Clinical trials: Prophylaxis
Hypercholesterolemia, Coronary Heart Disease
Assessment of the Efficacy of Rosuvastatin in Patient Groups With a Dissimilar Risk Profile in an Observational Study (HEROS)
In an observational multi-centre study (HEROS), the effects of starting treatment with rosuvastatin were assessed, on low-density lipoprotein cholesterol (LDL-C) goal achievement, in patients with a dissimilar high-risk profile…
- Conditions
- Hypercholesterolemia, Coronary Heart Disease, Peripheral Vascular Disease, Cerebrovascular Accident
- Trial name
- HEROS (NCT00660764)
- Testing
- Rosuvastatin
- Sponsor
- AstraZeneca
Cancer, Tumors
Ramosetron, Aprepitant, and Dexamethasone Versus Palonosetron, Aprepitant, and Dexamethasone
The purpose of this study is to compare the anti-emetic effect of ramosetron plus aprepitant and dexamethasone with palonosetron plus aprepitant and dexamethasone in patients receiving highly emetogenic chemotherapy.
- Trial name
- RAPA (NCT02532634)
- Testing
- ramosetron, aprepitant, dexamethasone, palonosetron, aprepitant, dexamethasone
- Where
- 10 sites in South Korea
- Volunteers
- 292 people
- Sponsor
- Kangdong Sacred Heart Hospital
Nephropathy, Diabetic Nephropathies
Prevention of Chronic Kidney Disease(CDK) Progression in Type 1 Diabetes With Long Term Use of Sodium-Glucose-coTransporter Inhibitors Avoiding Kidney hypOxia
Background: Sodium-glucose-cotransporter (SGLT) inhibition has been observed to reduce risk of cardiovascular events and kidney failure in persons with type 2 diabetes.
- Conditions
- Nephropathy, Diabetic Nephropathies, Diabetes Mellitus, Type 1, Albuminuria
- Trial name
- PLUTO (NCT06147232)
- Testing
- Sotagliflozin
- Where
- 2 sites in Denmark, United Kingdom
- Volunteers
- 69 people
- Sponsor
- Steno Diabetes Center Copenhagen
Colorectal Neoplasms
EffectiveNess of Low Dose Aspirin in GastrointEstinal Cancer Prevention - Taiwan
The study evaluates the protective effect of low-dose aspirin use on gastrointestinal cancers (colorectal, esophageal and gastric cancers) in long-term users, episodic users and non-users of aspirin in Taiwan.
- Trial name
- ENgAGE-Taiwan (NCT03579732)
- Testing
- Aspirin (Acetylsalicylic Acid, BAYE4465), No drug
- Where
- Taiwan
- Volunteers
- 4,710,504 people
- Sponsor
- Bayer
Intraoperative Shivering, Ketamine With Shivering
Comparison of Ketamine Plus Dexamethasone Versus Ketamine Alone for Prevention of Severe Shivering After Spinal Anesthesia in Cesarean Section
Shivering is one of the most distressing events of the birth experience for patients. Shivering that occurs with spinal anesthesia is a frequent event, with a reported incidence of up to 50-65%.
- Conditions
- Intraoperative Shivering, Ketamine With Shivering, Dexamethasone for Shivering, Severe Shivering
- Trial name
- NCT06091657
- Testing
- Ketamine Hydrochloride
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Kasr El Aini Hospital
Post-Traumatic Headache
Treximet for Prevention of Post Traumatic Headache Associated With Cognitive Dysfunction
This study will evaluate the effectiveness of Treximet when taken for post traumatic headache by measuring any change in the number of headache days or any change in a subject's ability to think following treatment with study…
- Trial name
- NCT01053507
- Testing
- sumatriptan/naproxen sodium
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Cady, Roger, M.D.
Osteoporotic Fracture
Prevention of Residual Low Back Pain After Percutaneous Kyphosis(PKP) Using Posterior Branch Block of Spinal Nerve
The purpose of this study was to block the posterior branch of lumbar spinal nerve during PKP operation and compare it with the patients without spinal nerve block, so as to verify the effect of posterior branch block of spinal…
- Trial name
- NCT04108507
- Testing
- posterior branch block of spinal nerve
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Hemophilia A, Hemophilia B
Study of the Efficacy and Safety PF-06741086 in Adult and Teenage Participants With Severe Hemophilia A or Moderately Severe to Severe Hemophilia B
Treatment with PF-06741086 is anticipated to demonstrate a clinically relevant advantage and/or a major contribution to patient care in comparison to current methods of treatment for hemophilia A or B because it works differently…
- Trial name
- NCT03938792
- Testing
- PF-06741086
- Where
- 62 sites in United States, Bulgaria and 18 more
- Volunteers
- 188 people
- Sponsor
- Pfizer
Spinal Hypotension
Ephedrine and Phenylephrine for Spinal Hypotension
Spinal anesthesia is widely used as the procedure of choice for cesarean delivery. In comparison to epidural anesthesia it is faster, easier to perform, patients are more comfortable, complication rates are lower, and it is more…
- Trial name
- NCT03047109
- Testing
- Phenylephrine, Ephedrine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Sexually Transmitted Diseases
HIV Prevention for African American Teens
AFIYA aims to reduce both the risk of Sexually Transmitted Infections (STIs) and HIV in young African American females through a culturally and gender appropriate intervention (group sessions) coupled with an individualized HIV…
- Trial name
- NCT00279799
- Testing
- Afiya HIV Prevention Intervention
- Where
- 3 sites in United States
- Volunteers
- 701 people, healthy volunteers welcome
- Sponsor
- Emory University
Laparoscopic Surgery, Pediatrics
Effect of Palonosetron, Ondansetron and Dexamethasone in the Prevention of Postoperative Nausea and Vomiting
Postoperative nausea and vomiting (PONV) is an important outcome for the patient; patients generally rate PONV as worse than postoperative pain.
- Conditions
- Laparoscopic Surgery, Pediatrics, Nausea and Vomiting, Postoperative, Antiemetics
- Trial name
- NCT05439798
- Testing
- Ondansetron+Dexamethasone, Palonosetron+Dexamethasone, Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Selcuk University
Ataxia
Fall Prevention in a Geriatric Nursing Home Setting Using the Music of Nolwenn Leroy
Falls are the largest cause of death in the elderly and those with dementia have even a higher incidence of falling. The purpose of this study is to determine whether listening to the Music of Nolwenn Leroy is effective in fall…
- Trial name
- NCT00272272
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Carrick Institute for Graduate Studies
Neonatal Sepsis, Neonatal Mortality Rate
Chlorhexidine Skin Application for Prevention of Infection in Infants Weighing <1500 g at Birth
Purpose of this study is determine if skin application of chlorhexidine at birth would reduce infection in infants weighing <1500 g at birth.
- Trial name
- CAPS (NCT01723501)
- Testing
- 0.25% chlorhexidine, sterile water
- Where
- 3 sites in India
- Sponsor
- All India Institute of Medical Sciences
HIV Infections
SWEET: Once Daily Truvada Versus Twice Daily Combivir for the Treatment of HIV Infection
This study will investigate whether the simplified regimen of a once daily fixed dose combination of Truvada (emtricitabine and tenofovir disoproxil fumarate [DF]) will be associated with a reduced rate of adverse events, seen…
- Trial name
- NCT00323544
- Testing
- zidovudine and lamivudine (Combivir®), emtricitabine and tenofovir DF
- Where
- United Kingdom
- Volunteers
- 220 people
- Sponsor
- Gilead Sciences
Venous Thrombosis, Pulmonary Embolism
Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK)
This prospective cohort study will provide information about: characteristics of Rivaroxaban use in patients who are prescribed Rivaroxaban for the first time compared to patients who are prescribed Warfarin for the first time…
- Conditions
- Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation, Acute Coronary Syndrome
- Trial name
- NCT01947998
- Testing
- Rivaroxaban (Xarelto, Bay59-7939), Warfarin, Antiplatelet drugs
- Where
- United Kingdom
- Volunteers
- 50,299 people
- Sponsor
- Bayer
Sarcopenia, Frailty
Sarcopenia Prevention With a Targeted Exercise and Protein Supplementation Program
Physical inactivity and protein malnutrition have been implicated to be key and modifiable causes of enhanced muscle mass loss among seniors.
- Conditions
- Sarcopenia, Frailty, Malnutrition; Protein, Fall
- Trial name
- STRONG (NCT03417531)
- Testing
- Protein Supplement, Protein-free Supplement, Active Exercise
- Where
- 2 sites in Switzerland
- Volunteers
- 801 people, healthy volunteers welcome
- Sponsor
- University of Zurich
HIV Infections, Sexually Transmitted Diseases
Evaluation of Many Men, Many Voices, An STD/HIV Prevention Intervention for Black MSM
The purpose of this program evaluation is to determine whether the "Many Men, Many Voices" HIV/STD prevention intervention is effective in reducing HIV sex risk behaviors and increasing HIV testing among African-American men who…
- Trial name
- 3MV (NCT00137631)
- Testing
- Many Men, Many Voices (3MV)
- Where
- United States
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Graft-versus-host Disease, Hematological Malignancies
Combination of ATG-based Conditioning Regimen and PTCy for GVHD Prevention in Allo-HSCT After PD-1 Blockade
The aim of this study is to evaluate the efficacy and safety of anti-thymocyte globulin combined with PTCy (post-HSCT cyclophosphamide, PTCy) in preventing graft-versus-host disease (GVHD) in allo-HSCT patients after…
- Trial name
- NCT06238245
- Testing
- Cyclophosphamid
- Volunteers
- 22 people
- Sponsor
- Beijing 302 Hospital
Breast Cancer
Human Breast Tissue Bioavailability of Topically Applied Limonene
The overall objective of this project is to determine the safety and breast tissue bioavailability of limonene following massage application of limonene containing massage oil to the breast.
- Trial name
- NCT01459172
- Testing
- limonene containing massage oil
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Major Depressive Disorder, Recurrent, in Remission
Light and Ion Maintenance In Treatment for Depression (LIMIT-D): Feasibility Study
Antidepressants are widely used as first-line treatments for major depressive disorder (MDD). Clinical guidelines recommend 6-24 months of "maintenance" antidepressant treatment, after patients achieve symptom remission, to…
- Trial name
- NCT05423275
- Testing
- Negative ion therapy, Light therapy
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia