Clinical trials: Prostate Disease
Prostate Cancer
Diagnostic Performance Of Non-Endorectal Coil Multiparametric Magnetic Resonance Imaging Of Prostate With Flexible AIR Coil (DoNEMAC Study)
Multiparametric MRI (mpMRI) of the prostate is an important tool for diagnosis of clinically significant prostate cancer (csPCa) in men with an elevated serum prostate specific antigen, which can decrease the rate of unnecessary…
- Trial name
- NCT05043012
- Testing
- flexible AIR coil, endorectal coi
- Where
- United States
- Volunteers
- 258 people
- Sponsor
- M.D. Anderson Cancer Center
Benign Prostatic Hyperplasia
A Smart Wearable Device for Monitoring Urination Function in Benign Prostatic Hyperplasia
Benign Prostatic Hyperplasia (BPH) is a common condition that can cause bothersome urination problems and reduce quality of life.
- Trial name
- NCT07357012
- Testing
- Electrical Impedance Tomography (EIT) Wearable Monitoring Device
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Peking University Third Hospital
Breast Cancer, Lung Cancer
S0702: Osteonecrosis of the Jaw in Patients With Cancer Receiving Zoledronic Acid for Bone Metastases
RATIONALE: Gathering information about how often osteonecrosis of the jaw occurs in patients receiving zoledronic acid for bone metastases may help doctors learn more about the disease and provide the best follow-up care.
- Conditions
- Breast Cancer, Lung Cancer, Metastatic Cancer, Multiple Myeloma
- Trial name
- NCT00874211
- Testing
- assessment of therapy complications
- Where
- 453 sites in United States, Mexico and 1 more
- Volunteers
- 3,571 people
- Sponsor
- SWOG Cancer Research Network
Benign Prostatic Hypertrophy
Dutasteride After Failure of Finasteride In the Management of Symptomatic Prostatic Enlargement/Hypertrophy (BPE/H)
The study is to determine the safety and efficacy of Dutasteride in patients who have failed Finasteride therapy for their symptomatic benign prostatic enlargement/ hypertrophy (BPE/H).
- Trial name
- NCT00382356
- Testing
- Dutasteride
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- North Florida/South Georgia Veterans Health System
Prostate Cancer, Prostate Carcinoma
The Study of Olaparib Combined With Abiraterone and Prednisone in mHSPC Patients With HRR Gene Mutation
This is a single-center, single-arm, prospective study to assess the efficacy and safety of Olaparib combined with Abiraterone plus Prednisone in subjects with metastatic hormone sensitive prostate cancer (mHSPC) who carry…
- Conditions
- Prostate Cancer, Prostate Carcinoma, Metastatic Prostate Cancer
- Trial name
- NCT05167175
- Testing
- Olaparib tablet, Abiraterone acetate, Prednisone tablet
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hongqian Guo
Orchiectomy, Spermatic Cord Block
Comparison of Spinal Anesthesia and Spermatic Cord Block for Bilateral Orchiectomy
The goal of this randomized controlled trial is to compare intraoperative pain score, Morphine consumption during 6 and 12 hour after surgery, and postoperative complications between SA and SCB groups in metastatic prostate…
- Conditions
- Orchiectomy, Spermatic Cord Block, Spinal Anesthesia, Pain Score
- Trial name
- NCT06313775
- Testing
- bilateral orchiectomy
- Where
- Thailand
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Sanpasitthiprasong Hospital
Chronic Prostatitis With Chronic Pelvic Pain Syndrome, Prostatitis
Chemokine Mechanisms in Chronic Pelvic Pain
The purpose of this study is to identify biomarkers that can be utilized in the diagnosis of chronic pelvic pain syndrome in men.
- Trial name
- NCT01676857
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms
Omega Study: Evaluation of the Safety and Efficacy of the Omega System for the Treatment of BPH
The ProArc Medical Omega system is a prostatic reshaping device that is designed to treat Lower Urinary Tract Symptoms (LUTS) due to BPH.
- Trial name
- NCT04627701
- Testing
- Omega
- Where
- 4 sites in Israel, New Zealand
- Volunteers
- 26 people
- Sponsor
- ProArc Medical
Obesity, Colon Cancer
Proteomic Analysis of Patients Undergoing Bariatric Surgery
The expression of proteins in the blood of obese individuals is different from the expression of proteins in healthy individuals, and is also different in individuals after bariatric surgery.
- Conditions
- Obesity, Colon Cancer, Thyroid Cancer, Esophageal Cancer
- Trial name
- NCT06787807
- Testing
- bariatric surgery
- Where
- Brazil
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Adenocarcinoma of the Prostate
Stereotactic Boost and Long-Term Androgen Deprivation for Adenocarcinoma of the Prostate
We hypothesize that Stereotactic Body Radiotherapy Boost (SBRT) as a boost to the prostate following whole pelvic intensity modulated radiotherapy (IMRT) can be delivered effectively and safely in a population of men with…
- Trial name
- CCRO025 (NCT02064036)
- Testing
- Stereotactic Radiosurgical Boost, Casodex, Leuprolide
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of California, Davis
Benign Prostatic Hyperplasia
Comparison of Functional Outcomes of Ejaculation-preserving Partial Trans Urethral Resection of the Prostate With Complete Trans Urethral Resection of the Prostate for Benign Prostatic Obstruction
It has been demonstrated that sexual activity was common in the majority of men over 50 years old and was an important component of overall quality of life (QoL).
- Trial name
- PARTURP (NCT05574244)
- Testing
- Partial surgery preserving the prostatic apex, Conventional endoscopic prostatic surgery
- Where
- 17 sites in France
- Volunteers
- 336 people
- Sponsor
- University Hospital, Bordeaux
Prostate Cancer
The Safety, Dosimetry and Efficacy of 177Lu-FC516 in Patients With Prostate Cancer
This study is a prospective, single-arm, open-label, dose-escalation study. A total of 5 dose groups were pre-defined in this study. The drug was administered once every 6 weeks.The drug would be administered for 1 to 4 cycles.
- Trial name
- NCT07542379
- Testing
- 177Lu-FC516
- Where
- China
- Volunteers
- 13 people
- Sponsor
- FindCure Biosciences (ZhongShan) Co., Ltd.
Prostate Neoplasm
Targeted Biopsy or Standard Biopsy for Clinical Significant Prostate Cancer Detection
This randomized controlled trial aims to assess the detection rate of clinically significant and clinically insignificant cancer of mpMRI-targeted biopsy compared to transperineal standard biopsy in men with clinical suspicion of…
- Trial name
- NCT03572946
- Testing
- Targeted prostate biopsy, Standard biopsy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Prostate Cancer
Androgen Deprivation, With or Without pTVG-AR, and With or Without T-Cell Checkpoint Blockade, in Patients With Newly Diagnosed, High-Risk Prostate Cancer
The current protocol will examine the use of a plasmid DNA vaccine encoding AR, alone or with T-cell checkpoint blockade, to induce and/or augment therapeutic T-cells following androgen deprivation in patients with newly…
- Trial name
- NCT04989946
- Testing
- Degarelix, pTVG-AR, Nivolumab
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Wisconsin, Madison
Prostate Cancer
Neoadjuvant Hiltonol® (PolyICLC) for Prostate Cancer
The purpose of this study is to test an approach of stimulating the body's immune system to attack prostate cancer. This study will test injection of a substance polylysine and carboxymethylcellulose (Poly-ICLC, Hiltonol®)through…
- Trial name
- NCT03262103
- Testing
- Intratumoral (IT) Poly ICLC 0.5 mg, Intratumoral (IT) Poly ICLC 1.0 mg, Intramuscular (IM) Poly ICLC
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Ashutosh Kumar Tewari
Metastasis From Malignant Tumor of Prostate (Disorder)
Cu-64-PSMA-I&T Positron Emission Tomography (PET) Imaging of Metastatic PSMA Positive Lesions in Men With Prostate Cancer
This is a prospective, open-label Phase 2 study to evaluate copper Cu 64 PSMA I\&T injection for PET/CT imaging in patients with recurrent metastatic prostate cancer after radical prostatectomy or radiation therapy.
- Trial name
- NCT05653856
- Testing
- 64Cu-PSMA I&T
- Where
- 9 sites in United States
- Volunteers
- 26 people
- Sponsor
- Curium US LLC
Prostatic Neoplasms
Correlation Between PSA Levels and F-18 PSMA PET/CT Findings in Prostate Cancer Patient
It is a cross sectional study aimed to correlate between PSA Levels and F-18 PSMA PET/CT Scan findings and to evaluate the impact of PET/CT findings on the patient management
- Trial name
- NCT06209853
- Testing
- PSMA PET/CT
- Where
- Egypt
- Volunteers
- 59 people
- Sponsor
- Assiut University
mCRPC
Continuation Protocol for ZEN003694 in Patients Experiencing Clinical Benefit While Enrolled in a ZEN003694 Protocol
Continuation Protocol for ZEN003694 in Patients Experiencing Clinical Benefit While Enrolled in a ZEN003694 Protocol
- Trial name
- NCT04145375
- Testing
- ZEN003694, Enzalutamide
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Zenith Epigenetics
Breast Cancer, Pancreas Cancer
Clinical Trial of Metastasis Inhibitor NP-G2-044 in Patients With Advanced or Metastatic Treatment-Refractory Solid Tumor Malignancies
Phase 1 A: First-in-human phase 1 study to determine safety of NP-G2-044 when given orally on a daily X 28 days followed by a 14 day rest period.
- Conditions
- Breast Cancer, Pancreas Cancer, Prostate Cancer, Lung Cancer
- Trial name
- NCT03199586
- Testing
- NP-G2-044
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Novita Pharmaceuticals, Inc.
Benign Prostate Hyperplasia, Bladder Outlet Obstruction
En-bloc With Early Apical Release Versus Lobe-by-lobe LASER Enucleation of the Prostate
Since its introduction in 1998 , and through numerous level 1a evidence, Holmium Laser enucleation of the prostate (HoLEP) has come to be considered a size-independent golden standard treatment for management of bladder outlet…
- Trial name
- NCT07014969
- Testing
- En-bloc HoLEP
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Mansoura University
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