Clinical trials: Prostate Cancer Detection
Benign Prostate Hypertrophy(BPH), Prostate Cancer (Diagnosis)
Application of Quantum Detection-Driven Artificial Intelligence Algorithms for Single-Molecule cfDNA Characterization in the Early Diagnosis of Prostate Cancer
This research project aims to develop a novel blood testing method integrating cutting-edge quantum sensing and artificial intelligence technologies to achieve precise, non-invasive early diagnosis of prostate cancer.
- Conditions
- Benign Prostate Hypertrophy(BPH), Prostate Cancer (Diagnosis), Prostate Neoplasm
- Trial name
- NCT07238959
- Testing
- Quantum Detection
- Where
- 7 sites in China
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Prostate Cancer
Study of Current Practice Which Compare the Rate of Prostate Cancer by Using 2 Kind of Transrectal Biopsies: 3 by IRM-echography Image Fusion and 12 Systematized Guided Echographies.
The purpose of the study is to show that 3 targeted biopsies on the suspicious image detected by IRM, guided by a fusion of MRI and ultrasound- images with the Koelis ® system, will get no lower rate of cancer detection than…
- Trial name
- MURIELLE (NCT02050542)
- Testing
- systematic biopsies, Targeted biopsies guided by a fusion of MRI and ultrasound- images
- Where
- 6 sites in France
- Volunteers
- 108 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prostate Cancer
Comparing MRI-Ultrasound Fusion and Cognitive-guided Biopsy for the Detection of csPCa: the PROFUSION Trial
This study is an international multicentre RCT to compare the linically significant prostate cancer (csPCa) detection of cognitive-guided and MRI-USG guided biopsies in men with suspicious MRI lesion.
- Trial name
- NCT06303622
- Testing
- MRI-USG fusion approach, Cognitive-guided approach
- Where
- Hong Kong
- Volunteers
- 1,620 people
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
Prostate Cancer in Firemen: Early Diagnosis Because of Increased Diagnostic Pressure?
Firefighters, police, military personnel and pilots are all shown to have a higher incidence of prostate cancer than the general population.
- Trial name
- NCT03896178
- Testing
- None, observational study
- Where
- Norway
- Volunteers
- 137,536 people
- Sponsor
- Oslo University Hospital
Prostatic Neoplasms
Sentinel Lymph Node Detection in Prostate Surgery by Laparoscopy
In this study the investigators want to determine if the detection of lymph node is applicable in prostatectomy by laparoscopy.
- Trial name
- NCT01296217
- Testing
- lymph nod detection
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Centre René Gauducheau
Prostate Neoplasm
PRostate Evaluation for Clinically Important Disease: Sampling Using Image-guidance Or Not?
This evaluates the detection rates of prostate cancer by MRI-targeted prostate biopsy compared to standard 12-core trans-rectal ultrasound guided (TRUS) prostate biopsy.
- Trial name
- PRECISION (NCT02380027)
- Testing
- MRI, MRI-targeted biopsy, TRUS-biopsy
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University College, London
Prostate Cancer, Prostate Cancer Recurrent
F-18-PSMA-1007 Versus F-18-Fluorocholine PET in Patients With Biochemical Recurrence
This study evaluates the diagnostic performance and safety of F-18-PSMA-1007 and F-18-Fluorocholine PET/CT imaging in patients with suspected recurrence of prostate cancer after previous definitive treatment.
- Trial name
- NCT04102553
- Testing
- F-18-PSMA-1007, F-18-Fluorocholine
- Where
- 6 sites in France
- Volunteers
- 200 people
- Sponsor
- ABX advanced biochemical compounds GmbH
Prostate Cancers
Prospective Evaluation of 68Ga-PSMA PET-CT for Recurrence Detection of Prostate Cancer and Its Impact on Patient Management
Single arm, phase II exploratory trial to prospectively evaluate the impact of 68Ga-PSMA-PET/CT on the therapeutic management of patients with biological recurrent prostate cancer and negative, equivocal or oligometastatic…
- Trial name
- ProsPERo (NCT02810886)
- Testing
- 68Ga-(HBED-CC)-PSMA
- Sponsor
- Jules Bordet Institute
Prostate Cancer, Prostate Adenocarcinoma
Detection of Prostate Cancer With Non-invasive Method Based on DNA Methylation of Circulated Tumor DNA, PBMC
Prostate cancer is a leading cause of mortality and morbidity. The purpose of this study is to develop and test non-invasive biomarkers based on methylation changes in PBMC, T-cells and circulated tumor DNA in prostate cancer…
- Conditions
- Prostate Cancer, Prostate Adenocarcinoma, Prostate Cancer Metastatic
- Trial name
- NCT03494803
- Where
- Kazakhstan
- Sponsor
- HKGepitherapeutics
Prostate Cancer
For Cause Prostate Biopsy in REDUCE Population Trial
The REDUCE trial was conducted to determine whether dutasteride reduces the risk of incident prostate cancer, as detected on biopsy, among men who are at increased risk for the disease.
