Clinical trials: Prostate Neoplasm, open to volunteers
Primary Malignant Neoplasm of Prostate (Diagnosis)
MRI-Guided Cryoablation for Focal Native Prostate Cancer
The purpose of this research is to collect data about the MRI cryoablation procedure your doctor(s) would normally perform in order to treat the participants focal prostate cancer and to evaluate the participants condition after…
- Trial name
- NCT04797039
- Testing
- MR guided cryoablation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Prostatic Neoplasms, Prostate Cancer
Imaging Studies to Check the Local Response of Prostate Cancer to Radiation Therapy
Background: Radiation is a common treatment for prostate cancer. It helps damage tumor cells and causes them to die. Radiation can be effective, but some tumors may be harder to treat with radiation or even with surgery.
- Trial name
- NCT01834001
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Cancer Institute (NCI)
Metastatic Prostate Cancer
AI-Assisted Patient Support in mHSPC
The purpose of this multicenter, open-label, randomized controlled trial is to evaluate whether patient-centered support delivered through a large language model (LLM)-based artificial intelligence (AI) agent reduces anxiety in…
- Trial name
- LUMINOUS (NCT07804030)
- Testing
- The Same Platform without AI Agent, AI Agent-Assisted Patient-Centered Support, Delayed AI Agent-Assisted Patient-Centered Support
- Where
- 4 sites in China
- Volunteers
- 160 people
- Sponsor
- Fudan University
Prostate Cancer, Metastatic Prostate Cancer
Sipuleucel-T (Sip-T) in Combination With N-803 in Metastatic Androgen Pathway Modulation Resistant (mAPMR) Prostate Cancer
This phase Ib single-center open-label de-escalation study uses a modified 3+3 design to determine the safety, tolerability, and recommended phase II dose (RP2D) of the combination of standard of care Sip-T and N-803 in patients…
- Trial name
- NCT07756593
- Testing
- Sipuleucel-T, N803
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Oligo-metastatic Prostate Carcinoma
Radiotherapy for Prostate and Oligo-metastatic Lesions in Patients With Low-burden Oligo-metastatic Prostate Cancer
The existing large prospective study demonstrates the benefits of primary radiotherapy in patients with low-volume oligo-metastatic prostate cancer (OMPC), and there is also more evidence of the benefits of local…
- Trial name
- NCT06198387
- Testing
- hormone and RT, ADT combined with abiraterone
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Changhai Hospital
Urothelial Cancer, Bladder Cancer
A Multi-Center Natural History of Urothelial Cancer and Rare Genitourinary Tract Malignancies
Background: Tumors in the genitourinary tracts can occur in the kidney, bladder, prostate, and testicles and can have common and rare histologies. Some cancers that occur along the genitourinary (GU) tract are rare.
- Conditions
- Urothelial Cancer, Bladder Cancer, Genitourinary Cancer, Urogenital Neoplasms
- Trial name
- NCT04923178
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- National Cancer Institute (NCI)
Prostate Cancer
Comparing Two Different Boost Approaches in Radiation Therapy for People With Prostate Cancer
In this study the investigators will find out whether the use of a new type of boost approach called irreversible electroporation (IRE) is as effective as the standard boost approach of radiation therapy for participants with…
- Trial name
- NCT07548164
- Testing
- NanoKnife System, Stereotactic Body Radiation Therapy
- Where
- 8 sites in United States
- Volunteers
- 224 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Prostate Cancer
Focal Therapy for Localized Prostate Cancer
This prospective registry and longitudinal study that is designed to carefully measure details of prostate cancer patients' outcomes with focal therapy. The goal of which is to improve patient care.
- Trial name
- NCT06270043
- Testing
- Focal Therapy
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Prostate Cancer, Polygenic Risk Score
Polygenic Risk Stratification Combined With mpMRI to Identify Clinically Relevant Prostate Cancer
The goal of this clinical trial is to evaluate a screening method to detect clinically relevant prostate cancer. This clinical trial is using genetic data to determine a man's risk of cancer, together with multiparametric…
- Trial name
- PRS (NCT06398639)
- Testing
- Polygenic Risk Score (PRS)
- Where
- 5 sites in United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Adam S. Kibel, MD
Prostatic Neoplasms
Men at High Genetic Risk for Prostate Cancer
Background: Research studies have shown that genetic changes and family history may increase a man s risk for prostate cancer. Researchers want to follow the prostate health of men who have specific genetic changes associated…
- Trial name
- NCT03805919
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Cancer Institute (NCI)
Postoperative Delirium (POD), Prostate Cancer
A Phase II Clinical Two-Stage Study of Transcranial Magnetic Stimulation in Preventing Postoperative Delirium in Elderly Patients After Urological Surgery
Cases were included based on the inclusion and exclusion criteria, and induction, maintenance, and recovery were conducted in accordance with the standard protocol for general anesthesia.
