Clinical trials: Prostaglandins
Open-Angle Glaucoma
Influence of Prostaglandins on Ocular Blood Flow in Glaucoma Patients
Vasoactivity of topical drugs may be of prognostic relevance in glaucoma. There is very little information for a major class, the prostaglandin analogues with regard to this aspect.
- Trial name
- NCT00308945
- Testing
- travoprost 0.004% (drug), latanoprost 0.005% (drug)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Basel, Switzerland
Malposition of the Lower Lid
Expression and Localization of FP Prostaglandin Receptor in Human Ocular Tissues
to approve the expression of PGF2α receptors in hair follicle in ocular skin tissue, explaining the hypertrichotic effect of PG analogues as intraocular pressure lowering treatment.
- Trial name
- NCT01054157
- Volunteers
- 50 people
- Sponsor
- Meir Medical Center
Frostbite
Epoprostenol Plus Conventional Therapy in COld and Frostbite Injury (ECCO)
Severe frostbite injury can result in significant lifelong disability and amputation. Various medicines, including intravenous vasodilators (prostaglandins/iloprost, pentoxifylline, buflomedil) along with thrombolytics…
- Trial name
- ECCO (NCT07424378)
- Testing
- Standard of care plus Epoprostenol infusion for 8 hours (hrs) per day up to 5 days maximum
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of Colorado, Denver
Induction of Labor
Methods of Labor Induction and Perinatal Outcomes
Since it is a frequent intervention in Obstetrics, labor induction is rarely evaluated from national population-based cohorts. The study aims to assess the frequency of different induction methods used in France from a…
- Trial name
- MEDIP (NCT02477085)
- Testing
- all women with an induced labor
- Where
- France
- Volunteers
- 3,049 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Abortion Early
Mid Trimester Abortion Effectiveness by Dilapan s
This study is done aiming to find out an effective method to induce second trimester abortion within a reasonable time and with the least possible cost and complications.
- Trial name
- NCT05147857
- Testing
- Dilapan s, Misoprostol
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Pregnancy, Premature Rupture of Membranes
Cervical Ripening in Premature Rupture of Membranes
Premature rupture of membranes (PROM) is diagnosed by demonstrating amniotic fluid in the vaginal canal before the onset of labor.
- Conditions
- Pregnancy, Premature Rupture of Membranes, Preterm Premature Rupture of Membranes, Unfavorable Cervix
- Trial name
- NCT02314728
- Testing
- Misoprostol, Oxytocin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Open-angle Glaucoma
Safety and Tolerability of a Prostaglandin Ocular Implant for Treatment of Open Angle Glaucoma
A single centre, open label, study to assess the safety, tolerability and biodegradation of PA5108 ocular implant in adults who have Open Angle Glaucoma (Primary or Secondary).
- Trial name
- NCT03604328
- Testing
- PA5108
- Where
- 2 sites in Australia
- Volunteers
- 8 people
- Sponsor
- PolyActiva Pty Ltd
Normal Tension Glaucoma, Primary Open-angle Glaucoma
Study in Prostaglandin Associated Peri-orbitopathy Switching From Prostaglandin Monotherapy to Omidenepag Isopropyl
This study is for patients have been using prostaglandin analogue eye drops with a preservative for 3 months or more and have been diagnosed with prostaglandin-associated peri-orbital disease.
- Conditions
- Normal Tension Glaucoma, Primary Open-angle Glaucoma, Glaucoma, Suspect, Ocular Hypertension
- Trial name
- NOPAPS (NCT05279716)
- Testing
- Eybelis ophthalmic solution 0.002%
- Where
- 8 sites in South Korea
- Volunteers
- 150 people
- Sponsor
- Santen Pharmaceutical Asia Pte. Ltd.
Age Related Cataracts
Changes in Prostaglandin Levels in Laser Cataract Surgery (LCS) Subject to Laser Prevalence
The investigational device is an approved femtosecond laser (FSL) device with an integrated imaging system to perform certain steps of the cataract procedure.
- Trial name
- Femto-PG (NCT03390400)
- Testing
- Femtosecondlaser-assisted, Anterior Capsulotomy, Lens Fragmentation
- Where
- Austria
- Volunteers
- 70 people
- Sponsor
- Rupert Menapace
Periodontal Diseases, Smoking Cessation
Effect of Smoking Cessation on Salivary IL-1β and PGE-2 Levels Following Non-Surgical Periodontal Therapy
The aim of this study is to evaluate the effect of smoking cessation on inflammatory markers following non-surgical treatment of periodontal disease.
- Trial name
- NCT06145685
- Testing
- Minimally invasive non-surgical periodontal therapy, Conventional non-surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- October 6 University
Pregnancy Complications
Increase of Prostaglandin E2 in Reversal of Ductal Constriction After Dietary Restriction of Polyphenols
INCREASE OF PROSTAGLANDIN E2 IN REVERSAL OF DUCTAL CONSTRICTION AFTER DIETARY RESTRICTION OF POLYPHENOLS. Clinical trial with a healthy group as comparator.
- Trial name
- NCT03111602
- Testing
- restrict polyphenol-rich foods
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
POAG, Primary Open Angle Glaucoma
A Comparison of Xalatan (Latanoprost) to Apo-latanoprost and Co-latanoprost in the Treatment of Glaucoma
The purpose of the study is to provide evidence that the efficacy of Xalatan will be superior to Apo-latanoprost and Co-latanoprost in the reduction of intraocular pressure in patients with primary open angle glaucoma.
- Conditions
- POAG, Primary Open Angle Glaucoma, Ocular Hypertension
- Trial name
- NCT02792803
- Testing
- Xalatan, Apo-Latanoprost, Co-Latanoprost
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dr. David Yan
Cataracts
A Comparison of Prostaglandin E2 (PGE2) Inhibition of Acuvail(Ketorolac 0.45%), Xibrom (Bromfenac 0.09%)and Nevanac (Nepafenac)in Patients Undergoing Phacoemulsification
Approximately 126 subjects scheduled to undergo cataract surgery by phacoemulsification, will be randomized in an even allocation (1:1:1) to either Acuvail, Xibrom or Nevanac.
- Trial name
- NCT01021761
- Testing
- Ketorolac Tromethamine, Bromfenac, nepafenac
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Frank A. Bucci, Jr., M.D.
Normal Tension Glaucoma
Intraocular Pressure Reduction Efficacy of Rhopressa and Lumigan in Normal Tension Glaucoma
Glaucoma is the second leading cause of blindness and the first leading cause of irreversible vision loss worldwide. The intraocular pressure (IOP) is the only modifiable risk factor for all the spectrum of glaucoma.
- Trial name
- NTG (NCT04981886)
- Testing
- Netarsudil Ophthalmic, Bimatoprost Ophthalmic
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Salus University
Cesarean Section
Ripening Interventions: Prostaglandins vs EASI Catheter
The primary aim of this randomized clinical trial is to compare the effect of misoprostol vs extra amniotic saline infusion via a catheter (EASI) for cervical ripening on the proportion of patients delivered by cesarean section…
- Trial name
- RIPE (NCT00383942)
- Testing
- Misoprostol, Catheter
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Loyola University