- Trial name
- NCT01529086
- Where
- United States
- Volunteers
- 6,608 people
- Sponsor
- The Cleveland Clinic
Prostate Cancer
PSMA-PET Imaging in Patients With Metastatic Prostate Cancer: Institutional Evaluation of Detection Yield Performance and Reproducibility
A promising imaging technique involving new prostate specific membrane antigen (PSMA) positron emission tomography (PET) tracers is emerging in metastatic prostate cancer (PCa).
- Trial name
- NCT03486886
- Testing
- PSMA -PET/CT scanning
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Prostate Cancer
Cognitive and Fusion Prostatic Biopsy
The goal of this study is to compare two different prostate biopsy techniques used to detect prostate cancer. These techniques are cognitive-targeted biopsy (CTB) and magnetic resonance imaging-ultrasound fusion-targeted…
- Trial name
- CTB-FTB (NCT07306741)
- Testing
- Cognitive-targeted prostate biopsy
- Where
- 2 sites in Egypt
- Volunteers
- 80 people
- Sponsor
- Menoufia University
Elevated PSA, Prostate Cancer
Functional and Morphologic MRI in the Detection of Prostate Cancer in Patients With Prior Negative Biopsy
Prostate specific antigen (PSA) and digital rectal exam (DRE) are used to screen for prostate cancer. Patients with abnormal DRE or elevated PSA undergo transrectal ultrasound guided biopsy (TRUS-Bx).
- Trial name
- NCT00242060
- Testing
- MRI
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Prostate Cancer
Ciprofloxacin Compared to Placebo in Diagnosing Prostate Cancer in Patients Undergoing Prostate Biopsy
This phase II trial studies ciprofloxacin compared to an inactive treatment (placebo) in diagnosing prostate cancer in patients undergoing removal of prostate cells or tissues for examination (biopsy).
- Trial name
- NCT02252978
- Testing
- ciprofloxacin, quality-of-life assessment, laboratory biomarker analysis
- Where
- 2 sites in United States
- Sponsor
- Wake Forest University Health Sciences
Prostate Carcinoma
MRI-Based Machine Learning Approach Versus Radiologist MRI Reading for the Detection of Prostate Cancer, The PRIMER Trial
This clinical trial studies how well a magnetic resonance imaging (MRI)-based machine learning approach (i.e., artificial intelligence [AI]) works as compared to radiologist MRI readings in detecting prostate cancer.
- Trial name
- NCT07162194
- Testing
- Targeted Prostate Biopsy, Prostate Imaging Reporting & Data System, Deep Learning Artificial Intelligence
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Southern California
Prostate Cancer
Detection of Minimal Residual Disease Post-prostatectomy
The clinical objective for this pilot study is to determine whether minimal residual disease (MRD) detection in high-risk prostate cancer, utilizing a custom-made prostate-specific circulating tumor DNA (ctDNA) panel, may lead to…
- Trial name
- MiRaDE (NCT07334275)
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Prostate Cancer
Prostate Cancer Early Detection Using Serial MRI Examinations
The rationale of the PROCEDE trial is to explore a novel early detection strategy in which biopsy decision does not rely on one single MRI examination, but on the progression of the MRI lesion between 2 consecutive exams, with…
- Trial name
- PROCEDE (NCT07355504)
- Testing
- MRI Examination
- Where
- France
- Volunteers
- 380 people
- Sponsor
- University Hospital, Grenoble
Prostate Carcinoma
[18F]-rhPSMA PET-CT Imaging Performance in Patients With Prostate Cancer
This clinical trial evaluates [18F]-rh PSMA positron emission tomography (PET)-computed tomography (CT) imaging performance in patients with prostate cancer.
- Trial name
- NCT06580015
- Testing
- Computed Tomography, Flotufolastat F-18 Gallium, Medical Device Usage and Evaluation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center
Prostate Cancer
Extended Systematic Versus Mri-Assisted pRostate Transperineal Biopsy
This is a randomized controlled trial to evaluate the detection of clinically significant prostate cancer (csPCa) by MRI-targeted approach (MRI-arm) versus 24-core transperineal (TP) systematic biopsy (TP-arm).
- Trial name
- SMART (NCT04685928)
- Testing
- MRI and MRI-guided prostate biopsy, TP-arm Systematic biopsy
- Where
- 8 sites in Hong Kong
- Volunteers
- 403 people
- Sponsor
- Chinese University of Hong Kong
Prostate Cancer
European Multicenter Validation of PCaVision: A Head-to-Head Diagnostic Accuracy Study Comparing Multiparametric Transrectal Ultrasound to MRI for Clinically Significant Prostate Cancer Detection
The goal of this clinical trial is to learn if a new ultrasound-based imaging method (PCaVision) can accurately detect clinically significant prostate cancer in adult men (18 years and older) who are either undergoing initial…
- Trial name
- PCaVISTA (NCT06935487)
- Testing
- transrectal ultrasound of prostate (TRUS) with AI software algorithm, MRI prostate
- Where
- 10 sites in France, Germany and 4 more
- Volunteers
- 806 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)