- Conditions
- Postoperative Delirium (POD), Prostate Cancer, Kidney Tumor
- Trial name
- NCT07480044
- Testing
- Transcranial Magnetic Stimulation Device
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Zhejiang University
Metastatic Castration-resistant Prostate Cancer
Supraphysiologic Testosterone Priming Induces Darolutamide Extended Response
The objective of this study is to determine the safety and clinical effects of alternating pharmacologic (i.e. supraphysiologic) testosterone therapy with darolutamide in men with metastatic prostate cancer as first line hormonal…
- Trial name
- NCT07142551
- Testing
- Testosterone cypionate, Luteinizing hormone-releasing hormone (LHRH) analogue, Darolutamide
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
High-risk Prostate Cancer
A Platform Study of Epigenetic Therapy Before Prostatectomy in Men With Prostate Cancer
This is an open-label, non-randomized, exploratory platform protocol designed to assess the safety and antitumor activity of epigenetic therapies in participants with localized prostate cancer who are undergoing radical…
- Trial name
- NCT06888102
- Testing
- Neoadjuvant Epigenetic Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Edwin Posadas, MD
Prostate Cancer Patients Treated by Radiotherapy
SpaceOAR Post-Market Registry Study
Recently, concerns have been raised by regulators that there is little data about the long-term safety of rectal hydrogel spacers for use in conjunction with radiotherapy treatment for prostate cancer.
- Trial name
- OASIS (NCT07300631)
- Testing
- SpaceOAR / SpaceOAR Vue hydrogel system
- Where
- 8 sites in France, United Kingdom
- Volunteers
- 320 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Prostate Cancer (Adenocarcinoma)
Molecular Imaging Informed Radiation Dose Escalation to Sites of Recurrent Disease and De-escalation to Uninvolved Areas in Salvage Radiotherapy Using SBRT for Prostate Cancer to Reduce Treatment Toxicity
This is a single arm trial that is recruiting a total of 50 participants that have been diagnosed with prostate bed (where the prostate was taken out) or regional (surrounding lymph nodes) recurrence of a prostate cancer…
- Trial name
- MIDAS-SBRT (NCT07515651)
- Testing
- Image-guided Radiotherapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Androgen Deprivation Therapy, Prostate Cancer
Exercise to Enhance Cardiovascular Health Among Black Prostate Cancer Patients With Androgen Deprivation Therapy
The purpose of this research is to determine whether a 16-week culturally tailored, technology-based, aerobic and resistance exercise intervention improves cardiovascular risk factors in Black men diagnosed with prostate cancer…
- Conditions
- Androgen Deprivation Therapy, Prostate Cancer, Prostate Cancer Metastatic
- Trial name
- NCT05327465
- Testing
- Aerobic and resistance exercise, Usual Care
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Dana-Farber Cancer Institute
Prostate Cancer
Hypofractionated Radiosurgery for Localised Prostate Cancer (HYPOSTAT-III)
Hypofractionated radiosurgery with 5 fractions is considered standard of care for localized prostate cancer. The investigators initiated this multicenter phase II prospective trial to analyse feasibility (toxicity) of…
- Trial name
- HYPOSTAT-III (NCT06914544)
- Testing
- Hypofractionated Radiosurgery
- Where
- 6 sites in Germany
- Volunteers
- 175 people
- Sponsor
- University Hospital Schleswig-Holstein
Prostate Cancer, Prostate Adenocarcinoma
Using Tissue-based Spatial Data to Understand How Obesity-related Tumor Metabolites Fuel Prostate Cancer Progression
Evaluate the protein expression of lactate dehydrogenase enzyme (LDHA) and MCT-1/-4 transporters, involved in lactate synthesis and transport, in prostate carcinoma tissues from severely overweight/obese (BMI > 27.5) and…
- Conditions
- Prostate Cancer, Prostate Adenocarcinoma, Prostate Neoplasm, Prostatic Neoplasm
- Trial name
- OBESITA'&PCa (NCT06292897)
- Testing
- observational study
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Metastatic Castration-resistant Prostate Cancer
Darolutamide in Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Despite improvements in treatment, metastatic prostate cancer remains incurable, especially in the case of pretreated metastatic castration-resistant disease (mCRPC), where treatment options are limited, leading to an unmet need.
- Trial name
- NCT06401980
- Testing
- Darolutamide, Standard of care
- Where
- 13 sites in Switzerland
- Volunteers
- 162 people
- Sponsor
- Swiss Cancer Institute
Prostate Cancer
Cost-utility of Focal HIFU vs Prostatectomy
Medico-Economic Randomized Trial comparing Focal HIFU Treatment to Radical Prostatectomy in Patients with Favorable Intermediate Risk Prostate Cancer
- Trial name
- EMERHIT (NCT05710861)
- Testing
- F-HIFU, Radical Prostatectomy
- Where
- 20 sites in France, Guadeloupe
- Volunteers
- 346 people
- Sponsor
- University Hospital, Bordeaux
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