Clinical trials: Prodromal Schizophrenia
Schizophrenia, Psychosis
Aripiprazole Treatment of Prodromal Patients
We hypothesize that symptoms will improve in patients who meet diagnostic criteria for the schizophrenia prodrome when they are prescribed aripiprazole.
- Trial name
- NCT00237874
- Testing
- Aripiprazole
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Yale University
Schizophrenia, Bipolar Disorder
Early Detection and Intervention for the Prevention of Psychosis
EDIPP is a multisite trial of early identification and intervention to prevent the onset of psychosis in adolescents and young adults, carried out at six sites across the United States.
- Conditions
- Schizophrenia, Bipolar Disorder, Depression, Psychotic Disorders
- Trial name
- EDIPP (NCT00531518)
- Testing
- aripiprazole; fluoxetine; bupropion; sertraline; lamotrigine, Psychoeducational multifamily group treatment, Supported employment and education
- Where
- 6 sites in United States
- Volunteers
- 292 people
- Sponsor
- MaineHealth
Prodromal Schizophrenia
Effects of Cognitive Remediation on Cognition in Young People at Clinical High Risk of Psychosis
Onset of psychotic disorders such as schizophrenia, typically occurs during late adolescence or early adulthood often resulting in chronic social and occupational disability.
- Trial name
- NCT01619319
- Testing
- Cognitive Remediation Therapy, computer games
- Volunteers
- 32 people
- Sponsor
- University of Calgary
Schizophrenia Prodromal, Schizophrenia, Childhood
Patientheque in Patients With a Psychosis
Establishment of a patient library for patients who have had a first psychotic episode and who have an "at risk" status for psychotic disorder (GRD, APS, BLIPS group) or a psychosis threshold during CAARMS administration.
- Conditions
- Schizophrenia Prodromal, Schizophrenia, Childhood, Schizophrenia
- Trial name
- LONGIPEP (NCT05340348)
- Testing
- Blood samples (36 mL) + fecal samples + hair sample
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Brest
Prodromal Schizophrenia
Early Intervention of Prodromal Schizophrenia Using an NMDA Enhancer
Previous studies found that some NMDA-enhancing agents were able to improve clinical symptoms of patients with schizophrenia. Whether treatment of an NMDA-enhancing agent can benefit the treatment of prodromal schizophrenia…
- Trial name
- NCT05052853
- Testing
- NMDAE
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- China Medical University Hospital
Schizophrenia; Psychosis, First Episode Psychosis
Repetitive Transcranial Magnetic Stimulation in Early Psychosis and The Functional Connectivity Biotypes
The present study plans to explore different cortical targets of repetitive transcranial magnetic stimulation (rTMS) for populations at the early phase of psychosis, including those at clinical high risk of psychosis and in the…
- Conditions
- Schizophrenia; Psychosis, First Episode Psychosis, Clinical High Risk
- Trial name
- NCT04853485
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- 6 sites in China
- Volunteers
- 300 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Prodromal Schizophrenia
Evaluation of Step-Based Care for Individuals at Clinical High Risk for Psychosis
The Ohio State University Early Psychosis Intervention Center is implementing a specialized clinical program to serve individuals who meet clinical high risk criteria for a psychosis.
- Trial name
- NCT03970005
- Testing
- Step-Based Care Model
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University
Schizophrenia, Cannabis Dependence
Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
The aim of the present study is to assess the availability of cannabinoid receptors (CB1R) in the human brain. CB1R are present in everyone's brain, regardless of whether or not someone has used cannabis.
- Conditions
- Schizophrenia, Cannabis Dependence, Prodromal for Psychotic Illness, Family History of Alcoholism
- Trial name
- NCT01730781
- Testing
- [11-C]OMAR
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yale University
Prodromal Schizophrenia, Psychotic Disorders
Psychosis: Early Detection, Intervention and Prevention
The primary aim of this application is to conduct a randomized, controlled clinical trial of a specialized mental health service delivery system specifically developed for prodromal psychotic disorders.
- Conditions
- Prodromal Schizophrenia, Psychotic Disorders, Severe Bipolar Disorder With Psychotic Features, Severe Major Depression With Psychotic Features
- Trial name
- EDIP (NCT01597141)
- Testing
- Family-aided Assertive Community Treatment, Enhanced standard treatment
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- MaineHealth
ARMS, APS
Cognitive Behavioral Therapy for the Prevention of Paranoia in Adolescents at High Risk
The main objective of this study is to decrease the severity of symptoms and improve psycho-social functioning in youth at high risk of developing psychosis by providing a specialized Group-and-Family-based Cognitive Behavioral…
- Conditions
- ARMS, APS, Prodromal Symptoms
- Trial name
- NCT01923701
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Psychotic Disorders, Prodromal Symptoms
Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy Trial
The present study is a confirmatory efficacy trial of Family Focused Therapy for youth at clinical high risk for psychosis (FFT-CHR).
- Conditions
- Psychotic Disorders, Prodromal Symptoms, Prodromal Schizophrenia, Psychosis
- Trial name
- NCT04338152
- Testing
- Family Focused Therapy for Clinical High Risk Youth (FFT-CHR), Enhanced Care (EC)
- Where
- 7 sites in United States, Canada
- Volunteers
- 220 people
- Sponsor
- University of California, Los Angeles
Prodromal Symptoms, Prodromal Stage
HOPE TEAM - Clinical High Risk Group CBSST
Community-based treatments for adolescents at risk for psychosis are not widely available, nor are there established, gold-standard psychosocial group interventions for this population.
- Conditions
- Prodromal Symptoms, Prodromal Stage, Prodromal States, Psychosis
- Trial name
- NCT03738046
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Sponsor
- University of Pittsburgh
Psychosis Prodrome
Ziprasidone in the Psychosis Prodrome
This study aims to determine whether ziprasidone is superior to placebo over 24 weeks for patients with the psychosis prodrome.
- Trial name
- ZIP (NCT00635700)
- Testing
- ziprasidone
- Where
- 11 sites in United States, Canada
- Volunteers
- 51 people
- Sponsor
- Yale University
Early Psychosis, Schizophrenia Prodromal
Perception and Integration of Sensory Information in the Early Stages of Psychosis
The goal of this observational study is to investigate the early sensory system in clinical high risk (CHR), first episode psychosis (FEP) individuals and heathly controls.
- Trial name
- PRIOR-ePSY (NCT07446569)
- Testing
- behavioral tasks, Electroretinography, Comprehensive Assessment of At Risk Mental States (CAARMS)
- Where
- 4 sites in France
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- Centre Psychothérapique de Nancy
Clinical High Risk for Psychosis (CHR), Psychotic Disorders
Accelerated Neuromodulation Therapy and Neurocomputational Biomarkers in Individuals at Clinical High Risk for Psychosis
The goal of this study is to learn whether an accelerated form of neuromodulation therapy is safe, feasible, and well tolerated in young people at clinical high risk for psychosis (CHR-P), and whether it is associated with…
- Conditions
- Clinical High Risk for Psychosis (CHR), Psychotic Disorders, Prodromal Symptoms
- Trial name
- TMS-CHR (NCT07786714)
- Testing
- Active Intermittent Theta Burst Stimulation (BEAM-F3 Targeting)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Douglas Mental Health University Institute
Prodromal Schizophrenia
Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk
This study will investigate whether a single dose of diazepam (5mg) compared to placebo can modulate brain chemistry (GABA/glutamate levels) and function (blood flow, neural response and connectivity during tasks and at-rest) in…
- Trial name
- BENZOGAP (NCT06190483)
- Testing
- Diazepam 5 Mg Oral Tablet, Ascorbic Acid 50 Mg Oral Tablet
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- King's College London
Prodromal Schizophrenia, Psychotic Disorders
Antidepressant and Antipsychotic to Treat Attenuated Positive and Negative Symptoms
The Recognition and Prevention (RAP) Program is conducting a research study comparing an antidepressant, sertraline, alone versus in combination with a second-generation antipsychotic, risperidone, to evaluate their ability to…
- Trial name
- NCT00169988
- Testing
- risperidone, sertraline-primary
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Northwell Health
Psychotic Disorders, Psychiatric Hospitalization
Youth Experiences and Health Study
This study aims to identify unusual experiences and psychiatric symptoms that indicate a heightened risk for severe mental disorders - especially psychoses.
- Conditions
- Psychotic Disorders, Psychiatric Hospitalization, Prodromal Symptoms, Cannabis Use
- Trial name
- YEAH (NCT03332966)
- Testing
- Psychiatric questionnaires, Semi-structured psychiatric interview
- Where
- 3 sites in Finland
- Volunteers
- 1,000 people
- Sponsor
- Finnish Institute for Health and Welfare
Schizophrenia, Psychosis
Psychological Intervention for Persons in the Early Initial Prodromal State
The purpose of this randomized controlled trial is to develop a cognitive behavioral therapy (CBT) for persons with at risk mental states in the early initial prodromal state and to evaluate CBT in comparison to supportive…
- Trial name
- NCT00204087
- Testing
- Cognitive behavioral therapy (CBT), Supportive Counselling (SC)
- Where
- Germany
- Volunteers
- 126 people
- Sponsor
- University of Cologne
Psychosis, Prodromal Schizophrenia
Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk
This 10 week intervention, Specific Cognitive Remediation with Surround (or SCORES), is designed to target processing speed, a cognitive domain related directly to social functioning, which in turn, represents a vulnerability…
- Conditions
- Psychosis, Prodromal Schizophrenia, Prodromal Symptoms
- Trial name
- SCORES (NCT05131035)
- Testing
- SCORES (Specific COgnitive Remediation with Support)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Northwell Health