Clinical trials: Prospective
Diabetic Macular Edema
A Study to Investigate Aqueous Humor and Multimodal Imaging Biomarkers in Treatment-Naïve Participants With Diabetic Macular Edema Treated With Faricimab
This is an exploratory, prospective, multicenter, open-label, single-arm, interventional, Phase IIb study designed to explore the associations over time between clinical assessments, multimodal imaging assessments, aqueous humor…
- Trial name
- ALTIMETER (NCT04597918)
- Testing
- Faricimab
- Where
- 23 sites in United States, Argentina and 5 more
- Volunteers
- 99 people
- Sponsor
- Hoffmann-La Roche
Myopia, Hyperopia
A Prospective Safety and Effectiveness Study of the 500 Hz Technolas Perfect Vision Excimer Laser Using LASIK
This clinical study has been planned to evaluate the safety and effectiveness of a common treatment algorithms (Proscan) using 500 Hz laser repetition rate.
- Trial name
- NCT02071576
- Testing
- Proscan
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Technolas Perfect Vision GmbH
Myopia
Evaluating the Efficacy and Safety of Contact Lens Lubricant in Rigid Gas Permeable Corneal Contact Lens Wearers
This trial aims to evaluate the safety and effectiveness of LACRIFRESH OCU-DRY 0.3% OSD, a contact lens lubricant produced by AVIZOR, S.A.
- Trial name
- NCT07091825
- Testing
- LACRIFRESH OCU-DRY 0.3% OSD, Rigid contact lens lubricant
- Where
- 3 sites in China
- Volunteers
- 152 people
- Sponsor
- Avizor SA
Autoimmune Diseases
Trial Assessing Safety and Efficacy of Gammanorm® in Autoimmune Diseases
This observational trial assesses the safety and efficacy of Gammanorm® in autoimmune diseases.
- Trial name
- NCT03656640
- Testing
- Gammanorm
- Where
- 3 sites in France, Martinique
- Volunteers
- 60 people
- Sponsor
- Octapharma
Allergy, Insect Venom, Allergy Insect Stinging
Immunotherapy for the Treatment of Hymenoptera Venom Allergy in Real-life Conditions.
Observational clinical follow-up to evaluate the safety of immunotherapy for the treatment of hymenoptera venom allergy in real-life conditions. It includes the evaluation of controlled and spontaneous stings.
- Conditions
- Allergy, Insect Venom, Allergy Insect Stinging, Insect Sting Allergy
- Trial name
- Venox-23 (NCT06790368)
- Testing
- VENOX
- Where
- 3 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Inmunotek S.L.
Hernia, Ventral, Hernia, Inguinal
Ventral or Inguinal Hernia, Robotically Repaired With OviTex Mesh
This study is designed to evaluate the post-operative complications and hernia recurrence following the use of OviTex in subjects with ventral or inguinal hernias.
- Trial name
- BRAVOII (NCT04779918)
- Testing
- OviTex Reinforced Tissue Matrix
- Where
- 10 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Tela Bio Inc
Knee Osteoarthritis
A Study to Evaluate the Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee
This study is being conducted to evaluate the efficacy and safety of ASA compared to placebo in the management of osteoarthritis (OA) symptoms of the knee.
- Trial name
- NCT06000410
- Testing
- Amniotic Suspension Allograft
- Where
- 41 sites in United States
- Volunteers
- 594 people
- Sponsor
- Organogenesis
Advanced Heart Failure
DuoCor 2 DOMINATE Study
Advanced heart failure is a life-threatening condition characterized by the inability of one or both ventricles to maintain adequate blood circulation.
- Trial name
- NCT07233876
- Testing
- DuoCor Ventricular Assist System
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Shenzhen Core Medical Technology CO.,LTD.
Cataract
Laser Treatment of the Crystalline Lens
The use of a femtosecond laser in cataract surgery that gives equivalent or improved results comapred to conventional phaco-emulsification surgery.
- Trial name
- NCT01001117
- Testing
- LensAR laser surgery, Phaco-emulsification cataract surgery
- Where
- Mexico
- Volunteers
- 75 people
- Sponsor
- LensAR Incorporated
Sleep
Eschscholzia Study
This is a clinical study aimed at evaluating the efficacy and safety of Eschscholzia tablets in adults with insomnia disorder symptoms.
- Trial name
- NCT06795776
- Testing
- Eschscholzia tablets
- Where
- Bulgaria
- Volunteers
- 104 people
- Sponsor
- A. Vogel AG
Diabetic Foot Ulcer
A Study to Evaluate the Efficacy of a Purified Native Type 1 Collagen Extracellular Matrix With Polyhexamethylene Biguanide Antimicrobial (PCMP) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers
This prospective, multi-center, randomized, controlled modified platform Trial compares Purified Native Type 1 Collagen Extracellular Matrix with Polyhexamethylene Biguanide Antimicrobial (PCMP) and Standard of Care versus…
- Trial name
- PREPARE (NCT06618612)
- Testing
- Standard of Care, PuraPly AM, PuraPly XT
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Organogenesis
Tendon Injuries- Subscapularis
Embody Post-Market Clinical Follow-Up Study
A multi-center, prospective post-market clinical follow-up study: subscapularis repair augmented with Tapestry Biointegrative Implant after shoulder arthroplasty.
