Clinical trials: Prolapse Pelvic, open to volunteers
Pelvic Organ Prolapse
Comparison of V-NOTES and Laparoscopic Mesh-Free Sacrocolpopexy Techniques
This study aims to compare the surgical outcomes, safety profiles, and patient satisfaction between two minimally invasive techniques for pelvic organ prolapse repair: Vaginal Natural Orifice Transluminal Endoscopic Surgery…
- Trial name
- vnotes (NCT07082023)
- Testing
- V-NOTES Mesh-Free Sacrocolpopexy, Laparoscopic Mesh-Free Sacrocolpopexy
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Havva Betül Bacak
Pelvic Floor Dysfunction, Perineal Laceration
Perineal Protection Device for Reducing Perineal Trauma During Vaginal Delivery in First-time Mothers: a Multicenter Randomized Controlled Trial
The goal of this clinical trial is to determine whether using a soft perineal protection device (BabySlide®) in addition to standard manual perineal support during vaginal delivery can reduce the risk of perineal trauma in…
- Conditions
- Pelvic Floor Dysfunction, Perineal Laceration, Wound Dehiscence, Anal Incontinence
- Trial name
- PeriPROTECT (NCT07862660)
- Testing
- Perineal protection device, BabySlide, Standard manual perineal support
- Where
- Sweden
- Volunteers
- 4,226 people
- Sponsor
- Region Skane
Uterine Prolapse
Combined Effects of Pelvic Floor Retraining and Hypopressive Exercises in Uterine Prolapse Outcomes
One common pelvic floor condition, particularly in postpartum or later life, is uterine prolapse. It is caused by weak pelvic floor muscles and connective tissues and often presents with pain, urinary incontinence, and reduced…
- Trial name
- NCT07642180
- Testing
- Functional Movement Retraining + Hypopressive Exercises, Pelvic Floor Functional Movement Retraining
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI)
Development and Validation of a Risk Prediction Model for De Novo Stress Urinary Incontinence After Pelvic Floor Reconstruction Surgery
This observational study aims to develop a predictive model for the occurrence of new-onset stress urinary incontinence (SUI) after pelvic organ prolapse (POP) repair surgery in women.
- Trial name
- NCT07601282
- Testing
- Telephone follow-up
- Where
- China
- Volunteers
- 382 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Pelvic Organ Prolapse
How Low Can You Go
This is a randomized controlled trial to determine if lower intraabdominal operating pressure reduces post-operative pain in patients scheduled to undergo laparoscopic uterosacral suspension surgery of the uterus or vaginal vault.
- Trial name
- NCT07786337
- Testing
- Standard insufflation, Low insufflation
- Volunteers
- 164 people
- Sponsor
- University of Calgary
Pelvic Organ Prolapse, Urinary Incontinence
Improving Uroflowmetry Interpretability: Evaluating the Impact of Patient Reminder Systems
The purpose of this study is to evaluate the impact of pre-procedure patient reminder systems on patient satisfaction, preparedness, and anxiety among patients undergoing urodynamics studies.
- Trial name
- NCT07692789
- Testing
- Patient reminder system
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Ohio State University
Urinary Incontinence,Stress, Stress Urinary Incontinence
Synchronized Core-Pelvic Floor Activation in Urinary Incontinence
This study aims to investigate whether co-activation of the pelvic floor and core muscles improves treatment outcomes in individuals with urinary incontinence.
- Conditions
- Urinary Incontinence,Stress, Stress Urinary Incontinence, Mixed Incontinence Due to Prolapse of Female Genital Organ, Urinary Incontinence
- Trial name
- NCT07387640
- Testing
- Conventional Pelvic Floor Muscle Training, Pelvic Floor and Core Muscle Co-activation Training
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Bezmialem Vakif University
Pelvic Organ Prolapse (POP), Postoperative Pain
Effect of Paracervical Block on Postoperative Pain After vNOTES Uterosacral Ligament Suspension
This study is a prospective, randomized, double-blind, placebo-controlled clinical trial designed to evaluate the effect of paracervical block on early postoperative pain after vaginal natural orifice transluminal endoscopic…
- Trial name
- vNOTES-PB (NCT07440576)
- Testing
- Bupivacaine, Normal Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Erkan Gol
Pelvic Organ Prolapse, Stage III and IV High Grade Pelvic Organ Prolapse
Efficacy/Safety of Urogynecology Synthetic Mesh Surgery
This is a retrospective cohort study, aiming at analyzing the efficacy and safety of mesh surgery in pelvic organ prolapse. The synthetic mesh for pelvic organ prolapse include transvaginal mesh or laparotomy, laparoscope, or…
- Trial name
- NCT05682989
- Testing
- Urodynamic investigations before and after a mesh surgery protocol., Urodynamic investigations before and after a robotic-assisted sacrocolpopexy protocol., Urodynamic investigations before and after a hysterectomy with trans-vaginal mesh repair
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Mackay Medical College
Rectal Prolapse, Surgery
The Nordic Rectal Prolapse Study
The goal of this observational study is to gather data about surgical procedures for rectal prolapse in adult human subjects. The main question it aims to answer is: Which procedure is best for treating external rectal prolapse?…
- Conditions
- Rectal Prolapse, Surgery, Recurrence, Quality of Life
- Trial name
- NORDIC (NCT05569980)
- Where
- Denmark
- Volunteers
- 430 people
- Sponsor
- Aarhus University Hospital
Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery
Vaginal Mesh Surgery Versus Robotic-assisted Abdominal Mesh Surgery in the Treatment of Apical Prolapse - Prospective Randomized Non-inferiority Study
The goal of this study is to compare vaginal mesh surgery with abdominal robotic-assisted mesh surgery for the treatment of genital prolapse in women.
- Conditions
- Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery, Mesh Reinforcement, Vaginal Apex/Uterine Prolapse
- Trial name
- NCT07359755
- Testing
- Vaginal mesh surgery for apical prolapse, Robotic-assisted abdominal mesh surgery with Upsylon device (Boston Scientific - USA) for vaginal apical prolapse
- Where
- Brazil
- Volunteers
- 86 people
- Sponsor
- University of Sao Paulo General Hospital
Pelvic Floor Disorders, Pelvic Organ Prolapse
The Intermediate and Long-term Follow up of Home Based Pelvic Muscle Training
When participants present with symptoms of pelvic organ prolapse (POP) and stress urinary incontinence (SUI), the investigators will perform a comprehensive evaluation and initially provide conservative treatment.
- Conditions
- Pelvic Floor Disorders, Pelvic Organ Prolapse, Stress Urinary Incontinence
- Trial name
- NCT05778552
- Testing
- Home-based pelvic muscle training devices or traditional PFMT at hospital
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Prolapse Pelvic
Prophylactic Laparoscopic Suspension After McCall
There is prove of prolapse prevention in vaginal hysterectomy using the McCall suture. Poor and especially no long-term data exists for a standardized laparoscopic approach, but the few studies could show good anatomic results.
- Trial name
- LAPCALL (NCT04560543)
- Testing
- McCall suture, Standard cuff closure
- Where
- Switzerland
- Volunteers
- 114 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Vaginal Prolapse
Prospective Observational Prolapse Study
The rationale of the study is to investigate the results of a prolapse treatment in adult women with a vaginal prolapse. The investigators will investigate this by taking questionnaires in women undergoing a surgical prolapse…
- Trial name
- NCT04701047
- Testing
- vaginal pessary, Vaginal prolapse surgery
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- University Hospital, Ghent
Pelvic Organ Prolapse (POP), Genital Prolapse
Safety and Performance of a Pelvic Floor Mesh Implant (LatGYNious)
The purpose of the clinical investigation is to verify that the investigational device (LatGYNious) is appropriate to significantly improve the pelvic organ prolapse in patients.
- Conditions
- Pelvic Organ Prolapse (POP), Genital Prolapse, Uterus Prolapse, Laparoscopic Surgery
- Trial name
- NCT07066761
- Testing
- Laparoscopic lateral suspension with surgical mesh (LatGYNious)
- Where
- 5 sites in Austria, Germany
- Volunteers
- 85 people
- Sponsor
- A.M.I. Agency for Medical Innovations GmbH
Genital Prolapse
Laparoscopic Pectopexy With and Without Mesh Use for Pelvic Organ Prolapse.
Genital apical prolapse refers to the descent of the vaginal apex, uterus, or cervix, and surgical treatment is required for adequate apical support.
- Trial name
- NCT07306715
- Testing
- Meshless Laparoscopic Pectopexy, Laparoscopic Pectopexy with mesh
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kocaeli University
Pelvic Floor Dysfunction, Urinary Incontinence
Impact of Equestrian Sports, CrossFit, and Gym Training on Pelvic Floor Health (PELFISPORT )
This observational cross-sectional study investigates the impact of equestrian sports, CrossFit, and gym training on pelvic floor health in both athletes and non-athletes.
- Conditions
- Pelvic Floor Dysfunction, Urinary Incontinence, Pelvic Organ Prolapse (POP), Chronic Pelvic Pain
- Trial name
- PELFISPORT (NCT06848634)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Oviedo
Pelvic Floor Dysfunction, Postpartum Care
Comparison of Outpatient Rehabilitation Versus Self-training for the Treatment and Prevention of Postpartum Pelvic Floor Dysfunction
The main goal of this study to compare self-training postpartum and training with a specialist support (physiotherapist and physical medicine and rehabilitation doctor) effect on pelvic floor dysfunction prevention and treatment…
- Conditions
- Pelvic Floor Dysfunction, Postpartum Care, Postpartum Comfort, Female Urinary Incontinence and Pelvic Organ Prolapse
- Trial name
- DDDPREV (NCT07426770)
- Testing
- Rehabilitation postpartum, Self-training
- Where
- Lithuania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vilnius University
Leiomyoma, Uterine, Benign Gynecological Disease
Deep Neuromuscular Blockade and a Low-Residue Diet for the Surgical Field in vNOTES Hysterectomy
vNOTES (vaginal natural orifice transluminal endoscopic surgery) hysterectomy is performed entirely through the vagina, with no abdominal incision.
- Conditions
- Leiomyoma, Uterine, Benign Gynecological Disease, Abnormal Uterine Bleeding (AUB), Uterine Prolapse
- Trial name
- vNOTES_NMBDIET (NCT07730970)
- Testing
- Deep Neuromuscular Blockade (NMB), Standard (moderate) neuromuscular blockade, Preoperative low-residue diet
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Prolapse Pelvic, Hysterectomy
Vaginal Natural Orifice Transluminal Endoscopic (vNOTE) Hysterectomy With Uterosacral Suspension
As the adoption of Vaginal natural orifice transluminal endoscopic surgery (vNOTES) expands, attention is shifting from feasibility studies to the refinement of surgical steps that optimize long-term pelvic health.
- Trial name
- VENUS (NCT07413861)
- Testing
- Uterosacral suspension, Hysterectomy by vNOTES approach
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston