Clinical trials: Prostate Cancer Detection
Prostate Cancer
Detection of Minimal Residual Disease Post-prostatectomy
The clinical objective for this pilot study is to determine whether minimal residual disease (MRD) detection in high-risk prostate cancer, utilizing a custom-made prostate-specific circulating tumor DNA (ctDNA) panel, may lead to…
- Trial name
- MiRaDE (NCT07334275)
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Prostate Cancer
Ultrasound for Detection of Prostate Cancer
Clinical proof of concept of dual-frequency ultrasound imaging for detection and visualization of prostate cancer.
- Trial name
- SURF (NCT05736094)
- Testing
- SURF
- Where
- Norway
- Volunteers
- 11 people
- Sponsor
- Oslo University Hospital
Prostate Cancer
TULIP ReTrain Study
This prospective clinical study aims to retrain and validate the PCaVision AI algorithm for the detection and localization of clinically significant prostate cancer (csPCa) using multiparametric ultrasound (mpUS) with two…
- Trial name
- TULIP ReTrain (NCT06974539)
- Testing
- Multiparametric ultrasound with contrast (Sonovue and Optison)
- Where
- Netherlands
- Volunteers
- 212 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Prostate Cancer
Comparison of MRI Fusion Biopsy Techniques in Men With Elevated PSA and Prior Negative Prostate Biopsy
Men with elevated prostate specific antigen bloodtest and prior negative prostate biopsy have a 30-60% of harboring occult prostate cancer.
- Trial name
- NCT02138760
- Testing
- MRI UroNav fusion biopsy
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Prostate Cancer
Prostate Cancer Early Detection Using Serial MRI Examinations
The rationale of the PROCEDE trial is to explore a novel early detection strategy in which biopsy decision does not rely on one single MRI examination, but on the progression of the MRI lesion between 2 consecutive exams, with…
- Trial name
- PROCEDE (NCT07355504)
- Testing
- MRI Examination
- Where
- France
- Volunteers
- 380 people
- Sponsor
- University Hospital, Grenoble
Prostate Cancer, PSA
MRI Prostate for Chinese Men Being Screened for Prostate Cancer
Under the prostate cancer screening protocol of the project 'Prevention of Obesity-related Cancers', men with elevated PSA with higher prostate cancer risk (PSA 4-10 ng/mL with high Prostate Health Index (PHI) ≥35, or PSA>10…
- Conditions
- Prostate Cancer, PSA, MRI
- Trial name
- NCT03891732
- Testing
- MRI prostate
- Where
- 2 sites in Hong Kong
- Volunteers
- 690 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
Single Fraction Real-time High-Dose-Rate Brachytherapy in Patients With Low and Intermediate Risk Prostate Cancer
High-dose rate brachytherapy (HDR-BT) is an advanced technology theorized to be more advantageous than LDR-BT and External Beam Radiotherapy (EBRT), to the patient himself, and in terms of resource allocation.
- Trial name
- SINFRA_PROST (NCT02342054)
- Testing
- MRI-TRUS fusion guided Single Frac HDR
- Where
- Spain
- Volunteers
- 49 people
- Sponsor
- Hospital de Cruces
Stage II Prostate Adenocarcinoma, Stage III Prostate Adenocarcinoma
68Ga-RM2 PET/CT in Detecting Regional Nodal and Distant Metastases in Patients With Intermediate or High-Risk Prostate Cancer
This phase II trial studies how well gallium Ga 68-labeled gastrin-releasing peptide receptor (GRPR) antagonist BAY86-7548 (68Ga-RM2) positron emission tomography (PET)/computed tomography (CT) works in detecting regional nodal…
- Conditions
- Stage II Prostate Adenocarcinoma, Stage III Prostate Adenocarcinoma, Stage IV Prostate Adenocarcinoma
- Trial name
- NCT03113617
- Testing
- Computed Tomography, Gallium Ga 68-labeled GRPR Antagonist BAY86-7548, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Andrei Iagaru
Prostate Cancer
Choline PET/CT vs. Dual Time Point FDG PET/CT in Prostate Cancer
Prostate cancer is currently the leading newly diagnosed cancer in the industrialized world. Treatment of prostate cancer is highly dependent on the stage of the disease.
