Clinical trials: Prophylactic, open to volunteers
Pancreatic Surgery, Prophylactic SBRT
Stereotactic Body Radiotherapy (SBRT) Induced Pancreatic Atrophy for Prevention of Post Operative Pancreatic Fistulae (POPF) After Pancreatoduodenectomy in Very High-Risk Patients (STEREOPANC)
STEREOPANC is a randomized, controlled, open label, multicenter study initiated by the Oulu HPB Study Group. Patients with a very high risk of B/C POPF (soft pancreas) scheduled for PD for any indication are recognized at a local…
- Conditions
- Pancreatic Surgery, Prophylactic SBRT, Pancreatic Leak
- Trial name
- STEREOPANC (NCT07884019)
- Testing
- Remnant pancreas SBRT
- Where
- 3 sites in Finland
- Volunteers
- 70 people
- Sponsor
- Oulu University Hospital
Prophylactic, Anticoagulation
Prophylactic Anticoagulation for Central Venous Line Insertion in Critically Ill Children
This will be a Prospective, randomized, open- label, parallel-group, center trial, which will include 80 of Children which will be admitted at Pediatric Intensive Care Unit (PICU) of Menoufia university Hospital from August 2026…
- Trial name
- NCT07710482
- Testing
- Enoxaparin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Menoufia University
Infection Post Op, Hysterectomy
Does Additional Use of Preoperative Azithromycin Decrease Posthysterectomy Infections
During hysterectomy bacteria may enter into the peritoneal cavity through vaginal opening and contaminate the healing tissues. The risk for deep infection after hysterectomy is about 5%.
- Conditions
- Infection Post Op, Hysterectomy, Antibiotics, Prophylactic
- Trial name
- NCT05337566
- Testing
- Azithromycin Pill + Cefuroxime
- Where
- 6 sites in Finland
- Volunteers
- 2,278 people
- Sponsor
- Helsinki University Central Hospital
Open Abdomen, Incisional Hernia
Synthetic Mesh for Prevention of HernIa After opEn Abdomen cLosure stuDy
The aim of this clinical trial is to evaluate whether placement of a synthetic prophylactic onlay mesh during definitive fascial closure can reduce the incidence of incisional hernia in adult patients managed with an open abdomen…
- Conditions
- Open Abdomen, Incisional Hernia, Definitive Fascial Closure, Emergency Abdominal Surgery
- Trial name
- SHIELD (NCT07835334)
- Testing
- Definitive Fascial Closure Without Prophylactic Mesh, Prophylactic Onlay Mesh Placement
- Volunteers
- 30 people
- Sponsor
- Hospital San Juan de Dios Tenerife
Surgery Date, Age
Quality of Life of Patients Who Have Undergone Bilateral Mastectomy
The investigators therefore aim to determine whether the type of mastectomy (preventive in a high-risk patient or therapeutic in a patient with a history of cancer), as well as the timing (immediate or delayed) and type of breast…
- Conditions
- Surgery Date, Age, BMI, Height
- Trial name
- RM BREAST Q (NCT07699913)
- Volunteers
- 115 people
- Sponsor
- University Hospital, Grenoble
Thrombocytopenia, Prophylactic Platelet Transfusion
EFFECT OF PLATELET CONCENTRATE TRANSFUSION ON MICROCIRCULATORY ENDOTHELIAL FUNCTION IN INTENSIVE CARE UNIT
This study aims to investigate the impact of platelet concentrate (PC) transfusions on endothelial function and the systemic inflammatory response in thrombopenic patients admitted to intensive care who require prophylactic…
- Conditions
- Thrombocytopenia, Prophylactic Platelet Transfusion, Platelet Transfusion, Endothelial Function
- Trial name
- PLATOMIR (NCT07682246)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Abortion, Dilation and Evacuation
Tranexamic Acid for Second Trimester Dilation and Evacuation and Bleeding Outcomes
Although procedural abortion in the second trimester is extremely safe, hemorrhage is one of the leading causes of morbidity and mortality.
- Conditions
- Abortion, Dilation and Evacuation, Hemorrhage, Prophylactic Tranexamic Acid Use
- Trial name
- NCT06820177
- Testing
- Tranexamic Acid
- Where
- 3 sites in United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Hepatobiliary Surgery, Prophylactic Antibiotics
Prophylactic Antibiotics in Preventing Surgical Site Infection After Hepatobiliary Surgery in High-Resistant Settings
To analyse the efficacy of different preoperative prophylactic antimicrobial regimens for perioperative infection prevention in patients undergoing hepatobiliary surgery in a high antimicrobial resistance setting.
- Trial name
- PASH (NCT07620223)
- Testing
- Piperacillin-tazobactam
- Where
- China
- Volunteers
- 378 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Mastectomy, Gender Affirmation Surgery
The Role of Amnion Membrane Allografts in Nipple Preservation
The overall objective of this proposal is to conduct a randomized-controlled study to determine whether treatment with dehydrated human amnion/chorion membrane (dHACMs) allografts can improve NAC viability in patients undergoing…
- Conditions
- Mastectomy, Gender Affirmation Surgery, Nipple Sparing Mastectomy, Prophylactic Mastectomy
- Trial name
- AmnioFix (NCT06073808)
- Testing
- AmnioFix dehydrated Human Amnion/Chorion Membrane Allograft, Control Device
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Stanford University
Prophylactic Anticoagulation
Prophylactic ANTicoagulation With HEparine in Critically Ill Patients With Renal Impairment
Intensive care patients have an increased risk of venous thromboembolic events (deep vein thrombosis (DVT) and pulmonary embolism (PE)) due to the presence of general risk factors for thrombosis (age, immobilization, obesity…
- Trial name
- PANTHER (NCT07365644)
- Where
- 15 sites in France
- Volunteers
- 1,111 people
- Sponsor
- Centre Hospitalier le Mans
Stent Dislodgement, ERCP
Spontaneous Dislocation and Adverse Events of a Prophylactic Pancreatic Stent
A multicenter, prospective, controlled randomized study to investigate the optimal duration of protective pancreatic stents after endoscopic retrograde cholangiopancreatography (ERCP).
- Conditions
- Stent Dislodgement, ERCP, Pancreas Stent, Post-ERCP Pancreatitis
- Trial name
- SAFE PANCREAS (NCT07346365)
- Testing
- pancreatic stent removal, standard group
- Where
- Germany
- Volunteers
- 358 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Prophylactic Mastectomy
Prophylactic Mastectomy: Prospective Evaluation of the Correlation Between Skin Flap Thickness, Residual Glandular Tissue and Skin Necrosis by Imaging and Clinical Examination
Breast cancer is the most common form of cancer among women. Five to ten percent of all breast cancers are due to hereditary factors, with pathogenic variants in the breast cancer genes BRCA1/2 accounting for 2-5% of all breast…
- Trial name
- NCT05162677
- Where
- Sweden
- Volunteers
- 45 people
- Sponsor
- Umeå University