Clinical trials: Processes, Metabolic
Processes, Metabolic
Plasma-Induced Changes in the Metabolome Following Polyphenol Consumption
The goal of this clinical trial is to compare the changes in the human metabolome following a low or high acute dose of European tart cherries.
- Trial name
- NCT06144489
- Testing
- Tart Cherry
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Dehydration in Children, Dehydration
The Impact of Brief One-time Education and Coach Encouragement on Hydration Status in Child Judo Athletes
Due to the lack of any comparative study related to effect of different hydration processes, this study aimed to compare the effectiveness of coach encouragement and hydration education in maintaining hydration status in child…
- Trial name
- NCT06992817
- Testing
- Hydration-Coach Encouragement, Short Hydration Informative Session
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Kastamonu University
Metabolism, Gut Microbiota
The Impact of Plant-Based Protein-rich Food Products With Varying Degree of Processing on the Human Gut Microbiome Composition and Human Metabolome
It is observed that replacing meat with protein-rich plant-based food products are associated with lower mortality and obesity prevention.
- Conditions
- Metabolism, Gut Microbiota, Inflammation
- Trial name
- NCT05885750
- Testing
- Unprocessed, Mildly processed, Heavily refined
- Where
- Finland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Turku
Tetraplegia, Locked-in Syndrome
Investigation on the Cortical Communication (CortiCom) System
The CortiCom system consists of 510(k)-cleared components: platinum PMT subdural cortical electrode grids, a Blackrock Microsystems patient pedestal, and an external NeuroPort Neural Signal Processor.
- Conditions
- Tetraplegia, Locked-in Syndrome, Brainstem Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- CortiCom (NCT03567213)
- Testing
- Surgical implantation of CortiCom system
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Johns Hopkins University
Sepsis, Diabetes Mellitus
The Prognostic Value of Lactate is Different Among Septic Patients
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Early diagnosis of sepsis and identification of more severe sepsis is important to improve the outcomes .Therefore…
- Trial name
- NCT04155060
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Shanghai Zhongshan Hospital
Infant Malnutrition, Fetal Growth Retardation
DEUX OEUFs: Cracking the Potential of Eggs to Improve Child Growth and Development
This proposed randomized controlled trial aims to investigate the effect of maternal egg consumption during pregnancy on birth length.
- Trial name
- NCT06405360
- Testing
- Egg consumption
- Where
- Rwanda
- Volunteers
- 464 people, healthy volunteers welcome
- Sponsor
- University of Florida
Chronic Lymphocytic Leukemia
In Vivo Metabolic Profiling of CLL (Chronic Lymphocytic Leukemia)
Metabolic reprogramming has been identified as a hallmark of cancer. Almost a century after Otto Warburg initially discovered increased glycolytic activity in tumor tissue ("Warburg effect"), therapeutic targeting of cancer…
- Trial name
- NCT04785989
- Testing
- [U-13C]glucose, [13C5]glutamine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Impaired Glucose Tolerance, Myocardial Infarction
Assessment of an Alpha-glucosidase Inhibitor to Block Cardiac Events in Patients With MI and IGT
The purpose of this study is to evaluate whether an alpha-glucosidase inhibitor, a drug for the suppression of postprandial hyperglycemia, could reduce the recurrence of myocardial infarction in patients with impaired glucose…
- Trial name
- NCT00212017
- Testing
- voglibose, diet and exercise therapy
- Where
- Japan
- Volunteers
- 3,000 people
- Sponsor
- National Cerebral and Cardiovascular Center, Japan
Atrial Fibrillation, Stroke
Atrial Fibrillation Detected by Continuous ECG Monitoring
The LOOP study aims to determine whether screening for atrial fibrillation (AF) with implantable loop recorder and initiation of oral anticoagulation (OAC) if AF is detected will reduce the risk of stroke and systemic arterial…
- Conditions
- Atrial Fibrillation, Stroke, Hypertension, Diabetes
- Trial name
- LOOP (NCT02036450)
- Testing
- Implantable loop recorder (Medtronic Reveal LINQ(TM))
- Where
- Denmark
- Volunteers
- 6,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Obesity, Insulin Sensitivity
Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity.
- Conditions
- Obesity, Insulin Sensitivity, Muscle Weakness, Adiposity
- Trial name
- NCT06129110
- Testing
- Diet Weight Loss
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Wound Infection, Postoperative Complication
Incisional Wound Vac in Obese Patients
It is the belief of the investigators that the current trends in complication rates associated with fixation of pelvic ring injuries and acetabular fractures in the obese are unacceptable.
