Clinical trials: Prognostic Factors
Infection, Mediastinitis
Prognostic Factors for Descending Necrotizing Mediastinitis Development in Deep Space Neck Infections
Descending necrotizing mediastinitis (DNM) is the most serious complication of deep neck infections (DNI) with high mortality. The objective of this retrospective study was to evaluate possible prognostic factors for DNM…
- Conditions
- Infection, Mediastinitis, Neck Abscess, Inflammation
- Trial name
- NCT04865003
- Testing
- treatment of infection
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- Clinical Center of Vojvodina
Sacrococcygeal Teratoma
Improving Prenatal Parental Counseling in Cases of Sacrococcygeal Teratoma
Sacrococcygeal teratoma (SCT) is the most common fetal and neonatal tumor. However, predicting factors of evolution, sequelae and relapse are still unreliable because of small-cohort studies.
- Trial name
- PROSTEO (NCT04623658)
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metastatic Renal Cell Carcinoma, Good or Only One Adverse Prognostic Factor Intermediate Risk Per IMDC Score
Treatment Pause Versus Treatment Continuation in IMDC Good or Intermediate Risk With Only One Adverse Prognostic Factor in mRCC Patients With an Objective Response at 12 Months of Treatment With PD1/ PDL1 ICIs + VEGFR-Tyrosine Kinase Inhibitors
The purpose of this study is to demonstrate the non-inferiority of treatment pause versus treatment continuation in good or intermediate risk with only one adverse prognostic factor as per IMDC mRCC patients with a confirmed…
- Trial name
- SPICI (NCT05219318)
- Testing
- Combination PD-1/PD-L1 ICI + VEGFR-TKI, Treatment pause
- Where
- 26 sites in France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Bordeaux
Breast Cancer
Prognostic and Predictive Factors for Small Breast Tumors
Because of mammography screening increasingly more women are diagnosed with centimeter or subcentimeter node-negative breast cancer (i.e., T1abN0); these tumors account for approximately 19% of all newly diagnosed breast cancers…
- Trial name
- NCT03390608
- Testing
- Endocrine therapy, Radiotherapy, Herceptin
- Where
- Sweden
- Volunteers
- 35,002 people
- Sponsor
- Karolinska Institutet
Prostate Cancer
MR Radiomic Features in Prostate Cancer
A combination of correct interpretation of imaging and biopsy has given promising results in terms of detecting clinically significant cancer at radical prostatectomy.
- Trial name
- NCT04219059
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Acute Mastoiditis
Outcomes and Prognostic Factors of Acute Mastoiditis in the Grand-Est Region
There is an increased incidence of acute mastoïditis and a lack of homogeneity in management. The investigator aim to refine the epidemiological knowledge on this pathology.
- Trial name
- MAGE (NCT07122440)
- Testing
- acute mastoiditis
- Where
- France
- Volunteers
- 326 people
- Sponsor
- Cécile RUMEAU
Stroke, Transient Ischemic Attack
The "COSMOS"-Study (Copeptin in Osmoregulation and Stress Assessment)
Sodium imbalance is common and an adverse prognostic factor in hospitalized patients. However, identifying the causes of sodium imbalance is challenging in clinical practice.
- Trial name
- NCT00390962
- Where
- Switzerland
- Volunteers
- 469 people
- Sponsor
- University Hospital, Basel, Switzerland
Cutaneous Melanoma, Anatomical Pathological Condition
Location of Lower Limb Cutaneous Melanomas as a Prognostic Factor.
Observational study to know the relevance of specific anatomical location of cutaneous melanoma on lower limbs.
- Trial name
- NCT04625491
- Testing
- Observational
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Hospital Universitario Virgen de la Arrixaca
Drug Resistance, Multiple, Bacterial
Prognostic Factors and Therapeutic Management of ESBL Enterobacteriaceae in the ICU
Multicenter retrospective study conducted in the intensive care units of Tourcoing, Roubaix, and Lille hospitals. Patients hospitalized in the ICU with EBLSE bacteremia within 24 hours before or during their stay in the ICU will…
- Trial name
- BLSE-REA (NCT05833282)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Tourcoing Hospital
Lupus Erythematosus, Systemic
Prognostic Factors for Fatigue in Patients With Systemic Lupus Erythematosus
Introduction: Fatigue is a well-established symptom in systemic lupus erythematosus. Depression and anxiety can develop at different stages of systemic lupus erythematosus and their severity can range from mild symptoms to more…
- Trial name
- NCT07123220
- Where
- Spain
- Volunteers
- 884 people
- Sponsor
- Investigación en Hemofilia y Fisioterapia
Healthy Volunteers, Children With HSP
Polymorphism of the IgH Locus Regulatory Region as a Prognostic Factor During Immune Pathologies.
The investigators previously showed that both antibody class switching (from IgM to IgG, IgA or IgE) and antibody secretion are controlled by a polymorphic "3' regulatory region" (3'RR) of the immunoglobulin heavy chain (IgH)…
- Conditions
- Healthy Volunteers, Children With HSP, Subject With Allergy, Lymphoma
- Trial name
- PRIERR (NCT01715623)
- Testing
- a blood sample
- Where
- 4 sites in France
- Volunteers
- 486 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Lymphoma
Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Aggressive Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining peripheral stem cell transplantation with more than one drug regimen may kill more tumor cells.
- Trial name
- NCT00003215
- Testing
- filgrastim, CHOP regimen, cyclophosphamide
- Where
- 12 sites in Austria, Germany and 3 more
- Volunteers
- 400 people
- Sponsor
- Swiss Cancer Institute
Nutritional Deficiency, Neuro-Degenerative Disease
Nutritional Prognostic Factors in ALS
Background. Several nutritional factors have been evaluated as prognostic factors for survival in ALS patients at earlier stages of the disease [body mass index (BMI), body composition expressed as fat free mass (FFM), fat mass…
- Conditions
- Nutritional Deficiency, Neuro-Degenerative Disease, Gastrostomy
- Trial name
- PEG-ALS (NCT03487536)
- Testing
- Nutritional assessment
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- University of Bari
Escherichia Coli Bloodstream Infection
Prognostic Factors of Escherichia Coli Bloodstream Infections: Severity Score and Therapeutic Implications
The determinants associated with severe outcome and death from Escherichia coli bloodstream infections (BSI) remain poorly understood. The epidemiology of E.
- Trial name
- SEPTICOLI (NCT02890901)
- Where
- France
- Volunteers
- 553 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lumbar Spinal Stenosis
Comparative Effectiveness and Prognostic Factors of Surgical and Non-surgical Management of Lumbar Spinal Stenosis
Introduction: Lumbar spinal stenosis is a common cause of low back and leg pain in elderly impacting physical activity and quality of life. Initial treatments are non-surgical options. If unsuccessful, surgery is advocated.
- Trial name
- NCT03548441
- Testing
- Surgery, Non-surgical management
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Spine Centre of Southern Denmark
Pneumonia
Procalcitonin at Zero and 24 Hours as a Prognostic Factor in Patients With Pneumonia
Procalcitonin levels checked initially and at 24 hours will correlate with disease severity, morbidity, and mortality. Patients who have a higher procalcitonin level initially and at 24 hours will likely have higher qSOFA scores…
- Trial name
- NCT03711227
- Testing
- Procalcitonin lab test
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- Corewell Health South
Brain Ischemia
Informative of Surface Electromyography and Prognostic Factors in Assessing the Recovery of Balance and Gait After Stroke
The aim of the biomedical research is to determine the informativeness and prognostic factors of surface electromyography by assessing the probability of recovery of balance and gait parameters in the second stage of…
- Trial name
- NCT04981184
- Testing
- Gait and balance measurement
- Where
- Lithuania
- Volunteers
- 100 people
- Sponsor
- Lithuanian University of Health Sciences
Acute Myeloid Leukemia
Prognostic Factors and the Impact of Various Management of Acute Myeloid Leukemia in Real Life Condition
The treatment of older patients with acute myeloid leukemia that is secondary to previous myelodysplastic syndrome, myeloproliferative neoplasm, or prior cytotoxic exposure remains unsatisfactory.
- Trial name
- LAM-BDD (NCT03284593)
- Testing
- intensive chemotherapy, Azacitidine
- Where
- 2 sites in France
- Volunteers
- 199 people
- Sponsor
- University Hospital, Toulouse
Muscular Dystrophies, Intensive Care (ICU) Myopathy
Prognostic Factors , Morbidity and Mortality in Patients With Neuromuscular Disorders Admitted in ICU
Muscular dystrophies are neuromuscular disorders with disability. Restrictive pulmonary failure and cardiomyopathy affect prognosis.The investigators aim to establish predictive factors for mortality and morbidity in Intensive…
- Trial name
- NCT02685215
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Pulmonary Arterial Hypertension
Study Performed at Various Medical Centers to Learn More About Survival and Expected Course of Pulmonary Arterial Hypertension, a Type of High Blood Pressure in the Lungs Related to the Narrowing of the Small Blood Vessels in the Lungs
In this study researchers want to learn more about Pulmonary Arterial Hypertension, a type of high blood pressure in the lungs related to the narrowing of the small blood vessels in the lungs (group 1 according to WHO…
- Trial name
- START (NCT03863990)
- Testing
- PAH medication
- Where
- Argentina
- Volunteers
- 104 people
- Sponsor
- Bayer