Clinical trials: Proliferative Vitreoretinopathy
Proliferative Vitreoretinopathy
The GUARD Trial - Part 1: A Phase 3 Clinical Trial for Prevention of Proliferative Vitreoretinopathy
The GUARD Trial is a multi-center, randomized, controlled, adaptive Phase 3 clinical trial of repeated intravitreal injections of ADX-2191 versus standard-of-care for the prevention of proliferative vitreoretinopathy.
- Trial name
- NCT04136366
- Testing
- ADX-2191 (intravitreal methotrexate 0.8%), Standard surgical care procedure
- Where
- 23 sites in United States
- Volunteers
- 106 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Retinal Detachment, Proliferative Vitreoretinopathy
Bevacizumab Against Recurrent Retinal Detachment
The investigators hypothesize that bevacizumab instilled into the vitreous after primary retinal detachment surgery will reduce the formation of proliferative vitreoretinopathy and subsequent retinal re-detachment.
- Trial name
- BEARRD (NCT02192970)
- Testing
- Bevacizumab
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- University of Wisconsin, Madison
Proliferative Vitreoretinopathy
Isotretinoin for Proliferative Vitreoretinopathy
Proliferative vitreoretinopathy (PVR), or secondary scarring on and around the retina, is an important cause of retinal re-detachment.
- Trial name
- DELIVER (NCT01445028)
- Testing
- Isotretinoin
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Retinal Detachment, Vitreoretinopathy Proliferative
Eye Injections of Bevacizumab for Lowering Risk of Scar Tissue in the Retina and Repeated Retinal Detachment.
The purpose of this study is to examine the effects of a drug called bevacizumab (Avastin) on the rates of recurrent retinal detachment and scar tissue formation.
- Trial name
- NCT01860586
- Testing
- Bevacizumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wills Eye
Retinal Detachment, Proliferative Vitreoretinopathy
Postoperative Pain Control Following Vitreoretinal Surgery
The aim of this study is to evaluate if patients receiving a steroid (triamcinolone acetonide) combined with local anesthesia and antibiotic following retina surgery have better postoperative pain control those receiving local…
- Conditions
- Retinal Detachment, Proliferative Vitreoretinopathy, Retinoschisis
- Trial name
- NCT01995045
- Testing
- Triamcinolone, Bupivicaine Hydrochloride
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Emory University