Clinical trials: Prostate Disease
Prostate Cancer
A Phase I/IIa Study of UV1 Vaccine in Patients With Prostate Cancer
In this study, up to 21 patients with metastatic prostate cancer will receive UV1 (a therapeutic synthetic peptide vaccine) at different dose levels.
- Trial name
- UV1/hTERT2012P (NCT01784913)
- Testing
- UV1 synthetic peptide vaccine and GM-CSF
- Where
- Norway
- Volunteers
- 22 people
- Sponsor
- Ultimovacs ASA
Prostate Cancer
Abiraterone Acetate Trial in African American Prostate Cancer Patients
This is a pilot study of abiraterone acetate in African American/Black patients with castration-resistant prostate cancer. The primary objective is to determine the correlation between germline polymorphisms and antitumor…
- Trial name
- NCT01735396
- Testing
- Abiraterone Acetate
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Prostate Cancer
Docetaxel Followed by Radical Prostatectomy in Patients With High Risk Localized Prostate Cancer
The purpose of this research study is to determine if the combination of chemotherapy and hormone therapy is safe and helpful for patients who plan to have their high-risk prostate cancer surgically removed.
- Trial name
- NCT01250717
- Testing
- Docetaxel, Dexamethasone, Estramustine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Beth Israel Deaconess Medical Center
Prostate Cancer Metastatic
Data Collection in Lutetium Treated Prostate Cancer: Recording of Progression and Tumor Characteristics
This prospective study aims to collect data and blood biomarkers from patients undergoing Lu-PSMA therapy at the Erasmus MC. In doing so, it will provide real-world efficacy and safety data on the drug, gather dosimetry data and…
- Trial name
- LUTRAC (NCT06260410)
- Testing
- Blood draw for ctDNA and circulating tumor cell collection.
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Erasmus Medical Center
ATM Gene Mutation, BRCA1 Gene Mutation
Niraparib Before Surgery in Treating Patients With High Risk Localized Prostate Cancer and DNA Damage Response Defects
This phase II trial studies how well niraparib, when given before surgery, works in treating patients with high risk prostate cancer that has not spread to other parts of the body (localized) and alterations in deoxyribonucleic…
- Conditions
- ATM Gene Mutation, BRCA1 Gene Mutation, BRCA2 Gene Mutation, BRIP1 Gene Mutation
- Trial name
- NCT04030559
- Testing
- Niraparib, Niraparib Tosylate Monohydrate, Radical Prostatectomy
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, Davis
Prostate Cancer
Prostate Ablation Registry and Database for Information, Surveillance, and Evaluation (PARADISE)
Prostate cancer (PCa) is the most commonly diagnosed non-cutaneous cancer of men in the world. In 2023 alone, it is estimated that 288,300 US men will be diagnosed with prostate cancer and 34,700 will die from the disease despite…
- Trial name
- NCT06705803
- Testing
- Prostate Ablation
- Where
- 2 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- University of Chicago
Breast Cancer, Prostate Cancer
Patient Preference Survey for Radiation Oncologists
Limited data exists for the cancer patients' preferences on their patient-doctor interaction with their radiation oncologist. These physicians have the opportunity to develop intimate relationships with their patients since these…
- Conditions
- Breast Cancer, Prostate Cancer, Lung Cancer
- Trial name
- NCT00595218
- Testing
- Physician behavior related to Patient Preference Survey, Patient Preference Results
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Pittsburgh
Prostate Cancer
Development of a Therapeutic Education Program for Patients Operated for Prostate Cancer
The aim is to built a Therapeutic Education Program for patients treated with radical prostatectomy in order to improve their sexuality.
- Trial name
- PEPs PROSTATE (NCT02379260)
- Testing
- Interview with a sociologist
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Institut de Cancérologie de la Loire
Prostate Cancer
Assessing Radio-hybrid Prostate Specific Membrane Antigen (rhPSMA-7.3) (18F) in Healthy Volunteers and Subjects With Prostate Cancer
A Phase 1, Open-label Study to Assess Safety, Biodistribution, and Internal Radiation Dosimetry of rhPSMA-7.3 (18F) Injection in Healthy Volunteers, and to Assess Safety and Investigate the Imaging Characteristics in Subjects…
- Trial name
- NCT03995888
- Testing
- rhPSMA-7.3 (18F) Injection
- Where
- Finland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Blue Earth Diagnostics
Prostatic Neoplasms
Shared Decision Making for Prostate Cancer Screening: a Practice-Based Randomized Controlled Trial
The purpose of this study is to determine whether an intervention designed to help men share decisions about prostate cancer screening with their physician results in better decision making, more shared decisions, and changes in…
- Trial name
- NCT00630188
- Testing
- You Decide, Reducing Your Risks in the Crash
- Where
- 4 sites in United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of North Carolina
Prostate Cancer
Comparison of New SUREcore Biopsy of Needle to Standard of Care During Transperineal Prostate Biopsies
To study a novel biopsy needle system for performing transperineal prostate biopsy. Prostate biopsy remains the standard approach for prostate cancer detection.
- Trial name
- NCT06907446
- Testing
- Comparison of Biopsy Needle Types for Prostate Biopsy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, Davis
Insomnia
Assessing the Feasibility of Web-based Insomnia Treatment Among Prostate Cancer Survivors
This pilot study will recruit Black/African American prostate cancer survivors into a clinical trial and will randomize each person to 1 of 2 possible treatments - an internet-based treatment for insomnia called Sleep Healthy…
- Trial name
- SIESTA-P (NCT07128927)
- Testing
- Sleep Healthy Using the Internet (SHUTi), Patient education
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Georgetown University
Bladder Cancer
Measurements of Sexual Steroids' Concentrations in Prostatic Tissue
In the investigators's previous work, measurements of intra-prostatic concentrations of sex steroids were determined on samples taken from the operating room using a punch.
- Trial name
- Pré-HORM (NCT04256161)
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Hopital Foch
Metastatic Prostate Cancer, Bone Metastasis
Duration of Suppression of Bone Turnover Following Treatment With Zoledronic Acid in Men With Metastatic CRPC
Bone is the most common site of metastases in prostate cancer and bone complications cause substantial morbidity to this population.
- Trial name
- SubDueP (NCT01062503)
- Testing
- Zoledronic acid
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- University Health Network, Toronto
Prostate Cancer, Metastatic Prostate Adenocarcinoma
Tumor Molecular Profiling in Patients With Prostate Cancer
The aim of the study was to evaluate the prevalence, the prognostic and predictive value of gene alterations in unselected patients with prostate cancer.
- Trial name
- NCT05573789
- Testing
- Tumor molecular profiling
- Where
- Greece
- Volunteers
- 220 people
- Sponsor
- Hellenic Cooperative Oncology Group
Prostate Cancer
Study of Anatomic Nerve Sparing Radical Perineal Prostatectomy
Our objective is to evaluate the clinical outcomes for the anatomic radical perineal prostatectomy (RPP) for the surgical management of prostate cancer.
- Trial name
- RPP (NCT00922818)
- Where
- United States
- Sponsor
- Maimonides Medical Center
Prostate Cancer
Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer
RATIONALE: Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells and shrink tumors. Androgens can cause the growth of prostate cancer cells.
- Trial name
- NCT00936390
- Testing
- bicalutamide, flutamide, LHRH agonist (antagonist) therapy
- Where
- 518 sites in United States, Canada
- Volunteers
- 1,538 people
- Sponsor
- Radiation Therapy Oncology Group
Cardiovascular Diseases, Cancer
Phase I Human Analytics (HALO) Study
Discover, optimize, standardize, and validate clinical-trial measures and biomarkers used to diagnose and differentiate cardiovascular, oncologic, neurologic, and other diseases and disorders.
- Conditions
- Cardiovascular Diseases, Cancer, Dementia, Traumatic Brain Injury
- Trial name
- HALO (NCT05423860)
- Testing
- no interventions will be performed (observational)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- HALO Diagnostics
Prostate Cancer
Safety and Efficacy Study of Enzalutamide Versus Bicalutamide in Men With Prostate Cancer
The purpose of this study is to determine the safety and efficacy of enzalutamide vs bicalutamide in asymptomatic or mildly symptomatic patients with prostate cancer who have disease progression despite primary androgen…
- Trial name
- STRIVE (NCT01664923)
- Testing
- Enzalutamide, Bicalutamide
- Where
- 109 sites in United States
- Volunteers
- 396 people
- Sponsor
- Pfizer
Cancer, Breast Cancer
A Study Evaluating the Safety and Pharmacokinetics of ABBV-075 in Subjects With Cancer
This is a Phase 1, first-in-human, dose escalation study in participants with advanced solid tumors to determine the pharmacokinetics, maximum tolerated dose and the recommended Phase 2 dose of ABBV-075 at different monotherapy…
- Conditions
- Cancer, Breast Cancer, Non-Small Cell Lung Cancer, Acute Myeloid Leukemia (AML)
- Trial name
- NCT02391480
- Testing
- ABBV-075, Venetoclax
- Where
- 10 sites in United States
- Volunteers
- 128 people
- Sponsor
- AbbVie
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