Clinical trials: Proliferative Vitreoretinopathy
Rhegmatogenous Retinal Detachment, Proliferative Vitreoretinopathy
A Multi-Center Study on the Use of Rho-Kinase Inhibitor to Reduce or Prevent PVR in RRD Eyes at High Risk for PVR
The purpose of this study is to determine if a drug called netarsudil is safe and able to prevent the development of scar tissue after retinal detachment repair.
- Trial name
- NCT05660447
- Testing
- Netarsudil 0.02% Ophthalmic Solution [RHOPRESSA], Glycerin 0.2%/Hypromellose 0.2%/Peg 1%/Soln,Oph,Ud
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Wills Eye
Retinal Detachment
Comparison High-density Silicone Oils in Retinal Detachment
The purpose of the study is to compare the safety, intraocular adverse effects and the anatomic and functional outcome with two endotamponade silicone oil after a 3-month in complex inferior retinal re-detachments.
- Trial name
- NCT00403702
- Testing
- Oxane HD [oil-RMN3-mixture], Densiron [(F6H8)
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Rhegmatogenous Retinal Detachment, Proliferative Vitreoretinopathy
Intravitreal Infliximab for Proliferative Vitreoretinopathy
Proliferative vitreoretinopathy (PVR) is the most common cause for failure of rhegmatogenous retinal detachment repair and is characterized by the growth and contraction of cellular membranes within the vitreous cavity on both…
- Conditions
- Rhegmatogenous Retinal Detachment, Proliferative Vitreoretinopathy, Retinal Detachment
- Trial name
- FIXER (NCT04891991)
- Testing
- Intravitreal infliximab, Pars plana vitrectomy
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Cairo University
Proliferative Vitreoretinopathy
Outcomes of Extensive Brilliant Blue G-Assisted Internal Limiting Membrane Peeling in Proliferative Vitreoretinopathy
The aim of this study is to report outcomes of pars plana vitrectomy (PPV) in retinal detachment (RD) accompanied with proliferative vitreoretinopathy (PVR) after extensive Brilliant Blue G-Assisted internal limiting membrane…
- Trial name
- ILM (NCT04490876)
- Testing
- 3D Pars Plana Vitrectomy associated with Extensive Brilliant Blue G-Assisted ILM Peeling Method
- Where
- Argentina
- Volunteers
- 14 people
- Sponsor
- Centro Oftalmológico Dr Charles
Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment
Intravitreal Topotecan in the Repair of Rhegmatogenous Retinal Detachment with Proliferative Vitreoretinopathy
Intravitreal topotecan has anti-inflammatory, anti-proliferative and anti-fibrotic activity that we hypothesize may exhibit high efficacy for the treatment of proliferative vitreoretinopathy (PVR) in patients with rhegmatogenous…
- Trial name
- TOPO-RD (NCT05523869)
- Testing
- Intravitreal topotecan, Pars plana vitrectomy with or without scleral buckle
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Retinal Detachment Rhegmatogenous, Proliferative Vitreoretinopathy
Intravitreal Topotecan for Prevention or Treatment of Proliferative Vitreoretinopathy in Retinal Detachment
Intravitreal topotecan exhibits strong anti-inflammatory, anti-proliferative, and anti-fibrotic properties, making it a promising option for preventing and treating proliferative vitreoretinopathy in rhegmatogenous retinal…
- Trial name
- TOPO-PT (NCT06818721)
- Testing
- Intravitreal topotecan, Retinal detachment surgery
- Where
- 2 sites in Canada
- Volunteers
- 394 people
- Sponsor
- Unity Health Toronto
Retinal Detachment, Proliferative Vitreoretinopathy
Bevacizumab Against Recurrent Retinal Detachment
The investigators hypothesize that bevacizumab instilled into the vitreous after primary retinal detachment surgery will reduce the formation of proliferative vitreoretinopathy and subsequent retinal re-detachment.
- Trial name
- BEARRD (NCT02192970)
- Testing
- Bevacizumab
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- University of Wisconsin, Madison
Proliferative Vitreoretinopathy
The GUARD Trial - Part 1: A Phase 3 Clinical Trial for Prevention of Proliferative Vitreoretinopathy
The GUARD Trial is a multi-center, randomized, controlled, adaptive Phase 3 clinical trial of repeated intravitreal injections of ADX-2191 versus standard-of-care for the prevention of proliferative vitreoretinopathy.
- Trial name
- NCT04136366
- Testing
- ADX-2191 (intravitreal methotrexate 0.8%), Standard surgical care procedure
- Where
- 23 sites in United States
- Volunteers
- 106 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Retinal Detachment, Proliferative Vitreoretinopathy
Efficacy of 5-fluorouracil and Low Molecular Weight Heparin in High-risk Pediatric Retinal Detachment
EVALUATION OF 5-FLOUROURACIL AND LOW MOLECULAR WEIGHT HEPARIN INTRAOPERATIVE INFUSION IN PREVENTING PROLIFERATIVE VITREORETINOPATHY IN HIGH RISK PEDIATRIC RHEGMATOGENOUS RETINAL DETACHMENT
- Trial name
- NCT06166914
- Testing
- Intraoperative infusion of 5-FU (200 µg/ml) and LMWH (5 IU/ml)
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Alexandria University
Proliferative Vitreoretinopathy
Imaging and Predictive Modelling of Proliferative Vitreoretinopathy.
Patients with retinal detachment are at risk of recurrence and failure of surgery requiring multiple surgeries due to a condition called proliferative vitreoretinopathy (PVR).
- Trial name
- NCT07682025
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London
Diabetic Retinopathy, Proliferative Vitreoretinopathy
Molecular Taxonomy of Surgically-harvested Ocular Tissues Defined by Single-cell Transcriptomics
The surgically-harvested eye tissue (ie. vitreous-retinal proliferative membrane, outflow pathway, retinas, and pterygium) is a complex tissue responsible for maintaining intraocular homeostasis or mediating ocular pathogenesis.
- Conditions
- Diabetic Retinopathy, Proliferative Vitreoretinopathy, Pterygium, Glaucoma
- Trial name
- Eyesinglecell (NCT04682054)
- Testing
- ocular surgery
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment
Intravitreal Triamcinolone and Biomarkers in Rhegmatogenous Retinal Detachment
This prospective, randomized, controlled clinical study evaluates the effects of preoperative intravitreal triamcinolone acetonide (TA) on growth factors and inflammatory mediators in patients with rhegmatogenous retinal…
- Trial name
- NCT07774182
- Testing
- Standard Vitrectomy, Triamcinolone acetonide (TA)
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Anggun Rama Yudantha
Retinal Detachment
Methotrexate in Retinal Detachment With Proliferative Vitreoretinopathy
The aim of this study is to evaluate the efficacy and safety of intraocular methotrexate (MTX) in preventing and managing proliferative vitreoretinopathy (PVR) in patients undergoing retinal detachment surgery
- Trial name
- Methotrexate (NCT07058337)
- Testing
- parsplana vitrectomy, adjunctive use of Methotrexate
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Benha University
Proliferative Vitreoretinopathy, Proliferative Vitreo-Retinopathy
The Safety and Efficacy of Intravitreal Topotecan for the Treatment of Proliferative Vitreoretinopathy
The goal of this clinical trial is to evaluate the safety and efficacy of intravitreal topotecan for the treatment of patients with rhegmatogenous retinal detachment due to proliferative vitreoretinopathy (PVR) or resulting from…
- Conditions
- Proliferative Vitreoretinopathy, Proliferative Vitreo-Retinopathy, Rhegmatogenous Retinal Detachment
- Trial name
- NCT06425419
- Testing
- Topotecan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Macular Hole, Epiretinal Membrane
Optical Coherence Tomography - Rescan During Dissection of Macular Membranes
In our study , the investigators will use the microscope with OCT ( Lumera with RESCAN OCT ) coupled to assess the extent , depth and change of retinal architecture in the perioperative period .
- Conditions
- Macular Hole, Epiretinal Membrane, Traction Syndrome Vitreomacular, Proliferative Vitreoretinopathy
- Trial name
- NCT02748421
- Testing
- Lumera Microscope with OCT RESCAN, Conventional Microscope
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo
Proliferative Vitreoretinopathy
Repeated Methotrexate for Proliferative Vitreoretinopathy Grade C
This multicenter randomized clinical trial evaluates the effect of multiple intra-silicone oil injections of methotrexate (MTX) on rhegmatogenous retinal detachment (RRD) with grade C proliferative vitreoretinopathy (PVR).
- Trial name
- NCT04482543
- Testing
- Methotrexate
- Where
- Iran
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Retinal Redetachment After Silicone Oil Removal
Retinal Redetachment After Silicone Oil Removal : a Risk Factor Analysis
To report the rate of retinal redetachment after silicone oil removal (SOR) following rhegmatogenous retinal detachment (RRD) surgery and to determine potential risk factors
- Trial name
- NCT05647928
- Testing
- no intervention
- Where
- France
- Volunteers
- 307 people
- Sponsor
- Central Hospital, Nancy, France
Rhegmatogenous Retinal Detachment, High-risk for Proliferative Vitreoretinopathy (PVR)
Prophylactic Intravitreal 5-Fluorouracil and Heparin to Prevent PVR in High-risk Patients With Retinal Detachment.
This study investigates the effectiveness of a simple treatment to prevent proliferative vitreoretinopathy (PVR). Intraoperative intravitreal 5-fluorouracil (5-FU) and low molecular weight heparin (LMWH) is used as a prophylactic…
- Trial name
- PRIVENT (NCT02834559)
- Testing
- 5-fluorouracil and low molecular weight heparin
- Where
- 13 sites in Germany
- Volunteers
- 326 people
- Sponsor
- Universitätsklinikum Köln
Proliferative Vitreoretinopathy, Retinal Detachment
The Silicone Study
To compare, through a randomized, multicenter surgical trial, the postoperative tamponade effectiveness of intraocular silicone oil with that of an intraocular long-acting gas (initially sulfur hexafluoride [SF 6 ], later…
- Trial name
- NCT00000140
- Testing
- Perfluoropropane, Sulfur Hexafluoride, Silicone Oil
- Sponsor
- National Eye Institute (NEI)
Retinal Detachment, Proliferative Vitreoretinopathy
Internal Limiting Membrane Peeling in Retinal Detachment Surgery
Despite advances in surgical techniques over the recent decades, proliferative vitreoretinopathy (PVR) remains the main obstacle to successful rhegmatogenous retinal detachment (RRD) repair, accounting for nearly 75% of all…
- Trial name
- IMPURITY (NCT05538156)
- Testing
- Control group, Intervention group
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France