- Trial name
- NCT02232724
- Testing
- Choline PET/CT and Dual time point FDG PET/CT
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Odense University Hospital
PSA, Prostate Cancer
EDRN Prostate MRI Biomarker Study
The commercialization of MRI fusion biopsies has resulted in a dramatic increase in the use of MRI imaging for prostate cancer. How best to use MRI in the initial prostate biopsy setting given the availability of validated…
- Trial name
- P-MRI (NCT03784924)
- Testing
- MRI prostate
- Where
- United States
- Volunteers
- 950 people
- Sponsor
- University of Michigan
Prostate Cancer
PRISM Study: Prostate Recurrence Detection Using Imaging With PSMA PET/MRI Post-high Intensity Focused Ultrasound
The purpose of this study is to compare the sensitivity of PSMA PET/MRI and standard MRI in detecting focal therapy failure in the prostate one year after High-Intensity Focused Ultrasound (HIFU) treatment.
- Trial name
- NCT07184970
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Prostate Cancer
Comparison of PET With [89Zr]-Df-IAb2M and [111In]-Capromab Pendetide in the Detection of Prostate Cancer Pre-Prostatectomy
The purpose of this study is to compare the diagnostic performance of [89Zr]-Df-IAB2M PET/CT with that of [111In]-capromab pendetide as an immuno PET tracer in the detection of prostate cancer pre-prostatectomy as confirmed by…
- Trial name
- NCT02349022
- Testing
- [89Zr]Df-IAB2M
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- ImaginAb, Inc.
Prostatic Neoplasms
Sentinel Lymph Node Detection in Prostate Surgery by Laparoscopy
In this study the investigators want to determine if the detection of lymph node is applicable in prostatectomy by laparoscopy.
- Trial name
- NCT01296217
- Testing
- lymph nod detection
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Centre René Gauducheau
Prostate Cancer, Prostate Adenocarcinoma
Utility of Adding MR Fusion to Standard US Guided Prostate Biopsy
The purpose of this study is to utilize this technology in the early detection and staging of pathologic states within prostate cancer patients using the information obtained on mpMRI and serum biomarkers from the patient's blood…
- Trial name
- NCT05064111
- Testing
- TRUS biopsy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Arizona
Prostatic Neoplasms
Identification of Prostate Cancer Specific Markers in Patients Compared to Healthy Participants
This is an exploratory research study with the aim of identifying specific cancer biomarkers in various subtypes of prostate cancer.
- Trial name
- NCT04964271
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tethis S.p.A.
Prostatic Neoplasms
Verification of Shear Wave Elastography for DEtection of Prostate Cancer
1. Objective To provide evidence that adding shear wave elastography during sono-guided prostate biopsy can increase prostate cancer detection rate and to demonstrate that shear wave elastography of the prostate can discriminate…
- Trial name
- NCT04836949
- Testing
- Shear Wave Elastography of prostate, Conventional Prostate Ultrasound
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- Yonsei University
Prostate Cancer
Improving Prostate Cancer Detection Using MRI-Targeted TRUS-Guided Biopsy
The purpose of this study is to determine if using MRI can improve cancer detection by identifying potential cancer targets prior to TRUS-guided biopsy in populations that have previous inconclusive results from TRUS-guided…
- Trial name
- NCT02488096
- Testing
- TRUS-Guided Biopsy, MRI + TRUS-Guided Biopsy
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Saskatchewan Health Authority - Regina Area
Prostate Cancer, Prostate Cancer Recurrent
Efficacy of [18F]PSMA-1007 PET/CT in Patients With Biochemial Recurrent Prostate Cancer
This study evaluates the diagnostic performance and safety of [18F]PSMA-1007 PET/CT imaging in patients with suspected recurrence of prostate cancer after previous definitive treatment.
- Trial name
- NCT04742361
- Testing
- [18F]PSMA-1007
- Where
- 6 sites in United States, Netherlands and 1 more
- Volunteers
- 136 people
- Sponsor
- ABX advanced biochemical compounds GmbH
Prostate Cancer
Targeted And Perilesional Or Systematic Biopsy In Prostate Cancer
Magnetic Resonance Imaging (MRI) improves the detection of clinically significant prostate cancer (PCa) by guiding biopsies of MRI-visible lesions (targeted biopsies) in patients suspected with having PCa.
- Trial name
- TARGET (NCT07296042)
- Testing
- Prostate biopsy
- Where
- 5 sites in France
- Volunteers
- 456 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Prostate Cancer
Diagnostic Accuracy and Performance of 18F-PSMA-1007
Whereas 18F-PSMA-1007 has rapidly established itself as a radiotracer for the investigation of prostate cancer, there are no studies confirming its diagnostic performance.
- Trial name
- NCT04986280
- Testing
- [18F]PSMA-1007
- Where
- Switzerland
- Volunteers
- 174 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern