Clinical trials: Prostaglandin E2
Labor Induction, Induced Delivery
Foley Catheter Versus PGE2 for Labor Induction at Term: a Pilot Study
Induction of labor is one of the most common interventions in obstetrics. In the past decade, the rates of labor induction at term have doubled from approximately 9% to 23% in the United States and from 10% to 20.4% in China.
- Trial name
- NCT04780269
- Testing
- Induction of labor with Foley catheter, Induction of labor with PGE2
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Failed Medical or Unspecified Induction of Labor
Comparing Cervical Foley Catheter, Dinoprostone and a Combination of the Two for Labor Induction
The investigators intend to conduct a randomized clinical trial comparing 3 methods of induction of labor in term primiparous women with singleton.
- Trial name
- Induction (NCT02815865)
- Testing
- Foley catheter and pitocin, Foley catheter and Dinoprostone, Dinoprostone
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
Eczema
PGE2/IL-22 Pathway in Various Forms of Eczema
Objectives: Eczema is a chronic inflammatory skin condition characterised immunologically by T cellmediated inflammation. The pathogenic mechanisms involved in its development are incompletely understood and targeted treatment…
- Trial name
- NCT04133506
- Testing
- Aspirin 300mg
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Ulcerative Colitis
Therapeutic Study of ONO-4819CD for Ulcerative Colitis
The purpose of this study is to investigate whether ONO-4819CD is safe and effective in the treatment of mild to moderate ulcerative colitis.
- Trial name
- NCT00296556
- Testing
- Rivenprost (drug)
- Where
- Japan
- Volunteers
- 7 people
- Sponsor
- Kyoto University, Graduate School of Medicine
Cervical Ripening, Labor, Induced
Cervical Ripening Before Induction of Labour at Term: a Randomised Comparison of Prostin vs Propess
The aim of this study is to compare two different preparation
- Trial name
- NCT00545194
- Testing
- Prostaglandin E2
- Where
- France
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Preeclampsia, Fetal Death
Comparing the Effect of Vaginal Misoprostol With Dinoprostone in Term Pregnancies
Hypothesis (H0): Labor duration and obstetric complications are not significantly different in the three groups (misoprostol-dinoprostone-oxytocin).
- Conditions
- Preeclampsia, Fetal Death, Fetal Membranes, Premature Rupture
- Trial name
- NCT00432588
- Testing
- misoprostol, dinoprostone
- Where
- Iran
- Sponsor
- Hormozgan University of Medical Sciences
Failed Induction of Labor
Concurrent Oxytocin With Membrane Sweeping Versus Dinoprostone Pessary in Labor Induction of Multiparous Women at Term
The purpose of this study is to compare concurrent oxytocin with membrane sweeping versus dinoprostone pessary in labor induction for multiparas at term with an unfavorable cervix.
- Trial name
- NCT02618096
- Testing
- Oxytocin, Dinoprostone, Membrane sweeping
- Where
- South Korea
- Volunteers
- 154 people
- Sponsor
- Seoul National University Hospital
Delivery
Comparing the Efficiency of Cervical Ripening BALLoon (Cook) to the DINOprostone (Propess) for the Cervical Maturation in Case of Unfavorable Cervix (Bishop <6) in the Population of Obese Pregnant Women (BMI >= 30 kg/m²)
At the moment in France, one delivery on four is induced for a medical indication. In this context, the practitioners are exposed to an additional difficulty when the clinical examination of the patient reveals a unfavorable…
- Trial name
- BALLODINO (NCT02649920)
- Testing
- Cervical ripening balloon, Dinoprostone
- Where
- 2 sites in France
- Volunteers
- 2 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Premature Rupture of Membranes at Term
Comparison of Misoprostol and PGE2 Gel for Induction of Labour in Women With Premature Rupture of Membranes at Term
Induction of labour with vaginal misoprostol, in women with premature rupture of membranes at term, results in significant shortening of induction to delivery time in comparison to vaginal PGE2 gel induction.
- Trial name
- NCT00355966
- Testing
- Misoprostol, PGE2 gel
- Where
- India
- Volunteers
- 212 people
- Sponsor
- Nilratan Sircar Medical College
Headache, Migraine
Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2
Before, during and after intravenous administration of PGE2 we score/measure headache, rCBF, blood flow in the middle cerebral artery and diameter of superficial temporal artery and correlate that to known pathophysiology of…
- Trial name
- NCT00374530
- Testing
- PGE2
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Periodontal Diseases, Smoking Cessation
Effect of Smoking Cessation on Salivary IL-1β and PGE-2 Levels Following Non-Surgical Periodontal Therapy
The aim of this study is to evaluate the effect of smoking cessation on inflammatory markers following non-surgical treatment of periodontal disease.
