Clinical trials: Prostaglandin E2
Colon Cancer
Healthy Eating for Colon Cancer Prevention
The purpose of this study is to help develop diets for colon cancer prevention. This study will compare the Mediterranean diet to the Healthy People 2010 diet in 120 subjects with increased risk for colorectal cancer.
- Trial name
- NCT00475722
- Testing
- 1 Healthy Eating, 2 Mediterranean
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Apical Periodontitis
Sclerostin Regulation in Apical Periodontitis Lesions in Apical Periodontitis Lesions
Our aim was to examine the relationship between inflammatory bone resorption associated with the severity of AP and gingival crevicular fluid (GCF) and blood sclerostin and PGE2 levels in cases of AP.
- Trial name
- NCT06512103
- Testing
- Apical periodontitis group
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Overactive Bladder
Urinary Nerve Growth Factor (NGF), Prostaglandin E2 (PGE2)and Adenosine Triphosphate (ATP): Potential Biomarkers in Overactive Bladder Patients
Nerve growth factor (NGF), prostaglandin E2 (PGE2)and adenosine triphosphate (ATP) levels in urine were reported to increase in patients with overactive bladder (OAB).
- Trial name
- NCT01499069
- Testing
- Oxybutinin, Fesoterodine, Solifenacin, Propiverin, Trospium
- Where
- South Korea
- Volunteers
- 191 people
- Sponsor
- Samsung Medical Center
Induction of Labor Affected Fetus / Newborn, Obese
Modality of Induction of Labor in Obese Women at Term (MODOBAT)
In normal-weight patients, numerous studies show an equivalence of efficacy between dinoprostone and balloon to induce labor. In obese patients, this efficacy is not known, although inductions of labor are more frequent.
- Trial name
- MODOBAT (NCT04299854)
- Testing
- Dinoprostone 10mg, single balloon Foley catheter
- Where
- 2 sites in France
- Volunteers
- 77 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Asymptomatic Apical Periodontitis, Endodontic Retreatment
Cryotherapy, PGE2, NGF Levels and Pain After Endodontic Retreatment
This prospective, randomized, controlled, single-blind, parallel-group clinical trial evaluates whether intracanal cryotherapy reduces postoperative pain and inflammatory biomarker levels following single-visit endodontic…
- Conditions
- Asymptomatic Apical Periodontitis, Endodontic Retreatment, Cryotherapy
- Trial name
- ICE-PAIN (NCT07733700)
- Testing
- Intracanal cryotherapy, Room-temperature saline irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Alanya Alaaddin Keykubat University
IUD Insertion Complication
Comparison of Vaginal Misoprostol and Dinoprostone Prior to Copper Intrauterine Device Insertion in Nulliparous Women
To compare the effect of vaginal dinoprostone versus vaginal misoprostol administered before the copper intrauterine device(IUD) insertion in reducing IUD inertion pain and the difficulty in inserting the IUD in nulliparous women.
- Trial name
- NCT04080336
- Testing
- Dinoprostone, Misoprostol
- Where
- Egypt
- Volunteers
- 129 people
- Sponsor
- Cairo University
Fetal Growth Retardation
Cook´s Balloon Versus Dinoprostone for Labor Induction of Term Pregnancies With Fetal Growth Restriction
The goal of this clinical trial is to compare how two methods for cervical ripening work in a population of singleton pregnancies with late-onset fetal growth restriction (FGR) at term.
- Trial name
- COLIGROW (NCT05774236)
- Testing
- Cook´s balloon, Vaginal dinoprostone
- Where
- 5 sites in Spain
- Volunteers
- 172 people
- Sponsor
- Hospital Universitario 12 de Octubre
Cervical Ripening, Induction of Labor
Efficacy of Induction of Labor on Term Using a Double Balloon Catheter Compared to Dinoprostone Vaginal-insert
The purpose of the study is to determine the efficacy of a silicone-double-balloon-catheter for cervical ripening and labor induction in women with unfavorable cervix (Bishop Score not greater than 6) compared to medical…
- Trial name
- NCT01720394
- Testing
- Cervical Ripening Balloon, Cook Medical Inc., Dinoprostone
- Where
- 7 sites in Austria
- Volunteers
- 253 people
- Sponsor
- Medical University of Graz
Premature Rupture of Membranes at Term
Comparison of Misoprostol and Prostaglandin E2 (PGE2) Gel for Induction of Labour in Premature Rupture of Membranes at Term
The purpose of this study is to determine whether induction of labor with vaginal misoprostol application will result in fewer cesarean deliveries than vaginal PGE2 gel application in women with premature rupture of membranes at…
- Trial name
- NCT00355303
- Testing
- Misoprostol, PGE2 gel
- Where
- India
- Volunteers
- 932 people
- Sponsor
- Nilratan Sircar Medical College
Induction of Labor Affected Fetus / Newborn
A Trial of Cervidil for Outpatient Pre-induction of Cervical Ripening
Induction of labor is a frequently planned obstetric procedure. Induction for women with an unfavorable cervix (bishop score <6) increases the risk of cesarean section.
- Trial name
- NCT03806231
- Testing
- Outpatient Dinoprostone 10mg, Inpatient Dinoprostone 10 mg
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.
Contraception
Comparative Safety and Efficacy of Vaginal Dinoprostone Versus Lidocaine-prilocaine Cream in Copper IUD Insertion
the aim of the present study is to Compare Safety and Efficacy of Vaginal dinoprostone Versus Lidocaine-prilocaine Cream in copper IUD Insertion in nulliparous women: a randomized controlled trial
- Trial name
- NCT04340778
- Testing
- vaginal dinoprostone, Lidocaine-prilocaine Cream
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Cairo University
Non-Hodgkin's Lymphoma (NHL), Hodgkin's Disease
Single Treatment With FT1050 of an Ex-vivo Modulated Umbilical Cord Blood Unit
This trial is a prospective, open-label, single-arm trial of the safety of a single FT1050-treated CB unit for hematopoietic reconstitution after a reduced-intensity conditioning regimen for hematologic malignancies.
- Conditions
- Non-Hodgkin's Lymphoma (NHL), Hodgkin's Disease, Chronic Lymphocytic Leukemia (CLL), Acute Myelogenous Leukemia (AML)
- Trial name
- NCT01527838
- Testing
- Single FT1050 treated UCB unit
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- Fate Therapeutics
Orthodontic Tooth Movement, Tooth Movement
Evaluation of the Biomechanical Response of Orthodontic Tooth Movement to Clear Aligner vs Fixed Orthodontic Appliance
Abstract Background: Orthodontic tooth movement (OTM) is mediated by biologic responses of the periodontal ligament (PDL) and alveolar bone to applied mechanical forces, involving release of inflammatory mediators such as…
- Trial name
- NCT07399483
- Testing
- diagnostic Test: Collection of GCF: from the gingival sulcus using paper point ,Tooth Mobility via Periotest ,3D Digital Model Superimposition using Intraoral Scanning
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Mansoura University
Cataracts
A Comparison of Prostaglandin E2 (PGE2) Inhibition of Acuvail(Ketorolac 0.45%), Xibrom (Bromfenac 0.09%)and Nevanac (Nepafenac)in Patients Undergoing Phacoemulsification
Approximately 126 subjects scheduled to undergo cataract surgery by phacoemulsification, will be randomized in an even allocation (1:1:1) to either Acuvail, Xibrom or Nevanac.
- Trial name
- NCT01021761
- Testing
- Ketorolac Tromethamine, Bromfenac, nepafenac
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Frank A. Bucci, Jr., M.D.
Cataract
Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients
Evaluation of the aqueous concentrations of 2 topical NSAIDS as well as the PGE2 inhibition in human patients.
- Trial name
- NCT00347503
- Testing
- ketorolac 0.4%, bromfenac 0.09%
- Where
- United States
- Sponsor
- Innovative Medical
Induction of Labor, Vaginal Delivery
Efficacy and Safety of Oral Misoprostol 25 μg vs. Vaginal Dinoprostone in Induction of Labor at Term
Labor induction is a common medical technique. There is no consensus on which technique is better than the others. Misoprostol is an analogue of Prostaglandin E1 previously used off-label in labor induction.
- Conditions
- Induction of Labor, Vaginal Delivery, Cesarean Section
- Trial name
- MISODINO (NCT04955847)
- Where
- France
- Volunteers
- 706 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Obesity, Pregnancy
Randomized Controlled Trial: Induction of Labour of Obese Women With Dinoprostone or Single Balloon Catheter
The purpose of this study is to compare the efficacy of single balloon foley catheters to dinoprostone for the induction of labour of obese women.
- Conditions
- Obesity, Pregnancy, Labor, Induced
- Trial name
- NCT01962831
- Testing
- Dinoprostone, Single balloon foley catheter
- Where
- Canada
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area
Premature Newborns, Premature Newborns With Gestational Age 28 to 33 Weeks
Role of Interleukin-1β and Prostaglandin E2 in Prediction and Outcome of Apnea in Neonates
Our thesis proposed that IL-1β may affect brainstem respiratory control via prostaglandin-dependant mechanism so we investigated the mediator roles of IL-1β and PGE2 levels in predicting apnea in pretertm newborn and their…
- Trial name
- NCT06827197
- Testing
- Blood test
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Labor Induction
Dinoprostone Vaginal Insert Versus Double Balloon Catheter for Preinduction Cervical Ripening
Effıcacy of dinoprostone vaginal insert versus double- balloon catheter among women in the induction of labor
- Trial name
- NCT03016442
- Testing
- Cook Double Balloon Catheter, Dinoprostone
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Induction of Labor
Safety and Efficacy of Dinoprostone (Propess) in the Women With Premature Rupture of Membrane or Gestational Age <38
Dinoprostone(propess) is commonly used for induction of labor in the pregnant women who has intact membrane after 38weeks of gestational age.
- Trial name
- NCT01916291
- Testing
- Propess insertion group
- Where
- 2 sites in South Korea
- Volunteers
- 189 people
- Sponsor
- Seoul National University Hospital