Clinical trials: Prostate Disease
Cancer of the Prostate
Neoadjuvant Apalutamide (ARN509) and Radical Prostatectomy in Treatment of Intermediate to High Risk Prostate Cancer
This is an investigator-initiated phase II single arm trial, combining neoadjuvant apalutamide (ARN509) with radical prostatectomy, in the treatment of D'Amico intermediate to high risk organ-confined prostate cancer.
- Trial name
- NCT03124433
- Testing
- Apalutamide
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Singapore General Hospital
Prostate Cancer
Radiation Therapy and Docetaxel in Treating Patients Who Are Undergoing Surgery for Localized Prostate Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them…
- Trial name
- NCT00321698
- Testing
- Intensity-Modulated Radiation Therapy (IMRT), Docetaxel+IMRT
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- OHSU Knight Cancer Institute
Bone Cancer, Brain Cancer
Enhanced Assistance During Radiotherapy for Unmet Essential Needs
This is a prospective single-arm study of an enhanced assistance intervention for patients with unmet essential needs undergoing >10 fractions of radiotherapy comparing delay-free completion of radiotherapy in study participants…
- Conditions
- Bone Cancer, Brain Cancer, Colorectal Cancer, Esophagus Cancer
- Trial name
- EARN (NCT06582849)
- Testing
- Standard assistance, Enhanced assistance
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Washington University School of Medicine
Prostate Cancer
Role of Dutasteride in Patients Undergoing 3D Mapping Biopsy in Early Stage Prostate Cancer
The purpose of this study is to determine the effect of short-term intake of daily Dutasteride in patients with prostate cancer.
- Trial name
- NCT00985738
- Testing
- Dutasteride
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Osteoporosis
Frequency of Zoledronic Acid to Prevent Further Bone Loss in Osteoporotic Patients Requiring Androgen Deprivation Therapy for Prostate Cancer
The aim of this study is to determine if 3 monthly infusions of zoledronic acid, given over one year, improves the bone mineral density in osteoporotic patients undergoing androgen deprivation therapy for prostate cancer
- Trial name
- NCT00520052
- Testing
- zoledronic acid
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- Wirral University Teaching Hospital NHS Trust
Prostate Cancer
PRostate Evaluation for Clinically Important Disease: MRI vs Standard Evaluation Procedures
The aim of this study is to assess the efficacy of MRI-targeted biopsy compared to standard of care systematic TRUS guided biopsy in the detection of clinically significant and clinically insignificant prostate cancer in men…
- Trial name
- PRECISE (NCT02936258)
- Testing
- Standard of Care, MRI, MRI Targeted Biopsy
- Where
- 5 sites in Canada
- Volunteers
- 450 people
- Sponsor
- Canadian Urology Research Consortium
Benign Prostatic Hyperplasia, Prostatic Diseases
European Registry for Transperineal Laser Ablation of Prostate (TPLA) for Lower Urinary Tract Symptoms
The goal of this observational study is to assess mid- and long-term effectiveness of Transperineal Laser Ablation of Prostate (TPLA) for the treatment of lower urinary tract symptoms (LUTS) due to benign prostatic obstruction…
- Trial name
- NCT06564415
- Testing
- Transperineal Laser Ablation of Prostate
- Where
- Italy
- Volunteers
- 2,500 people
- Sponsor
- University of Florence
Prostatitis
A Study to Evaluate the Safety and Effectiveness of Levofloxacin Compared With Ciprofloxacin in Patients With Chronic Bacterial Prostatitis
The purpose of this study is to compare the safety and effectiveness of levofloxacin to ciprofloxacin in patients with chronic bacterial prostatitis.
- Trial name
- NCT00236808
- Testing
- levofloxacin
- Volunteers
- 383 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Prostate Cancer
64Cu-SAR-bisPSMA Positron Emission Tomography of Patients With Known or Suspected Prostate Cancer
This research project is testing a new compound which may potentially detect specific cancer lesions in men with prostate cancer.
- Trial name
- NCT05286840
- Testing
- 64Cu-SAR-bisPSMA
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Luke Nordquist, MD
Castration Levels of Testosterone, Castration-Resistant Prostate Carcinoma
Enzalutamide and Decitabine in Treating Patients With Metastatic Castration Resistant Prostate Cancer
This phase I/II trial studies the side effects and best dose of decitabine and how well it works when given together with enzalutamide in treating patients with castration resistant prostate cancer that has spread to other places…
- Conditions
- Castration Levels of Testosterone, Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma in the Soft Tissue, Prostate Carcinoma Metastatic in the Bone
- Trial name
- NCT03709550
- Testing
- Decitabine, Enzalutamide
- Where
- United States
- Sponsor
- Roswell Park Cancer Institute
Psychological Distress, Depression - Major Depressive Disorder
Internet-based Support for Adjustment to Prostate Cancer
The study aims to study the efficacy of internet-based cognitive behavior therapy (ICBT) in reducing subjective distress and comorbid psychiatric symptoms in men diagnosed with prostate cancer.
- Conditions
- Psychological Distress, Depression - Major Depressive Disorder, Insomnia, Anxiety
- Trial name
- ISAC (NCT06766526)
- Testing
- Internet-based cognitive behavioral therapy, Non-directive support
- Where
- Sweden
- Volunteers
- 180 people
- Sponsor
- Linkoeping University
Prostate Cancer
Fertility After Prostate Brachytherapy
Although brachytherapy toxicity data on erectile dysfunction, urethral dysfunction and bladder and bowel impact has been collected for a number of years, there is limited information on its effect on male fertility.
- Trial name
- NCT04278443
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- East and North Hertfordshire NHS Trust
Prostate Cancer
Evaluation of Clarity Ultrasound Guidance for Prostate Therapy
Radiotherapy (RT) is an important treatment for prostate cancer with over 10,000 men receiving RT per year in the UK. Prostate RT aims to deliver radiation dose to the prostate to kill cancer cells whilst minimizing the dose…
- Trial name
- Clarity-Pro (NCT02388308)
- Testing
- Clarity ultrasound
- Where
- United Kingdom
- Volunteers
- 61 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Hormone-Refractory Prostate Cancer
Multi-Center Phase II Study to Compare MER-101 20mg Tablets to Intravenous Zometa 4mg in Male Bisphosphonate-Naive, Hormone Refractory Prostate Cancer Patients
The objective of MER-101-03 is to examine the effects of two different dosing regimens of MER-101 20mg tablets versus Zometa 4mg IV infusion once-monthly therapy.
- Trial name
- NCT00636740
- Testing
- Zoledronic Acid 20mg Tablets, Zoledronic Acid
- Where
- 13 sites in United States, Estonia and 1 more
- Volunteers
- 30 people
- Sponsor
- Merrion Pharmaceuticals, LLC
Benign Prostatic Hyperplasia, Bladder Outlet Obstruction
Bipolar Transurethral Enucleation (BipolEP) vs Bipolar Transurethral Resection of the Prostate
The aim of this study is to compare two different surgical methods for treating benign prostatic obstruction (BPO). The investigators are going to compare the risks and benefits of bipolar transurethral resection of the prostate…
- Trial name
- NCT03503721
- Testing
- BipolEP, bipolarTURP
- Where
- 2 sites in Austria, Switzerland
- Volunteers
- 84 people
- Sponsor
- Salzburger Landeskliniken
Prostate Hyperplasia, Thulium Fiber Laser
Thulium Fiber Laser Enucleation of the Prostate: Learning Curve and Functional Outcomes - A Prospective Study
The aim of this prospective study is to evaluate the learning curve and functional outcomes of Thulium Fiber Laser Enucleation of the Prostate (TfLEP) performed by a single surgeon.
- Conditions
- Prostate Hyperplasia, Thulium Fiber Laser, Laser Prostate Enucleation
- Trial name
- ThuFLEP (NCT07349147)
- Testing
- Thulium Fiber Laser (TFL) Enucleation
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Muharrem Baturu
Ovarian Neoplasms, Breast Neoplasms
A Phase I Safety Study of a Cancer Vaccine to Treat HLA-A2 Positive Advanced Stage Ovarian, Breast and Prostate Cancer
To determine the safety and immunogenicity profile of two (2) different doses of the vaccine DPX-0907 to treat breast, ovarian and prostate cancer.
- Conditions
- Ovarian Neoplasms, Breast Neoplasms, Prostatic Neoplasms
- Trial name
- NCT01095848
- Testing
- DPX-0907 consists of 7 tumor-specific HLA-A2-restricted peptides, a universal T Helper peptide, a polynucleotide adjuvant, a liposome and Montanide ISA51 VG
- Where
- 5 sites in United States
- Volunteers
- 23 people
- Sponsor
- ImmunoVaccine Technologies, Inc. (IMV Inc.)
Prostate Cancer
Prostate Immobilization Device Used During Radiation Treatments to Decrease Rectal Bleeding
During 3D-conformal external beam radiation therapy treatments for prostate cancer, the prostate gland moves. The purpose of this study is to determine whether the placement of a prostate immobilization device into the rectum…
- Trial name
- NCT00114985
- Testing
- Prostate Immobilization Device
- Volunteers
- 100 people
- Sponsor
- Dana-Farber Cancer Institute
Prostate Cancer
Once-daily Oral Seviteronel in Patients With Castration-Resistant Prostate Cancer Progressing on Enzalutamide or Abiraterone.
The goal of this clinical study is to determine the efficacy and safety of Seviteronel, a lyase-selective inhibitor of CYP17 and an androgen receptor antagonist, in patients with castration-resistant prostate cancer (CRPC) who…
- Trial name
- NCT02445976
- Testing
- Seviteronel: given orally once daily in 28-day cycles
- Where
- 21 sites in United States
- Volunteers
- 197 people
- Sponsor
- Innocrin Pharmaceutical
Advanced Prostate Adenocarcinoma With Neuroendocrine Differentiation, Castration-Resistant Prostate Carcinoma
Testing Two Oral Drugs Combination (Cediranib and Olaparib) Compared to a Single Drug (Olaparib) for Men With Advanced Prostate Cancer
This randomized phase II trial studies how well olaparib with or without cediranib works in treating patients with castration-resistant prostate cancer that has spread to other places in the body (metastatic).
- Conditions
- Advanced Prostate Adenocarcinoma With Neuroendocrine Differentiation, Castration-Resistant Prostate Carcinoma, Metastatic Prostate Adenocarcinoma With Neuroendocrine Differentiation, Metastatic Prostate Carcinoma
- Trial name
- NCT02893917
- Testing
- Cediranib, Olaparib
- Where
- 16 sites in United States
- Volunteers
- 90 people
- Sponsor
- National Cancer Institute (NCI)
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