Clinical trials: Proctitis
Rectal Neoplasm Malignant
Metabolomics to Predict Treatment Response and Toxicities in Rectal Cancer
Background: Colorectal cancer is the leading cause of cancer-related deaths in Taiwan, with rectal cancer accounting for approximately 27% of all cases.
- Trial name
- NCT06831669
- Testing
- Collecting biospecimens
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- Chang Gung Memorial Hospital
Radiation Injuries, Telangiectasis
Comparison Between Two Different Parameters of Argon Plasma Coagulation in the Treatment of Chronic Radiation Proctitis: Historical Control Trial.
There is a wide variability of options for treatment of chronic radiation proctitis. However, studies are still limited, usually case reports from a single center and few are comparative studies between methods.
- Conditions
- Radiation Injuries, Telangiectasis, Rectal Bleeding
- Trial name
- NCT02104271
- Testing
- Argon Plasma Coagulation, Historical control
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- Barretos Cancer Hospital
Pelvic Neoplasms
Treatment of Hemorrhagic Radiation Proctitis Using the Halo System
This study involves evaluating a procedure in which the study device, the HALO90 Ablation catheter, is used to heat a thin layer of tissue lining the rectum using radiofrequency (RF) energy in subjects suffering from radiation…
- Trial name
- NCT01103492
- Testing
- HALO90 Ablation catheter
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Proctitis, Proctosigmoiditis
Efficacy and Safety of Budesonide Foam for Participants With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis
The purpose of this study is to establish the efficacy profile of rectally administered budesonide foam, as compared to an equivalent volume of rectally administered placebo foam over the same dosing schedule, in participants who…
- Trial name
- NCT01008423
- Testing
- Budesonide
- Where
- 62 sites in United States
- Volunteers
- 281 people
- Sponsor
- Bausch Health Americas, Inc.
Radiotherapy, Radiation Proctitis
Association Between Clinical Classification and Prognosis in Chronic Radiation Enteropathy
This is a prospective, observational study aimed at exploring the associations between the clinical classification of chronic radiation enteropathy and prognosis.
- Conditions
- Radiotherapy, Radiation Proctitis, Radiation Enteritis
- Trial name
- NCT07378631
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Ulcerative Colitis, Ulcerative Proctitis
A Study of Niclosamide Enemas in Subjects With Active Ulcerative Proctitis or Ulcerative Proctosigmoiditis
This will be a phase I/IIa, open-label, three-stage, single center study aimed at investigating the safety, the efficacy (clinical and endoscopic effects) and the pharmacokinetics of Niclosamide enema 150 mg/60 ml and 450 mg/60…
- Conditions
- Ulcerative Colitis, Ulcerative Proctitis, Ulcerative Proctosigmoiditis
- Trial name
- NCT03521232
- Testing
- Niclosamide
- Where
- Italy
- Volunteers
- 27 people
- Sponsor
- Entero Therapeutics
Ulcerative Colitis
Rectal Tacrolimus in the Treatment of Resistant Ulcerative Proctitis
Ulcerative Colitis (UC) is a life-long incurable disease with remissions and exacerbations. Inflammation confined to the rectum occurs in a quarter of patients and can be extremely hard to treat.
- Trial name
- NCT01418131
- Testing
- Rectal tacrolimus
- Where
- 4 sites in Australia
- Volunteers
- 21 people
- Sponsor
- The University of Western Australia
Radiation Proctitis, Probiotics
The Effects of Probiotics Combined With Glutamine in the Prevention and Treatment of Radiation Proctitis
Radiation proctitis is a common complication after radiation therapy for pelvic tumors. The investigators found that live bifidobacterium and lactobacillus tablets combined with compound glutamine enteric-coated capsules can…
- Conditions
- Radiation Proctitis, Probiotics, Glutamine, Gut Microbiota
- Trial name
- NCT05406882
- Testing
- Live Combined Bifidobacterium and Lactobacillus Tablets、Compound Glutamine Entersoluble capsules
- Where
- 2 sites in China
- Volunteers
- 176 people
- Sponsor
- West China Hospital
Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC)
Family Members at INcreased-risk for Developing Inflammatory Bowel Disease
First-degree relatives of people with inflammatory bowel disease ("IBD," including Crohn's disease and ulcerative colitis) have an increased risk for developing IBD themselves.
- Conditions
- Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC), IBD-unclassified (IBD-U), Indeterminate Colitis
- Trial name
- FIND-IBD (NCT06655415)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Radiation Enteritis, Radiation Proctitis
Study to Prevent Radiation Induced Damage to Bowel Using a Prebiotic Enhanced Diet.
The study will consist of pair of double-blind placebo-controlled trials of dietary supplementation with 15g/day FructoOligoSaccharide (FOS) for 7.5 weeks in patients with prostate carcinoma or 5 weeks in patients with cervical…
- Trial name
- NCT01414517
- Testing
- FructoOligoSaccharide, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 220 people
- Sponsor
- University College London Hospitals
Proctitis
Clinical Trial With Mesalamine 1g Suppositories
An Investigator-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Establish Therapeutic Equivalence of 1000 mg Mesalamine Rectal Suppositories and Canasa® Rectal Suppositories (1000 mg Mesalamine, USP) in the…
- Trial name
- NCT01172444
- Testing
- Mesalamine, Canasa
- Where
- 38 sites in India
- Volunteers
- 158 people
- Sponsor
- Sandoz
Rectal Bleeding
Trial of Argon Plasma Coagulation Versus APC and APC and Hemospray in the Treatment of Radiation Proctitis
Randomized trial of Argon Plasma Coagulation compared with Argon Plasma Coagulation and Hemospray in the therapy of bleeding from Radiation Proctitis
- Trial name
- NCT02233933
- Testing
- Hemospray
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- British Columbia Cancer Agency
Cystitis, Radio Induced, Soft Tissue Radionecrosis (STRN)
Soft Tissue Radiation Injury; Patient Reported Evaluation in a Single Centre Cohort Study (STRIPE)
Radiotherapy cures many cancers but can cause late radiation-induced tissue injury (LRTI), leading to long-term symptoms from the bladder and bowel and reduced health-related quality of life (HRQoL).
- Conditions
- Cystitis, Radio Induced, Soft Tissue Radionecrosis (STRN), Radiation Proctitis
- Trial name
- karolinskaUH (NCT07611864)
- Where
- Sweden
- Volunteers
- 1,000 people
- Sponsor
- Karolinska University Hospital
Acute Radiation Proctitis, Acute Radiation Enteritis
Efficacy of Hyaluronic Acid in Prevention of Acute Radiation Proctitis
A randomized placebo-controlled clinical trial to evaluate efficacy of hyaluronic acid in prevention of acute radiation proctitis among oncology patient population especially who are diagnosed with abdomeno-pelvic tumors and…
- Trial name
- NCT06469216
- Testing
- Hyaluronic Acid
- Where
- 2 sites in Egypt
- Volunteers
- 44 people
- Sponsor
- Assiut University
Inflammatory Bowel Diseases
Pilot Study for the Evaluation of Food Choices in Patients With Inflammatory Bowel Diseases (MICI2021)
This project is a pilot study exploring the effects of dietary choices and quantitative digestion of gluten ingested by individuals with IBD compared to a control population.
- Trial name
- MICI2021 (NCT05079932)
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Safety
A Phase I/II Clinical Study to Evaluate the Safety and Efficacy of Oral Teslanbaicin in Patients With Radiation Proctitis
Radiation Proctitis refers to rectal radiation injury caused by radiotherapy for pelvic malignancies. It is classified into Acute Radiation Proctitis (ARP) and Chronic Radiation Proctitis (CRP) based on onset time and disease…
- Trial name
- NCT06974123
- Testing
- A Phase I/II Clinical Study to Evaluate the Safety and Efficacy of Oral Tesilanbaiju in Patients with Radiation Proctitis, Teslanbai oral therapy
- Where
- China
- Volunteers
- 29 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Radiation Proctitis
Budesonide Foam Versus Placebo for Prevention of Acute Radiation Proctitis
To proof the superiority of an 8-week rectal treatment with once-daily 2 mg budesonide versus placebo for the prevention of acute radiation proctitis, and to evaluate the occurrence of chronic radiation proctitis 1 year after…
- Trial name
- NCT00828230
- Testing
- budesonide
- Where
- 3 sites in Germany
- Volunteers
- 17 people
- Sponsor
- Dr. Falk Pharma GmbH
Inflammatory Bowel Diseases, Proctosigmoiditis
Role of FCI in the Detection of Proctosigmoiditis Caused by IBD
The goal of this pilot study is to explore the ability of field-cycling imaging, a new scanning technology being developed at the University of Aberdeen, to detect active disease in patients with proctosigmoiditis caused by…
- Trial name
- ROOFTOPS-IBD (NCT05817266)
- Testing
- Field-cycling imaging (FCI)
- Where
- United Kingdom
- Sponsor
- NHS Grampian
Chronic Radiation-induced Proctitis
KANGFUPEN Liquid Dressing for Chronic Radiation-Induced Rectal Injury
This clinical trial aims to evaluate the efficacy and safety of Kangfupen (a topical liquid dressing) in treating chronic radiation-induced proctitis (RTOG Grade 2 or higher). The key questions we aim to answer are: 1.
- Trial name
- NCT07065175
- Testing
- Kangfupen (liquid dressing) retention enema administration
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Peking Union Medical College Hospital
Proctitis, Ulcerative, Sexually Transmitted Disease (STD)
The Prevalence of Chlamydia Trachomatis and Neisseria Gonorrhoeae in Patients Suspected of Hemorrhagic Proctosigmoiditis
Background Chlamydia trachomatis and Neisseria gonorrhoeae can cause infectious proctitis, which macroscopically cannot be distinguished from haemorrhagic proctosigmoiditis (HP) caused by inflammatory bowel disease.
- Conditions
- Proctitis, Ulcerative, Sexually Transmitted Disease (STD), Ulcerative Proctosigmoiditis
- Trial name
- SOSProctitis (NCT07061899)
- Testing
- Anal swap for Chlamydia and Gonorrhoea
- Where
- 5 sites in Denmark
- Volunteers
- 214 people
- Sponsor
- University of Aarhus