Clinical trials: Prostate Biopsy
Prostate Cancer
Extended Systematic Versus Mri-Assisted pRostate Transperineal Biopsy
This is a randomized controlled trial to evaluate the detection of clinically significant prostate cancer (csPCa) by MRI-targeted approach (MRI-arm) versus 24-core transperineal (TP) systematic biopsy (TP-arm).
- Trial name
- SMART (NCT04685928)
- Testing
- MRI and MRI-guided prostate biopsy, TP-arm Systematic biopsy
- Where
- 8 sites in Hong Kong
- Volunteers
- 403 people
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
Cancer of the Prostate Treated With Focal Implantation of a RadioactivE Source
The purpose is to assess and describe the oncological and functional outcomes following the introduction of curative targeted focal brachytherapy of prostate cancer in Denmark.
- Trial name
- CAPFIRE (NCT06080113)
- Testing
- Focal Brachytherapy
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Herlev Hospital
Fluoroquinolone Resistant Enteric Bacteria
Incidence of Fluoroquinolone Resistant Bacteria in Patients Undergoing Prostate Biopsy
In this study, the investigators aim to establish the incidence of enteric fluoroquinolone resistant bacteria in a contemporary clinical cohort.
- Trial name
- NCT02140502
- Where
- 2 sites in Finland
- Volunteers
- 200 people
- Sponsor
- Helsinki University Central Hospital
Prostate Cancer
GUidance In Prostate Cancer DEtection With 18F-PSMA-1007-PET/MRI and Targeted Biopsies
The goal of this clinical study is to test the performance of PSMA PET/MRI-guided biopsies against systematic biopsies in men with negative MRI scan (PI-RADS 1-2) of the prostate with continuous suspicion of clinically…
- Trial name
- GUIDE PSMA PET (NCT07258056)
- Testing
- PSMA-guided and systematic biopsies
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Mads Ryo Jochumsen
Prostatic Neoplasms
Analysis of Cell-free DNA (cfDNA) in Men With Elevated PSA Levels
This is a multi-centre prospective study in which blood samples will be taken from 1500 male patients aged between 21-80 scheduled for prostate biopsy.
- Trial name
- NCT02771769
- Testing
- blood draw
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chronix Biomedical Corporation
Prostate Cancer, Prostate Adenocarcinoma
The Efficacy of Mapping for Cognitive Prostate Biopsy
Today, many centers still perform Magnetic Resonance Imaging (MRI) cognitive prostate biopsy. The efficacy of detecting clinically significant prostate cancer, which is thought to be due to the experience of the urologist who…
- Conditions
- Prostate Cancer, Prostate Adenocarcinoma, Prostatic Neoplasms, Prostate Disease
- Trial name
- MAPROSTATE (NCT05902637)
- Testing
- Performing cognitive prostate biopsy with a radiologist's guidance with map, Performing cognitive prostate biopsy without a radiologist's guidance with map
- Where
- Turkey (Türkiye)
- Volunteers
- 175 people
- Sponsor
- Marmara University
Prostate Cancer
Sequential Imaging of Suspicion of Prostate Cancer Reducing Overdiagnosis and Unnecessary Biopsy With Timely Diagnosis of Significant Cancer
The goal of this clinical trial is to evaluate the safety and effectiveness of a novel diagnostic strategy for prostate cancer, in which men with a moderate risk of prostate cancer are monitored using PSA and MRI instead of…
- Trial name
- SPROUT (NCT07180381)
- Testing
- PSA and MRI-monitoring
- Where
- 7 sites in Netherlands
- Volunteers
- 503 people
- Sponsor
- St. Antonius Hospital
Prostate Biopsy
A Multicenter, Randomized Controlled Superiority Trial Comparing Robotic-Assisted Versus Expert Cognitive Fusion Prostate Biopsy in Obese Men
The trial aims to find out if using a robotic system to help perform prostate biopsies is better than having a highly experienced doctor perform the biopsy by hand in men with a high Body Mass Index (BMI).
- Trial name
- NCT07600216
- Testing
- Robotic-Assisted Fusion Biopsy, Expert Cognitive Fusion Biopsy
- Volunteers
- 570 people
- Sponsor
- Shanghai East Hospital
Prostate Cancer
Optimization of the Core Number and Location for Targeted Prostate Biopsy
This study aims to investigate the effect of core number and location optimization for targeted prostate biopsy on pathological accuracy.
- Trial name
- NCT04983706
- Testing
- MRI/Ultrasound Fusion Saturation Biopsy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Prostate Cancer
Polyunsaturated Fatty Acids in Treating Patients With Prostate Cancer Undergoing Prostate Biopsy and/or Surgery
RATIONALE: Polyunsaturated fatty acids are important for normal growth and development. One type, called omega-3 fatty acids (found in fish, fish oil, and some other foods), may affect the growth of prostate cancer.
- Trial name
- NCT00458549
- Testing
- omega-3 fatty acids, biopsy
- Where
- 2 sites in United States
- Volunteers
- 232 people
- Sponsor
- Dana-Farber Cancer Institute
Prostate Cancer
Observational Study of Patients Who Underwent Diagnostic Investigation (Prostate Biopsy) and/or Radical Prostatectomy Surgery.
This is a single-center, observational, prospective and retrospective study on quality of life and disease status of patients who underwent prostate biopsy and/or radical prostatectomy.
- Trial name
- NCT06397755
- Testing
- Prostate Biopsy and/or Radical Prostatectomy
- Where
- Italy
- Volunteers
- 20,000 people
- Sponsor
- IRCCS San Raffaele
Prostatic Cancer
Clinical Trial to Examine Individual Pain Tolerance in the Use of Two Anesthetic Techniques to Perform Saturation Prostate Biopsy
To assess the effectiveness of two anesthetic techniques by measuring the pain through visual analog scale (VAS), to obtain saturation prostate biopsies.
- Trial name
- NCT02909049
- Testing
- MIDAZOLAM, MEPIVACAÍNE, FENTANILE
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Complexo Hospitalario Universitario de A Coruña
Prostate Cancer (Adenocarcinoma), Prostate Biopsy
RegisterPROS - A Registry for Prostate Cancers
Prostate cancers are derived from epithelial cells in the prostate gland. Treatment options include surgery, medical (androgen signaling targeted and chemotherapy) and radiation therapy including radioligand therapy (RLT).
- Conditions
- Prostate Cancer (Adenocarcinoma), Prostate Biopsy, Prostatectomy, Radioligand
- Trial name
- RegisterPROS (NCT06872619)
- Testing
- PROSTest
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Wren Laboratories LLC
Prostate Cancer (Diagnosis), Bone Metastasis
Plasma Exosomal RNA Signature for Prostate Cancer Bone Metastasis
Brief Summary: This prospective, multicenter study aims to discover, develop, and validate a plasma exosomal RNA-based signature as a rule-out test for predicting bone metastasis in prostate cancer, using baseline treatment-naïve…
- Conditions
- Prostate Cancer (Diagnosis), Bone Metastasis, PSMA PET, Liquid Biopsy
- Trial name
- EXO-MET (NCT07553754)
- Where
- 9 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Xijing Hospital
Pain, Acute
Periprostatic Nerve Block vs. Intravenous Ibuprofen for Pain Management During Transrectal Prostate Biopsy
This study aimed to compare the efficacy of intravenous ibuprofen with peri-prostatic nerve block in pain control during prostate biopsy and to investigate factors influencing pain scores.
- Trial name
- NCT06737939
- Testing
- intravenous ibuprofen, periprostatic nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- University of Gaziantep
Head and Neck Squamous Cell Carcinoma, Breast Cancer
A Study of Tremelimumab and IV Durvalumab Plus Poly-ICLC in Subjects With Biopsy-accessible Cancers
This is an open-label, multicenter, Phase 1/2 study of the CTLA-4 antibody, tremelimumab, and the PD-L1 antibody, durvalumab (MEDI4736), in combination with the tumor microenvironment (TME) modulator poly-ICLC, a TLR3 agonist, in…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Breast Cancer, Sarcoma, Merkel Cell Carcinoma
- Trial name
- NCT02643303
- Testing
- Durvalumab, Tremelimumab, Poly-ICLC
- Where
- 7 sites in United States
- Volunteers
- 58 people
- Sponsor
- Ludwig Institute for Cancer Research
Prostate Cancer Diagnosis
PROVIZ - a Machine Learning Software, to Support Targeting of Prostate Biopsies on MR Images in Biopsy-naive Patients
To perform a traditional feasibility clinical investigation, as defined in ISO 14155:2020, to investigate preliminary feasibility, safety, and clinical performance information of a near-final design of the investigational…
- Trial name
- NCT06000046
- Testing
- Automatic image analysis
- Where
- Norway
- Volunteers
- 82 people
- Sponsor
- Norwegian University of Science and Technology
Adenocarcinoma, Prostate Neoplasms
Use of Tracking Devices to Locate Abnormalities During Invasive Procedures
This study will evaluate the accuracy and effectiveness of an experimental tracking device for locating abnormalities during invasive procedures, such as biopsy or ablation, that cannot easily be visualized by usual imaging…
- Conditions
- Adenocarcinoma, Prostate Neoplasms, Prostate Cancer, Renal Cell Carcinoma
- Trial name
- NCT00102544
- Testing
- EM Tracking
- Where
- United States
- Volunteers
- 3,894 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Prostate Neoplasm, Inflammation
Protein Kinase A in Prostate Cancer Tissue.
Prostate cancer is the most common malignancy in men. documented risk factors of prostate cancer are age, ethnicity, various genomic mutations and family history of prostate cancer.
- Conditions
- Prostate Neoplasm, Inflammation, Benign Hyperplasia of Prostate
- Trial name
- NCT05460312
- Testing
- prostate biopsy
- Volunteers
- 100 people
- Sponsor
- Ziv Hospital
Prostate Cancer
Measurements Of Zinc Concentration On Specimens Taken During Trans-Perineal Prostate Biopsy
The purposes of this study are to: i) confirm and improve the accuracy of the correlation between levels of Zinc in prostate tissue and the grade of prostate cancer in that tissue as determined through pathology; and ii)…
- Trial name
- NCT01915316
- Testing
- prostate biopsy
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- ProSight