Clinical trials: Prostaglandins
Covid19
Cri Analog PG1 Effectiveness and Safety in Covid-19
The Clinical trial aim to evaluate the effectiveness and safety of the administration of the intravenous prostaglandin E1 analog in the reduction of mortality and complications of patients with COVID-19 diagnosis.
- Trial name
- PGE1-COVID19 (NCT04536363)
- Testing
- Analogs, Prostaglandin E1, Standard therapeutic protocol
- Sponsor
- Alonso Vera Torres
Asthma, Rhinovirus
Effect of OC459 on the Response to Rhinovirus Challenge in Asthma
The aim of this study is to assess the effectiveness of a CRTH2 receptor antagonist, OC459, in preventing or attenuating the worsening of asthma symptoms during rhinovirus infection.
- Conditions
- Asthma, Rhinovirus, Picornaviridae Infections, Common Cold
- Trial name
- NCT02660489
- Testing
- OC459, Rhinovirus
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- Imperial College London
Open Angle Glaucoma
Aqueous Humor Dynamics of NCX 470 Ophthalmic Solution
This is a double-masked, placebo-controlled study which will determine the action of NCX 470 ophthalmic solution, 0.1% on aqueous humor dynamic parameters in healthy volunteers or subjects with OHT.
- Trial name
- Whistler (NCT05938699)
- Testing
- NCX 470
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Nicox Ophthalmics, Inc.
Peripheral Arterial Occlusive Disease
Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV
The study is to confirmatorily show a superior effect of Alprostadil compared to placebo on the rate of complete healing of ischemic necroses and ulcerations as well as on the frequency and height of major amputations in patients…
- Trial name
- ESPECIAL (NCT00596752)
- Testing
- Alprostadil
- Where
- 78 sites in Czechia, Germany and 4 more
- Volunteers
- 840 people
- Sponsor
- UCB BIOSCIENCES GmbH
Laminectomy, Postperative Pain Management
Dexamethasone as ESPB Adjuvant in Lumbar Laminectomy
Laminectomy is a routine procedure for patients with lumbar spinal stenosis, offering significant benefits such as reduced low back pain, alleviation of radiculopathy, and improved motor strength 1 23.
- Conditions
- Laminectomy, Postperative Pain Management, Prostaglandin E2, Lumbal Disc Herniation
- Trial name
- NCT07429708
- Testing
- Bilateral ESPB: Ropivacaine 0.375% + Dexamethasone 5mg, Bilateral ESPB: Ropivacaine 0.375%
- Where
- Indonesia
- Volunteers
- 36 people
- Sponsor
- Udayana University
"Migraine-like" Headache
Prostaglandin E2 in Migraine Suffers Without Aura.
The hypothesis of this study is that Prostaglandin E2 (PGE2) induces headache and dilatation of brain vessels in migraine patients without aura.
- Trial name
- NCT01384812
- Testing
- dinoprostone, isoton sodium chloride
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Troels Wienecke
Glaucoma, Open-Angle, Ocular Hypertension
Ocular Surface Tolerability Study of Prostaglandin Analogues in Patients With Open-Angle Glaucoma or Ocular Hypertension
This study evaluated the ocular surface tolerability of the prostaglandin analogues bimatoprost ophthalmic solution 0.01% (Lumigan® 0.01%), travoprost ophthalmic solution 0.004% (Travatan Z®) and latanoprost ophthalmic solution…
- Trial name
- NCT01253902
- Testing
- bimatoprost ophthalmic solution 0.01%, travoprost ophthalmic solution 0.004%, latanoprost ophthalmic solution 0.005%
- Where
- 2 sites in United States, Canada
- Volunteers
- 164 people
- Sponsor
- Allergan
Asthma
Prostaglandin E2 as a Critical Mediator of Sex Disparities in Asthma
This study seeks to understand how biological sex influences airway hyperresponsiveness in adult asthma.
- Trial name
- NCT03825302
- Testing
- Methacholine challenge, Mannitol challenge
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Ulcerative Colitis (UC)
Urinary PGE-MUM as a Marker for Ulcerative Colitis Activity
Ulcerative colitis (UC) is a chronic inflammatory bowel disease that requires regular monitoring of disease activity. Currently, assessment depends on invasive colonoscopy or clinical scores that may not accurately reflect…
- Trial name
- PGE-MUM_UC (NCT07637045)
- Where
- Egypt
- Volunteers
- 114 people
- Sponsor
- Assiut University
Asymptomatic Apical Periodontitis, Endodontic Retreatment
Cryotherapy, PGE2, NGF Levels and Pain After Endodontic Retreatment
This prospective, randomized, controlled, single-blind, parallel-group clinical trial evaluates whether intracanal cryotherapy reduces postoperative pain and inflammatory biomarker levels following single-visit endodontic…
- Conditions
- Asymptomatic Apical Periodontitis, Endodontic Retreatment, Cryotherapy
- Trial name
- ICE-PAIN (NCT07733700)
- Testing
- Intracanal cryotherapy, Room-temperature saline irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Alanya Alaaddin Keykubat University
Acute Appendicitis, Acute Appendicitis With Rupture
Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children
Diagnosing acute appendicitis in children remains a clinical challenge, with delayed or incorrect diagnosis potentially leading to serious complications or unnecessary surgery.
- Conditions
- Acute Appendicitis, Acute Appendicitis With Rupture, Abdominal Pain (AP)
- Trial name
- NCT07008092
- Testing
- Blood specimen collection, Urine collection
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- KBC Split
Open Angle Glaucoma
Two Second-Generation Trabecular Micro-bypass Stents to Treat Glaucoma Subjects on One Hypotensive Medication
This study objective is to evaluate the intraocular pressure (IOP) lowering effect of two trabecular micro-bypass stents (iStent inject) in eyes of subjects with primary open-angle glaucoma on one topical hypotensive medication
- Trial name
- NCT02868190
- Testing
- Two trabecular micro-bypass stents (iStent inject)
- Where
- Armenia
- Volunteers
- 57 people
- Sponsor
- Glaukos Corporation
Graves' Ophthalmopathy
Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study)
The purpose of the study is to establish whether Bimatoprost eye drops are effective in reducing proptosis in inactive thyroid eye disease (TED) patients and improving quality of life in patients with TED.
- Trial name
- BIMA (NCT02059655)
- Testing
- Bimatoprost, Eye drop solution
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Cardiff University
Fetus or Newborn or Maternal; Effects of Induction of Labor
Tearing of Membranes Before Birth - a Comparison Between Two Ways of Induction of Labor Pitocin Opposite Prostaglandin
Premature rupture of membranes (PROM) is a common occurrence that occurs in the incidence of 8-10% of births. Since the duration until delivery is important in avoiding the risk of complications, several studies have been…
- Trial name
- NCT02720978
- Testing
- Intravenous oxytocin, vaginal prostaglandin
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Myocardial Infarction, Arthritis
Mechanisms of Action of Acetaminophen
This research study investigates whether the ability of aspirin to reduce the risk of heart attacks may be diminished by the administration of acetaminophen.
- Trial name
- NCT00646906
- Testing
- Aspirin First, Aspirin Last, Acetaminophen 1000 mg/d
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Hypertrichosis
Eyelash Growth From Application of Bimatoprost in Gel Suspension to the Base of the Eyelashes
Objective: To determine if Lumigan (bimatoprost) causes increased lash length when used in gel suspension applied to the base of the eyelashes.
- Trial name
- NCT00773136
- Testing
- Bimatoprost Suspension
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Miami
Glaucoma
Tolerability of Bimatoprost 0.01% vs Latanoprost Eye Drops
This study examines patient perceptions regarding the tolerability of two classes of glaucoma medication: bimatoprost and latanoprost.
- Trial name
- NCT02138461
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- MDbackline, LLC
Inflammatory Disorder of the Cardiovascular System
Polyphenols Supplementation on Prostaglandin E2 in Women - Randomized Clinical Trial
The aim of this study was to evaluate the effect of polyphenol supplementation on plasma levels of prostaglandin E2 in women during the reproductive period.
- Trial name
- NCT02567617
- Testing
- Polyphenols
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Healthy
GRC 27864 First in Man, Single Ascending Dose Study in Healthy Volunteers
A Single Dose Study of GRC 27864 in Healthy Volunteers.
- Trial name
- NCT02179645
- Testing
- GRC 27864, Celecoxib
- Where
- United Kingdom
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Glenmark Pharmaceuticals Ltd. India
Glaucoma
Retinal Ganglion Cell Neuroprotection Under Prostaglandin Analogues
The goal of this observational study is to evaluate whether prostaglandin analogue eye drops have a direct neuroprotective effect on retinal ganglion cells - beyond their intraocular pressure (IOP)-lowering effect - in adult…
- Trial name
- NEUROPA (NCT07074782)
- Where
- 10 sites in Germany, Italy and 3 more
- Volunteers
- 1,500 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image