Clinical trials: Prostaglandin E2
Reducing Time to Vaginal Delivery, Cervical Ripening
Efficacy & Safety Study Comparing Misoprostol Vaginal Insert (MVI) Versus Dinoprostone Vaginal Insert (DVI) for Reducing Time to Vaginal Delivery
The purpose of this study is to determine whether the Misoprostol Vaginal Insert (MVI) 200 microgram (mcg) can decrease the time to vaginal delivery compared to the Dinoprostone Vaginal Insert (DVI) 10 milligram (mg) in pregnant…
- Conditions
- Reducing Time to Vaginal Delivery, Cervical Ripening, Induction of Labor
- Trial name
- EXPEDITE (NCT01127581)
- Testing
- MVI 200, Dinoprostone Vaginal Insert (DVI)
- Where
- 34 sites in United States
- Volunteers
- 1,358 people
- Sponsor
- Ferring Pharmaceuticals
Neonatal Prematurity, Patent Ductus Arteriosus in Preterm Infants
Relation Between Prostaglandin E2 Metabolite Levels and the Development of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Neonates
prospective observational cohort study to explore the relationship between PGE2 metabolite levels and the development of hemodynamically significant PDA in preterm neonates.
- Conditions
- Neonatal Prematurity, Patent Ductus Arteriosus in Preterm Infants, Prostaglandins
- Trial name
- NCT07338370
- Testing
- Ibuprofen (Brufen®)
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Ain Shams University
Vitamin D Deficiency, Chronic Pain Syndrome
The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain
Vitamin D3 is produced in the skin following exposure to UVB light from the sun or artificial sources, and occurs naturally in a small range of foods.More recently, several reports underlined the impact of vitamin D on the…
- Conditions
- Vitamin D Deficiency, Chronic Pain Syndrome, Inflammatory Response
- Trial name
- NCT01417923
- Testing
- vitamin D
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Meir Medical Center
Cataract
Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients: Trough Drug Effects
The purpose of this study is to compare the ability of two different topical NSAIDs (non-steroidal anti-inflammatory medications used for pain relief) to reach the back of the eye and to stop inflammation.
- Trial name
- NCT00469690
- Testing
- Acular, Xibrom
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Innovative Medical
Office Hysteroscopy
Vaginal Dinoprostone Prior to Diagnostic Office Hysteroscopy in Postmenopausal Patients
To compare the effectiveness of vaginal dinoprostone with placebo in minimising the pain experienced by postmenopausal patients during diagnostic office hysteroscopy and to assess the ease of insertion of hysteroscope as reported…
- Trial name
- NCT03683914
- Testing
- Dinoprostone 3Mg Vaginal Tablet
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Cairo University
Crohn's Disease
Urinary Prostaglandin E Metabolite (PGE-M), A Metabolite of Prostaglandin E2 (PGE2): A Novel Biomarker of Crohn's Disease Activity
The purpose of this study is to determine whether urinary PGE-M levels correlate with Crohn's disease activity and to compare how well urinary PGE-M correlates with other non-invasive biomarkers of disease activity such as…
- Trial name
- NCT00496548
- Testing
- Fecal calprotectin, Urinary PGE-M Level
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Vanderbilt University Medical Center
Missed Abortion, Medical; Abortion, Fetus
Gemeprost Versus Dinoprostone in First Trimester Miscarriages
Comparison between gemeprost and dinoprostone to evacuate first trimester miscarriages.
- Conditions
- Missed Abortion, Medical; Abortion, Fetus, Incomplete Abortion
- Trial name
- NCT05342467
- Testing
- Gemeprost 1 Mg Vaginal Pessary, Dinoprostone 3 mg
- Where
- 2 sites in Malaysia
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Labour Induction
Oral Misoprostol Versus Vaginal Dinoprostone For Induction Of Labour: A Randomized Controlled Clinical Trial
This study is to compare between oral misoprostol in solution and vaginal dinoprostone in induction of labour in primiparous women with singleton pregnancy as regards efficiency and safety to both mother and fetus.
- Trial name
- NCT02168881
- Testing
- Misoprostol, Dinoprostone
- Where
- Egypt
- Volunteers
- 342 people
- Sponsor
- Ain Shams University
Hysteroscopy
Vaginal Dinoprostone Prior to Diagnostic Office Hysteroscopy in Primarily Infertile Patients
To compare the effectiveness of vaginal dinoprostone with placebo in minimizing the pain experienced by primarily infertile patients during diagnostic office hysteroscopy and to assess the ease of insertion of hysteroscope as…
- Trial name
- NCT04042974
- Testing
- vaginal dinoprostone
- Volunteers
- 100 people
- Sponsor
- Cairo University
Cervical Ripening
Intravaginal Misoprostol Versus Dinoprostone Before Diagnostik Hysteroscopy
Comparison of intravaginal misoprostol and dinoprostol for the purpose of cervical ripening before diagnostic hysteroscopy in the women at the reproductive age:RANDOMİSED,CONTROLLED PROSPECTİVE TRİAL Objective.
- Trial name
- NCT01620814
- Testing
- Dinoprostone, misoprostol, control
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
IUD Insertion Pain
Dinoprostone vs Misoprostol Before LNG-IUD Insertion
the aim of this study is to compare the safety and efficacy of vaginal dinoprostone vs vaginal misoprostol administration prior to IUD insertion in multiparous women regarding reduction in iud insertion pain
- Trial name
- NCT04301349
- Testing
- vaginal dinoprostone, vaginal misoprostol
- Volunteers
- 200 people
- Sponsor
- Cairo University
GYN Disorders
Cervical Preparation in Hysteroscopy
The hysteroscopy was performed in the proliferativephase of the menstrual cycle. The patients were given generalintravenous anesthesia (propofol/fentanyl) after the vulvar and the vaginal area had been disinfected with a 7.5%…
- Trial name
- NCT03675802
- Testing
- misoprostol, dinoprostone
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Contraception
Comparative Efficacy of Lidocaine Spray Versus Vaginal Dinoprostone in IUD Insertion
the aim of this study is to compare the safety and Efficacy of Lidocaine Spray Versus Vaginal dinoprostone in relieving pain during levonorgestrel IUD Insertion in nulliparous women
- Trial name
- NCT04339361
- Testing
- lidocaine spray, vaginal dinoprostone
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Cairo University
Myoma;Uterus
Preoperative Vaginal Dinoprostone Versus Misoprostone in Abdominal Myomectomy
Aim and objectives; To compare the efficacy of preoperative administration of dinoprostone 20 mg versus 400 ug misoprostol vaginally in decreasing the amount of bleeding during abdominal myomectomy
- Trial name
- NCT05761418
- Testing
- Dinoprostone, Misoprostol
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Pregnancy
Labour Induction With Misoprostol, Dinoprostone and Bard Catheter
This is a randomised study aimed at comparing the currently most frequently used prostaglandin dinoprostone to two other methods, the cheaper and perhaps more effective prostaglandin misoprostol and a transcervical catheter.
- Trial name
- LI (NCT00602095)
- Testing
- misoprostol, dinoprostone, Bard Catheter (balloon catheter)
- Volunteers
- 592 people
- Sponsor
- Karolinska University Hospital
Early Amniotomy, Unfavorable Cervix
Early Amniotomy After Vaginal Prostaglandin E2 for Induction of Labor at Term: a Randomized Clinical Trial
This study evaluates the effectiveness and safety of early amniotomy after vaginal prostaglandin E2 for induction of labor at term.
- Trial name
- PGE2 (NCT02856724)
- Testing
- PGE2
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Labor Induction
Foley Catheter Versus Cervidil for Induction of Labor at Term
OBJECTIVE: To assess the efficacy of transcervical Foley catheter compared to controlled release prostaglandin (Cervidil™) for cervical ripening in term and near term women presenting for labor induction.
- Trial name
- NCT01402050
- Testing
- CERVIDIL (Dinoprostone), FOLEY BALLOON
- Where
- 2 sites in United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- Pediatrix
Barrett's Esophagus
Barrett's Esophagus - 315 - 3 Way Cross Over
This study evaluates PGE2 production, COX-2 enzyme activity and PCNA expression in Barrett's metaplastic tissue. All patients will have a baseline endoscopy with multiple biopsies.
- Trial name
- NCT00637988
- Testing
- Esomeprazole, Aspirin, Rofecoxib
- Volunteers
- 32 people
- Sponsor
- AstraZeneca
IUD Insertion
Vaginal Dinoprostone Administration Prior to an Intrauterine Device Insertion in Multiparous Women.
To investigate whether vaginal dinoprostone administered before intrauterine device (IUD) insertion reduces failed insertions, insertion-related complications, and pain in multiparous women.
- Trial name
- NCT04046302
- Testing
- Dinoprostone
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Cairo University
Induction of Labor
Labor Induction With Dinoprostone in Oppose to Cervical Ripening Balloon as a Factor of BMI.
Women with a BMI>30 and women with a BMI<30 will be divided in a randomized controlled manor to 4 groups depending on the mode of labor induction and BMI value: 1. Dinoprostone in women with a BMI>30. 2.
- Trial name
- NCT03033264
- Testing
- Dinoprostone, Double lumen cervical ripening balloon.
- Where
- Israel
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus