People with chronic diseases such as diabetes, hypertension (high blood pressure) and cardiac (heart) arrhythmias tend to go to the doctor more often and have more tests done than those without those diseases.
- Conditions
- Diabetes, Hypertension, Cardiac Arrhythmia
- Trial name
- NCT01975428
- Testing
- DM Pgm + device, Control
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- Scripps Translational Science Institute
Malnutrition
Chronic Obstructive Pulmonary Disease (COPD) Nutrition Support Trial
The purpose of this study is to determine the best form of dietary intervention to undernourished individuals with COPD. The research aims to test the null hypothesis that there is no difference between oral nutritional…
- Trial name
- NCT00538200
- Testing
- Oral Nutritional Supplements (Fortisip), Dietary Advice
- Where
- United Kingdom
- Volunteers
- 85 people
- Sponsor
- University of Southampton
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