Clinical trials: Propofol
Bispectral Index, Transcutaneous Carbon Dioxide
Compare the Side Effects and Difference Awake Level of Three TCI Propofol Formula in TVOR Patients
This study is to find the fewer side effects formula of anesthesia for TVOR patients, to compare the BIS level during emergence and to find the correlation between BIS and transcutaneous carbon dioxide concentration.
- Conditions
- Bispectral Index, Transcutaneous Carbon Dioxide, PONV, Blood Pressure
- Trial name
- NCT00760253
- Where
- Taiwan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Intraoperative Hypotension, Hepatectomy
Remimazolam Versus Propofol for Maintenance of Anaesthesia During Major Hepatectomy Under Low Central Venous Pressure
The goal of this clinical trial is to learn whether remimazolam helps prevent low blood pressure better than propofol during major liver surgery in adults.
- Trial name
- NCT07789275
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Flexible Bronchoscopy, Sedation
Nurse Administered Propofol Sedation vs. Midazolam With Fentanyl-sedation for Flexible Bronchoscopy: A Randomized, Single Blind, Controlled Study of Satisfaction and Safety.
Flexible bronchoscopy almost always requires sedation to be successful. In order to increase the availability of propofol for sedation, non-anaesthesiologist administered propofol sedation has been suggested as an alternative to…
- Conditions
- Flexible Bronchoscopy, Sedation, Satisfaction, Safety
- Trial name
- NCT02226328
- Testing
- Propofol sedation, Midazolam and Fentanyl sedation
- Where
- Denmark
- Volunteers
- 128 people
- Sponsor
- Copenhagen University Hospital at Herlev
Hepatectomy
Propofol/Dexmedetomidine Versus Desflurane Effects on Post Hepatectomy Hepatocellular Injury
This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.
- Trial name
- NCT05246371
- Testing
- Propofol, dexmedetomidine, Desflurane
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Frailty, Telomere
A Study of the Correlation Between the Debilitating State of the Elderly and Propofol Sensitivity
In an aging society, there is a surge in the number of surgeries for elderly patients in hospitals, and the elderly are at greater risk of anesthesia due to their own characteristics: slowing metabolism, decreasing resistance…
- Trial name
- NCT06870357
- Testing
- propofol
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Second Hospital of Shanxi Medical University
Mental Retardation
Accurate Controlled Dental Sedation
The aim of this study is to evaluate benefits of the method of dental sedation using Target controlled infusion (TCI) combined with Bispectral index (BIS) monitoring in patients with Mental Retardation and challenging behavior.
- Trial name
- ACDS (NCT00963898)
- Testing
- Target controlled infusion(TCI), Bispectral index(BIS)
- Where
- Japan
- Volunteers
- 40 people
- Sponsor
- Okayama University
Oral Surgical Procedures, Surgery, Oral
Effect Site Controlled, Reaction Time Safeguarded, Patient Maintained Sedation With Propofol in Anxious Patients
Whether patient-maintained sedation (the patient controls his/her degree of sedation using a hand-held device) using the drug propofol is safer and more effective when using deteriorating reaction time as an added safeguard…
- Conditions
- Oral Surgical Procedures, Surgery, Oral, Dental Anxiety, Surgery
- Trial name
- NCT00355693
- Testing
- Pump for propofol delivery
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Glasgow
Effect of Drug
Effective Dose of Remimazolam Combined With Propofol in Painless Gastroscopy
This study used sequential method（Dixon's up and douwn） to determine the effective dose of remiazolam combined with propofol in painless upper gastrointestinal endoscopy
- Trial name
- NCT05876793
- Testing
- Remimazolam tosilate
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Sichuan Provincial People's Hospital
Delirium
Is Dexmedetomidine Associated With a Lower Incidence of Postoperative Delirium When Compared to Propofol or Midazolam in Cardiac Surgery Patients
The purpose of this chart review study is to determine whether the use of dexmedetomidine, a selective α2-adrenergic receptor agonist with sedative, analgesic, and antinociceptive properties, would be associated with a lower…
- Trial name
- NCT00417664
- Testing
- Dexmedetomidine, Propofol, Midazolam
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Stanford University
Anesthesia Recovery Period ； Postoperative Pain； Hemodynamic Stability During Surgery
Afentanil and Remifentanil for Anesthesia Quality and Recovery
The goal of this clinical trial is to compare two commonly used opioid pain medications-alfentanil and remifentanil-during general anesthesia for surgery, and to find out whether alfentanil is as good as (not worse than)…
- Trial name
- NCT07761312
- Testing
- alfentanil, Remifentanil
- Volunteers
- 990 people
- Sponsor
- Qianfoshan Hospital
Colon Cancer, Rectal Cancer
Compare Propofol to Fentanyl and Midazolam for Colonoscopy
The study aim is to determine if Propofol or the combination of Fentanyl and low-dose Midazolam, are equivalent for patient satisfaction and discomfort when undergoing a colonoscopy. This is a prospective randomized study of 262.
- Conditions
- Colon Cancer, Rectal Cancer, Colonic Diverticulosis
- Trial name
- NCT01488045
- Testing
- Fentanyl, Propofol, Midazolam
- Where
- United States
- Volunteers
- 289 people
- Sponsor
- Trinity Health Michigan
Pharmacodynamic Interaction
Pharmacodynamic Interactions of Propofol and Dexmedetomidine on Intravenous Anesthesia
The purpose of this study is to determine pharmacodynamic interactions of propofol and dexmedetomidine,exploring the effect of dexmedetomidine on propofol unconsciousness median effective concentration (EC50).
- Trial name
- PIPDIA (NCT02777619)
- Testing
- 0.0ng/ml Dexmedetomidine, 0.4ng/ml Dexmedetomidine, 0.6ng/ml Dexmedetomidine
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Unconsciousness, Consciousness
UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study
This study will be a single-site, controlled, unblinded study at the University of Wisconsin to examine changes in the electroencephalogram during anesthesia and waking.
- Trial name
- UN-CONSCIOUS (NCT03284307)
- Testing
- Dexmedetomidine, Ketamine, Propofol
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cholangiopancreatography, Endoscopic Retrograde, Intracranial Pressure
The Effect of Anesthesia Management on Optic Nerve Sheath Diameter in the Ercp Procedures
Aim: To compare the effect of procedural anesthesia management with ketofol and propofol on the sonographic optic nerve sheath diameter in the endoscopic retrograde cholangiopancreatography (ERCP) procedures.
- Conditions
- Cholangiopancreatography, Endoscopic Retrograde, Intracranial Pressure, Optic Nerve Sheath Diameter, Ketofol
- Trial name
- NCT04910087
- Testing
- Sonographic optic nerve sheath diameter measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ankara City Hospital Bilkent
Schizophrenia
Comparison of Ketamine Combine Propofol vs Propofol Anesthesia in Schizophrenia Electroconvulsive Therapy
Electroconvulsive therapy (ECT) serves as an effective adjuvant modality for major depressive disorder, schizophrenia, or bipolar affective disorder refractory to or contraindicated to psychopharmacological treatment.
- Trial name
- NCT03829124
- Testing
- Propofol, Ketamine
- Volunteers
- 1 people
- Sponsor
- Chang Gung Memorial Hospital
Hemodynamic Instability
Advanced vs Standard Hemodynamic Monitoring During Propofol Sedation for ERCP: A Prospective Study
The aim of this study is to evaluate whether there is a difference in hemodynamic events requiring intervention between patients monitored with advanced hemodynamic monitoring using the MostCare system and those monitored with…
- Trial name
- NCT07538115
- Testing
- Hemodynamic Monitoring, Standard Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Hitit University
Elderly Patients, Gastrointestinal Endoscopy
A Comparative Study of Rimazolam and Propofol Combined With Etomidate in Gastroenteroscopy in Elderly Patients
Studies have shown that etomidate combined with propofol in gastroscopy has high safety and lower incidence of hypoxia and hypotension, suggesting the advantages of etomidate combined with propofol in elderly patients.
- Conditions
- Elderly Patients, Gastrointestinal Endoscopy, Remimazolam Besylate, Etomidate Combined With Propofol
- Trial name
- NCT05103696
- Testing
- Remimazolam Besylate, etomidate combined with propofol
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University People's Hospital
Pain on Propofol IV Injection
In Children, Does Using a Synera Patch Decrease Pain When Injecting Propofol at Anesthesia Induction?
The purpose of this study is to evaluate if the Synera Patch (lidocaine/tetracaine patch), used to numb the skin before IV placement, is effective in reducing pain associated with propofol IV administration when inducing general…
- Trial name
- Synera patch (NCT01576770)
- Testing
- lidocaine/tetracaine transdermal patch (NDC 43469-864-01), Gebauer's Ethyl Chloride
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center, Houston
General Anesthesia
Influence of Equilibration Rate Constant (ke0) of Propofol on the Effect Site Concentration for Loss of Consciousness
The aim of this study is to validate that an effect compartment concentration for loss of consciousness (LOC) was varied according to different Keo value.
- Trial name
- NCT01091350
- Testing
- Diprifusor (Target-controlled infusion), Orchestra (Target-controlled infusion)
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Colonoscopy
Effects of Intravenous Lidocaine During Sedation for Colonoscopy.
This study assesses the benefits of continuous intravenous lidocaine administration during sedation for colonoscopy. Sedation will consist of propofol infusion titrated to provide adequate working conditions to the…
- Trial name
- NCT02784860
- Testing
- Lidocaine, normal saline
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Liege