Clinical trials: Processes, Metabolic
Obesity, Hepatic Insufficiency
Study Examining The Effect Of Hepatic Impairment On Safety, Toleration And How The Body Processes An Experimental Drug
CP-945,598 is eliminated following extensive metabolism. Decrease hepatic function can affect its elimination from the body via metabolism.
- Trial name
- NCT00645021
- Testing
- CP-945,598
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Hyperglycemia, Cardiovascular Diseases
REsearching Coronary REduction by Appropriately Targeting Euglycemia (RECREATE Pilot Study)
Insulin will safely reduce glucose levels in patients with acute ST-elevation myocardial infarction and admission hyperglycemia.
- Conditions
- Hyperglycemia, Cardiovascular Diseases, Myocardial Infarction
- Trial name
- RECREATE Pilot (NCT00640991)
- Testing
- glulisine insulin, glargine insulin
- Where
- 13 sites in Argentina, Canada and 1 more
- Volunteers
- 500 people
- Sponsor
- Population Health Research Institute
Liver Cirrhosis, Hepatic Encephalopathy
Quality of Life and Nutritional Improvements in Cirrhotic Patients
The purpose of this study is to determine whether taking Rifaximin (Xifaxan) in conjunction with the use of nutritional concepts is effective in improving morbidity and quality of life in cirrhotic patients suffering from hepatic…
- Conditions
- Liver Cirrhosis, Hepatic Encephalopathy, Portal Hypertension
- Trial name
- NCT01842113
- Testing
- Rifaximin, Lactulose
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Tampa General Hospital
Obesity
Study of Changes in Skeletal Muscle After Caloric Restriction
Research has shown that fat stored within muscles affects the muscle's sensitivity to insulin and ability to handle blood glucose.
- Trial name
- NCT00993460
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Oxidative Stress, Healthy
A Randomized, Double-Blind Study to Assess the Effect of a Postbiotic on Oxidative Stress and Exercise Performance
This is a prospective, randomized, placebo controlled, double-blind study to assess the effects of a postbiotic blend on exercise induced oxidative stress markers and exercise performance in healthy adult.
- Conditions
- Oxidative Stress, Healthy, Exercise-induced Muscle Damage, Exercise-induced Muscle Soreness
- Trial name
- PBE (NCT06795425)
- Testing
- Postbiotic Active Lifestyle Blend
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Gout, Hyperuricemia
Relative Bioavailability Study to Assess an LC350189 Tablet Compared to an LC350189 Capsule in Healthy Adults
This is an open-label, randomized, crossover, single dose study. Two single doses of LC350189(tablet or capsule formulations) will be administered with a washout period of at least 4-day between the doses to investigate the…
- Trial name
- NCT04886050
- Testing
- LC350189 Tablet, LC350189 Capsule
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- LG Chem
Fabry Disease
Podocyturia - Predictor of Renal Dysfunction in Fabry Nephropathy
In patients with Fabry disease, this research study explores the presence of podocytes in their urine as a potential non-invasive biomarker for baseline kidney disease; and explores changes in the quantity of podocytes in their…
- Trial name
- NCT02994303
- Where
- 3 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of Washington
Hyperuricemia or Gout
Clinical Efficacy Trial of Burdock Root Extract in Patients With Asymptomatic Hyperuricaemia
Multicentre, double-blind, randomized, placebo-controlled trial of the clinical efficacy of burdock root extract in patients with asymptomatic hyperuricemia, with the primary objective to assess the efficacy of the use of burdock…
- Trial name
- NCT07002762
- Testing
- Burdock ( Arctium lappa L.) root extract in a form of a nutritional additive
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- OMNIFARMA LLC
Metabolic Syndrome, Hypertension
Development and Multicenter Validation of an AI-Based Remote Photoplethysmography (rPPG) Facial Scan for Multimodal Health Assessment
The goal of this observational study is to learn if a non-contact facial scan using artificial intelligence (AI) can be used to check health status in adults living in urban areas such as Jakarta.
- Conditions
- Metabolic Syndrome, Hypertension, Diabetes (DM), Tachycardia
- Trial name
- NCT07491978
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tarumanagara University
MASH, MASH - Metabolic Dysfunction-Associated Steatohepatitis
Study of Resmetirom in Children and Adolescents With MASH
This study will evaluate the safety, pharmacokinetics (how the body absorbs, distributes, metabolizes, and eliminates the drug), and pharmacodynamics (how the drug affects the body) of resmetirom in children and adolescents with…
- Trial name
- NCT07763015
- Testing
- Resmetirom
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Madrigal Pharmaceuticals, Inc.
Aging, Inflammation
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence
The MIRACLE study aims to investigate age-related mitochondrial dysfunction, mitochondrial RNA (mtRNA) release, inflammation, and cellular senescence in adult participants across three age groups.
- Conditions
- Aging, Inflammation, Healthy Ageing
- Trial name
- MIRACLE (NCT07596615)
- Testing
- Skin biopsy and venous blood sampling
- Where
- 2 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Congenital Heart Disease, Dysbiosis
The Influence of Probiotics on Metabolome and Heart Rate Variability in Heart Failure of Structure Heart Disease
Poor body weight gain and failure to thrive is a very common condition in patients with congenital heart disease (CHD) with advanced HF and/or cyanosis, which are considered a predictor of morbidity and complicate the prognosis…
- Conditions
- Congenital Heart Disease, Dysbiosis, Malnutrition, Child, Probiotics
- Trial name
- NCT06872320
- Testing
- Lactobacillus Rhamnosus
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Diabetes Mellitus (Type 2), Inflammation
Probiotic Effects in Type 2 Diabetes
Adult-onset diabetes is a disease characterized by high blood glucose levels and is one of the leading causes of cardiovascular disease, blindness, end-stage renal failure, and hospitalization.
- Conditions
- Diabetes Mellitus (Type 2), Inflammation, Probiotics, Antioxidant Effect
- Trial name
- NCT07330388
- Testing
- Probiotic group
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Ege University
Prosthesis Survival, Bone Loss
Four-unit Implant Supported Fixed Partial Dentures Fabricated From Different Materials
Implant supported superstructure is necessary for long term success and durability of the implant itself in terms of stresses distribution and fracture strength capability.
- Trial name
- NCT06422260
- Testing
- Prosthesis superstructure
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Menoufia University
Metabolic Syndrome X, Inflammation
Effect of Dietary Flavonoids on Intestinal Microbiota, Intestinal Inflammation and Metabolic Syndrome
The investigators have hypothesized that dietary flavonoids reduce insulin resistance and subclinical inflammation secondary to reductions in intestinal inflammation and permeability and that these events are mediated through…
- Trial name
- NCT02728570
- Testing
- High Dietary Flavonoids, Low Dietary Flavonoids
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Utah State University
Obesity, Diet Habit
FTO Gene Variants and Diet in Obesity
Studies have shown that the effect of fat mass and obesity-associated (FTO) gene on obesity is modulated by lifestyle factors. Hence, we aimed to determine whether two single nucleotide polymorphisms (SNPs) in the FTO gene are…
- Conditions
- Obesity, Diet Habit, Genetic Predisposition
- Trial name
- NCT04205318
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Cardiac Arrest, Ischemia Reperfusion Injury
Hypertonic Lactate After Cardiac Arrest
The study is intended to test the hypothesis that sodium lactate infusion after resuscitation from a cardiac arrest will decrease the magnitude of brain damage, as measured by the serum biomarker concentration of NSE.
- Conditions
- Cardiac Arrest, Ischemia Reperfusion Injury, Anoxic Brain Injury
- Trial name
- LATTE (NCT05004610)
- Testing
- Sodium Lactate Solution
- Where
- Belgium
- Volunteers
- 125 people
- Sponsor
- Erasme University Hospital
Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
An Evaluation of Home-Based Telemedicine Services
Tele-home health care, which providers for video interactions between home-based veterans and home care nurses, is a potentially useful adjunct to home care services.
- Conditions
- Congestive Heart Failure, Chronic Obstructive Pulmonary Disease, Diabetes
- Trial name
- NCT00105846
- Testing
- Home care telemedicine
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Cardiovascular Disease, Inflammation
Impact of EPA and DHA Supplementation on Plasma Biomarkers of Inflammation (n3)
Subclinical inflammation is now indisputably recognized as a key etiological factor in the development of atherosclerosis and subsequent cardiovascular disease.
- Trial name
- n3 (NCT01810003)
- Testing
- High DHA, High EPA
- Where
- Canada
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Laval University
Polycystic Ovary Syndrome
Metformin Treatment in Polycystic Ovary Syndrome (PCOS)
PCOS occurs when a woman does not release an egg regularly each month, causing her periods to be irregular. Women with PCOS can also have increased hair growth on the face and body, acne, head balding, infertility, pre-diabetes…
- Trial name
- NCT02198417
- Testing
- Metformin ER
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
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