- Trial name
- NCT00789659
- Testing
- Negative pressure dressing
- Where
- United States
- Sponsor
- University of Mississippi Medical Center
Ventricular Arrhythmias and Cardiac Arrest, Implantable Defibrillator User
Targeted Potassium Levels for Prevention of ICD Therapy
This study evaluates whether a rigorously controlled high-normal level of serum-potassium (4.5-5.0 mEq/L) using dietary recommendations, potassium supplements and mineralocorticoid receptor antagonists will results in a lower…
- Conditions
- Ventricular Arrhythmias and Cardiac Arrest, Implantable Defibrillator User, Hypokalemia, Hyperkalemia
- Trial name
- NCT03833089
- Testing
- Targeted serum potassium level
- Where
- 3 sites in Denmark
- Volunteers
- 1,200 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiovascular Diseases
Continuation of the nuMoM2b Heart Health Study
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in U.S. women at all ages, and large knowledge gaps exist in CVD predictive and preventative strategies for women.
- Trial name
- nuMoM2b-HHS2 (NCT05472597)
- Where
- 14 sites in United States
- Volunteers
- 4,048 people, healthy volunteers welcome
- Sponsor
- RTI International
Basal Cell Carcinoma, Keratosis Palmaris et Plantaris
The Evaluation of Oral Acitretin in the Treatment of Psoriasis, Cutaneous Disorders of Keratinization, Multiple Basal Cell Carcinomas and Other Retinoid Responsive Diseases
This is a continuing study which evaluates the long-term safety and efficacy of oral acitretin in an open manner in the treatment of psoriasis, cutaneous disorders of keratinization, multiple basal cell carcinomas and other…
- Conditions
- Basal Cell Carcinoma, Keratosis Palmaris et Plantaris, Psoriasis
- Trial name
- NCT00005660
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- National Cancer Institute (NCI)
Sleep Apnea Syndromes in Children, Obesity in Children
Overview: Use of Respiratory Support At Home in Children
the primary outcome is to describe the perceived success of the use of the respiratory support from the parent's point of view
- Conditions
- Sleep Apnea Syndromes in Children, Obesity in Children, Bronchopulmonary Dysplasia (BPD), Neuromuscular Disease
- Trial name
- ELIPSE (NCT06692660)
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Nutrition Disorders, Critical Illness
Pectin Start Early Enteral Nutritional Support in Critically Ill Patients
Acute lower gastrointestinal dysfunction is a kind of much common complication which occurred in critically ill patients. Once it developed, enteral nutrition would be disturbed.
- Trial name
- NCT02379624
- Testing
- pectin
- Volunteers
- 125 people
- Sponsor
- Xingwei Xu
Obesity, Insulin Resistance
Impact of FTO Gene Variation on Body Composition, Lipid Profile, Insulin Resistance, Advanced Glycation End-Products and Ghrelin Levels in Response to Hypocaloric, Protein Rich-Diet
Obesity is a widespread disease that basically develops from unhealthy lifestyle and genetics. The Fat-mass and obesity associated (FTO) gene affects appetite and energy intake of the body, thus elevating fat mass and body…
- Conditions
- Obesity, Insulin Resistance, Dyslipidemias, Advance Glycation
- Trial name
- NCT06426017
- Testing
- High Protein Low Calorie Dietary Intervention
- Where
- 2 sites in Pakistan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Traditional Chinese Medicine, Dyslipidemias
PDR and SKYD of Dyslipidemia's Characteristics From the Oxidative Stress Enhancement Caused by Inhibition of Serine Metabolic Pathway
Clinical epidemiological investigation and modern statistics will be used. Syndrome was quantified by TCM syndrome score scale. Metabonomics, proteomics, transcriptomics, enzyme-linked immunosorbent assay, xanthine oxidation…
- Conditions
- Traditional Chinese Medicine, Dyslipidemias, Syndrome
- Trial name
- PDR SKYD (NCT04909489)
- Testing
- cross-sectional study without intervention
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Dongzhimen Hospital, Beijing
Tuberculosis, Severe Acute Malnutrition
Development of a Diagnostic Prediction Score for Tuberculosis in Hospitalized Children With Severe Acute Malnutrition (TB-Speed SAM)
TB-Speed SAM is a multicentric, prospective diagnostic cohort study conducted in two countries with high and very high TB incidence (Uganda and Zambia).
- Trial name
- NCT04240990
- Testing
- Development of a score and algorithm for TB treatment decision in hospitalised children with SAM.
- Where
- 3 sites in Uganda, Zambia
- Volunteers
- 603 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Frail Elderly
Compliance to Oral Nutritional Supplements (ONS) in Undernourished Frail Older Adults Living at Home.
In this study, patients are supposed to take Fortimel® Protein, an Oral Nutritional Supplement (ONS) recommended in case of malnutrition once daily during the study period.
- Trial name
- OFraDDom (NCT03501290)
- Testing
- Fortimel® Protein supplementation
- Where
- France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Toulouse
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