- Trial name
- NCT06145685
- Testing
- Minimally invasive non-surgical periodontal therapy, Conventional non-surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- October 6 University
Ovulation (Follicular Rupture Yes/no), Menstrual Cycles (Total Length, Bleeding Days)
The Effects of a Prostaglandin Inhibitor on Ovulation and the Menstrual Cycle
The investigators propose to test the hypothesis that the use of a prostaglandin inhibitor will result in premature luteolysis (ovulation failure) in women.
- Conditions
- Ovulation (Follicular Rupture Yes/no), Menstrual Cycles (Total Length, Bleeding Days), Gonadotropin and Ovarian Hormone Levels (FSH, LH, E2, P)
- Trial name
- NCT00614406
- Testing
- Celebrex
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Intrauterine Device
Vaginal Dinoprostone Administration Prior to Insertion Levonorgestrel-releasing Intrauterine System in Women With no Previous Vaginal Delivery
To investigate whether vaginal dinoprostone administered before the levonorgestrel-releasing intrauterine system(IUs) insertion reduces failed insertions, insertion-related complications, and pain in Women With no Previous…
- Trial name
- NCT04045548
- Testing
- Dinoprostone
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Cairo University
Inflammatory Disorder of the Cardiovascular System
Polyphenols Supplementation on Prostaglandin E2 in Women - Randomized Clinical Trial
The aim of this study was to evaluate the effect of polyphenol supplementation on plasma levels of prostaglandin E2 in women during the reproductive period.
- Trial name
- NCT02567617
- Testing
- Polyphenols
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Age Related Cataracts
Changes in Prostaglandin Levels in Laser Cataract Surgery (LCS) Subject to Laser Prevalence
The investigational device is an approved femtosecond laser (FSL) device with an integrated imaging system to perform certain steps of the cataract procedure.
- Trial name
- Femto-PG (NCT03390400)
- Testing
- Femtosecondlaser-assisted, Anterior Capsulotomy, Lens Fragmentation
- Where
- Austria
- Volunteers
- 70 people
- Sponsor
- Rupert Menapace
"Migraine-like" Headache
Prostaglandin E2 in Migraine Suffers Without Aura.
The hypothesis of this study is that Prostaglandin E2 (PGE2) induces headache and dilatation of brain vessels in migraine patients without aura.
- Trial name
- NCT01384812
- Testing
- dinoprostone, isoton sodium chloride
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Troels Wienecke
Pain, Acupuncture
Effect of Acupuncture on Nausea, Vomiting, Pain, PGE2 and IL 6 in Septorhinoplasty
Acupuncture has emerged in China about 2,000 years ago and is one of the oldest medical procedures in the world.Later acupuncture was introduced to other regions such as Asia, Europe and the United States.The most extensive use…
- Trial name
- NCT04009070
- Testing
- Acupuncture Pres Needle: 0.22x1.5 mm needle
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Pregnancy Complications
Increase of Prostaglandin E2 in Reversal of Ductal Constriction After Dietary Restriction of Polyphenols
INCREASE OF PROSTAGLANDIN E2 IN REVERSAL OF DUCTAL CONSTRICTION AFTER DIETARY RESTRICTION OF POLYPHENOLS. Clinical trial with a healthy group as comparator.
- Trial name
- NCT03111602
- Testing
- restrict polyphenol-rich foods
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Anterior Teeth Alignment Efficiency, Pain Perception
Comparison of Conventional and Cu-NiTi Archwires Regarding Clinical Efficiency and Pain Intensity Using Prostaglandin E2 Biomarker During Alignment and Leveling
Orthodontic treatment can inflame the periodontium and dental pulp, it can be uncomfortable and even painful at times. This may induce discomfort and the release of different biochemical mediators, which is one of the main causes…
- Conditions
- Anterior Teeth Alignment Efficiency, Pain Perception, PGE2 Biomarker and Their Correlation
- Trial name
- NCT06653881
- Testing
- ARCHWIRE
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Induction of Labour, Labour, Induced
Misoprostol Labour Induction Study
Labour induction is a frequent obstetric intervention (~20%). Prostaglandins (PGs) are effective agents, but gastrointestinal (GI) intolerance has limited use to non-oral routes.
- Trial name
- NCT03489928
- Testing
- Oral Misoprostol, Vaginal Misoprostol, Dinoprostone
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- David Young