Clinical trials: Prophylaxis, open to volunteers
Hereditary Pancreatic Cancer
The PREPAIRD Study: Personalized Surveillance for Early Detection of Pancreatic Cancer in High Risk Individuals
The objective of this national and multidisciplinary project is to establish and evaluate a personalized surveillance program (SP) for early diagnosis of pancreatic cancer (PC) and its precursors in individuals with a hereditary…
- Trial name
- PREPAIRD (NCT05740111)
- Testing
- Annual surveillance
- Where
- Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Balance Disorders, Rehabilitation
Identify the Most Effective Rehabilitation Method Between a Treatment with a Sensorized Treadmill (Walker View) and a Treatment with Conventional Group Therapy in Balance Disorders and the Use of Artificial Intelligence to Identify Predictive Indices to Prevent Falls and Diagnose Promptly the Risk
Falls in the elderly are one of the main sources of disability and hospitalization, with a significant impact on quality of life and social and healthcare costs.
- Conditions
- Balance Disorders, Rehabilitation, Falls, Falls Prevention
- Trial name
- UAI (NCT06649500)
- Testing
- Treadmill, conventional therapy
- Where
- Italy
- Volunteers
- 108 people
- Sponsor
- Fondazione Policlinico Universitario Campus Bio-Medico
Child-Adult Interaction Training
Interacting With Children Training for Undergraduates
The adult-child relationship plays an important role in childhood development. Many of the skills and techniques used by adults while interacting with kids sometimes come naturally but often require direct instruction to reach…
- Trial name
- NCT07696611
- Testing
- CARE Training, Psychoeducation Training
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Auburn University
Preterm Birth Complication, Preterm Birth
Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities
The goal of this clinical trial is to learn if a personalized prenatal support program [(Personalized Toolkit Building a Comprehensive Approach to Resource optimization and Empowerment in Pregnancy \& Beyond, (PTBCARE+)] works to…
- Conditions
- Preterm Birth Complication, Preterm Birth, Preterm Birth Recurrence, Preeclampsia
- Trial name
- PTBCARE+ (NCT06915428)
- Testing
- Care coordination, Electronic massage, support gift #1
- Where
- United States
- Volunteers
- 1,228 people
- Sponsor
- University of North Carolina, Chapel Hill
Oral Leukoplakia
Pioglitazone-Metformin Combination Treatment for High Risk Oral Preneoplasia
This is a Phase IIa oral cavity leukoplakia study of pioglitazone 15mg and metformin 500mg BID for 12 weeks. The primary objective is to determine the clinical and histologic changes of leukoplakia from baseline following a 12…
- Trial name
- NCT05727761
- Testing
- pioglitazone-metformin
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- University of Minnesota
Atrial Fibrillation, Arrhythmias, Cardiac
Accuracy of LAA Occluder Size Selection: CT vs. DSA During Combined AF Ablation and LAA Occlusion
This study is a prospective, multi-center, randomized controlled trial. The subjects are patients scheduled to undergo a combined procedure of atrial fibrillation (AF) ablation and left atrial appendage (LAA) occlusion.
- Conditions
- Atrial Fibrillation, Arrhythmias, Cardiac, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT06455644
- Testing
- CT group, DSA group
- Where
- 5 sites in China
- Volunteers
- 238 people
- Sponsor
- First Affiliated Hospital of Shantou University Medical College
Parenting, Mental Health
Mama Empoderada: Parenting and Mental Health Intervention
This project focuses on the implementation and preliminary evaluation of Mama Empoderada, a brief 12-week group intervention that is based on a parenting program (Mom Power). The researcher's hypotheses are that: 1.
- Trial name
- NCT07569393
- Testing
- Mama Empoderada
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Nausea With Vomiting Chemotherapy-Induced
BMT-08: A Comparative Effectiveness Study of Transdermal Granisetron to Ondansetron
Patients undergoing either an autologous or allogeneic hematopoietic stem cell transplant (HSCT) and receiving preparative chemotherapy experience a considerable amount of chemotherapy-induced nausea and vomiting (CINV).
- Trial name
- NCT04150614
- Testing
- Granisetron Transdermal Patch, Intravenous Dexamethasone, Ondansetron
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Illinois at Chicago
Antibiotic Prophylaxis Surgery
Efficacy and Safety of Intraosseous Antibiotic Prophylaxis in Total Hip Replacement
The goal of this clinical trial is to learn if intraosseous antibiotic (cefazolin) administration can improve antibiotic levels in adults undergoing primary total hip replacement.
- Trial name
- NCT07549542
- Testing
- CeFAZolin 1000 MG, Saline (0.9%, sterile, for infusion)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Rutgers, The State University of New Jersey
Delirium in Old Age
Quality Contract: Prevention of Postoperative Delirium in the Care of Older Patients (QV-POD-2)
The project "QV-POD-2" is a prolongation based on "QV-POD-1", which was a quality contract program of the IQTIG - Institute for Quality and Transparency in Health Care.
- Trial name
- NCT04355195
- Where
- 2 sites in Germany
- Volunteers
- 18,100 people
- Sponsor
- Charite University, Berlin, Germany
Pressure Ulcers Prevention in Prone Positioning in Intensive Care
Pressure Sore Prevention Strategy for the Prone Position
The aim of this clinical trial is to determine whether 5-layer hydrocellular dressings are effective in preventing the development of pressure sores during prone positioning in the intensive care unit.
- Trial name
- DERM-H-PROTECT (NCT06442657)
- Testing
- Hydrocellular dressing, Hydrocolloids dressing
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Caen
Suicide Prevention, Suicidal Ideation
Co-creation of Tools for Children and Adolescents with Suicidal Thoughts And/or Behaviour
Evidence shows that there are very few evidence-based tools or interventions specifically targeting suicidality in children and adolescents.
- Conditions
- Suicide Prevention, Suicidal Ideation, Suicidal Behaviors
- Trial name
- Co-crea K&J (NCT06776328)
- Testing
- Tools
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Ghent
Breast Cancer, Radio Dermatitis
Photobiomodulation in Radiodermatitis in People With Breast Cancer
Most breast cancer patients undergoing radiotherapy develop radiodermatitis, making it one of the most prevalent adverse events during cancer treatment.
- Trial name
- NCT06990165
- Testing
- Photobiomodulation
- Where
- 2 sites in Brazil
- Volunteers
- 148 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Breast Cancer
To Evaluate the Clinical Efficacy of Probiotics in Patients With the Breast Cancer
Chemotherapy-associated side-effects would affect therapeutic effect, quality of life, and cause permanent harm to breast cancer patients.
- Trial name
- NCT06039644
- Testing
- Probiotic
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- GenMont Biotech Incorporation
Dysphagia, Dysphagia Rehabilitation
the Effect of Adult Intubated Patient Clinical Pathway on Post-extubation Complications Prevention
Post- extubation complications delay the complete recovery of critically ill patient. The clinical pathway is one strategies that help to manage and control these complications.
- Trial name
- CP (NCT07081399)
- Testing
- ETT cuff pressure monitoring, ETT suctioning, cough augmentation technique, swallowing exercises,: Nebulized budesonide 1mg and IV methylprednisolone 40 mg we
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Damanhour University
Prevention, Malnutrition, Child
Evaluation of 7-day vs 1-day Packaging of Small Quantity Lipid-based Nutrition Supplementation (SQ-LNS)
Small Quantity Lipid-based Nutrient Supplements (SQ-LNS), are fortified, lipid-based nutritional supplements that were specifically designed for children 6-24 months to prevent malnutrition.
- Conditions
- Prevention, Malnutrition, Child, Nutrition
- Trial name
- NCT07540793
- Testing
- 7dp SQ-LNS, 1dp SQ-LNS
- Where
- 3 sites in Ethiopia, Germany and 1 more
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Type 1 Diabetes
M1no-Study - Early Identification of Infants With High Type 1 Diabetes Risk for Participation in Primary Prevention Trials
The goal of this observational study is to identify newborns at increased genetic risk of developing type 1 diabetes-specific beta-cell autoantibodies in order to determine eligibility for participation in primary prevention…
- Trial name
- M1N0 (NCT07670143)
- Where
- 5 sites in Italy
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Healthy Adult Participants, Toxic Chemicals
Turkish Validity and Reliability Study of PRevention of Toxic Chemicals in the Environment for Children Tool
The aim of this study is to conduct a Turkish validity and reliability study of the "Prevention of Toxic Chemicals in the Environment for Children Tool," developed to examine the knowledge and attitudes of parents and prospective…
- Conditions
- Healthy Adult Participants, Toxic Chemicals, Environmental Toxins
- Trial name
- NCT07483606
- Where
- Turkey (Türkiye)
- Volunteers
- 204 people
- Sponsor
- Istanbul University - Cerrahpasa
Geriatric, Fall
Occupation-Based Multicomponent Intervention to Reduce Fall Risk in Older Adults
This study aims to examine the effects of an occupation-based, multicomponent occupational therapy intervention on older adults aged 65 years and above with a history of falls living in the community.
- Conditions
- Geriatric, Fall, Cognition, Balance
- Trial name
- NCT07258355
- Testing
- Occupation-Based Multi-Component Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Hacettepe University
Sickle Cell Disease
PASS of Xromi Comparing Safety and Effectiveness in Children Under 2 Years With Sickle Cell Disease [PRECISE PASS]
This post-authorisation safety and efficacy study (PRECISE PASS) evaluates the use of Xromi® (hydroxycarbamide 100 mg/mL oral solution) in children aged 9 months to under 2 years with sickle cell disease (SCD).
- Trial name
- PRECISE (NCT06923111)
- Testing
- Xromi
- Where
- 12 sites in Germany, United Kingdom
- Volunteers
- 180 people
- Sponsor
- Nova Laboratories Limited
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