- Trial name
- RAISE (NCT05735119)
- Testing
- Tapestry Biointegrative Implant
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Zimmer Biomet
Dyspepsia
Preliminarily Evaluate the Efficacy of Domperidone in Adult Chinese Participants With Functional Dyspepsia
The main purpose of the study is to assess the efficacy of domperidone in treatment of functional dyspepsia (FD) in Chinese participants and identify sub-populations (subtype of the disease) who are sensitive to domperidone…
- Trial name
- NCT03617016
- Testing
- Domperidone
- Where
- 5 sites in China
- Volunteers
- 160 people
- Sponsor
- Xian-Janssen Pharmaceutical Ltd.
Non-inflammatory Degenerative Joint Disease
A Trial Evaluating TKR Compared to BKR Performed Using Stryker's Mako Robot
A prospective, randomised controlled trial evaluating Total Knee Replacement with the Stryker Triathlon Primary Total Knee System, compared to Bicompartmental Knee Replacement with Restoris MCK Multicompartmental Knee System…
- Trial name
- NCT02650284
- Testing
- Stryker Triathlon Primary Total Knee System, Restoris MCK Multicompartmental Knee System
- Where
- Australia
- Volunteers
- 18 people
- Sponsor
- Stryker South Pacific
Lupus Erythematosus, Cutaneous, Lupus Erythematosus, Systemic
A Study of Skin and Systemic Biomarkers In Patients With Active Cutaneous Lupus Erythematosus And In Healthy Volunteers
The purpose of this study is to obtain skin, blood, and urine samples from patients with active cutaneous lupus lesions and from healthy participants.
- Conditions
- Lupus Erythematosus, Cutaneous, Lupus Erythematosus, Systemic, Lupus Erythematosus, Discoid, Healthy
- Trial name
- NCT02034344
- Testing
- Skin biopsy, Blood collection, Urine collection
- Where
- 21 sites in United States, Germany and 4 more
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Focal Onset Seizure, Focal Onset Epilepsy
Extension Study to Evaluate the Safety and Tolerability of NBI-921352 When Used With Anti-seizure Medications in Adults With Focal Onset Seizures
This Phase 2, prospective, interventional, active extension study was designed to evaluate the long-term safety and tolerability of NBI-921352 as adjunctive therapy in adult participants with focal onset seizures who completed 11…
- Trial name
- NCT05493293
- Testing
- NBI-921352
- Where
- 26 sites in Australia, Belgium and 5 more
- Volunteers
- 82 people
- Sponsor
- Neurocrine Biosciences
Aneuploidy, Chromosome Abnormality
Multi-center Study to Validate niPGT-A
Abnormal chromosome number, or aneuploidy, is common in human embryos. It is responsible for more than half of all miscarriages, and it is the leading cause of congenital birth defects.
- Conditions
- Aneuploidy, Chromosome Abnormality, Infertility
- Trial name
- niPGT-A (NCT03520933)
- Testing
- PGT-A, niPGT-A
- Where
- 10 sites in United States, Argentina and 6 more
- Volunteers
- 2,586 people
- Sponsor
- Igenomix
Obstructive Sleep Apnea
Study of a Sleep Apnea System for the Treatment of Obstructive Sleep Apnea
This is a prospective study of the Attune Sleep Apnea System for the treatment of obstructive sleep apnea. The objective of the study is to demonstrate safety and effectiveness of the Attune Sleep Apnea System to support FDA…
- Trial name
- ATLAST (NCT01146782)
- Testing
- Attune Sleep Apnea System
- Where
- 6 sites in United States
- Volunteers
- 367 people
- Sponsor
- ApniCure, Inc.
Lateral Periorbital Wrinkles
Efficacy and Safety of NT 201 in the Treatment of Lateral Periorbital Wrinkles
To investigate the efficacy and safety of incobotulinumtoxinA (Xeomin) in comparison to placebo in the treatment of moderate to severe lateral periorbital wrinkles at maximum smile and to compare two different application schemes…
- Trial name
- NCT00541723
- Testing
- IncobotulinumtoxinA (Xeomin)
- Where
- 12 sites in France, Germany and 2 more
- Volunteers
- 111 people
- Sponsor
- Merz Pharmaceuticals GmbH
Vital Sign Evaluation
A Multi-Center Prospective Open Label Study of a Web-based Application for Pulse Rate in Adult Patients
Evaluating the Accuracy of a Web-Based Application - Vital Sign Measurement Platform Description This single-arm cohort, open-label, and multi-center study is designed to evaluate the accuracy of a web-based application designed…
- Trial name
- NCT05853380
- Testing
- Informed Vital Core App
- Where
- 6 sites in United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Mindset Medical