Clinical trials: Prolotherapy
Arthritis Knee
Dextrose Prolotherapy on Articular Cartilage
Dextrose prolotherapy is a controversial injection therapy in sports medicine. Currently, 25% hypertonic glucose solution is commonly used in clinical practice.
- Trial name
- NCT06301958
- Testing
- Dextrose prolotherapy
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Planter Fasciitis
Comparison of Platelet-Rich Plasma and Prolotherapy for Plantar Fasciitis
This randomized controlled trial evaluates the comparative effectiveness of platelet-rich plasma (PRP) therapy and prolotherapy in patients with plantar fasciitis.
- Trial name
- NCT07480967
- Testing
- platelet-rich plasma injection, Prolotherapy with 25% Dextrose
- Where
- Bangladesh
- Volunteers
- 68 people
- Sponsor
- Bangladesh Medical University
Temporomandibular Joint Disorders
Treatment of Temporomandibular Dysfunction With Hypertonic Dextrose Injection
Dysfunction of the jaw, associated with pain in the jaw or about the jaw in the face can be quite long lasting and debilitating.
- Trial name
- NCT01617356
- Testing
- Injection of 20% dextrose/ 0.2% lidocaine, Injection of 1 ml of 0.8 SW/0.2% lidocaine
- Where
- Argentina
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Frusso, Ricardo, M.D.
Osteoarthritis, Knee
Identification of Response to Hypertonic Dextrose Prolotherapy Markers in Knee Osteoarthritis Patients by Cytokine Array
Hypertonic dextrose prolotherapy has been used in knee osteoarthritis (OA) clinically for a long time. However the study about the mechanism is scant.
- Trial name
- NCT02888795
- Testing
- hypertonic dextrose prolotherapy
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- National Yang Ming Chiao Tung University Hospital
Knee Osteoarthritis
Effects of Dextrose Prolotherapy in Patients With Knee Osteoarthritis
In this prospective, randomized, controlled, single-blinded study, we aimed to evaluate the effects of Dextrose Prolotherapy injections in patients with chronic knee osteoarthritis.
- Trial name
- NCT06063356
- Testing
- Intra-articular and extra-articular Dextrose Prolotherapy injection, Intra-articular and extra-articular Saline injection
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Istanbul University
Plantar Fasciitis
Prolotherapy for the Treatment of Plantar Fasciitis
The purpose of this study is to demonstrate that prolotherapy in conjunction with a physiotherapy program looking at reinforcing calf muscle and muscle of the plantar fascia, relieves pain and improves function of people…
- Trial name
- NCT01326351
- Testing
- Regenerative injection therapy, Dry needle injection, Exercise
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Réseau de Santé Vitalité Health Network
Overactive Bladder, Underactive Bladder
The Treatment Efficacy of Prolotherapy in Bladder Voiding Dysfunction
Voiding dysfunction including overactive bladder, underactive bladder, and neuropathic bladder. Voiding dysfunction has a great impact on life quality, especially in the elderly society.
- Trial name
- NCT05485142
- Testing
- prolotherapy
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taichung Armed Forces General Hospital
Lateral Epicondylitis
Bundang Rehabilitative Impact Study of the Elbow Epicondylitis
This study is to assess the safety and effect of polydeoxyribonucleotide(PDRN) on the lateral epicondylitis with ultrasonography-guided injection of the PDRN or dextrose solution.
- Trial name
- BundangRISEe (NCT02492945)
- Testing
- 3ml-Rejuvinex, 3ml-15%-dextrose solution
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Bundang Hospital
Rotator Cuff Tear
Prolotherapy for the Treatment of Partial Rotator Cuff Tears
This is a Prospective Pilot Single Arm study on prolotherapy for the treatment of patients with pain due to Partial Rotator Cuff (RC) Tears of the Shoulder.
- Trial name
- NCT04062838
- Testing
- Dextrose 50
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Knee Osteoarthritis
Platelet Rich Plasma and Neural Prolotherapy Injections in Treating Knee Osteoarthritis
Osteoarthritis (OA) of the knees is the most common degenerative disorder seen in a rehabilitation outpatient clinic. It is characterized by metabolic, biochemical, and structural changes in the articular cartilage and the…
- Trial name
- NCT04006314
- Testing
- Autologous platelet rich plasma and dextrose solution.
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Chang Gung Memorial Hospital
Knee Osteoarthritis
Different Concentrations of Dextrose Prolotherapy Treatment in Knee Osteoartritis
In this study, the investigators aimed to compare the efficacy of %5, %10 and %20 concentration dextrose prolotherapy (DPT) treatments in patients with primary knee osteoarthritis (OA).
- Trial name
- NCT05537077
- Testing
- Prolotherapy, Home based exercise program, Hotpack therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Turkish League Against Rheumatism
Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS)
Regenerative Medicine for Joint Hypermobility and Instability
This clinical trial is designed to evaluate whether a stepwise injection-based treatment approach can reduce pain and improve function in adults with joint hypermobility, connective tissue laxity, and joint instability.
- Conditions
- Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS), Joint Hypermobility, Joint Instability
- Trial name
- NCT07688096
- Testing
- Dextrose 20% Prolotherapy, Autologous Platelet-Rich Plasma, Doxycycline Hyclate Injectable (Investigational)
- Volunteers
- 100 people
- Sponsor
- Manhattan Pain Medicine, PLLC
Plantar Fasciitis
Comparison of the Effectiveness of Dextrose Prolotherapy and Extracorporeal Shock Wave Therapy (ESWT) in Plantar Fasciitis
Plantar fasciitis is a degeneration of the plantar aponeurosis and is the most common cause of heel pain (11-15%). Although seen in both sexes, plantar fasciitis is more common in women, usually unilateral and bilateral in 30% of…
- Trial name
- NCT07233395
- Testing
- Dextrose Prolotherapy, Extracorporeal Shock Wave Therapy (ESWT)
- Volunteers
- 60 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Ehlers-Danlos Syndrome, Low Back Pain
The Ultrasound-Guided Dextrose Prolotherapy in Ehlers-Danlos Syndrome Patients
1. Specific Aim: To show the safety and efficacy of prolotherapy injection for chronic sacroiliac and myofascial lumbar pain while standardizing an ultrasound guided injection technique 2.
- Conditions
- Ehlers-Danlos Syndrome, Low Back Pain, Sacroiliac Instability
- Trial name
- NCT05279937
- Testing
- Dextrose 50% Intravenous Solution, Lidocaine 1% Injectable Solution
- Sponsor
- Tulane University
Knee Osteoarthritis
Cost Effectiveness of Prolotherapy Injections Prior to Total Knee Arthroplasty
This study compared the cost effectiveness of two-stage algorithm (prolotherapy injections (PrT) combined with rehabilitation protocol (RP) prior to total knee arthroplasty (TKA)) and one-stage algorithm (TKA) in the management…
- Trial name
- NCT03758183
- Testing
- total knee arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 197 people
- Sponsor
- Tokat State Hospital
Intraarticular, Ozone
Effect of Intraarticular Ozone, Prolotherapy or Dexmedetomidine in Pain Limitation in Knee Osteoarthritis
This study aimed to compare intraarticular ozone injection, prolotherapy, or dexmedetomidine effectiveness in knee osteoarthritis patients.
- Conditions
- Intraarticular, Ozone, Prolotherapy, Dexmedetomidine
- Trial name
- NCT06909305
- Testing
- Ozone, Dextrose prolotherapy, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Temporomandibular Disorders (TMDs)
Impact of Platelet Concentration in PRP on TMJ Subluxation
This study is about a treatment for a jaw condition called temporomandibular joint (TMJ) subluxation. In this condition, the jaw can move too far forward during mouth opening, which may cause repeated jaw locking and problems…
- Trial name
- PRPTMJ (NCT07532798)
- Testing
- Low Platelet Concentration PRP (L-PRP), High Platelet Concentration PRP (L-PRP)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- IBB University
Knee Osteoarthritis
Prolotherapy Intervention Effect in Patient With Knee Osteoarthritis
Introduction : Prolotherapy is regenerative tissue therapy which is considered to be efficacious in reducing symptoms and morbidity of Knee Osteoarthritis (KOA), but only a few studies demonstrate the effect of prolotherapy at…
- Trial name
- NCT04557943
- Testing
- Prolotherapy, Sodium Hyaluronate
- Where
- Indonesia
- Volunteers
- 36 people
- Sponsor
- Hasanuddin University
Tennis Elbow
Comparative Study for the Optimal Treatment Method of Lateral Epicondylosis
The purpose of this study is to find the optimal treatment method for chronic lateral epicondylosis, and focused on the 'healing mechanism' and 'pain modulation' of degenerated tendon.The hypothesis is that there will be…
- Trial name
- NCT02052089
- Testing
- physiotherapy, extracorporeal shockwave therapy, prolotherapy
- Where
- South Korea
- Volunteers
- 231 people
- Sponsor
- CM Chungmu Hospital