Clinical trials: Proctitis
Ulcerative Colitis
Rectal Tacrolimus in the Treatment of Resistant Ulcerative Proctitis
Ulcerative Colitis (UC) is a life-long incurable disease with remissions and exacerbations. Inflammation confined to the rectum occurs in a quarter of patients and can be extremely hard to treat.
- Trial name
- NCT01418131
- Testing
- Rectal tacrolimus
- Where
- 4 sites in Australia
- Volunteers
- 21 people
- Sponsor
- The University of Western Australia
Chronic Radiation Proctitis, Rectal Bleeding
Transverse Colostomy for Refractory Hemorrhagic Chronic Radiation Proctitis: a Prospective Cohort Study
Refractory rectal bleeding of chronic radiation proctitis (CRP) is still problematic and does not respond to medical treatments including reagents, endoscopic argon plasma coagulation (APC) or topical formalin.
- Conditions
- Chronic Radiation Proctitis, Rectal Bleeding, Colostomy Stoma, Anemia
- Trial name
- NCT03397901
- Testing
- Transverse colostomy
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Ulcerative Colitis, Proctitis
Assessment of Photopill Capsule Treatment for Safety and Feasibility in Ulcerative Proctitis
Low Level Light therapy (LLLT) has been used for tissue healing in many mucosal diseases that involve wounds, ulcers and inflammation, oral chemotherapy-induced mucositis in particular.
- Trial name
- Photopill (NCT01837615)
- Testing
- Photopill treatment
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Proctitis
Budesonide vs. Mesalazine vs. Budesonide/Mesalazine Suppository Combination Therapy in Acute Ulcerative Proctitis
The purpose of this study is to investigate the efficacy and safety of budesonide suppository for the treatment of acute ulcerative proctitis.
- Trial name
- NCT01966783
- Testing
- Budesonide 2 mg suppository, Budesonide 4 mg suppository, Mesalazine 1 g suppository
- Where
- 2 sites in Germany
- Volunteers
- 320 people
- Sponsor
- Dr. Falk Pharma GmbH
Radiation Proctitis, Probiotics
The Effects of Probiotics Combined With Glutamine in the Prevention and Treatment of Radiation Proctitis
Radiation proctitis is a common complication after radiation therapy for pelvic tumors. The investigators found that live bifidobacterium and lactobacillus tablets combined with compound glutamine enteric-coated capsules can…
- Conditions
- Radiation Proctitis, Probiotics, Glutamine, Gut Microbiota
- Trial name
- NCT05406882
- Testing
- Live Combined Bifidobacterium and Lactobacillus Tablets、Compound Glutamine Entersoluble capsules
- Where
- 2 sites in China
- Volunteers
- 176 people
- Sponsor
- West China Hospital
Pelvic Cancer
Post Radiotherapy MRI Based AI System to Predict Radiation Proctitis for Pelvic Cancers
In this study, investigators utilize a Artificial Intelligence (AI) supportive system to predict radiation proctitis for patients with pelvic cancers underwent radiotherapy.
- Trial name
- MRI-RP-2021 (NCT04918992)
- Testing
- Artificial Intelligence
- Where
- 4 sites in China
- Volunteers
- 400 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Chronic Radiation-induced Proctitis
KANGFUPEN Liquid Dressing for Chronic Radiation-Induced Rectal Injury
This clinical trial aims to evaluate the efficacy and safety of Kangfupen (a topical liquid dressing) in treating chronic radiation-induced proctitis (RTOG Grade 2 or higher). The key questions we aim to answer are: 1.
- Trial name
- NCT07065175
- Testing
- Kangfupen (liquid dressing) retention enema administration
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Peking Union Medical College Hospital
Chronic Radiation Proctitis
Combined Therapy in Radiation Proctopathy
The aim of this study was to compare the efficacy and safety of two treatment regimens: argon plasma coagulation (APC) alone and APC in combination with sucralfate administered for chronic hemorrhagic radiation proctopathy.
- Trial name
- NCT01613534
- Testing
- Sucralfate
- Where
- Poland
- Volunteers
- 122 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Radiation Induced Proctitis
Fecal Microbiota Transplantation for Radiation-Induced Proctopathy
The goal of this single-arm trial is to learn if Fecal Microbiota Transplantation (FMT) works to treat hemorrhagic radiation-induced proctopathy.
- Trial name
- NCT06776029
- Testing
- Fecal Microbiota Transplantation Capsule
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Ulcerative Proctitis
Phase 3 Study to Evaluate the Safety and Efficacy of Hydrocortisone Acetate Suppositories
A randomized, multi-center, double-blind, three arm placebo-controlled study in male and non-pregnant, non-lactating female subjects aged 18 years to examine the safety and efficacy of two dosing regimens of hydrocortisone…
- Trial name
- NCT04469686
- Testing
- Twice daily 90 mg hydrocortisone acetate suppository administered with Sephure applicator
- Where
- 189 sites in United States, Bulgaria and 21 more
- Volunteers
- 200 people
- Sponsor
- Cristcot HCA LLC
Fecal Incontinence, Inflammatory Bowel Disease (IBD)
Faecal Incontinence iNtervention Study
Inflammatory Bowel Disease (IBD) affects 250,000 adults in the United Kingdom (UK) and causes bouts of diarrhoea which are hard to control. Over a quarter of patients experience extremely distressing faecal incontinence (FI).
- Trial name
- FINS (NCT02355834)
- Testing
- IBD nurse intervention
- Where
- 6 sites in United Kingdom
- Volunteers
- 67 people
- Sponsor
- London North West Healthcare NHS Trust
Prostate Cancer, Radiotherapy Side Effect
PROstate CAncer Radiotherapy - Bowel Quality of Life (PROCAR-BQ)
This is a prospective pilot study to evaluate the mean increase of bowel symptoms after pelvic radiotherapy (RT) in prostate cancer (PCa) patient using the validated \& newly translated EORTC-QLQ PRT20 module.
- Conditions
- Prostate Cancer, Radiotherapy Side Effect, Bowel Dysfunction, Quality of Life
- Trial name
- PROCAR-BQ (NCT05880446)
- Testing
- Bowel symptoms & QoL assessment
- Where
- Belgium
- Volunteers
- 41 people
- Sponsor
- Jules Bordet Institute
Radiation - Induced Proctitis
A Randomized Controlled Trial of Five - Flavor Sophora Flavescens Enteric - Coated Capsules for Radiation - Induced Proctitis After Pelvic Radiotherapy
The goal of this single - center, prospective, randomized controlled study is to assess the therapeutic effects of five - flavor sophora flavescens enteric - coated capsules on radiation - induced proctitis in patients who have…
- Trial name
- NCT07053761
- Testing
- five - flavor sophora flavescens enteric - coated capsules plus glutamine and warm - water sitz baths, glutamine and warm - water sitz baths
- Volunteers
- 124 people
- Sponsor
- Peking University First Hospital
Cystitis, Radio Induced, Soft Tissue Radionecrosis (STRN)
Soft Tissue Radiation Injury; Patient Reported Evaluation in a Single Centre Cohort Study (STRIPE)
Radiotherapy cures many cancers but can cause late radiation-induced tissue injury (LRTI), leading to long-term symptoms from the bladder and bowel and reduced health-related quality of life (HRQoL).
- Conditions
- Cystitis, Radio Induced, Soft Tissue Radionecrosis (STRN), Radiation Proctitis
- Trial name
- karolinskaUH (NCT07611864)
- Where
- Sweden
- Volunteers
- 1,000 people
- Sponsor
- Karolinska University Hospital
Rectal Bleeding
Trial of Argon Plasma Coagulation Versus APC and APC and Hemospray in the Treatment of Radiation Proctitis
Randomized trial of Argon Plasma Coagulation compared with Argon Plasma Coagulation and Hemospray in the therapy of bleeding from Radiation Proctitis
- Trial name
- NCT02233933
- Testing
- Hemospray
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- British Columbia Cancer Agency
Inflammatory Bowel Diseases
Serologic Markers for Inflammatory Bowel Disease During Clinical Forms With Weak or Strong Evolution Capacities
Factors forecast Chronic Inflammatory Bowel Diseases (IBD) remain at present essentially on clinical factors (extension of the disease, achievement of the perianal ring, requirement of surgery, treatment by immunomodulators…).
- Trial name
- NCT01216514
- Where
- France
- Volunteers
- 194 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne