Clinical trials: Prolapse; Female
Pelvic Organ Prolapse
Clinical Trial of Solifenacin Versus Placebo Plus Pessary for Women With Vaginal Prolapse
This study will evaluate the effect of pessary therapy, with and without Solifenacin (Vesicare), on symptoms of over active bladder and bladder function in women with overactive bladder symptoms and pelvic organ prolapse.
- Trial name
- PESSARY (NCT01092624)
- Testing
- Solifenacin, Ring pessary with support, Cooper Surgical, Trumbell, CT Ref # MXPRS03 non-latex
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Hartford Hospital
Vaginal Prolapse
Posterior IVS Versus Sacrospinous Suspension in Vaginal Vault Prolapse Repair
Hypothesis / aims of study The aim of this multicentre study is to evaluate anatomical and functional results of an innovative posterior tape in vaginal prolapse repair by vaginal route, in comparison to the sacrospinous…
- Trial name
- NCT00153231
- Testing
- IVS, Sacrospinofixation
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Urinary Incontinence, Pelvic Organ Prolapse
Evaluate Women After Vaginal Surgery for Urinary Symptoms and Sexual Function
Assess the outcomes of vaginal surgeries and its impact on sexual function and urinary symptoms.
- Conditions
- Urinary Incontinence, Pelvic Organ Prolapse, Surgery
- Trial name
- NCT00376441
- Testing
- Vaginal Surgery
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Stress Urinary Incontinence, Vaginal Hysterectomy
Vaginal Prolapse Surgery Accompanied by Mid Urethral Sling Versus no Sling for Reduction of Postoperative Incontinence
Prevalence of pelvic organ prolapsed is high in Nepal. After prolapse surgery many patients are affected with incontinence. Incontinence has physical, social and mental effect to the individual.
- Conditions
- Stress Urinary Incontinence, Vaginal Hysterectomy, Quality of Life
- Trial name
- NCT04251923
- Testing
- Retro pubic sling
- Volunteers
- 56 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Postoperative Urinary Tract Infection, Pelvic Organ Prolapse
Gentamicin Intravesical Efficacy for Infection of Urinary Tract
Urinary tract infection (UTI) is a common problem after surgery for pelvic organ prolapse and stress urinary incontinence. This prospective, randomized, single-masked (subject), two-parallel armed study aims to determine the…
- Conditions
- Postoperative Urinary Tract Infection, Pelvic Organ Prolapse, Stress Urinary Incontinence
- Trial name
- GIVEIT (NCT04246996)
- Testing
- gentamicin sulfate, Catheter clamping only
- Where
- 2 sites in United States
- Volunteers
- 370 people
- Sponsor
- Kaiser Permanente
Vaginal Vault Prolapse, Enterocele
Sacrocolpopexy Versus Vaginal Mesh Procedure for Pelvic Prolapse
Pelvic prolapse is one of the most frequent pathology in Gynecology. Recurrency of the prolapse after primary surgery is relatively high, 15-30%.
- Conditions
- Vaginal Vault Prolapse, Enterocele, Uterine Prolapse, Cystocele
- Trial name
- NCT01097200
- Testing
- Elevate mesh, Sacrocolpopexy
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Francisco Carmona
Constipation, Surgical Procedure, Unspecified
Pre-operative Polyethylene Glycol 3350 for Minimally Invasive Urogynecologic Surgery
The goal of this clinical trial is to test the use of a laxative before surgery in women having surgery to fix pelvic prolapse that do not have constipation.
- Conditions
- Constipation, Surgical Procedure, Unspecified, Prolapse; Female
- Trial name
- NCT06159777
- Testing
- Polyethylene Glycol 3350
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University Hospitals Cleveland Medical Center
Patients With Pelvic Organs Prolapse
Rating Pelvic Organs Prolapse in Women According to the POPQ Method Before and After Emptying the Urinary Bladder
Pelvic organ prolapse is a common disorder that affects 3-9% of adult women. Treatment of this disorder varies and includes conservative and interventional treatment.
- Trial name
- NCT01518296
- Testing
- Medtronic-Dantec Urodynamic System
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Carmel Medical Center
Nerve Block, Pain, Postoperative
Pudendal Nerve Block in Vaginal Surgery
The objective of this this randomized controlled study is to determine whether a pudendal nerve block at the time of vaginal surgery is associated with improved postoperative pain control and decrease opioid consumption compared…
- Conditions
- Nerve Block, Pain, Postoperative, Pelvic Floor Disorders, Pelvic Organ Prolapse
- Trial name
- NCT04198714
- Testing
- Pudendal block
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Urinary Retention, Lower Urinary Tract Symptoms
Tamsulosin vs Placebo to Prevent Postoperative Urinary Retention in Female Pelvic Reconstructive Surgery
This is a placebo controlled randomized controlled trial of perioperative use of tamsulosin to prevent postoperative urinary retention in female pelvic reconstructive surgery.
- Conditions
- Urinary Retention, Lower Urinary Tract Symptoms, Stress Urinary Incontinence, Pelvic Organ Prolapse
- Trial name
- NCT03524339
- Testing
- Tamsulosin
- Where
- 2 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Pelvic Organ Prolapse
Preoperative Oestrogen in Postmenopausal Women With Pelvic Organ Prolapse
Introduction With increasing age the incidence of pelvic organ prolapse (POP) rises and will increase substantially in the future according to forecasting studies.
- Trial name
- NCT03779633
- Testing
- Linoladiol Estradiol
- Where
- 2 sites in Austria
- Volunteers
- 120 people
- Sponsor
- Medical University of Vienna
Vaginal Prolapse
Surgical Outcomes of Vaginal Prolapse Repair With Elevate
The purpose of this study is to evaluate outcomes in patients having vaginal prolapse repair with the Elevate prolapse repair kit and compare these outcomes to patients who had a repair with Prolift. .
- Trial name
- NCT01190618
- Where
- United States
- Volunteers
- 417 people
- Sponsor
- Larry Sirls
Pelvic Organ Prolapse
Physical Therapy on Pelvic Organ Prolapse
OBJECTIVE: To evaluate the effectiveness of an individualized pelvic floor physiotherapy programme combined with lifestyle education compared with lifestyle education alone in women with stage I or II pelvic organ prolapse (POP).
- Trial name
- PT-POP (NCT03244397)
- Testing
- Physical therapy + educational strategy, Educational strategy
- Where
- 2 sites in Spain
- Volunteers
- 120 people
- Sponsor
- University of Alcala
Pelvic Organ Prolapse
Comparisons of Clinical Outcomes Between Novel Tailored Transvaginal Mesh Surgery and Vaginal Native Tissue Repair Surgery for Pelvic Organ Prolapse
The issue of whether utilizing the mesh in the surgical treatment of pelvic organ prolapse remained undetermined.Thus, the aim of this study is to analyze clinical outcome of women who underwent pelvic organ prolapse surgeries…
- Trial name
- NCT02465710
- Testing
- Pelvic organ prolapse surgery without mesh, Pelvic organ prolapse surgery with mesh
- Where
- Taiwan
- Volunteers
- 350 people
- Sponsor
- National Taiwan University Hospital
Pelvic Organ Prolapse, Surgery
Comparison of Two Apical Repair Methods in Women Undergoing Repairs for Prolapse
To date no study has determined prospectively which technique is superior to prevent recurrent Pelvic Organ Prolapse (POP) after vaginal hysterectomy- a major unmet clinical need.
- Conditions
- Pelvic Organ Prolapse, Surgery, Quality of Life, Complication
- Trial name
- NCT03113513
- Testing
- fixation of the vaginal apex
- Where
- Austria
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Sexual Function Disturbances, Pelvic Organ Prolapse
Pelvic Floor Disorders Among Sexual Minoritized Women
The investigators aim to perform cognitive interviews to assess how pelvic floor disorders impact sexual functioning in women who have sex with women (WSW).
- Conditions
- Sexual Function Disturbances, Pelvic Organ Prolapse, Urinary Incontinence, Fecal Incontinence
- Trial name
- PRIDE (NCT05072158)
- Testing
- None, this is an observational study
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of New Mexico
Pelvic Floor Disorders, Vaginal Atrophy
Effect of Laser Therapy on Vaginal Tissue
Pelvic floor disorders, including prolapse, incontinence, and vulvovaginal atrophy decrease the quality of life of every fourth woman.
- Trial name
- NCT05898191
- Testing
- vaginal laser treatment
- Where
- Czechia
- Volunteers
- 15 people
- Sponsor
- Institute for the Care of Mother and Child, Prague, Czech Republic
SMAD2, SMAD3
SMAD2, SMAD3 AND TGF-β GENE EXPRESSION IN URGE URINARY INCONTINENCE
Urge urinary incontinence (UUI) is a common health problem. Changes in collagen metabolism in pelvic support organs, such as uterosacral ligaments (USLs), might be responsible for the complex pathophysiology of UUI.
- Conditions
- SMAD2, SMAD3, TGF-β, Pelvic Organ Prolapse
- Trial name
- NCT04525105
- Testing
- SMAD2
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Muğla Sıtkı Koçman University
Pelvic Organ Prolapse
Hysterectomy Versus Uterine Preservation for Pelvic Organ Prolapse Surgery
Pelvic organ prolapse (POP) is the descent of pelvic organs into the vagina resulting in bulge symptoms and occurs in approximately 50% of women. Almost 20% of women will elect surgical correction of this condition by age 85.
- Trial name
- HUPPS (NCT04890951)
- Testing
- Hysteropexy, Hysterectomy and vaginal vault suspension
- Where
- Canada
- Volunteers
- 321 people
- Sponsor
- University of Calgary
Quality of Life, Urinary Incontinence
The Pelvic Floor Function and Sexual Life of the Women After Different Type of Hysterectomy
In this prospective, comparative non-randomized multiple teaching hospitals study, the investigators try to determine the relationship of total hysterectomy and Taiwanese female pelvic floor and sexual function from the view of…
- Conditions
- Quality of Life, Urinary Incontinence, Pelvic Organ Prolapse
- Trial name
- HYS-PF-QOL (NCT02841059)
- Testing
- LSH, CLSH, LAVH
- Where
- 4 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- Buddhist Tzu Chi General Hospital